ACR Meeting Abstracts

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Abstracts tagged "Treg cells"

  • Abstract Number: 1864 • ACR Convergence 2024

    S-4321, a Novel Dual-cell Bidirectional PD-1:FcγRIIb Selective Agonist Antibody for the Treatment of Autoimmune Disease

    Julia Manasson1, Marisella Panduro2, Michael Cianci2, Minasri Borah2, Stephanie Grebinoski2, Joshua Vitlip2, Stephen Lutz2, Ishan Sharma2, Elliott Wittenberg2, Allison Colthart2, Samuel Perry2, Maria Cecilia Ramello2, Chelsea R. Parker Harp2, Jyothsna Visweswaraiah2, Ryan Peckner2, Alex Pellerin2, Heather Vital3, John Sundy4, Nathan Higginson-Scott2, Kevin L. Otipoby2 and Daniela Cipolletta2, 1Seismic Therapeutic, New York, NY, 2Seismic Therapeutic, Watertown, MA, 3Seismic Therapeutic, Lexington, MA, 4Seismic Therapeutic, Chapel Hill, NC

    Background/Purpose: The dysregulation of immune checkpoint receptors on T cells and antigen presenting cells (APCs) drives autoimmunity while receptor agonism is expected to restore immune…
  • Abstract Number: 2632 • ACR Convergence 2024

    Genetically-engineered Ro-specific Regulatory T Cells to Treat Primary Sjögren’s Disease

    Zhi Feng sherman Lim1, Yi Tian Ting1, Fabien Vincent2, Maureen Rischmueller3, Eric Morand4 and Joshua Ooi1, 1Monash University-T Cell Therapies Research Group, Clayton, Victoria, Australia, 2Monash University, Clayton, Victoria, Australia, 3RheumatologySA, Adelaide, Australia, 4School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia

    Background/Purpose: Autoantigen-specific regulatory T cells (Tregs) are potent, and specific, suppressors of pathogenic autoimmunity, and can be harnessed to treat autoimmune disease. In primary Sjögren’s…
  • Abstract Number: 0092 • ACR Convergence 2024

    A New Generation Mesenchymal Stromal Cell (MSC)-based Cell Therapy Using Design of Experiments Halts Pristane Induced Glomerulosclerosis

    Hulya Bukulmez1, Adrienne Dennis2, kristine Highland3 and Steven N. Emancipator4, 1MetroHealth Medical Center, Case Western Reserve, Pepper Pike, OH, 2MetroHealth Medical Center, Case Western Reserve, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH, 4Case Western Reserve University, Cleveland, OH

    Background/Purpose: MSCs, exposed to a disease-specific cytokine profile, can accurately sense the composition of the inflammatory microenvironment. We have harnessed this adaptive ability of MSCs…
  • Abstract Number: 0514 • ACR Convergence 2024

    Efficacy, Safety and Mechanism of Butyrate in the Treatment of Rheumatoid Arthritis (RA)

    Jing He1, Naidi Wang2, Yuhui Li3, Ruoyi Wang2, Xiao Tan2, Runzhi Zhufeng2, Yipeng Han2, Hao Li2, Yuebo Jin2 and Zhanguo Li4, 1Rheumatology, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China, 3Peking University, BeiJing, China, 4People’s Hospital Peking University Health Sciences Centre, Beijing, China

    Background/Purpose: This study aims to investigate the safety and efficacy of butyrate capsules in treating patients with rheumatoid arthritis (RA) and elucidate the underlying mechanisms.Methods:…
  • Abstract Number: 0874 • ACR Convergence 2024

    Defining a Protective Role for Mucosal-associated Invariant T (MAIT) Cells in Spontaneous Cutaneous Lupus Erythematosus

    Grace Crossland1, Lindsay Mendyka2, Michael Constantinides3 and Sladjana Skopelja-Gardner1, 1Dartmouth Geisel School of Medicine, Lebanon, NH, 2Dartmouth Hitchcock Memorial Hospital, Lyme, NH, 3Scripps Research Institute, San Diego, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a leading cause of death in young females, and 70-85% of patients experience skin disease (cutaneous LE, CLE). The…
  • Abstract Number: 0875 • ACR Convergence 2024

    Targeted IL-15 Muteins Provide Selective Expansion of KIR+ CD8 Regulatory T Cells, with the Potential to Ameliorate Disease in Autoimmune Patients with Deficient CD8 Treg Populations

