Clinical Characteristics of Patients with Rheumatism of Juvenile Onset and Adult Onset in the BIOBADAGUAY Cohort

Natalia Cabrera¹, Vannia Valinotti², Gabriela Avila-Pedretti¹, Sonia Cabrera², Patricia Melgarejo³, Zoilo Morel⁴, Lourdes Roman², Pedro Babak⁴, Rodrigo Acosta², Romina Glitz⁴, Darwin Cordovilla⁵, Roger Rolon⁴, Magali Zanotti-Cavazzoni¹, Marco Antonio Franco Britos⁶, Marcos Vazquez², Pedro Delgadillo⁴, Isabel Acosta², María del Carmen Martinez⁴, Gabriel Elizaur⁴, María Teresa Romero⁴, Ernesto Paredes⁴, Paloma de Abreu¹ and Leticia Segovia⁷, ¹Sociedad Paraguaya de Reumatología, Asunción, Paraguay, ²Hospital de Clínicas, Asunción, Paraguay, ³Hospital IPS, Villa Rica, Paraguay, ⁴Hospital Central del Instituto de Previsión Social, Asunción, Paraguay, ⁵Instituto Nacional de Reumatología, Montevideo, Uruguay, ⁶Instituto de Previsi�n Social, Asunci�n, Central, Paraguay, ⁷Hospital del IPS, Asunción, Paraguay

Meeting: ACR Convergence 2020

Keywords: Ankylosing spondylitis (AS), Biologicals, Juvenile idiopathic arthritis, Psoriatic arthritis, rheumatoid arthritis

Session Information

Date: Friday, November 6, 2020

Title: Miscellaneous Rheumatic & Inflammatory Diseases Poster I: Diagnosis and Testing

Session Type: Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: The Paraguayan-Uruguayan cohort of patients with rheumatic inflammatory diseases (BIOBADAGUAY), collect clinical and epidemiological information on adults and children patients receiving biological therapies (BT). The obtained data enable to describe with comparative purposes the cohort of patients, considering the age of symptom onset (i.e. juvenile or adult)

Methods: BIOBADAGUAY cohort includes 18 centers (9 in Uruguay and 9 in Paraguay). The descriptive analysis was made in two phases. First, we have selected the adult population on BT and second, we have separated it in two groups according onset of disease considering the age when diagnosis of rheumatic disease was made. Clinical features of both populations were described in a second phase

Results: A total of 766 adult patients was included, in which 91,1% had adult-onset, and 8.9% had juvenile-onset rheumatic disease. Female predominance was observed in both adult-onset and juvenile-onset groups (74.1% vs 64.7%, respectively). Mean disease duration was 18.5 ± 11.2 years for juvenile-onset rheumatic disease and 13.1 ± 8.7 years for adult-onset rheumatic disease. Disease activity was similar for both rheumatoid arthritis and spondylarthritis in the two groups. All of juvenile-onset rheumatic disease patiets, did not have a comorbidity when starting a BT. Mean body mass index was 24.9 ± 4.5 for juvenile-onset rheumatic disease and 27.9 ± 6.0 for adult-onset rheumatic disease. Table 1 describes main clinical and epidemiological characteristics of analyzed populations.

Conclusion: Patients with juvenile-onset rheumatic disease present with particular characteristics (disease duration, comorbidities and mean body mass index) that differentiate them from adult-onset rheumatic disease patients. This should be taken into consideration when assessing and follow-up is being made on each patient

Disclosure: N. Cabrera, None; V. Valinotti, None; G. Avila-Pedretti, None; S. Cabrera, None; P. Melgarejo, None; Z. Morel, None; L. Roman, None; P. Babak, None; R. Acosta, None; R. Glitz, None; D. Cordovilla, None; R. Rolon, None; M. Zanotti-Cavazzoni, None; M. Franco Britos, None; M. Vazquez, None; P. Delgadillo, None; I. Acosta, None; M. Martinez, None; G. Elizaur, None; M. Romero, None; E. Paredes, None; P. de Abreu, None; L. Segovia, None.

To cite this abstract in AMA style:

Cabrera N, Valinotti V, Avila-Pedretti G, Cabrera S, Melgarejo P, Morel Z, Roman L, Babak P, Acosta R, Glitz R, Cordovilla D, Rolon R, Zanotti-Cavazzoni M, Franco Britos M, Vazquez M, Delgadillo P, Acosta I, Martinez M, Elizaur G, Romero M, Paredes E, de Abreu P, Segovia L. Clinical Characteristics of Patients with Rheumatism of Juvenile Onset and Adult Onset in the BIOBADAGUAY Cohort [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/clinical-characteristics-of-patients-with-rheumatism-of-juvenile-onset-and-adult-onset-in-the-biobadaguay-cohort/. Accessed .

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