ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 0718

Obesity Impairs Achievement of Clinical Inactive Disease (CID) in Patients with Juvenile Idiopathic Arthritis (JIA) Treated with TNF Inhibitors

Fabio Basta1, Denise Pires Marafon2, Angela Aquilani3, Maria Isabella Petrone4, Andrea Uva5, Hanan Jadoun6, Aurora Puccacco2, Rebecca Nicolai6, Silvia Magni Manzoni2 and Fabrizio De Benedetti7, 11 Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy 2 University Center of Autoimmunity, Johannes Gutenberg-University, Mainz, Germany 3 Acura Rheumatology Center Rhineland Palatinate, Bad Kreuznach, Germany, Mainz, Rheinland-Pfalz, Germany, 2Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, Italy, 3Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Lazio, Italy, 4Dipartimento Pediatrico Universitario Ospedaliero, Tor Vergata University, Roma, Italy, 5Dipartimento Materno-Infantile e Scienze Urologiche, La Sapienza University, Rome, Italy, 6Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, Lazio, Italy, 7Division of Rheumatology, Laboratory of Immuno-Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, Italy

Meeting: ACR Convergence 2020

Keywords: , , , ,

Session Information

Date: Saturday, November 7, 2020

Title: Pediatric Rheumatology – Clinical Poster II: JIA

Session Type: Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: to assess prevalence and disease features associated with obesity in juvenile idiopathic arthritis (JIA) and to evaluate the impact of obesity on the achievement of clinical inactive disease (CID) at six months from the start of treatment with tumor necrosis factor inhibitors (TNFi).

Methods: retrospective analysis of demographic, clinical and laboratory features and body mass index (BMI) collected at the start of TNFi treatment in patients with oligoarticular and rheumatoid factor (RF)-negative polyarticular JIA. Patients were divided into obese and non-obese; demographic, clinical and disease features were compared in the two groups. The distribution of obese, overweight, healthy-weight and underweight patients according to the achievement of CID at 6 months was investigated.

Results: 234 patients with JIA (39% RF-negative polyarthritis, 25% extended oligoarthritis, 36% persistent oligoarthritis) were enrolled in the study. Obesity (BMI ≥95th percentile for age and gender) was present in 31 patients (13.2%). Obese patients compared to non-obese patients, had an older age at disease onset (p=0.020), lower frequency of antinuclear-antibody positivity (p=0.043), a higher number of active joints at baseline (p=0.0048) and higher C-reactive protein at baseline (p=0.043). Obese JIA patients achieved clinical inactive disease (CID) at 6 months with a lower frequency compared to non-obese patients (p=0.005). In multivariate regression analysis obesity at baseline was confirmed as an independent risk factor for non-achievement of CID at 6 months from starting TNFi (OR 2.42 [95% CI 1.04-5.61]; p=0.040).

Conclusion: obesity negatively affects response to TNFi in oligo- and RF-negative polyarticular JIA, independently from other disease-associated variables.

Disclosure: F. Basta, None; D. Pires Marafon, None; A. Aquilani, None; M. Petrone, None; A. Uva, None; H. Jadoun, None; A. Puccacco, None; R. Nicolai, None; S. Magni Manzoni, None; F. De Benedetti, Novartis, 2, 8, Novimmune, 2, 9, Sobi, 2, 8, 9, Roche, 2, 8, Pfizer, 2, Sanofi, 2, AbbVie, 8.

To cite this abstract in AMA style:

Basta F, Pires Marafon D, Aquilani A, Petrone M, Uva A, Jadoun H, Puccacco A, Nicolai R, Magni Manzoni S, De Benedetti F. Obesity Impairs Achievement of Clinical Inactive Disease (CID) in Patients with Juvenile Idiopathic Arthritis (JIA) Treated with TNF Inhibitors [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/obesity-impairs-achievement-of-clinical-inactive-disease-cid-in-patients-with-juvenile-idiopathic-arthritis-jia-treated-with-tnf-inhibitors/. Accessed .

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/obesity-impairs-achievement-of-clinical-inactive-disease-cid-in-patients-with-juvenile-idiopathic-arthritis-jia-treated-with-tnf-inhibitors/