ACR Meeting Abstracts

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Abstracts tagged "T Cell"

  • Abstract Number: L03 • ACR Convergence 2022

    A Phase 2 Trial of Peresolimab for Adults with Rheumatoid Arthritis

    Jay Tuttle1, Edit Drescher2, Jesus Abraham Simón-Campos3, Paul Emery4, Maria Greenwald5, Alan Kivitz6, Hyungmin Rha1, Pia Yachi1, Christina Kiley1 and Ajay Nirula7, 1Eli Lilly and Company, Indianapolis, IN, 2Csolnoky Ferenc Hospital, Veszprém, Hungary, 3Köhler & Milstein Research/Hospital Agustín O'Horán, Merida, Yucatan, Mexico, 4University of Leeds, Leeds, United Kingdom, 5Desert Medical Advances, Palm Desert, CA, 6Altoona Center for Clinical Research, Duncansville, PA, 7Eli Lilly, San Diego, CA

    Background/Purpose: Peresolimab is a humanized immunoglobulin G1 monoclonal antibody that stimulates human programmed cell death protein 1 (PD-1). We hypothesized that peresolimab binding to PD-1,…
  • Abstract Number: 0053 • ACR Convergence 2022

    Natural Microbial Exposure Increases Susceptibility of C57BL/6 Mice to Collagen-induced Arthritis

    Sahar Lotfi-Emran1 and David Masopust2, 1University of Minnesota, Minneapolis, MN, 2University of Minnesota, Department of Microbiology and Immunology, Minneapolis, MN

    Background/Purpose: Mice exposed to natural microbes (NME) develop an appropriately mature immune system, one that resembles that of a non-neonatal human.1,2 Collagen induced arthritis is…
  • Abstract Number: 0651 • ACR Convergence 2022

    Inflammatory Dendritic Cell Drive Intra-renal T Cells to Double-negative T Cell in Lupus Nephritis

    Latha Prabha Ganesan, Shane Bruckner, Noushin Saljoughian, James Turman, Murugesan Rajaram, Brad Rovin, Wael Jarjour and Samir Parikh, The Ohio State University, Columbus, OH

    Background/Purpose: The pathogenesis of lupus nephritis (LN) is incompletely understood stalling progress and resulting in suboptimal patient outcomes. We previously identified a novel inflammatory dendritic…
  • Abstract Number: 1677 • ACR Convergence 2022

    Chimeric Autoantigen-T Cell Receptor (CATCR)-T Cell Therapies to Selectively Target Autoreactive B Cells

    Brian J. Mog1, Elana R. Shaw1, Michael S. Hwang1, Alexander H. Pearlman1, Sarah R. DiNapoli1, Suman Paul1, Chetan Bettegowda1, Nickolas Papadopoulos1, Sandra B. Gabelli1, Michelle Petri2, Antony Rosen1, Shibin Zhou1, Kenneth W. Kinzler1, Bert Vogelstein1 and Maximilian F. Konig1, 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the treatment of cancer and can be curative. CD19-targeted CAR-T cells hold promise for the treatment…
  • Abstract Number: 1742 • ACR Convergence 2022

    Shared Epitope Allomorphs Directly Influence Antigen-specific T-cell Responses in RA

    Ravi Kumar1, Anatoly Dubnovitsky1, Christina Gerstner1, Niyaz Yoosuf2, Sara Turcinov1, Sanjay Boddul1, Fredrik Wermeling1, Lars Klareskog1, Leonid Padyukov1 and vivianne malmström1, 1Karolinska Institutet, Stockholm, Sweden, 2Bioinvent International AB, Lund, Sweden

    Background/Purpose: The products of rheumatoid arthritis (RA)-associated MHC class II risk alleles HLA-DRB1*04:01 and *04:04 (DR4) differ only by two amino acids in the peptide…
  • Abstract Number: 0310 • ACR Convergence 2022

    Higher Baseline Circulating CD4+CXCR5+PD-1hi Follicular Helper T Cells Predict Therapeutic Efficacy of Abatacept in Moderate to Severe Rheumatoid Arthritis

    TING WANG, Natalia V. Giltiay, Christian Lood and Bobby Kwanghoon Han, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Activation of T cells plays a key role in the pathogenesis of rheumatoid arthritis (RA), which is characterized by inflammation of the synovial tissue…
  • Abstract Number: 0662 • ACR Convergence 2022

    Partial Correlations Network Models Show Th1, Th2 and Th17 Responses to Be Interlinked in Dermal Pathogenesis of Cutaneous Lupus Erythematous

    Felix Chin1, Thomas Vazquez2, Josh Dan3, DeAnna Diaz4, Grant Sprow5, Jay Patel6, Nilesh Kodali7, Rui Feng8 and Victoria Werth9, 1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2FIU Wertheim College of Medicine, Virginia Beach, VA, 3Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 4Philadelphia College of Medicine, Philadelphia, PA, 5Albert Einstein College of Medicine, Philadelphia, PA, 6Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PN, 7New Jersey Medical School, Coppell, TX, 8University of Pennsylvania, Philadelphia, 9University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Background/Purpose: The immunopathogenesis of cutaneous lupus erythematous (CLE) is highly diverse and involves activity of many different cell types and pathways. This heterogeneity is believed…
  • Abstract Number: 1702 • ACR Convergence 2022

    Targeting CD6-CD318 Axis with UMCD6 (anti-CD6) Enhances in Vivo Killing of Cancer Cells Through Direct Activation of NK Cells

