ACR Meeting Abstracts

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Abstracts tagged "T-Regulatory Cells"

  • Abstract Number: 2824 • 2018 ACR/ARHP Annual Meeting

    On Tapering Therapy for RA Patients in Clinical Remission; Flare on Csdmards Predicted By Clinical Features and Musculoskeletal Ultrasound, Whereas T-Cell Abnormalities Predictive for b-DMARD Tapering

    Hanna Gul1, Frederique Ponchel2 and Paul Emery3, 1Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & Leeds NIHR Biomedical Research Centre, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: Tapering of disease-modifying therapy (DMARDs) is recommended by EULAR/ACR for rheumatoid arthritis (RA) patients who achieve sustained remission on stable therapy. However, there is…
  • Abstract Number: 47 • 2018 ACR/ARHP Annual Meeting

    Analysis of the Role of RORγt+Foxp3+ T Regulatory 17 (Tr17) Cells in Murine Autoimmune Arthritis Model

    Kotona Furuyama1, Yuya Kondo1, Masaru Shimizu2, Iizuka Akira1, Masahiro Yokosawa1, Seiji Segawa1, Hiroto Tsuboi1, Isao Matsumoto1 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: RORγt+Foxp3+ regulatory T (Treg) cells, designated as Tr17 is one of the new subset of Treg cells, having the potential to regulate the development…
  • Abstract Number: 52 • 2018 ACR/ARHP Annual Meeting

    Interferon-Alpha Protects Against Pain and Joint Damages in Experimental Arthritis and Is Associated with Expansion of Highly Suppressive Regulatory T Lymphocytes in Protected Mice and in Tocilizumab-Treated Rheumatoid Arthritis Patients

    Matthieu Ribon1, Roxane Hervé2, Delphine Lemeiter2, Katarzyna Matyja1, François Santinon1, Darragh Duffy3, Ken Tsumiyama4, Shunichi Shiozawa5, Marie-Christophe Boissier6, Natacha Bessis2 and Patrice Decker1, 1Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 3Institut Pasteur, Paris, Paris, France, 4Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, 5Institute for Rheumatic Diseases, Nagahama, Japan, 6Rheumatology Department, AP-HP, Avicenne Hospital, Bobigny, France

    Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…
  • Abstract Number: 64 • 2018 ACR/ARHP Annual Meeting

    Dietary Magnesium Modulates the Intestinal Microbiome and T Cell Subsets

    Teresina Laragione1, Carolyn Harris1 and Percio S. Gulko2, 1Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Several studies have demonstrated that Magnesium (Mg) has a key role in the immune responses. Our previous studies showed that a short-term low Mg…
  • Abstract Number: 146 • 2018 ACR/ARHP Annual Meeting

    Mesenchymal Stromal Cell Transferred Mitochondria Elicit an Immune Function Reprogramming That Entails T Regulatory Cell Commitment and Clinical Improvement of Graft Vs Host Disease

    Angela C. Court1, Alice Le-Gatt1, Patricia Luz-Crawford2, Monica Kurte2, Maria Ignacia Ortuzar1, Roberto Elizondo2, Rafael A. Contreras2, Karina Pino-Lagos2, Maroun Khoury3,4 and Fernando E. Figueroa4, 1Cells for Cells, Santiago, Chile, 2Laboratorio de Inmunología Celular y Molecular, Universidad de los Andes, Santiago, Chile, 3Cells for Cells, Santiago de Chile, Chile, 4Program for Translational Research in Cell Therapy, Universidad de los Andes, Santiago de Chile, Chile

    Background/Purpose: Mesenchymal stromal cells (MSCs) are progenitor cells with suppressive capacities that have fueled ample translation for the treatment of immune mediated diseases including Graft…
  • Abstract Number: 399 • 2017 ACR/ARHP Annual Meeting

    Therapeutic Effect of Rosiglitazone-Mediated Dendritic Cells in Established Arthritis in Mice

    Jin Jung Choi1, Sang-Yoon Jung2, Kyung-Su Park3, Chong-Hyeon Yoon4 and Dae-Seog Lim5, 1Rheumatology, CHA University Medical Center at Bundang, Sungnam, Korea, Republic of (South), 2Internal Medicine, Bundang CHA Medical Center, Seongnam, Korea, Republic of (South), 3Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), 4Rheumatology, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of (South), 5Department of biotechnology, CHA University, Sungnam, Korea, Republic of (South)

    Background/Purpose: Rosiglitazone is a selective ligand for peroxisome proliferator-activated receptor-gamma (PPAR-γ), which is expressed by antigen presenting cells (APCs) and plays a fundamental role in…
  • Abstract Number: 1737 • 2017 ACR/ARHP Annual Meeting

    An Abundance of Butyrate-Producing Bacterium in the Intestine and Increased Foxp3 Gene Expression of T Cells in Patients with Relapsing Polychondritis

    Jun Shimizu1, Takao Kubota2 and Noboru Suzuki3, 1Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 2The Japan Self Defense Forces Central Hospital, Tokyo, Japan, 3Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan

    Background/Purpose: Helper T cell subsets including Th17 cells and regulatory T (Treg) cells play a role in the adaptive immune response. RORC and Foxp3 are…
  • Abstract Number: 1740 • 2017 ACR/ARHP Annual Meeting

    Fc-Derived Immunodominant Peptides Stimulate Natural Regulatory T Cells: A New Avenue to Overcome Defects in the Fc Antigen Processing and Restore Immune Regulation in Rheumatic Diseases

    Alessandra Franco, Pediatrics, University of California San Diego School of Medicine, La Jolla, CA

