Abstracts tagged "T-Regulatory Cells"

Abstract Number: 146 • 2018 ACR/ARHP Annual Meeting
Mesenchymal Stromal Cell Transferred Mitochondria Elicit an Immune Function Reprogramming That Entails T Regulatory Cell Commitment and Clinical Improvement of Graft Vs Host Disease
Angela C. Court¹, Alice Le-Gatt¹, Patricia Luz-Crawford², Monica Kurte², Maria Ignacia Ortuzar¹, Roberto Elizondo², Rafael A. Contreras², Karina Pino-Lagos², Maroun Khoury^3,4 and Fernando E. Figueroa⁴, ¹Cells for Cells, Santiago, Chile, ²Laboratorio de Inmunología Celular y Molecular, Universidad de los Andes, Santiago, Chile, ³Cells for Cells, Santiago de Chile, Chile, ⁴Program for Translational Research in Cell Therapy, Universidad de los Andes, Santiago de Chile, Chile
Background/Purpose: Mesenchymal stromal cells (MSCs) are progenitor cells with suppressive capacities that have fueled ample translation for the treatment of immune mediated diseases including Graft…
Abstract Number: 781 • 2018 ACR/ARHP Annual Meeting
Simultaneous Identification of Two Biomarkers in ACTIVE LUPUS Nephritis: Autophagy in Treg CELLS and Prolactin Receptors in B Lymphocytes
Luis J. Jara-Quezada¹, Emma Zurita², Ana Durán², Antonio Sanchez³, Reyna Bustamante³, Gabriela Medina⁴, Miguel A Saavedra⁵, María Pilar Cruz-Dominguez³, Olga Vera-Lastra⁶, María Pilar Jiménez-Arellano⁷, Michel Augusto Martínez-Bencomo³ and Azucena Rodriguez², ¹Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico, Mexico, ²Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico City, Mexico, ³Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico City, Mexico, ⁴Clinical Research Unit, Hospital de Especialidades Centro Medico La Raza,IMSS, Mexico City, Mexico, ⁵Novartis Farmaceutica, Calz de Tlaplan 1779, Mexico, Mexico, ⁶Rheumatology, Instituto Mexicano Seguro Social, Mexico City, Mexico, ⁷Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico CIty, Mexico
Background/Purpose: Recent studies suggest that autophagy defects contributes to systemic lupus erythematosus (SLE) pathogenesis. Prolactin (PRL) is associated with active SLE and stimulates the immune…
Abstract Number: 1086 • 2018 ACR/ARHP Annual Meeting
Low-Dose IL-2 Combined with Rapamycin Efficiently Promotes Remission of Refractory Systemic Lupus Erythematosus
Zhaoyun Liang¹, Xiaona Jing¹, Meihua Hao¹, Chong Gao², Xiao-Feng Li³ and Junwei Chen¹, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China, ²Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, ³Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China
Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease. Regulatory T (Treg) cells and T helper type 17 (Th17) cells play opposite roles…
Abstract Number: 1122 • 2018 ACR/ARHP Annual Meeting
Lymphocyte Immunophenotypes at Randomization on the Scleroderma: Cyclophosphamide or Transplantation Trial: Comparison of Treatment Naïve and DMARD Treated Participants with Healthy Controls
Ankoor Shah¹, Jan Storek², Rob Woolson³, Lynette Keyes-Elstein⁴, Paul Wallace⁵, Maureen D. Mayes⁶, Leslie Crofford⁷, Daniel E. Furst⁸, Ellen Goldmuntz⁹, Richard Nash¹⁰, Peter McSweeney¹⁰ and Keith Sullivan¹¹, ¹Medicine, Duke University Medical Center, Durham, NC, ²University of Calgary, Calgary, AB, Canada, ³Rho Inc, Chapel Hill, NC, ⁴Clinical Statistics, Rho Federal Systems, Inc., Chapel Hill, NC, ⁵Roswell Park Cancer Institute, Buffalo, NY, ⁶Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁷Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ⁸Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁹NIH, Bethesda, MD, ¹⁰Colorado Blood Cancer Institute, Denver, CO, ¹¹Duke University Medical Center, Durham, NC
Background/Purpose: The Scleroderma:Cyclophosphamide or Transplantation Trial (SCOT) study compared stem cell transplant to monthly cyclophosphamide (CYC) in patients with scleroderma (SSc). We studied baseline lymphocyte…
Abstract Number: 1465 • 2018 ACR/ARHP Annual Meeting