    Daniel Patton, Alex Chen, Justin Bowser, Kaelen Encarnacion, Jennifer Gardell, Emily Gilbertson, Susan Julien, Meghan Maurer, Brent Meengs, Nadine Morgan, Allison O'Rourke, Cong Tan, Jon Therriault, Kristine Swiderek and Courtney Crane, Mozart Therapeutics, Seattle, WA

    Background/Purpose: CD8 Treg, characterized in human peripheral blood mononuclear cells (PBMC) by expression of inhibitory killer immunoglobulin receptors (KIRs), regulate immune balance by eliminating self-reactive…
  • Abstract Number: 1797 • ACR Convergence 2024

    Characterizing Memory T Cell Subsets Associated with SLE Etiopathogenesis

    Carol Nassar1, Rene Quevedo2, M. Teresa Ciudad2, Zoha Faheem3, Kieran Manion4, Carolina Munoz-Grajales5, Michael Kim6, Dafna Gladman7, Murray Urowitz8, Zahi Touma1, Tracy McGaha9 and Joan Wither6, 1University of Toronto, Toronto, ON, Canada, 2Princess Margaret Cancer Centre, Toronto, ON, Canada, 3UHN, Toronto, ON, Canada, 4Toronto Western Hospital, Toronto, ON, Canada, 5UHN/TWH, Toronto, ON, Canada, 6University Health Network, Toronto, ON, Canada, 7University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 8Self employed, Toronto, ON, Canada, 9University Health Network, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease associated with severe morbidity and mortality. Around 70% of SLE patients follow a relapsing-remitting pattern…
  • Abstract Number: 1835 • ACR Convergence 2024

    FoxP3Hi CTLA4+ ICOS+ Regulatory T Cells Are Expanded in Patients with Sarcoidosis but Not Systemic Sclerosis or IgG4-Related Disease

    Laura Yockey1, Thomas Guy2, Chinmay Gadiraju3, Ian Doyle1, Jesse Akaa4, Alison Puri5, Zachary Wallace6, Guy Katz1, Sydney Montesi1, John Stone7, Flavia Castelino1, Shiv Pillai8, Andrew Luster9, Vinay Mahajan3 and Cory Perugino1, 1Massachusetts General Hospital, Boston, MA, 2Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 3Brigham and Women's Hospital, Boston, MA, 4Massachussets General Hospital, Boston, MA, 5Boston University, Brookline, MA, 6Massachusetts General Hospital, Newton, MA, 7Massachusetts General Hospital , Harvard Medical School, Concord, MA, 8Harvard Medical School, Cambridge, MA, 9Massachusetts General Hospital, Charlestown, MA

    Background/Purpose: The absence of regulatory T cells (Tregs) results in multiorgan autoimmunity in the context of monogenic “Tregopathies”, but their role in mediating polygenic autoimmune…
  • Abstract Number: 1845 • ACR Convergence 2024

    Treg Expansion and IL-6 Induced STAT3 Phosphorylation in CD4+ T Cells Is a Biomarker of Disease Flare in Rheumatoid Arthritis

    Amy Anderson1, Luke Jones2, Fiona Rayner3, Jessica Swift1, Daniel Maunder1, Henrique de Paula Lemos1, David Swan4, Abbie Degnan1, Imogen Wilson1, Julie Diboll1, Gary Reynolds1, Jasmine Sim1, Andrew Melville5, Stefan Siebert5, Iain McInnes6, Carl Goodyear5, Catharien Hilkens1, Karim Raza7, Christopher Buckley8, Kenneth Baker1, Arthur Pratt3, Andrew Filer7 and John Isaacs1, 1Translational and Clinical Research Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 2Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, Birmingham, United Kingdom, 3Translational and Clinical Research Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England, United Kingdom, 4Translational and Clinical Research Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, 5School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 6University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 7Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Birmingham, United Kingdom, 8Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom

    Background/Purpose: Understanding the mechanisms that drive disease flares in patients with rheumatoid arthritis (RA) may aid in the development of biomarkers to facilitate targeted treatment…
  • Abstract Number: 1846 • ACR Convergence 2024

    Citrullinated Vimentin-reactive Immune-regulatory CD4+CD39+TIGIThi T Cells Expand During Drug Free Remission in HLA-DR Shared-epitope+ ACPA+ Rheumatoid Arthritis

