Abstracts tagged "T cells"

Abstract Number: 936 • 2018 ACR/ARHP Annual Meeting
Selective Deficiency of Serine Arginine-Rich Splicing Factor 1 (SRSF1) in T Lymphocytes Leads to mTORC1 Activation, Treg Dysfunction and Systemic Autoimmune Disease
Takayuki Katsuyama¹, Hao Li¹, Denis Comte², Michael W. Mosho³, Andrew R. Gillooly³, George C Tsokos⁴ and Vaishali R. Moulton¹, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Rheumatology, Department of Medicine, Boston, MA, ³Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) exhibit defects in signaling and cytokine production, and aberrant numbers and/or function of regulatory T…
Abstract Number: 2094 • 2018 ACR/ARHP Annual Meeting
Examining T Cell Exhaustion in Murine Systemic Lupus Erythematosus
Jeremy Tilstra¹, Lyndsay Avery², Ashley Menk², Rachael Gordon², Shuchi Smita³, Lawrence Kane³, Maria Chikina², Greg Delgoffe³ and Mark Shlomchik⁴, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function…
Abstract Number: 937 • 2017 ACR/ARHP Annual Meeting
Treatment Response in Polyarticular JIA Is Associated with Transcriptional Changes and Chromatin Reorganization in CD4+ T Cells
Evan Tarbell¹, Kaiyu Jiang², Yanmin Chen², Tao Liu³ and James Jarvis⁴, ¹Biochemistry, University at Buffalo, Buffalo, NY, ²Pediatrics, University at Buffalo, Buffalo, NY, ³Biochemistry, University at Buffalo Jacobs School of Medicine, Buffalo, NY, ⁴Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY
Background/Purpose: To identify transcriptional changes in CD4+ T cells as children with polyarticular JIA transition from active disease to remission, and to identify underlying changes…
Abstract Number: 1731 • 2017 ACR/ARHP Annual Meeting
Abnormal Responses of γδ T Cell Subsets to Stimulation with Cardiolipin and Zoledronate in Systemic Sclerosis
Ilan Bank¹, Paul Fisch², Jose Villacorta Hidalgo³, Alexandra Balbir-Gurman⁴, Yolanda Braun-Moscovici⁵ and Helena Migalovich Sheikhet⁶, ¹Medicine, Maayenei Hayeshuah and Chaim Sheba Medical Center, Israel, Bnei Brak, Israel, ²3Department of Clinical Pathology, University of Freiburg Medical Center, Freiburg, Germany, ³Department of Clinical Pathology, University of Freiburg Medical Center, Freiburg, Germany, ⁴Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Haifa, Israel, ⁵B Shine Department of Rheumatology, Rambam Health Care Campus,. Rappaport Faculty of Medicine, Technion, Haifa, Israel, ⁶Medicine, Laboratory of Immunoregulation, Chaim Sheba Medical Center, Ramat Gan, Israel
Background/Purpose: Systemic sclerosis (SSc) is an auto-immune disorder leading to destructive tissue fibrosis. Abnormal responses of SSc T cells to lipid antigens and low molecular…
Abstract Number: 2636 • 2017 ACR/ARHP Annual Meeting
EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion through Junctional Adhesion Molecule-a in Lupus Patients
Pei-Suen Tsou¹, Patrick Coit¹, Nathan Kilian² and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: EZH2 is an epigenetic regulator that trimethylates lysine 27 of histone 3 (H3K27me3) and modulates DNA methylation patterns. We have previously suggested that EZH2…
Abstract Number: 2936 • 2017 ACR/ARHP Annual Meeting
B-Cell Depletion By Rituximab Affects the Distribution of Effector Th-Cell Subsets in Patients with ANCA Associated Vasculitis
Wayel H. Abdulahad¹, Ulrich Specks², Theo Bijma³, Deborah J. Phippard⁴, Fredrick Karnell⁵, Noha Lim⁵, John H. Stone⁶ and Cees G.M. Kallenberg¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Mayo Clinic College of Medicine, Rochester, MN, ³UMCG, Groningen, Netherlands, ⁴3 Bethesda Metro Center,, Suite 400, Bethesda, MD, ⁵Immune Tolerance Network, Bethesda, MD, ⁶Rheumatology Unit, Massachusetts General Hospital, Boston, MA
