Abstracts tagged "T cells"

Abstract Number: 1738 • 2017 ACR/ARHP Annual Meeting
The Pattern of Proinflamatory Cytokine Expression By CD4+ T Lymphocytes Segregates the Clinical Response to Methotrexate in Recently Diagnosed Rheumatoid Arthritis Patients
Jorge Monserrat Sanz¹, Ana Maria Gómez Lahoz², Cristina Bohórquez Heras³, Maria Dolores Sosa Reina², Atusa Movasat³, Ana Pérez Gómez³, Lucía Ruiz Gutiérrez³, Ana Sánchez Atrio³, Eduardo Cuende Quintana³, Maria José León³, David Diaz², Fernando Albarrán Hernández³ and Melchor Alvarez-Mon^2,3, ¹Laboratory of Inmune System Diseases, Deparment of Medicine and Medical Specialties. IRYCIS. University of Alcalá. Madrid. Spain, Alcalá de Henares. Madrid, Spain, ²Laboratory of Inmune System Diseases, Deparment of Medicine and Medical Specialties. IRYCIS. University of Alcalá. Madrid. Spain, Alcalá de Henares, Madrid, Spain, ³University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology Department, Alcalá de Henares, Madrid, Spain
Background/Purpose: Mechanisms regulating the autoimmune response in rheumatoid arthritis (RA) are not well understood. However, it is known that T CD4+ lymphocytes play a pivotal…
Abstract Number: 2702 • 2017 ACR/ARHP Annual Meeting
Tissue-Invasive T Cells in Rheumatoid Arthritis
Cornelia M. Weyand¹, Yi Shen², Yinyin Li¹, Eric L. Matteson³, Stuart Goodman⁴ and Jorg Goronzy⁵, ¹Medicine: Immunology and Rheumatology, Stanford University, Stanford, CA, ²Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁴Orthopaedic Surgery, Stanford Medical Center Outpatient Clinic, Redwood City, CA, ⁵Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: A key pathogenic event in rheumatoid arthritis (RA) is the formation of lasting lymphoid microstructures in the synovial tissue. It requires the transmigration of…
Abstract Number: 952 • 2017 ACR/ARHP Annual Meeting
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Is a Novel Regulator of T Lymphocyte Homeostasis In Vivo and Its Deficiency Associates with Lymphopenia in SLE Patients
Takayuki Katsuyama¹, Michael W. Mosho¹, Andrew R. Gillooly², George C. Tsokos¹ and Vaishali R. Moulton³, ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Lymphopenia is a common clinical feature in patients with systemic lupus erythematosus (SLE), and associates with high disease activity and comorbidities including infections. However,…
Abstract Number: 1739 • 2017 ACR/ARHP Annual Meeting
Vδ1, Vδ2, and Other γδT Cells in Blood and Synovium of Rheumatoid Arthritis and Other Autoimmune Arthritides
Anna Helena Jonsson¹, Michael Gurish¹, Lauren Henderson², Peter Nigrovic¹ and Michael Brenner³, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Innate-like T cells comprise on average 10-15% of peripheral T cell and have T-cell receptors (TCRs) that engage ligands other than classic HLA class…
Abstract Number: 2703 • 2017 ACR/ARHP Annual Meeting
Single Cell Analysis of TCRs from CD8+ T Cells in Sjogren’s Syndrome
Michelle L. Joachims¹, Christina Lawrence¹, Richard C. Pelikan¹, Kerry M. Leehan¹, Lida Radfar², David M. Lewis³, Astrid Rasmussen¹, R. Hal Scofield¹, Kiely Grundahl¹, Kathy L. Sivils¹, Linda F. Thompson¹ and A. Darise Farris¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ³Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune exocrinopathy characterized by focal lymphocytic infiltration of the salivary and lacrimal glands, severe dry eyes and mouth, fatigue…
Abstract Number: 953 • 2017 ACR/ARHP Annual Meeting
Persistence of Pathogenic CD4 Memory T Cells Revealed through Cytometry Time of Flight in Juvenile Idiopathic Arthritic Patients with Disease Resurgence upon Withdrawal of Anti-TNFA Biologics
