Abstracts tagged "T cells"

Abstract Number: 1567 • 2017 ACR/ARHP Annual Meeting
A Mitogen-Associated Protein Kinase (MAPK) Associated Kinase 2 Inhibitor Decreases in Vitro Th17 and Monocyte Inflammatory Responses in Spondyloarthritis
Davide Simone, Hui Shi, Nuha Ansar, Alison Davies, Karen Doig and Paul Bowness, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: The current biologic treatment for Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA) are limited to TNF-a inhibitors (TNFi) and, more recently, IL-17A monoclonal antibodies.…
Abstract Number: 1911 • 2017 ACR/ARHP Annual Meeting
Impaired Control of Autoreactive T Cell Expansion Is Coupled with Type-1 Regulatory T Cell Deficiency in BALB/c ZAP70W163C Mutant Mice
M. Arifur Rahman¹, Daphne Montizaan², Zaied Ahmed Bhuyan³, Linda Rehaume³ and Ranjeny Thomas⁴, ¹The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia, ²The University of Groningen, Groningen, Netherlands, ³The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ⁴Dendright Pty Ltd, Brisbane, Australia
Background/Purpose: In the context of reduced TCR signaling in the BALB/c ZAP70W163C mutant (SKG) mouse, development of arthritis, psoriasis-like skin inflammation and ileitis after intra-peritoneal…
Abstract Number: 2772 • 2017 ACR/ARHP Annual Meeting
Unbound IL-18 Distinguishes Human Macrophage Activation Syndrome from Familial Hemophagocytic Lymphohistiocytosis and Affects Innate Versus Adaptive Murine Lymphocytes Differently
Paul Tsoukas¹, Eric Weiss², Dirk Holzinger³, Charlotte Girard⁴, Dirk Foell⁵, Alexei A. Grom⁶, Sandra Ammann⁷, Stephan Ehl⁷, Eduardo Schiffrin⁸, Adriana Almeida de Jesus⁹, Raphaela Goldbach-Mansky⁹, Cem Gabay¹⁰ and Scott Canna¹¹, ¹Pediatric Rheumatology, Children’s Hospital of Pittsburgh, Pittsburgh, PA, ²RK Mellon Institute, Children’s Hospital of Pittsburgh, Pittsburgh, PA, ³Department of Pediatric Rheumatology and Immunology, University of Muenster, Muenster, Germany, ⁴Division of Rheumatology, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland, ⁵University of Muenster, Muenster, Germany, ⁶Pediatric Rheumatology, Cincinnati Children’s Hospital, Cincinnati, OH, ⁷Center for Chronic Immunodeficiency, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁸AB2 Bio, Lausanne, Switzerland, ⁹Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, ¹⁰SCQM, Geneva, Switzerland, Geneva, Switzerland, ¹¹Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburrgh, PA
Background/Purpose: Persistently and extremely elevated serum IL-18 has been associated with Macrophage Activation Syndrome (MAS). Chronic IL-18 is hypothesized to contribute to excessive interferon (IFN)-g…
Abstract Number: 658 • 2017 ACR/ARHP Annual Meeting
Functionally Active MAIT Cells in Psoriatic Arthritis: A New Member of the IL-23/IL-17 Cytokine Network
Siba P. Raychaudhuri¹ and Smriti K. Raychaudhuri², ¹Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: The mucosal-associated invariant T (MAIT) cells recently have been implicated in autoimmune diseases. Murine model experiments also suggest that MAIT cells are capable…
Abstract Number: 1575 • 2017 ACR/ARHP Annual Meeting
JMJD3 Epigenetically Regulate Ankylosing Spondylitis Inflammation through Th17 Differentiation
Hongxiao Liu¹, Ziqi Xu¹, Xinghua Feng¹, Xiaoyan Feng², Heqiu Zhang², Quan Jiang¹, Yanan Zhao³, Yuyang Wang¹ and Zhe Zhao¹, ¹Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ²Department of Vaccine Engineering, Beijing Institute of Basic Medical Sciences, Beijing, China, ³Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, BeiJing, China
JMJD3 epigenetically regulate ankylosing spondylitis inflammation through Th17 differentiation Background/Purpose: Inflammation is the initial stage of ankylosing spondylitis (AS), looking for possible inflammatory regulator will…
Abstract Number: 1912 • 2017 ACR/ARHP Annual Meeting
Broad Immunophenotyping Results: CCR10 Expressing CD8 T Cells Distinguish Psoriatic Arthritis from Psoriasis Limited to Skin Involvement
Emmerik F.A. Leijten^1,2, Tessa S. van Kempen^1,2, Michel A.M. Olde Nordkamp^1,2, Fleurieke H. Verhagen^2,3, Sanne Hiddingh^2,3, Jonas J.W. Kuiper^2,3, Marianne L. Boes^2,4 and Timothy R.D.J. Radstake^1,2, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Pediatrics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Studies that compare the immune cell phenotype or function from patients with psoriatic arthritis (PsA) to patients with psoriasis limited to cutaneous involvement (Pso)…
Abstract Number: 2792 • 2017 ACR/ARHP Annual Meeting
Th22 Cells Are a Potent Inducer of Osteoclastogenesis in Rheumatoid Arthritis
Yusuke Miyazaki¹, Shingo Nakayamada², Satoshi Kubo¹, Kazuhisa Nakano², Kei Sakata³, Shigeru Iwata⁴, Ippei Miyagawa⁵ and Yoshiya Tanaka⁶, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyshu, Japan, ⁴First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁶The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: CD4+ T cells can differentiate into functionally distinct subsets and play a pivotal role in rheumatoid arthritis (RA). Th22 cells have been identified as…
Abstract Number: 659 • 2017 ACR/ARHP Annual Meeting
IL-17 Producing T Cells and Its Dichotomy: A Mixed Response of the Innate and Acquired Immune System in Psoriatic Arthritis