    Mikel Gurrea-Rubio1, Qi Wu1, Eliza Pei-Suen Tsou1, M. Asif Amin1, Phillip Campbell1, Peggy Randon1, Matthew Lind1, Sarah Ory1, Camila Amarista1, Sirapa Vichaikul2, Jeffrey Ruth1, Feng Ling3 and David Fox1, 1University of Michigan, Ann Arbor, MI, 2Michigan Medicine, Howell, MI, 3Cleveland Clinic, Cleveland, OH

    Background/Purpose: Immune checkpoint inhibitors represent a major advance in cancer treatment, but disease prognosis continues to be poor for most patients. Resistance of cancer cells…
  • Abstract Number: 1745 • ACR Convergence 2022

    Effects of Excess IL-18 in Mixed Inflammatory Environments

    Vinh Dang1, Jemy Varghese1, Emily Landy2, Lauren Van Der Kraak2, Leonardo Huang1, Anastasia Frank-Kamenetskii1 and Scott Canna1, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Interleukin 18 (IL-18) is an inflammasome-activated, IL-1 family cytokine that canonically induces interferongamma (IFNg). IL-18 activity is potently inhibited by a soluble, IFNg-inducible antagonist,…
  • Abstract Number: 0385 • ACR Convergence 2022

    T Cell Receptor Sequencing Identifies Two Classes of T Cells Enriched in HLA-B27-associated Inflammation

    Michael Paley1, Lynn Hassman2, Grace Paley2, Nicole Linskey2, Philip Ruzycki2, Jennifer Laurent2, Lacey Feigl2, Luke Springer2 and Wayne Yokoyama2, 1Washington University in St. Louis, Saint Louis, MO, 2Washington University School of Medicine, St. Louis, MO

    Background/Purpose: HLA-B27 is genetically linked to Axial Spondyloarthritis (axSpA) and anterior uveitis (AU), an inflammatory ocular disease that can lead to cataract, glaucoma, and permanent…
  • Abstract Number: 0666 • ACR Convergence 2022

    HRES-1/Rab4 Controls the Overexpression of CD38 and Depletion of IL-2 in CD4+ T Cells; Potential Involvement in Proinflammatory Lineage Development in SLE

    Seong Hee (Joy) Park1, Akshay Patel2 and Andras Perl3, 1Upstate Medical University, Syracuse, NY, 2SUNY Upstate Medical University, Syracuse, NY, 3SUNY, Syracuse, NY

    Background/Purpose: HRES-1/Rab4 (Rab4A) is a small GTPase that is overexpressed in SLE patient T cells1,2, mediates the enhanced recycling of CD3 and CD4 cell surface…
  • Abstract Number: 1727 • ACR Convergence 2022

    BATF Represses BIM Expression to Sustain the T Cell Anergy Program

    Philip Titcombe, Milagros Silva-Morales, Na Zhang and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
  • Abstract Number: 1746 • ACR Convergence 2022

    Increased CD39+FoxP3+CD4+ Regulatory T Cells in Early Rheumatoid Arthritis Provide a Slot for Prompt Initiation of Methotrexate and Serve as Early Biomarkers of Clinical Response

    María-Eugenia Miranda-Carús1, Alejandro Villalba1, Laura Nuño1, Marta Benito-Miguel2, Irene Monjo1, Marta Novella-Navarro1, Diana Peiteado1, Sara Garcia-Carazo1 and Alejandro Balsa3, 1Hospital Universitario La Paz - IdiPAZ, Madrid, Spain, 2Universidad Nebrija, Physiology, Madrid, Spain, 3Hospital La Paz Institute for Health Research, Madrid, Spain

    Background/Purpose: FoxP3+ regulatory CD4+ T cells (Tregs) are key to the homeostasis of the immune system. Stressed cells at inflammatory foci release adenine nucleotides to…
  • Abstract Number: 0498 • ACR Convergence 2022

    A Longitudinal Assessment of Citrulline-specific CD4 T Cells in CCP+ at Risk Subjects and Patients with New-onset Rheumatoid Arthritis

    Jing Song1, Scott Presnell1, Cliff Rims2, Matthew Dufort1, Hannah DeBerg1, Peter Linsley2, V. Michael Holers3, Kevin D Deane4, Eddie James1 and Jane Buckner1, 1Benaroya Research Institute at Virginia Mason, Seattle, WA, 2Benaroya Research Institute, Seattle, WA, 3University of Colorado, Denver, CO, 4University of Colorado Denver Anschutz Medical Campus, Denver, CO

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease, in which autoantibodies targeting citrullinated (cit) peptides can be detected prior to diagnosis. We previously reported an…
  • Abstract Number: 0787 • ACR Convergence 2022

    Relationship Between Humoral and Cellular Immune Responses in Persons with Rheumatoid Arthritis Following a Third Dose of COVID-19 Vaccine

    Sara Tedeschi1, Daniel Solomon1, Yuezhou Chen2, Jack Ellrodt1, Mary Grace Whelan1, Jacklyn Stratton1, Keigo Hayashi3, Noah Whiteman2, Lin Chen1, Ifeoluwakiisi Adejoorin1, Kathryne Marks1, Emma Gomez-Rivas1, Deepak Rao1, Anna Jonsson1 and Duane Wesemann2, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital, Okayama, Japan

    Background/Purpose: DMARDs that treat RA may reduce immune responses to COVID-19 vaccination. We compared measures of humoral and cell-mediated immunity in RA patients before and…
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ACR Pediatric Rheumatology Symposium 2020

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