Background/Purpose: The current study is aimed to assess the effect of B-cell depletion on the distribution of effector T-cell subsets in AAV-patients. Alterations in CD4+…
Abstract Number: 949 • 2017 ACR/ARHP Annual Meeting
Sequence Homology and Immune Reactivity between T Cell Epitopes of Related Gut Microbes and Two Novel Autoantigens Provide a Link between Microbial and Host Immunity in Patients with Rheumatoid Arthritis
Annalisa Pianta¹, Sheila Arvikar², Klemen Strle³, Elise E. Drouin¹, Qi Wang⁴, Catherine E. Costello⁴ and Allen C. Steere⁵, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁵Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: It has been proposed that immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity affecting joints in patients with rheumatoid…
Abstract Number: 1732 • 2017 ACR/ARHP Annual Meeting
The Characteristic T-Cell Receptor-Mediated Signaling of Peripheral Blood T Cells in Dermatomyositis and Polymyositis
Yasuhiro Shimojima¹, Dai Kishida² and Yoshiki Sekijima², ¹Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan, ²Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan
Background/Purpose: In dermatomyositis (DM) and polymyositis (PM), the characteristics of T cell expression in peripheral blood have been previously described; especially, decreased expression of interferon-γ…
Abstract Number: 2640 • 2017 ACR/ARHP Annual Meeting
Response Gene to Complement-32 Expression Is Upregulated in Lupus T Cells and Promotes IL-17A Expression
Vinh Nguyen¹, Alexandru Tatomir², Cornelia Cudrici³, Horea Rus² and Violeta Rus¹, ¹Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ²Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ³NIAMS, NIAMS, NIH, Bethesda, MD
Background/Purpose: RGC (Response Gene to Complement)-32 is a cell cycle regulator widely expressed in normal tissues including brain, kidney, spleen, thymus, multiple tumors and in…
Abstract Number: 950 • 2017 ACR/ARHP Annual Meeting
Identification of Naturally Processed Immunodominant Topoisomerase I Epitopes in Patients with Systemic Sclerosis
Eleni Tiniakou¹, Andrea Fava², Tara Guhr³, Francesco Boin⁴ and Erika Darrah⁵, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³University of North Carolina, Chapel Hill, NC, ⁴Rheumatology, University California, San Francisco, San Francisco, CA, ⁵Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Identification of immunodominant T cell epitopes of autoantigens is crucial to understanding the pathogenesis of autoimmune diseases and developing disease-specific diagnostic and therapeutic tools.…
Abstract Number: 1734 • 2017 ACR/ARHP Annual Meeting
CXCR5+ CD4 T Cells Signature Differentiates Takayasu Arteritis from Giant Cell Arteritis
Anne-Claire Desbois¹, Valentin Quiniou², Patrick Bruneval³, Nicolas Derian², Anna Maciejewski-Duval², Marlène Garrido⁴, Cloé Comarmond⁵, Jacques Pouchot⁶, Michelle Rosenzwajg², David Klatzmann², Patrice Cacoub⁷ and David Saadoun⁸, ¹Hôpital Pitié-Salpêtrière, Internal Medicine and Clinical Immunology, Paris, France, ²GHPS, Paris, France, ³HEGP, Paris, France, ⁴I3 laboratory, Pitié-Salpétrière, Paris, France, ⁵DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ⁶Internal Medicine Department, European Hospital Georges Pompidou, Paris, France, ⁷Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ⁸Sorbonne Universités, UPMC Univ Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), F-75005, Paris, France; INSERM, UMR_S 959, F-75013, Paris, France; CNRS, FRE3632, F-75005, Paris, France; AP-HP, Groupe Hospitalier, Paris, France