Absolute Number of Regulatory T Cells Decreased While Osteopontin Increased in Peripheral Blood of New Onset Patients with Rheumatoid Arthritis
Jianfang Xie¹, Jiao-Jiao He², Xiao-Feng Li³ and Chong Gao⁴, ¹the second hospital of shanxi medical university, taiyuan, China, ²The Second Hospital of Shanxi Medical Univerity, Taiyuan, China, ³Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China, ⁴Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA
Background/Purpose: Rheumatoid arthritis (RA) is a progressive immune-mediated disease involving the synovitis that can culminate in joint destruction and early mortality.IL-17-producing T (Th17) cells and…
Abstract Number: 1740 • 2017 ACR/ARHP Annual Meeting
Fc-Derived Immunodominant Peptides Stimulate Natural Regulatory T Cells: A New Avenue to Overcome Defects in the Fc Antigen Processing and Restore Immune Regulation in Rheumatic Diseases
Alessandra Franco, Pediatrics, University of California San Diego School of Medicine, La Jolla, CA
Background/Purpose: The mechanisms of action of intravenous purified immunoglobulins (IVIG) in acute Kawasaki disease (KD) have been investigated in our laboratory and have led to…
Abstract Number: 1911 • 2017 ACR/ARHP Annual Meeting
Impaired Control of Autoreactive T Cell Expansion Is Coupled with Type-1 Regulatory T Cell Deficiency in BALB/c ZAP70W163C Mutant Mice
M. Arifur Rahman¹, Daphne Montizaan², Zaied Ahmed Bhuyan³, Linda Rehaume³ and Ranjeny Thomas⁴, ¹The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia, ²The University of Groningen, Groningen, Netherlands, ³The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ⁴Dendright Pty Ltd, Brisbane, Australia
Background/Purpose: In the context of reduced TCR signaling in the BALB/c ZAP70W163C mutant (SKG) mouse, development of arthritis, psoriasis-like skin inflammation and ileitis after intra-peritoneal…
Abstract Number: 2422 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA) Synovial Fluid Treg Cells Secrete IL-17 and at the Same Time Are Potent Suppressors of Tresp Cell Proliferation, TNF-α and Interferon γ Production
Lorena Valdeolivas-De Opazo¹, Paula Fortea-Gordo¹, Marta Benito-Miguel^1,2, Alejandro Villalba¹, Gema Bonilla¹, Diana Peiteado¹, Alejandro Balsa¹, Pilar Aguado¹, Paloma Sanchez-Mateos³, Amaya Puig-Kröger⁴, Emilio Martín-Mola¹ and Maria Eugenia Miranda-Carus¹, ¹Rheumatology, Hospital La Paz-IdiPAZ, Madrid, Spain, ²Biochemistry, Centro de Ciencias de la Salud San Rafael. Universidad Antonio de Nebrija, Madrid, Spain, ³Immunology, Hospital Gregorio Marañon, Madrid, Spain, ⁴Immuno-oncology, Hospital Gregorio Marañon, Madrid, Spain
Background/Purpose: IL-17-expressing FoxP3 regulatory T cells have been described, and their suppressive capacity has been questioned. An inflammatory environment seems to favor IL-17 secretion by…
Abstract Number: 2698 • 2017 ACR/ARHP Annual Meeting
IL-21-mTOR Axis Blocks the Differentiation and Function of SLE Tregs Via Suppression of Autophagy
Hiroshi Kato¹ and Andras Perl², ¹Division of Rheumatology/Internal Medicine, SUNY Upstate Medical University, Syracuse, NY, ²Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Mechanistic target of rapamycin (mTOR) activation has emerged as a prominent mediator of pro-inflammatory T-cell expansion and regulatory T (Treg) cell depletion in systemic…
Abstract Number: 2700 • 2017 ACR/ARHP Annual Meeting
Fra-2 Overexpression Leads to Systemic Autoimmunity By Affecting IL2 Dependent Treg Homeostasis
Florian Renoux¹, Mara Stellato¹, Daniela Impellizzieri², Alexander Vogetseder³, Przemyslaw Blyszczuk¹, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jörg Distler⁷, Gabriela Kania¹, Onur Boyman² and Oliver Distler⁸, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ³Department of Pathology, Cantonal Hospital Lucerne, Lucerne, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁸Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Fos-related antigen 2 (Fra-2) is a transcription factor belonging to the Fos family proteins which is part of the AP-1 transcription factor complex. We…