    Amy Anderson1, Henrique de Paula Lemos1, Hendrik Nel2, Sofia Sorbet Santiago1, Fiona Rayner3, Abbie Degnan1, Imogen Wilson1, Julie Diboll1, Jasmine Sim1, Andrew Melville4, Stefan Siebert4, Iain McInnes5, Carl Goodyear4, Catharien Hilkens1, Andrew Filer6, Karim Raza6, Christopher Buckley7, Hugh Reid8, Kenneth Baker1, Arthur Pratt3, Jamie Rossjohn8, Ranjeny Thomas9 and John Isaacs1, 1Translational and Clinical Research Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 2Frazer Institute, The University of Queensland, Translational Research Institute, Brisbane, Australia, 3Translational and Clinical Research Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University and The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, England, United Kingdom, 4School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 5University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 6Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Birmingham, United Kingdom, 7Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 8Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia, 9University of Queensland, Brisbane, Australia

    Background/Purpose: There is a need for immunotherapy that sustains symptom remission without ongoing need for disease modifying drugs (DMARDs). In a phase 1b trial of…
  • Abstract Number: 1848 • ACR Convergence 2024

    Characterization of Treg Phenotype, Function and Its Transcriptome Signatures in Treatment-naïve Rheumatoid Arthritis

    Vallayyachari Kommoju1, Sree Nethra Bulusu2, Shruthi S Vembar3, Chengappa Kavadichanda4, Molly Thabah5, Christina Mary Mariaselvam2 and Vir Singh Negi6, 1JIPMER, Pondicherry, India, 2JIPMER, Pondicherry, Puducherry, India, 3IGIB, Bengalore, India, 4Jawaharlal Institute of Postgraduate Medical Education and Research, pondicherry, Puducherry, India, 5Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Puducherry, India, 6AIIMS, Bilaspur, Puducherry, Puducherry, India

    Background/Purpose: Inflammatory cytokines in the periphery can affect Treg stability and function by altering its molecular signatures. We aimed to characterize Treg phenotype, function and…
  • Abstract Number: 1852 • ACR Convergence 2024

    Uncovering a MAIT-Treg Axis in Skin UV Response: Implications for Photosensitive Reactions in Cutaneous Lupus Erythematosus

    Grace Crossland1, Lindsay Mendyka2, Kaitlyn Dowling3, Michael Constantinides4 and Sladjana Skopelja-Gardner1, 1Dartmouth Geisel School of Medicine, Lebanon, NH, 2Dartmouth Hitchcock Memorial Hospital, Lyme, NH, 3Dartmouth College, Lebanon, NH, 4Scripps Research Institute, San Diego, CA

    Background/Purpose: Approximately 80% of cutaneous lupus erythematosus (CLE) patients experience sensitivity to ultraviolet (UV) sunlight rays, which leads to disfiguring skin lesions or systemic disease…
  • Abstract Number: 1373 • ACR Convergence 2023

    Deltex1 May Involve the Function of T Regulatory Cells and Regulate the Disease Activity of Sjögren’s Syndrome

    Ming-Han Chen, Division of Allergy, Immunology & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Background/Purpose: Deltex1 is a transcription target of nuclear factor of activated T cells in mice and promotes T cell anergy. We have previously reported that…
  • Abstract Number: 1560 • ACR Convergence 2023

    Decreased Level of Peripheral CLA+ Treg Is a Protective Factor of Nervous System Involvement in Behcet’s Syndrome: A Real-World Study in China

    Jiachen Li1, Feng Sun2, Wenyan Zhou1 and Tian Liu1, 1Peking University People's Hospital, Beijing, China, 2Peking University People’s Hospital, Beijing, China

    Background/Purpose: Behcet's syndrome (BS) is an autoimmune disease characterized by recurrent mucocutaneous ulcerations, vascular and nervous system involvement. While there have been a lot of…
  • Abstract Number: 1707 • ACR Convergence 2023

    PD1-Expressing Regulatory T Cells Found in Inflamed Joints Suppress Tph Cell-B Cell Interactions

    Ki Pui Lam1, Amélie M Julé1, Claudia Harris2, Maria Taylor1, Maryrose Hahn2, Laurie A Ohlms3, Pui Lee2, Margaret Chang4, Talal Chatila5, Peter Nigrovic4 and Lauren Henderson4, 1Division of Immunology, Boston Children’s Hospital, Boston, MA, 2Division of Immunology, Boston Children's Hospital, Boston, MA, 3Department of Otolaryngology & Communication Enhancement, Boston Children’s Hospital, Boston, MA, 4Boston Children's Hospital, Boston, MA, 5Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: T peripheral helper (Tph) cells promote B cell maturation and the generation of antibodies in the inflamed joints of adults with seropositive rheumatoid arthritis…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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