ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "T-Regulatory Cells"

  • Abstract Number: 1643 • 2013 ACR/ARHP Annual Meeting

    Ex Vivo Suppression Of RA Effector T Cells (Teff) By Mapc Media Is Synergistic With Treg

    Gali Malul1, David Soler2, Donald D. Anthony3, Hillard M. Lazarus4, Nicholas Lehman5, Thomas McCormick2, Julia M. Sugalski6, Anthony E. Ting5 and Nora G. Singer7, 1Rheumatology, MetroHealth Medical Center, Cleveland, OH, 2Dermatology, Case Medical Center, Cleveland, OH, 3Medicine, Case Western Reserve University, Cleveland, OH, 4Comprehensive Cancer Center, Case Medical Center, Cleveland, OH, 5Athersys, Inc., Cleveland, OH, 6Medicine/infectious disease, Case Western Reserve University, Cleveland, OH, 7Medicine, Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH

    Background/Purpose: Use of mesenchymal/multipotent stem cells (MSCs/MAPCs) is an emerging immune modulatory therapeutic strategy promising for a number of human diseases. Multipotent adult progenitor cells…
  • Abstract Number: 1641 • 2013 ACR/ARHP Annual Meeting

    Bispecific Antibodies For Redirection Of Human Regulatory T Cells To Surface-Inducible Autoantigen La/SS-B

    Stefanie Koristka1, Marc Cartellieri2, Claudia Arndt2, Anja Feldmann2, Irene Michalk2, Claudia C. Bippes2, Nicole Berndt2, Anne Hermsdorf2, Slava Stamova2, Biji T. Kurien3, Robert Hal Scofield4, A. Darise Farris5, Judith A. James6, Holger Bartsch7 and Michael Bachmann2, 1Carl Gustav Carus TU-Dresden, Dresden, Germany, 2Inst. Immunology, Carl Gustav Carus TU-Dresden, Dresden, Germany, 3College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, 5Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, 6Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Inst. Immunol., Carl Gustav Carus TU-Dresden, Dresden, Germany

    Background/Purpose: Adoptive transfer of regulatory T cells (Tregs)  represents a promising strategy for treatment of auto- and alloimmunity. However, it is difficult to obtain therapeutically…
  • Abstract Number: 1412 • 2013 ACR/ARHP Annual Meeting

    Use Of a Biologic Marker For An Integrated Pharmacodynamic and Clinical Analysis To Inform Further Clinical Development, Including Dose Selection For The Phase 2b Trial – Treat 2b – Of Tregalizumab In Rheumatoid Arthritis

    Eva Dokoupilova1, Slawomir Jeka2, Jiri Vencovsky3, Janusz Badurski4, Klaas Prins5, Vibeke Strand6, Edward C. Keystone7, Ronald F van Vollenhoven8, Jurgen Wollenhaupt9, Andrea Wartenberg-Demand10, Gabriele Niemann10, Ahmed Abufarag10, Silke Aigner10, Sibylle Kaiser10, Faiza Rharbaoui10, Niklas Czeloth11, Ralf Wolter10, Benjamin Dälken10 and Thorsten Holzkämper10, 1Medical Plus s.r.o, Uherske Hradiste, Czech Republic, 2Clinic of Rheumatology and Connective Tissue Diseases University Hospital No 2 in Bydgoszcz Collegium Medicum UMK in Torun, Bydgoszcz, Poland, 3Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 4Center of Osteoporosis and Osteo-articular Diseases, Bialystock, Poland, 5qPharmetra, Nijmegen, Netherlands, 6Adjunct, Division of Immunology / Rheumatology, Stanford University, Portola Valley, CA, 7Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 8ClinTRID, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 9Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 10Biotest AG, Dreieich, Germany, 11Global Research Immunology, Biotest AG, Dreieich, Germany

    Background/Purpose: In patients with rheumatoid arthritis (RA) reduced numbers and functional impairment of regulatory T cells (Tregs) have been observed. Tregalizumab is a humanized, agonistic…
  • Abstract Number: 719 • 2013 ACR/ARHP Annual Meeting

    Mammalian Target Of Rapamycin (mTOR) Skews T Cell Lineage Development In Systemic Lupus Erythematosus (SLE)

    Hiroshi Kato1 and Andras Perl2, 1Internal Medicine, Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY, 2Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: mTOR activity is increased in SLE T cells and its blockade has therapeutic efficacy in SLE. Murine studies showed essential roles of mTORC1 in…
  • Abstract Number: 665 • 2013 ACR/ARHP Annual Meeting

    DNA hypermethylation of Forkhead box protein 3 (FOXP3) locus leads to quantitative defects of regulatory T cells in systemic sclerosis

    Yaoyao Wang1, Ye Shu2, Qing Wang1, Ming Zhao1, Gongping Liang1, Qianjin Lu1 and Rong Xiao1, 1Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, 2Department of Dermatology, Hunan Children's Hospital, Changsha, China

    Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of which the etiology and pathogenesis remains complex and poorly understood.  Attention has recently been directed…
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