ACR Meeting Abstracts

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Abstracts tagged "T-Regulatory Cells"

  • Abstract Number: 87 • 2019 ACR/ARP Annual Meeting

    KINE-101, a Novel Synthetic Peptide with Potent Regulatory T Cells Activation to Treat Rheumatoid Arthritis

    Myun Soo Kim 1, Sora Lee 1, Jung Hyun Roh 1, Jung A Kwon 1, Sunyoung Park1 and Daeho Cho 2, 1KINE SCIENCES Co. Ltd., Seoul, Republic of Korea, 2Institute of convergence science/Korea university, Seoul, Republic of Korea

    Background/Purpose: Medical and patient unmet needs still existed in rheumatoid arthritis (RA) global market due to the side effects treated for long duration and sometimes…
  • Abstract Number: 95 • 2019 ACR/ARP Annual Meeting

    IL-21-mediated Suppression of STAT5 Phosphorylation Underlies Treg Depletion and Dysfunction in SLE

    Hiroshi Kato1 and Andras Perl 1, 1SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: IL-21 activates mechanistic target of rapamycin (mTOR) complexes 1 and 2 which in turn block regulatory T (Treg)-cell differentiation and function in patients with…
  • Abstract Number: 112 • 2019 ACR/ARP Annual Meeting

    Impact of Interleukin-9 on the Immune Suppressive Functions of Regulatory T Cells in Rheumatoid Arthritis

    Sushmita Chakraborty 1, Ranjan Gupta 2, Rinkee Kumari 1 and Dipendra Kumar Mitra1, 1All India Institute of Medical Sciences, Delhi, Delhi, India, 2All India Institute of Medical Sciences, New Delhi, India

    Background/Purpose: An important component of the immune tolerance is regulatory T cells (Tregs), which prevents autoimmunity and restrains inflammatory reactions. In Rheumatoid Arthritis (RA), there…
  • Abstract Number: 118 • 2019 ACR/ARP Annual Meeting

    Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity but This Interaction Is Altered in Rheumatoid Arthritis Patients

    Maxime Batignes 1, François Santinon 1, Marie-Christophe Boissier 2, Patrice Decker 1 and Natacha Bessis1, 1Inserm UMR 1125, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2Assistance Publique-Hôpitaux de Paris (AP-HP), Rheumatology Department, Avicenne Hospital, Bobigny, France

    Background/Purpose: Regulatory T cells (Treg) are necessary for immune homeostasis but are functionally deficient in inflammatory/autoimmune diseases such as rheumatoid arthritis (RA). On the other…
  • Abstract Number: 1063 • 2019 ACR/ARP Annual Meeting

    Effects of Abatacept on T Regulatory Cells in Early Diffuse Systemic Sclerosis

    David Fox1, Michael Whitfield 2, Veronica Berrocal 3, Steven K. Lundy 4, Phillip Campbell 5, Stephanie Rasmussen 5, Ray Ohara 6, Alexander Stinson 6, Evan Wiewiora 7, Cathie Spino 7, Erica Bush 8, Daniel Furst 9, Shiv Pillai 10 and Dinesh Khanna 11, 1Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI, 2Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hannover, NH, 3Department of Biostatistics, School of Publich Health, University of Michigan, Ann Arbor, MI, 4TBD, Seattle, WA, 5Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 6Washington University, St. Louis, MO, 7Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, 8Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 9University of California at Los Angeles, Los Angeles, CA, 10Ragon Institude of MGH, MIT and Harvard, Charlestown, MA, 11Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor

    Background/Purpose: Background: In a randomized controlled trial of abatacept in early diffuse systemic sclerosis (Khanna D, et al ACR 2018), we observed early clinical flares…
  • Abstract Number: 1293 • 2019 ACR/ARP Annual Meeting

    Multiple Subpopulations of Lymphocytes Were Absolutely Decreased in Dermatomyositis/polymyositis Patients and Restored by Low-dose IL-2

