ACR Meeting Abstracts

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Abstracts tagged "T cells"

  • Abstract Number: 1889 • ACR Convergence 2021

    Arthritogenic T Cells Harbor a Transcriptional Program of T Cell Activation and a Repertoire Pruned by Endogenous Superantigen

    JUDITH F ASHOURI, Elizabeth McCarthy, Steven Yu, Noah Perlmutter, Charles Lin, Chun Jimmie Yu and Arthur Weiss, University of California San Francisco, San Francisco, CA

    Background/Purpose: It is widely accepted that activation of specific CD4 T cells through their TCRs by self-antigen (Ag) is necessary for rheumatoid arthritis (RA) onset.…
  • Abstract Number: 0969 • ACR Convergence 2021

    Loss of Balance Between Protective and Pro-inflammatory Synovial Tissue T Cell Polyfunctionality Predates Clinical Onset of Rheumatoid Arthritis

    Achilleas Floudas1, Nuno Neto2, Carl Orr3, Mary Canavan4, Phil Gallagher3, Conor Hurson5, Michael Monaghan2, Nagpar Sunil6, Ronan Mullan7, Douglas Veale8 and Ursula Fearon2, 1Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, 2Trinity College Dublin, Dublin, Ireland, 3St Vincent's Hospital, Dublin, Ireland, 4Trinity College, Santry, Ireland, 5St Vincents University Hospital, Dublin, Ireland, 6Janssen R&D, Spring House, PA, 7Tallaght University Hospital, Dublin, Ireland, 8University College Dublin, Dublin, Ireland

    Background/Purpose: Effective treatment of Rheumatoid arthritis (RA) patients is achievable within a short window of opportunity. T-cells are early drivers of synovial inflammation of RA,…
  • Abstract Number: 1505 • ACR Convergence 2021

    Inflammatory Dendritic Cell and Th17 Polarization in Mouse Model of Lupus Nephritis

    Latha Prabha Ganesan1, Noushin Saljoughian1, James Turman1, Murugesan Rajaram1, Brad Rovin2, Wael Jarjour1 and Samir Parikh2, 1Ohio State University, Columbus, OH, 2Ohio State University Wexner Medical Center, Columbus, OH

    Background/Purpose: We have recently identified inflammatory dendritic cells (InfDC) in human lupus kidneys. These cells are over expressed in LN patients compared to healthy controls.…
  • Abstract Number: 1506 • ACR Convergence 2021

    SLAMF6 Compartmentalization Regulates Autoimmune T Cell Responses

    Yevgeniya Gartshteyn1, Anca Askanase2 and Adam Mor3, 1Columbia University Medical Center, Glen Rock, NJ, 2Columbia University Medical Center, New York, NY, 3CUIMC, New York, NY

    Background/Purpose: T cell activation is initiated by engagement of the T cell receptor (TCR) complex and requires co-receptor signaling. SLAMF6 is a major T cell…
  • Abstract Number: 154 • 2020 Pediatric Rheumatology Symposium

    T Helper Cell Differentiation in Polyarticular Juvenile Idiopathic Arthritis

    Anna Patrick1, Tashawna Esmond 2, David Flaherty 2, Thomas Brent Graham 2, Susan Thompson 3 and Thomas Aune 1, 1Vanderbilt University Medical Center, Nashville, Tennessee, 2Vanderbilt University Medical Center, Nashville, 3Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common autoimmune arthritis in children.  Polyarticular JIA and extended oligoarticular JIA both have genetic associations near genes…
  • Abstract Number: 166 • 2020 Pediatric Rheumatology Symposium

    Resident Memory T Cells in Human RA Synovium Display Restricted TCR Clones

    Margaret Chang1, Anais Levescot 2, Nathan Nelson-Maney 3, Rachel Blaustein 4, Kellen Winden 1, Allyn Morris 4, Spoorthi Balu 4, Alexandra Wactor 4, Kevin Wei 5, Lauren Henderson 6, Rachael Clark 4, Deepak Rao 4, Robert Fuhlbrigge 7 and Peter Nigrovic 8, 1Boston Children's Hospital, Boston, 2Boston, 3, 4Brigham and Women's Hospital, Boston, 5BWH, Boston, 6Boston Children's Hospital, Watertown, Massachusetts, 7University of Colorado, Aurora, 8Boston Children's Hospital, Boston, Massachusetts

    Background/Purpose: Resident memory T cells (TRM) are site-specific memory T cells that take up long-term residence in peripheral tissues and aid in pathogen defense. Dysregulated…
  • Abstract Number: 25 • 2019 ACR/ARP Annual Meeting

    Altered Distribution and Enhanced Osteoclastogenesis of Mucosal-associated Invariant T Cells in Gouty Arthritis

    Yong-Wook Park1, Young-Nan Cho 1, Hae-Seong Jeong 1, Hye-Mi Jin 1 and Seung-Jung Kee 1, 1Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are subsets of innate invariant T cells and rapidly produce Th1/Th17 cytokines including interferon (IFN)-γ, tumor necrosis factor (TNF)-α,…
  • Abstract Number: 1069 • 2019 ACR/ARP Annual Meeting

    CD4+ T Helper Cell Populations with High PD-1 Expression Are Expanded in Systemic Sclerosis

    Alisa Mueller1, Andrea Fava 2, Deepak Rao 1 and Francesco Boin 3, 1Brigham and Women's Hospital, Boston, MA, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3UCSF, San Francisco, CA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by tissue fibrosis, vascular injury, and autoantibody production. CXCR5+ PD-1+ T follicular helper (Tfh) cells, which…
  • Abstract Number: 66 • 2019 ACR/ARP Annual Meeting

    Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation

    Samantha Chalmers1, Sayra Garcia 1, Jeanette Ampudia 2, Cherie Ng 2, Stephen Connelly 2 and Chaim Putterman 3, 1Albert Einstein College of Medicine, Bronx, NY, 2Equillium, Inc, San Diego, CA, 3Albert Einstein College of Medicine, New York, NY

    Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…
  • Abstract Number: 1455 • 2019 ACR/ARP Annual Meeting

    B and T Cell Immunologic Features Associated with Higher Disease Activity Score and Focus Score in Primary Sjögren Syndrome

    Alice Mai1, Yuriy Baglaenko 2, Dario Ferri 3, Kieran Manion 4, Dennisse Bonilla 5, Arthur Bookman 6 and Joan Wither 7, 1University of British Columbia Department of Rheumatology, Vancouver, Canada, 2Brigham Woman's Hospital, Boston, 3University Health Network, Toronto, ON, Canada, 4Krembil Research Institute, Toronto, ON, Canada, 5University Health Network, University of Toronto, Toronto, ON, Canada, 6University Health Network, Toronto, Canada, 7University Health Network, Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease with an incompletely understood pathogenesis and heterogenous disease manifestations. Identifying cellular immune changes that may…
  • Abstract Number: 94 • 2019 ACR/ARP Annual Meeting

    Tumor Necrosis Factor Receptor 2 Signaling Potentiates Proliferation and Suppressive Activities of Follicular Regulatory T Cells

    Shotaro kawano1, Hiroki Mitoma 2, Shoichiro Inokuchi 3, Masahiro Ayano 2, Yasutaka Kimoto 4, Mitsuteru Akahoshi 2, Yojiro Arinobu 2, Koichi Akashi 2, Takahiko Horiuchi 5 and Hiroaki Niiro 6, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Japan, 3Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Fukuoka, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 5Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 6Clinical Education Centre, Kyushu University Hospital, Fukuoka, Japan, Fukuoka, Japan

    Background/Purpose: Tumor Necrosis Factor (TNF) α is a multifunctional cytokine with pro-inflammatory and anti-inflammatory characteristics. Regulatory T cells (Treg) express a remarkably high level of…
  • Abstract Number: 1774 • 2019 ACR/ARP Annual Meeting

    Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis

    Izumi Kurata1, Isao Matsumoto 1, Natsuko Mikami 1, Ayako Ohyama 1, Atsumu Osada 1, Yuya Kondo 1, Hiroto Tsuboi 1 and Takayuki Sumida 1, 1Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…
  • Abstract Number: 97 • 2019 ACR/ARP Annual Meeting

    Low Frequency of Circulating T Follicular Helper 1 Cells Is Associated to Adequate Response to Adalimumab Therapy in Rheumatoid Arthritis

    Charlotte Lucas1, Roussine Codo 2, Jean-David Albert 3, Rachel Jean 2, Stéphane Rodriguez 4, Patricia Amé-Thomas 5 and Aleth Perdriger 6, 1Rheumatology department, Rennes University Hospital, France, Rennes, Bretagne, France, 2SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 3Rheumatology department, Rennes University Hospital and Institut NUMECAN, INSERM U 1241, Rennes, Bretagne, France, 4PhD, SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 5SITI Laboratory, Univ Rennes, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, 6Rheumatology department, Rennes University Hospital, France, Rennes, France

    Background/Purpose: T follicular helper cells (Tfh) constitute a distinct CD4+ helper T-cell subset, promoting B-cell maturation and activation. Circulating Tfh (cTfh) seem to play a…
  • Abstract Number: 2035 • 2019 ACR/ARP Annual Meeting

    Systemic Lupus Erythematosus (SLE) Is Caused by Expanded DOCK8-Positive Autoantibody-Inducing CD4 T (aiCD4 T) Cell

    Shunichi Shiozawa1, Ken Tsumiyama 1, Yumi Miyazaki 2, Keiichi Sakurai 3, Takahiko Horiuchi 4, Motohiro Oribe 5, Takashi Yamane 6, Hidetoshi Kagawa 7 and Kazuko Shiozawa 8, 1Institute for Rheumatic Diseases, Ashiya, Japan, 2Kyushu University Beppu Hospital, Tokyo, Japan, 3Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, 4Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 5Oribe Rheumatology Clinic, Oita, Japan, 6Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan, 7Rheumatology, Red Cross Society Himeji Hospital, Himeji, Japan, 8Rheumatic Diseases Center, Hyogo Prefectural Kakogawa Medical Center, Ashiya, Japan

    Background/Purpose: We previously found in reproducible experiments in which the mice not prone to autoimmune disease were immunized repeatedly with antigen that overstimulation of CD4…
  • Abstract Number: 102 • 2019 ACR/ARP Annual Meeting

    Serine Arginine-Rich Splicing Factor 1 (SRSF1) Restrains IFN-γ and IL-17 Inflammatory Cytokine Production and Its Selective Deficiency in T Cells Exacerbates Experimental Autoimmune Encephalomyelitis (EAE) and Nephrotoxic Nephritis (NTN)

    Takayuki Katsuyama1, Kotaro Otomo 1, Hao Li 2, Michihito Kono 3, Nobuya Yoshida 1, George Tsokos 1 and Vaishali R. Moulton 1, 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Background/Purpose: CD4 T helper 1 (Th1) and Th17 cells producing IFN-γ and IL-17 are aberrantly increased and contribute to inflammatory responses in autoimmune diseases including…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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