Siba P. Raychaudhuri¹ and Smriti K. Raychaudhuri², ¹Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: Source of IL-17 in human has been mainly attributed to ab T cells, more specifically to the Th17 cells. However, some reports suggest…
Abstract Number: 1581 • 2017 ACR/ARHP Annual Meeting
Differential Involvement of Synovial and Entheseal Inflammation in Mediating Pathological IL23 Axis Signaling in Spondyloarthritis
Ed Purdue¹, Josselyn Galdamez¹, Madeline Epsten², Rima Abhyankar³, Kathleen Hoyt⁴, Michelle Lewis⁴, Devan Dove⁴, Jon Hill⁵, Alexander Klimowicz⁴, Gerald Nabozny⁶, Joseph Wahle⁴ and Lisa A. Mandl⁷, ¹Research, Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Department of Immunology and respiratory discovery research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Department of Discovery research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶[email protected], Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: Although accumulating evidence continues to point toward a critical role for IL23 signaling in spondyloarthritis (SpA), the cellular and molecular events involved, as well…
Abstract Number: 2421 • 2017 ACR/ARHP Annual Meeting
Aberrant Expression of CaMK4 in CD4 Positive T Cells Predicts Poor Response to Treatment in Patients with Active Rheumatoid Arthritis
Tomohiro Koga¹, Tomohito Sato¹, Masataka Umeda², Shoichi Fukui², Ayako Nishino¹, Shinya Kawashiri², Naoki Iwamoto², Kunihiro Ichinose², Mami Tamai¹, Tomoki Origuchi³, Hideki Nakamura² and Atsushi Kawakami⁴, ¹Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease arising from a breakdown of peripheral tolerance, which leads to aberrant Th1- or Th17-driven immune…
Abstract Number: 2860 • 2017 ACR/ARHP Annual Meeting
Enthesitis-Related Arthritis: Axial -Pattern Is Associated with an Expansion of Peripheral Th17 Populations .
Maria M. Katsicas¹, Carolina Carrara² and Ricardo Russo³, ¹Service of Immunology & Rheumatology., Hospital de Pediatría Prof Dr JP Garrahan, Buenos Aires, Argentina, ²Immunology& Rheumatology, Hospital de Pediatría Prof Dr JP Garrahan, Buenos Aires, Argentina, ³Service of Immunology/Rheumatology, Hospital de Pediatría Garrahan, Buenos Aires, Argentina
Background/Purpose: Enthesitis-related arthritis (ERA) is a category of juvenile idiopathic arthritis encompassing most cases of juvenile spondyloarthropathy. Two different clinical patterns (axial /peripheral) have been…
Abstract Number: 773 • 2017 ACR/ARHP Annual Meeting
The Immunophenotyping of Peripheral Blood Associates with Nailfold Microvascular Changes in Patients with Systemic Sclerosis
Satoshi Kubo¹, Shingo Nakayamada², Maiko Yoshikawa¹, Yusuke Miyazaki¹, Hiroko Yoshinari³, Yurie Satoh³, Yasuyuki Todoroki³, Kazuhisa Nakano², Shigeru Iwata⁴, Kentaro Hanami¹, Shunsuke Fukuyo³, Ippei Miyagawa⁵, Minoru Satoh⁶ and Yoshiya Tanaka⁷, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³University of Occupational and Environmental Health, Japan, Fukuoka, Japan, ⁴First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁵University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁶Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan, ⁷The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
The immunophenotyping of peripheral blood associates with nailfold microvascular changes in patients with systemic sclerosisBackground/Purpose: Systemic sclerosis (SSc) is a complex disease with autoimmunity and…
Abstract Number: 1661 • 2017 ACR/ARHP Annual Meeting
STAT4 Regulates Pathogenic IL-21 and IFN-γ in Tfh Cells in Murine and Human Lupus
Fotios Koumpouras¹, XueMei Dong², Jason Weinstein² and Joseph E. Craft³, ¹Internal Medicine, Rheumatology, Yale University School of Medicine, New Haven, CT, ²Rheumatology, Yale University School of Medicine, New Haven, CT, ³Department of Internal Medicine/Rheumatology, Yale University School of Medicine, New Haven, CT
Background/Purpose: Follicular helper T cells (Tfh) cells regulate the germinal center (GC) response by delivery of contact-dependent interactions and cytokines including IL-4, IFN-γ and IL-21.…
Abstract Number: 2573 • 2017 ACR/ARHP Annual Meeting
Lack of CD137-CD137 Ligand Signalling Aggravates Glomerulonephritis and Reduces the Survival of Lupus-Prone B6.MRLlpr Mice
Anselm Mak¹, Bhushan Dharmadhikari² and Herbert Schwarz², ¹Medicine, National University of Singapore, Singapore, Singapore, ²Physiology, National University of Singapore, Singapore, Singapore
Background/Purpose: Costimulatory molecules, which are expressed on leukocytes that facilitate their cross-talks via stimulatory and inhibitory signalling, play a potentially important role in the inflammatory…
Abstract Number: 2869 • 2017 ACR/ARHP Annual Meeting
Significant Decrease of T-Cells but Not Macrophages in the Synovium of Patients with Active Rheumatoid Arthritis after Treatment with Tocilizumab
Katerina Chatzidionysiou¹, Marianne Engström¹, Erik af Klint¹, Aase Hensvold¹ and Anca I Catrina², ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Tocilizumab (TCZ) is an anti-IL6R monoclonal antibody approved for the treatment of Rheumatoid Arthritis (RA). There is limited data on synovial tissue histology changes.…

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