ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 952 • 2017 ACR/ARHP Annual Meeting

    Serine Arginine-Rich Splicing Factor 1 (SRSF1) Is a Novel Regulator of T Lymphocyte Homeostasis In Vivo and Its Deficiency Associates with Lymphopenia in SLE Patients

    Takayuki Katsuyama1, Michael W. Mosho1, Andrew R. Gillooly2, George C. Tsokos1 and Vaishali R. Moulton3, 1Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA

    Background/Purpose: Lymphopenia is a common clinical feature in patients with systemic lupus erythematosus (SLE), and associates with high disease activity and comorbidities including infections. However,…
  • Abstract Number: 1739 • 2017 ACR/ARHP Annual Meeting

    Vδ1, Vδ2, and Other γδT Cells in Blood and Synovium of Rheumatoid Arthritis and Other Autoimmune Arthritides

    Anna Helena Jonsson1, Michael Gurish1, Lauren Henderson2, Peter Nigrovic1 and Michael Brenner3, 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Innate-like T cells comprise on average 10-15% of peripheral T cell and have T-cell receptors (TCRs) that engage ligands other than classic HLA class…
  • Abstract Number: 2703 • 2017 ACR/ARHP Annual Meeting

    Single Cell Analysis of TCRs from CD8+ T Cells in Sjogren’s Syndrome

    Michelle L. Joachims1, Christina Lawrence1, Richard C. Pelikan1, Kerry M. Leehan1, Lida Radfar2, David M. Lewis3, Astrid Rasmussen1, R. Hal Scofield1, Kiely Grundahl1, Kathy L. Sivils1, Linda F. Thompson1 and A. Darise Farris1, 1Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 3Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune exocrinopathy characterized by focal lymphocytic infiltration of the salivary and lacrimal glands, severe dry eyes and mouth, fatigue…
  • Abstract Number: 953 • 2017 ACR/ARHP Annual Meeting

    Persistence of Pathogenic CD4 Memory T Cells Revealed through Cytometry Time of Flight in Juvenile Idiopathic Arthritic Patients with Disease Resurgence upon Withdrawal of Anti-TNFA Biologics

    Jing Yao Leong1, Joo Guan Yeo2, Phyllis Chen3, Liyun Lai4, Fauziah Ally5, Loshinidevi D/O Thana Bathi3, Justin Hung Tiong Tan2, Thaschawee Arkachaisri2, Femke van Wijk6, Salvatore Albani4, Daniel J Lovell7 and Gerdien Mijnheer8, 1SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 2Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, 3Singhealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 4SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 5STIIC, SingHealth Translational Immunology and Inflammation Centre, Singapore, Singapore, 6University Medical Center Utrecht, Utrecht, Netherlands, 7Rheumatology, PRCSG - Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, 81Laboratory of Translational Immunology, Department of Paediatric Immunology, , The Netherlands, University Medical Centre Utrecht, Wilhelmina Children’s Hospital, Utrecht, Netherlands

    Background/Purpose: Treatment of polyarticular JIA with anti-TNFA biologics has experienced significant success, with up to 80% of patients demonstrating clinically meaningful efficacy. Yet concerns regarding…
  • Abstract Number: 1742 • 2017 ACR/ARHP Annual Meeting

    Involvement of T Helper 17 Cells in Inflammatory Arthritis Depends on the Host Intestinal Microbiota

    Heather Evans-Marin1, Rebecca Rogier2, Jose U. Scher3, Debbie M. Roeleveld2, Marije I. Koenders4 and Shahla Abdollahi-Roodsaz5,6, 1Division of Rheumatology, New York University School of Medicine, New York, NY, 2Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3New York University School of Medicine, New York, NY, 4Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 5Department of Medicine, Division of Rheumatoogy, New York University School of Medicine, New York, NY, 6Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands

    Background/Purpose: The intestinal microbiota has been associated with psoriatic and rheumatoid arthritis. One of the major effects of microbiota is the induction of mucosal T…
  • Abstract Number: 2706 • 2017 ACR/ARHP Annual Meeting

    T Follicular-Helper CELLS (TFH) Enrichment and  T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren’s Syndrome Patients

    Elena Pontarini1, William Murray Brown2, Cristina Croia2, Elisa Corsiero3, Davide Lucchesi2, Elisa Astorri2, Nurhan Sutcliffe2, Anwar Tappuni2, Costantino Pitzalis4 and Michele Bombardieri5, 1William Harvey Research Institute, London, United Kingdom, 2Queen Mary University of London, London, United Kingdom, 3Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 4Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 5Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom

    Background/Purpose: Lymphocytic aggregates in the salivary glands (SG) of Sjögren’s syndrome (SS) can organize in ectopic lymphoid structures (ELS) forming functional germinal centers (GCs), which…
  • Abstract Number: 954 • 2017 ACR/ARHP Annual Meeting

    Microrna-21 Is a Critical Regulator of Autoimmunity through Promoting Effector and Metabolic Function of Pathogenic TH17 Cells

    Xiang Yu1 and Nan Shen1,2,3, 1Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, and Shanghai Jiao Tong University, Shanghai, China, 2Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, 3Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that causes mortality and morbidity worldwide. Recent studies suggest proinflammatory TH17 cells are key pathogenic…
  • Abstract Number: 1743 • 2017 ACR/ARHP Annual Meeting

    Serine Arginine/Rich Splicing Factor 1 (SRSF1) Increases IL-2 Production in T Cells By Increasing the Expression of NFAT and c-Fos

    Takayuki Katsuyama1, Michael W. Mosho1, George C. Tsokos1 and Vaishali R. Moulton2, 1Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA

    Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) produce insufficient amounts of the vital cytokine IL-2, and the molecular mechanisms leading to this…
  • Abstract Number: 2708 • 2017 ACR/ARHP Annual Meeting

    Placental Growth Factor Regulates the Generation of T-Helper 17 Cells to Link Angiogenesis with Autoimmunity

    Seung-Ah Yoo Sr.1, Min-cheol Kang Sr.2, Mingyo Kim Sr.3, Jin-Sun Kong Sr.1, Ki-Myo Kim Sr.1, junghee Koh Sr.1, Chul-Soo Cho4, Seung-Hyo Lee Sr.5, Zae Young Ryoo Sr.6 and Wan-Uk Kim Sr.1,7, 1The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), 2School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, seoul, Korea, Republic of (South), 3Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, seoul, Korea, Republic of (South), 4Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South), 5Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, SEOUL, Korea, Republic of (South), 6School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, SEOUL, Korea, Republic of (South), 7The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)

    Background/Purpose: T-helper (Th) cells actively communicate with adjacent cells by secreting soluble mediators, and yet crosstalk between Th cells and endothelial cells is poorly understood.…
  • Abstract Number: 73 • 2017 ACR/ARHP Annual Meeting

    Regulation of Th17 Cell Responses By IL-25

    Sophie Archer, Ash Maroof, Meryn Griffiths and Stevan Shaw, UCB Pharma, Slough, United Kingdom

    Background/Purpose: IL-17A is a Th17 proinflammatory cytokine that contributes to the pathophysiology of several immune-mediated inflammatory diseases including PsA; while previously underestimated, there is increasing…
  • Abstract Number: 971 • 2017 ACR/ARHP Annual Meeting

    Synovial Fibroblast CD318 Expression Mediates T Cell Adhesion and Migration in Rheumatoid Arthritis

    Ray A. Ohara1, Stephanie M. Rasmussen1, W. Alexander Stinson1, Huadong Cui1, Yuxuan Du1, Daniel P. Weber1, M. Asif Amin1, Phillip L. Campbell2, Nora Singer3, Feng Lin4, David A. Fox1 and Jeffrey H. Ruth5, 1Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, 2Ann Arbor, MI, 3Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, 4Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, Cleveland, OH, 5Internal Medicine, Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI

    Background/Purpose: CD6 is an important marker and regulator of T cells and interacts with its known ligand, CD166. Our group has previously shown that interferon…
  • Abstract Number: 1744 • 2017 ACR/ARHP Annual Meeting

    Transciptome Profile of Inflammation Inducted Circulating Effector and Regulatory T Cells Is Dominated By HLA-DR Pivoted Functional Networks in Active Juvenile Idiopathic Arthritis Patients

    Jing Yao Leong1, Salvatore Albani2, Pavanish Kumar2, Joo Guan Yeo3, Phyllis Chen1, Sharifah Nur Hazirah2, Camillus Chua2, Suzan Saidin2, Justin Hung Tiong Tan3, Thaschawee Arkachaisri3, Alberto Martini4, Marco Gattorno5 and Alessandro Consolaro6, 1Singhealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 2SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, 3Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, 4PRINTO Coordinating Centre, Genoa, Italy, 5Pediatric Rheumatology, G. Gaslini Institute, Genoa, Italy, 6Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy

    Background/Purpose: We have previously identified two dichotomous CD4 pathogenic subsets in both T effector (CPLs: Circulating pathogenic like lymphocytes) and T regulatory (iaTreg: inflammation associated…
  • Abstract Number: 2709 • 2017 ACR/ARHP Annual Meeting

    Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target for Patients with Rheumatoid Arthritis

    Lisa Goschl1,2, Michael Bonelli3, Victoria Saferding4, Teresa Peglej2, Sylvia Knapp5, Johan Bäcklund6, Christoph Bock5, Patrick Matthias7, Kiyoshi Hirahara8, Clemens Scheinecker1, Günter Steiner9, Josef S. Smolen1 and Wilfried Ellmeier2, 1Medical University of Vienna, Devision of Rheumatology, Vienna, Austria, 2Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, 3Rheumatology, Medical University of Vienna, Vienna, Austria, 4Medical University of Vienna, Austria, Vienna, Austria, 5CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, 6Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, 7Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, 8Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan, 9Medical University of Vienna, Dvision of Rheumatology, Vienna, Austria

    Background/Purpose: Autoreactive T cells drive the inflammatory process, which leads to an irreversible destruction of the joints. Gene transcription and regulation of proinflammatory cytokine production…
  • Abstract Number: 176 • 2017 ACR/ARHP Annual Meeting

    SEC16A and Antigen Presentation Abnormalities in the Pathogenesis of Axial Spondyloarthritis

    Fanxing Zeng1, Vidya Ranganathan2, Proton Rahman3, Darren O’Rielly4 and Nigil Haroon5, 1University Health Network, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, 4Memorial University, St John's, NF, Canada, 5Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada

    Background/Purpose: Axial Spondyloarthritis (AxSpA) is a chronic inflammatory rheumatic disease of axial skeleton. Our group recently identified a novel rare mutation of the SEC16A gene…
  • Abstract Number: 1065 • 2017 ACR/ARHP Annual Meeting

    Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus Is Realted to an Intrinsic Defect in the Ca2+/Calcineurin/NFAT1 Signaling Pathway

    Yong-Wook Park1, Young-Nan Cho2, Hye-Mi Jin1, Tae-Jong Kim3 and Seung-Jung Kee4, 1Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), 2Rheumatology, Chonnam National University Hospital and Medical School, Gwangju, MN, Korea, Republic of (South), 3Chonnam Nat`l University Medical School&Hospital, Chonnam, Korea, Republic of (South), 4Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South)

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of…
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