    Jia Wang 1, He-hua Sun 1, Sheng-xiao Zhang2, Jia-qian Zhang 1, Jiang Bai 3, Jing Luo 3, Cai-hong Wang 4, Chong Gao 5 and Xiao-feng Li 1, 1The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), 2The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (People's Republic), 3Shanxi Medical University, Taiyuan, China (People's Republic), 4The Second Hospital of Shanxi Medical University, Tai Yuan, China (People's Republic), 5Brigham and Women’s Hospital, Harvard Medical School, Boston

    Background/Purpose: Dermatomyositis (DM) and polymyositis (PM) are rare chronicinflammatory disorders with significant associated morbidityand mortality despite treatment, characterized by subacute onset of proximal muscle weakness,…
  • Abstract Number: 2879 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of Low-dose IL-2 in Rebuilting Immunity Re-equilibrium of Psoriatic Arthritis Patients

    Jia Wang 1, Yu-fei Hao 2, Sheng-xiao Zhang2, Quan-run Li 3, Jing-yuan Yang 3, Jia-qian Zhang 1, Guang-ying Liu 1, Chong Gao 4 and Xiao-feng Li 1, 1The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), 2The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (People's Republic), 3Shanxi Medical University, Taiyuan, China (People's Republic), 4Brigham and Women’s Hospital, Harvard Medical School, Boston

    Background/Purpose: Psoriatic arthritis (PsA) is a T lymphocytes-mediated inflammatory condition. Although regulatory T cells (Tregs) isolated from blood and psoriatic skin have been showed a…
  • Abstract Number: 2824 • 2018 ACR/ARHP Annual Meeting

    On Tapering Therapy for RA Patients in Clinical Remission; Flare on Csdmards Predicted By Clinical Features and Musculoskeletal Ultrasound, Whereas T-Cell Abnormalities Predictive for b-DMARD Tapering

    Hanna Gul1, Frederique Ponchel2 and Paul Emery3, 1Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & Leeds NIHR Biomedical Research Centre, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: Tapering of disease-modifying therapy (DMARDs) is recommended by EULAR/ACR for rheumatoid arthritis (RA) patients who achieve sustained remission on stable therapy. However, there is…
  • Abstract Number: 47 • 2018 ACR/ARHP Annual Meeting

    Analysis of the Role of RORγt+Foxp3+ T Regulatory 17 (Tr17) Cells in Murine Autoimmune Arthritis Model

    Kotona Furuyama1, Yuya Kondo1, Masaru Shimizu2, Iizuka Akira1, Masahiro Yokosawa1, Seiji Segawa1, Hiroto Tsuboi1, Isao Matsumoto1 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Internal Medicine, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: RORγt+Foxp3+ regulatory T (Treg) cells, designated as Tr17 is one of the new subset of Treg cells, having the potential to regulate the development…
  • Abstract Number: 52 • 2018 ACR/ARHP Annual Meeting

    Interferon-Alpha Protects Against Pain and Joint Damages in Experimental Arthritis and Is Associated with Expansion of Highly Suppressive Regulatory T Lymphocytes in Protected Mice and in Tocilizumab-Treated Rheumatoid Arthritis Patients

    Matthieu Ribon1, Roxane Hervé2, Delphine Lemeiter2, Katarzyna Matyja1, François Santinon1, Darragh Duffy3, Ken Tsumiyama4, Shunichi Shiozawa5, Marie-Christophe Boissier6, Natacha Bessis2 and Patrice Decker1, 1Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 3Institut Pasteur, Paris, Paris, France, 4Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, 5Institute for Rheumatic Diseases, Nagahama, Japan, 6Rheumatology Department, AP-HP, Avicenne Hospital, Bobigny, France

    Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…
  • Abstract Number: 64 • 2018 ACR/ARHP Annual Meeting

    Dietary Magnesium Modulates the Intestinal Microbiome and T Cell Subsets

    Teresina Laragione1, Carolyn Harris1 and Percio S. Gulko2, 1Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Several studies have demonstrated that Magnesium (Mg) has a key role in the immune responses. Our previous studies showed that a short-term low Mg…
  • Abstract Number: 146 • 2018 ACR/ARHP Annual Meeting

    Mesenchymal Stromal Cell Transferred Mitochondria Elicit an Immune Function Reprogramming That Entails T Regulatory Cell Commitment and Clinical Improvement of Graft Vs Host Disease