    Background/Purpose: The mechanisms of action of intravenous purified immunoglobulins (IVIG) in acute Kawasaki disease (KD) have been investigated in our laboratory and have led to…
  • Abstract Number: 1911 • 2017 ACR/ARHP Annual Meeting

    Impaired Control of Autoreactive T Cell Expansion Is Coupled with Type-1 Regulatory T Cell Deficiency in BALB/c ZAP70W163C Mutant Mice

    M. Arifur Rahman1, Daphne Montizaan2, Zaied Ahmed Bhuyan3, Linda Rehaume3 and Ranjeny Thomas4, 1The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia, 2The University of Groningen, Groningen, Netherlands, 3The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, 4Dendright Pty Ltd, Brisbane, Australia

    Background/Purpose: In the context of reduced TCR signaling in the BALB/c ZAP70W163C mutant (SKG) mouse, development of arthritis, psoriasis-like skin inflammation and ileitis after intra-peritoneal…
  • Abstract Number: 2422 • 2017 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis (RA) Synovial Fluid Treg Cells Secrete IL-17 and at the Same Time Are Potent Suppressors of Tresp Cell Proliferation, TNF-α and Interferon γ Production

    Lorena Valdeolivas-De Opazo1, Paula Fortea-Gordo1, Marta Benito-Miguel1,2, Alejandro Villalba1, Gema Bonilla1, Diana Peiteado1, Alejandro Balsa1, Pilar Aguado1, Paloma Sanchez-Mateos3, Amaya Puig-Kröger4, Emilio Martín-Mola1 and Maria Eugenia Miranda-Carus1, 1Rheumatology, Hospital La Paz-IdiPAZ, Madrid, Spain, 2Biochemistry, Centro de Ciencias de la Salud San Rafael. Universidad Antonio de Nebrija, Madrid, Spain, 3Immunology, Hospital Gregorio Marañon, Madrid, Spain, 4Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain

    Background/Purpose: IL-17-expressing FoxP3 regulatory T cells have been described, and their suppressive capacity has been questioned. An inflammatory environment seems to favor IL-17 secretion by…
  • Abstract Number: 2698 • 2017 ACR/ARHP Annual Meeting

    IL-21-mTOR Axis Blocks the Differentiation and Function of SLE Tregs Via Suppression of Autophagy

    Hiroshi Kato1 and Andras Perl2, 1Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, 2Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Mechanistic target of rapamycin (mTOR) activation has emerged as a prominent mediator of pro-inflammatory T-cell expansion and regulatory T (Treg) cell depletion in systemic…
  • Abstract Number: 2700 • 2017 ACR/ARHP Annual Meeting

    Fra-2 Overexpression Leads to Systemic Autoimmunity By Affecting IL2 Dependent Treg Homeostasis

    Florian Renoux1, Mara Stellato1, Daniela Impellizzieri2, Alexander Vogetseder3, Przemyslaw Blyszczuk1, Riyun Huang4, Arun Subramaniam5, Clara Dees6, Jörg Distler7, Gabriela Kania1, Onur Boyman2 and Oliver Distler8, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, 3Department of Pathology, Cantonal Hospital Lucerne, Lucerne, Switzerland, 4Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, 5Sanofi-Genzyme, Framingham, MA, 6Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 7Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 8Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Fos-related antigen 2 (Fra-2) is a transcription factor belonging to the Fos family proteins which is part of the AP-1 transcription factor complex. We…
  • Abstract Number: 2701 • 2017 ACR/ARHP Annual Meeting

    TNFR2+ Regulatory T Cellssubpopulations ARE Highly Suppressive and Are Increased on Anti-TNF Treatment

    Francois Santinon1, Maxime Batignes2, Benoit Salomon3, Patrice Decker2, Marie-Christophe Boissier4, Luca Semerano5 and Natacha Bessis2, 1INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, bobigny, France, 2INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 3Sorbonne Universités, UPMC Université Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France, 4Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, 5INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité and Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Rheumatology Department, France, Bobigny, France

    Background/Purpose: In rheumatoid arthritis (RA), regulatory T cells (Tregs) are defective in their suppressive capacities and fail to control chronic inflammation. TNF-α is involved in…
  • Abstract Number: 2867 • 2017 ACR/ARHP Annual Meeting

    CD39 Positive Regulatory T Cells As a Biomarker of Responsiveness to Methotrexate in Rheumatoid Arthritis

    Vikas Gupta1, Shobhita Katiyar2, Ankita Singh2, Ramnath Misra1 and Amita Aggarwal1, 1Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: About 30-40% of patients with RA do not respond to MTX, the first-line therapy in RA. Early identification of responders may allow the use…
  • Abstract Number: 2978 • 2017 ACR/ARHP Annual Meeting

    OX40/OX40L Axis Impairs Follicular and Natural Regulatory T Cell Function in Human Systemic Lupus

    Christophe Richez1, Jean-Francois Augusto2, Clement Jacquemin3, Estibaliz Lazaro4, Marie-Elise Truchetet1, Noémie Gensous5, Isabelle Douchet5, Thierry Schaeverbeke6, Cécile Contin-Bordes7 and Patrick Blanco7, 1Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, 2Department of Nephrology, Angers University Hospital, Angers, France, 3Université de Bordeaux, Bordeaux, France, 4Department of Internal Medecine and Clinical Immunology, Bordeaux University Hospital, Pessac, France, 5UMR CNRS 5164, Bordeaux, France, 6Department of Rheumatology, Bordeaux University Hospital, BORDEAUX, France, 7Immunology, Department of Immunology, Bordeaux University Hospital, Bordeaux, France

    Background/Purpose: Regulatory T cells (Treg) are impaired in human Systemic Lupus Erythematosus (SLE) and contribute to T cell activation. However, the mechanisms responsible for the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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