Jing Yao Leong¹, Joo Guan Yeo², Phyllis Chen³, Liyun Lai⁴, Fauziah Ally⁵, Loshinidevi D/O Thana Bathi³, Justin Hung Tiong Tan², Thaschawee Arkachaisri², Femke van Wijk⁶, Salvatore Albani⁴, Daniel J Lovell⁷ and Gerdien Mijnheer⁸, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ⁵STIIC, SingHealth Translational Immunology and Inflammation Centre, Singapore, Singapore, ⁶University Medical Center Utrecht, Utrecht, Netherlands, ⁷Rheumatology, PRCSG - Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, ⁸1Laboratory of Translational Immunology, Department of Paediatric Immunology, , The Netherlands, University Medical Centre Utrecht, Wilhelmina Children’s Hospital, Utrecht, Netherlands
Background/Purpose: Treatment of polyarticular JIA with anti-TNFA biologics has experienced significant success, with up to 80% of patients demonstrating clinically meaningful efficacy. Yet concerns regarding…
Abstract Number: 1742 • 2017 ACR/ARHP Annual Meeting
Involvement of T Helper 17 Cells in Inflammatory Arthritis Depends on the Host Intestinal Microbiota
Heather Evans-Marin¹, Rebecca Rogier², Jose U. Scher³, Debbie M. Roeleveld², Marije I. Koenders⁴ and Shahla Abdollahi-Roodsaz^5,6, ¹Division of Rheumatology, New York University School of Medicine, New York, NY, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³New York University School of Medicine, New York, NY, ⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Department of Medicine, Division of Rheumatoogy, New York University School of Medicine, New York, NY, ⁶Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: The intestinal microbiota has been associated with psoriatic and rheumatoid arthritis. One of the major effects of microbiota is the induction of mucosal T…
Abstract Number: 2706 • 2017 ACR/ARHP Annual Meeting
T Follicular-Helper CELLS (TFH) Enrichment and T Follicular-Regulatory CELLS (TFR) Exclusion from Ectopic Germinal Centers in Salivary Glands of Sjogren’s Syndrome Patients
Elena Pontarini¹, William Murray Brown², Cristina Croia², Elisa Corsiero³, Davide Lucchesi², Elisa Astorri², Nurhan Sutcliffe², Anwar Tappuni², Costantino Pitzalis⁴ and Michele Bombardieri⁵, ¹William Harvey Research Institute, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom, ³Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: Lymphocytic aggregates in the salivary glands (SG) of Sjögren’s syndrome (SS) can organize in ectopic lymphoid structures (ELS) forming functional germinal centers (GCs), which…
Abstract Number: 954 • 2017 ACR/ARHP Annual Meeting
Microrna-21 Is a Critical Regulator of Autoimmunity through Promoting Effector and Metabolic Function of Pathogenic TH17 Cells
Xiang Yu¹ and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, and Shanghai Jiao Tong University, Shanghai, China, ²Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that causes mortality and morbidity worldwide. Recent studies suggest proinflammatory TH17 cells are key pathogenic…
Abstract Number: 1743 • 2017 ACR/ARHP Annual Meeting
Serine Arginine/Rich Splicing Factor 1 (SRSF1) Increases IL-2 Production in T Cells By Increasing the Expression of NFAT and c-Fos
Takayuki Katsuyama¹, Michael W. Mosho¹, George C. Tsokos¹ and Vaishali R. Moulton², ¹Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) produce insufficient amounts of the vital cytokine IL-2, and the molecular mechanisms leading to this…
Abstract Number: 2708 • 2017 ACR/ARHP Annual Meeting
Placental Growth Factor Regulates the Generation of T-Helper 17 Cells to Link Angiogenesis with Autoimmunity
Seung-Ah Yoo Sr.¹, Min-cheol Kang Sr.², Mingyo Kim Sr.³, Jin-Sun Kong Sr.¹, Ki-Myo Kim Sr.¹, junghee Koh Sr.¹, Chul-Soo Cho⁴, Seung-Hyo Lee Sr.⁵, Zae Young Ryoo Sr.⁶ and Wan-Uk Kim Sr.^1,7, ¹The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ²School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, seoul, Korea, Republic of (South), ³Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, seoul, Korea, Republic of (South), ⁴Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁵Graduate School of Medical Science and Engineering, BioMedical Research Center, KAIST Institute for the BioCentury, SEOUL, Korea, Republic of (South), ⁶School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, SEOUL, Korea, Republic of (South), ⁷The Catholic University of Korea, Department of Internal Medicine, seoul, Korea, Republic of (South)