Abstract Number: 2701 • 2017 ACR/ARHP Annual Meeting
TNFR2+ Regulatory T Cellssubpopulations ARE Highly Suppressive and Are Increased on Anti-TNF Treatment
Francois Santinon¹, Maxime Batignes², Benoit Salomon³, Patrice Decker², Marie-Christophe Boissier⁴, Luca Semerano⁵ and Natacha Bessis², ¹INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, bobigny, France, ²INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ³Sorbonne Universités, UPMC Université Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France, ⁴Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, ⁵INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité and Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Rheumatology Department, France, Bobigny, France
Background/Purpose: In rheumatoid arthritis (RA), regulatory T cells (Tregs) are defective in their suppressive capacities and fail to control chronic inflammation. TNF-α is involved in…
Abstract Number: 2867 • 2017 ACR/ARHP Annual Meeting
CD39 Positive Regulatory T Cells As a Biomarker of Responsiveness to Methotrexate in Rheumatoid Arthritis
Vikas Gupta¹, Shobhita Katiyar², Ankita Singh², Ramnath Misra¹ and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: About 30-40% of patients with RA do not respond to MTX, the first-line therapy in RA. Early identification of responders may allow the use…
Abstract Number: 2978 • 2017 ACR/ARHP Annual Meeting
OX40/OX40L Axis Impairs Follicular and Natural Regulatory T Cell Function in Human Systemic Lupus
Christophe Richez¹, Jean-Francois Augusto², Clement Jacquemin³, Estibaliz Lazaro⁴, Marie-Elise Truchetet¹, Noémie Gensous⁵, Isabelle Douchet⁵, Thierry Schaeverbeke⁶, Cécile Contin-Bordes⁷ and Patrick Blanco⁷, ¹Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, ²Department of Nephrology, Angers University Hospital, Angers, France, ³Université de Bordeaux, Bordeaux, France, ⁴Department of Internal Medecine and Clinical Immunology, Bordeaux University Hospital, Pessac, France, ⁵UMR CNRS 5164, Bordeaux, France, ⁶Department of Rheumatology, Bordeaux University Hospital, BORDEAUX, France, ⁷Immunology, Department of Immunology, Bordeaux University Hospital, Bordeaux, France
Background/Purpose: Regulatory T cells (Treg) are impaired in human Systemic Lupus Erythematosus (SLE) and contribute to T cell activation. However, the mechanisms responsible for the…
Abstract Number: 399 • 2017 ACR/ARHP Annual Meeting
Therapeutic Effect of Rosiglitazone-Mediated Dendritic Cells in Established Arthritis in Mice
Jin Jung Choi¹, Sang-Yoon Jung², Kyung-Su Park³, Chong-Hyeon Yoon⁴ and Dae-Seog Lim⁵, ¹Rheumatology, CHA University Medical Center at Bundang, Sungnam, Korea, Republic of (South), ²Internal Medicine, Bundang CHA Medical Center, Seongnam, Korea, Republic of (South), ³Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), ⁴Rheumatology, The Catholic University of Korea, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea, Republic of (South), ⁵Department of biotechnology, CHA University, Sungnam, Korea, Republic of (South)
Background/Purpose: Rosiglitazone is a selective ligand for peroxisome proliferator-activated receptor-gamma (PPAR-γ), which is expressed by antigen presenting cells (APCs) and plays a fundamental role in…
Abstract Number: 1737 • 2017 ACR/ARHP Annual Meeting
An Abundance of Butyrate-Producing Bacterium in the Intestine and Increased Foxp3 Gene Expression of T Cells in Patients with Relapsing Polychondritis
Jun Shimizu¹, Takao Kubota² and Noboru Suzuki³, ¹Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ²The Japan Self Defense Forces Central Hospital, Tokyo, Japan, ³Department of Immunology and medicine, St. Marianna University School of Medicine, Kawasaki-shi, 216-8511, Japan
Background/Purpose: Helper T cell subsets including Th17 cells and regulatory T (Treg) cells play a role in the adaptive immune response. RORC and Foxp3 are…

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