Background/Purpose: To compare microarray gene analysis of patients with Giant cell arteritis to patients with Takayasu arteritis. Methods: We performed comparative microarray gene analysis of…
Abstract Number: 2700 • 2017 ACR/ARHP Annual Meeting
Fra-2 Overexpression Leads to Systemic Autoimmunity By Affecting IL2 Dependent Treg Homeostasis
Florian Renoux¹, Mara Stellato¹, Daniela Impellizzieri², Alexander Vogetseder³, Przemyslaw Blyszczuk¹, Riyun Huang⁴, Arun Subramaniam⁵, Clara Dees⁶, Jörg Distler⁷, Gabriela Kania¹, Onur Boyman² and Oliver Distler⁸, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Division of Clinical Immunology, University Hospital Zurich, Zurich, Switzerland, ³Department of Pathology, Cantonal Hospital Lucerne, Lucerne, Switzerland, ⁴Immune Mediated Diseases, Sanofi-Genzyme, Framingham, MA, ⁵Sanofi-Genzyme, Framingham, MA, ⁶Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁸Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Fos-related antigen 2 (Fra-2) is a transcription factor belonging to the Fos family proteins which is part of the AP-1 transcription factor complex. We…
Abstract Number: 951 • 2017 ACR/ARHP Annual Meeting
Cross Sectional Analysis of Citrullinated-Synovial Antigen-Specific CD4+ T Cells in an RA Cohort Demonstrates Antigen Based Differences in T Cell Frequency, Phenotype and the Influence of Immunotherapy
Cliff Rims¹, Sylvia Posso¹, Bernard Ng², Jeffrey Carlin³, Eddie James⁴ and Jane H. Buckner⁴, ¹Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Rheumatology, VA Puget Sound Healthcare System, Seattle, WA, ³Rheumatology, Virginia Mason Medical Center, Seattle, WA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: The presence of ACPA in RA indicates that an immune response directed toward citrullinated synovial antigens participates in disease development or persistence. Research from…
Abstract Number: 1738 • 2017 ACR/ARHP Annual Meeting
The Pattern of Proinflamatory Cytokine Expression By CD4+ T Lymphocytes Segregates the Clinical Response to Methotrexate in Recently Diagnosed Rheumatoid Arthritis Patients
Jorge Monserrat Sanz¹, Ana Maria Gómez Lahoz², Cristina Bohórquez Heras³, Maria Dolores Sosa Reina², Atusa Movasat³, Ana Pérez Gómez³, Lucía Ruiz Gutiérrez³, Ana Sánchez Atrio³, Eduardo Cuende Quintana³, Maria José León³, David Diaz², Fernando Albarrán Hernández³ and Melchor Alvarez-Mon^2,3, ¹Laboratory of Inmune System Diseases, Deparment of Medicine and Medical Specialties. IRYCIS. University of Alcalá. Madrid. Spain, Alcalá de Henares. Madrid, Spain, ²Laboratory of Inmune System Diseases, Deparment of Medicine and Medical Specialties. IRYCIS. University of Alcalá. Madrid. Spain, Alcalá de Henares, Madrid, Spain, ³University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology Department, Alcalá de Henares, Madrid, Spain
Background/Purpose: Mechanisms regulating the autoimmune response in rheumatoid arthritis (RA) are not well understood. However, it is known that T CD4+ lymphocytes play a pivotal…
Abstract Number: 2702 • 2017 ACR/ARHP Annual Meeting
Tissue-Invasive T Cells in Rheumatoid Arthritis
Cornelia M. Weyand¹, Yi Shen², Yinyin Li¹, Eric L. Matteson³, Stuart Goodman⁴ and Jorg Goronzy⁵, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁴Orthopaedic Surgery, Stanford Medical Center Outpatient Clinic, Redwood City, CA, ⁵Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: A key pathogenic event in rheumatoid arthritis (RA) is the formation of lasting lymphoid microstructures in the synovial tissue. It requires the transmigration of…

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