Background/Purpose: T-helper (Th) cells actively communicate with adjacent cells by secreting soluble mediators, and yet crosstalk between Th cells and endothelial cells is poorly understood.…
Abstract Number: 73 • 2017 ACR/ARHP Annual Meeting
Regulation of Th17 Cell Responses By IL-25
Sophie Archer, Ash Maroof, Meryn Griffiths and Stevan Shaw, UCB Pharma, Slough, United Kingdom
Background/Purpose: IL-17A is a Th17 proinflammatory cytokine that contributes to the pathophysiology of several immune-mediated inflammatory diseases including PsA; while previously underestimated, there is increasing…
Abstract Number: 971 • 2017 ACR/ARHP Annual Meeting
Synovial Fibroblast CD318 Expression Mediates T Cell Adhesion and Migration in Rheumatoid Arthritis
Ray A. Ohara¹, Stephanie M. Rasmussen¹, W. Alexander Stinson¹, Huadong Cui¹, Yuxuan Du¹, Daniel P. Weber¹, M. Asif Amin¹, Phillip L. Campbell², Nora Singer³, Feng Lin⁴, David A. Fox¹ and Jeffrey H. Ruth⁵, ¹Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Ann Arbor, MI, ³Division of Rheumatology, MetroHealth Medical Center, Cleveland, OH, Cleveland, OH, ⁴Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, Cleveland, OH, ⁵Internal Medicine, Division of Rheumatology and Clinical Autoimmune Center of Excellence, University of Michigan, Ann Arbor, MI, Ann Arbor, MI
Background/Purpose: CD6 is an important marker and regulator of T cells and interacts with its known ligand, CD166. Our group has previously shown that interferon…
Abstract Number: 1744 • 2017 ACR/ARHP Annual Meeting
Transciptome Profile of Inflammation Inducted Circulating Effector and Regulatory T Cells Is Dominated By HLA-DR Pivoted Functional Networks in Active Juvenile Idiopathic Arthritis Patients
Jing Yao Leong¹, Salvatore Albani², Pavanish Kumar², Joo Guan Yeo³, Phyllis Chen¹, Sharifah Nur Hazirah², Camillus Chua², Suzan Saidin², Justin Hung Tiong Tan³, Thaschawee Arkachaisri³, Alberto Martini⁴, Marco Gattorno⁵ and Alessandro Consolaro⁶, ¹Singhealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ³Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, ⁴PRINTO Coordinating Centre, Genoa, Italy, ⁵Pediatric Rheumatology, G. Gaslini Institute, Genoa, Italy, ⁶Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: We have previously identified two dichotomous CD4 pathogenic subsets in both T effector (CPLs: Circulating pathogenic like lymphocytes) and T regulatory (iaTreg: inflammation associated…
Abstract Number: 2709 • 2017 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target for Patients with Rheumatoid Arthritis
Lisa Goschl^1,2, Michael Bonelli³, Victoria Saferding⁴, Teresa Peglej², Sylvia Knapp⁵, Johan Bäcklund⁶, Christoph Bock⁵, Patrick Matthias⁷, Kiyoshi Hirahara⁸, Clemens Scheinecker¹, Günter Steiner⁹, Josef S. Smolen¹ and Wilfried Ellmeier², ¹Medical University of Vienna, Devision of Rheumatology, Vienna, Austria, ²Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Austria, Vienna, Austria, ⁵CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ⁶Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁷Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ⁸Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan, ⁹Medical University of Vienna, Dvision of Rheumatology, Vienna, Austria
Background/Purpose: Autoreactive T cells drive the inflammatory process, which leads to an irreversible destruction of the joints. Gene transcription and regulation of proinflammatory cytokine production…

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