    Angela C. Court1, Alice Le-Gatt1, Patricia Luz-Crawford2, Monica Kurte2, Maria Ignacia Ortuzar1, Roberto Elizondo2, Rafael A. Contreras2, Karina Pino-Lagos2, Maroun Khoury3,4 and Fernando E. Figueroa4, 1Cells for Cells, Santiago, Chile, 2Laboratorio de Inmunología Celular y Molecular, Universidad de los Andes, Santiago, Chile, 3Cells for Cells, Santiago de Chile, Chile, 4Program for Translational Research in Cell Therapy, Universidad de los Andes, Santiago de Chile, Chile

    Background/Purpose: Mesenchymal stromal cells (MSCs) are progenitor cells with suppressive capacities that have fueled ample translation for the treatment of immune mediated diseases including Graft…
  • Abstract Number: 781 • 2018 ACR/ARHP Annual Meeting

    Simultaneous Identification of Two Biomarkers in ACTIVE LUPUS Nephritis: Autophagy in Treg CELLS and Prolactin Receptors in B Lymphocytes

    Luis J. Jara-Quezada1, Emma Zurita2, Ana Durán2, Antonio Sanchez3, Reyna Bustamante3, Gabriela Medina4, Miguel A Saavedra5, María Pilar Cruz-Dominguez3, Olga Vera-Lastra6, María Pilar Jiménez-Arellano7, Michel Augusto Martínez-Bencomo3 and Azucena Rodriguez2, 1Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico, Mexico, 2Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,, Mexico City, Mexico, 3Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico City, Mexico, 4Clinical Research Unit, Hospital de Especialidades Centro Medico La Raza,IMSS, Mexico City, Mexico, 5Novartis Farmaceutica, Calz de Tlaplan 1779, Mexico, Mexico, 6Rheumatology, Instituto Mexicano Seguro Social, Mexico City, Mexico, 7Hospital de Especialidades "Dr. Antonio Fraga Mouret", Centro Médico Nacional "La Raza", Mexico CIty, Mexico

    Background/Purpose: Recent studies suggest that autophagy defects contributes to systemic lupus erythematosus (SLE) pathogenesis. Prolactin (PRL) is associated with active SLE and stimulates the immune…
  • Abstract Number: 1086 • 2018 ACR/ARHP Annual Meeting

    Low-Dose IL-2 Combined with Rapamycin Efficiently Promotes Remission of Refractory Systemic Lupus Erythematosus

    Zhaoyun Liang1, Xiaona Jing1, Meihua Hao1, Chong Gao2, Xiao-Feng Li3 and Junwei Chen1, 1The Second Hospital of Shanxi Medical University, Taiyuan, China, 2Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA, 3Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease. Regulatory T (Treg) cells and T helper type 17 (Th17) cells play opposite roles…
  • Abstract Number: 1122 • 2018 ACR/ARHP Annual Meeting

    Lymphocyte Immunophenotypes at Randomization on the Scleroderma: Cyclophosphamide or Transplantation Trial: Comparison of Treatment Naïve and DMARD Treated Participants with Healthy Controls

    Ankoor Shah1, Jan Storek2, Rob Woolson3, Lynette Keyes-Elstein4, Paul Wallace5, Maureen D. Mayes6, Leslie Crofford7, Daniel E. Furst8, Ellen Goldmuntz9, Richard Nash10, Peter McSweeney10 and Keith Sullivan11, 1Medicine, Duke University Medical Center, Durham, NC, 2University of Calgary, Calgary, AB, Canada, 3Rho Inc, Chapel Hill, NC, 4Clinical Statistics, Rho Federal Systems, Inc., Chapel Hill, NC, 5Roswell Park Cancer Institute, Buffalo, NY, 6Rheumatology, University of Texas McGovern Medical School, Houston, TX, 7Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 8Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 9NIH, Bethesda, MD, 10Colorado Blood Cancer Institute, Denver, CO, 11Duke University Medical Center, Durham, NC

    Background/Purpose: The Scleroderma:Cyclophosphamide or Transplantation Trial (SCOT) study compared stem cell transplant to monthly cyclophosphamide (CYC) in patients with scleroderma (SSc). We studied baseline lymphocyte…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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