ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Systems-based Studies"

  • Abstract Number: 0077 • ACR Convergence 2022

    Rheumatoid Arthritis – Are We Getting to Target?

    myint Thway1, Gurjit S. Kaeley2, Karishma Ramsubeik3, Laurie Ramrattan1, Lilian Otalora Rojas4 and Sukhraj Singh1, 1University of Florida-Jacksonville, Jacksonville, FL, 2UF COM-J, Ponte Vedra Beach, FL, 3University of Florida, Jacksonville, FL, 4University of Florida, Ponte Vedra Beach, FL

    Background/Purpose: Low disease activity (LDA) is a key goal in treating Rheumatoid arthritis, but implementing the treat to target approach in clinical practice has been…
  • Abstract Number: 0329 • ACR Convergence 2022

    Scoring Personalized Molecular Portraits Identify Systemic Lupus Erythematosus Subtypes and Predict Individualized Drug Responses, Symptomatology and Disease Progression

    Daniel Toro-Domínguez1, Manuel Martinez-Bueno1, Raúl López-Domínguez2, Jordi Martorell-Marugán1, Elena Carnero-Montoro1, Guillermo Barturen1, Daniel W. Goldman3, Michelle Petri3, Pedro Carmona-Sáez2 and Marta Alarcon-Riquelme1, 1Center for Genomics and Oncological Research (GENYO), Granada, Spain, 2University of Granada, Granada, Spain, 3Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Systemic Lupus Erythematosus is a complex autoimmune disease that leads to important worsening of quality of life and mortality. Flares appear unpredictably during the…
  • Abstract Number: 0640 • ACR Convergence 2022

    Immune Cell Heterogeneity in Lupus Nephritis Kidneys and Its Relation to Histopathological Features

    Arnon Arazi1, Joseph Mears2, Thomas Eisenhaure3, Qian Xiao4, Paul Hoover4, Deepak Rao4, Celine Berthier5, Andrea Fava6, Siddarth Gurajala4, Michael Peters3, Tony Jones3, William Apruzzese4, Jennifer Barnas7, Richard Furie8, Anne Davidson9, David Hildeman10, Judith James11, Joel Guthridge11, Maria Dall'Era12, David Wofsy13, Peter Izmirly14, H Michael Belmont15, Robert Clancy14, Diane Kamen16, Chaim Putterman17, Thomas Tuschl18, Maureen McMahon19, Jennifer Grossman19, Kenneth Kalunian20, Michael Weisman21, Matthias Kretzler5, Michael Brenner22, Jennifer Anolik23, Michelle Petri24, Jill Buyon14, Soumya Raychaudhuri4, Nir Hacohen3, Betty Diamond9 and the Accelerating Medicines Partnership RA/SLE Network3, 1Feinstein Institutes for Medical Research, Melrose, MA, 2Michigan University, Ann Arbor, MI, 3Broad Institute, Cambridge, MA, 4Brigham and Women's Hospital, Boston, MA, 5University of Michigan, Ann Arbor, MI, 6Johns Hopkins University, Baltimore, MD, 7University of Rochester, Rochester, NY, 8Northwell Health, Great Neck, NY, 9Feinstein Institutes for Medical Research, Manhasset, NY, 10Cincinnati Children's Hospital, Cincinnati, OH, 11Oklahoma Medical Research Foundation, Oklahoma City, OK, 12University of California, Division of Rheumatology, San Francisco, CA, 13University of California San Francisco, SF, CA, 14NYU Grossman School of Medicine, New York, NY, 15NYU School of Medicine, New York, NY, 16Medical University of South Carolina, Charleston, SC, 17Albert Einstein College of Medicine, Bronx, NY, 18Rockefeller University, New York, NY, 19University of California Los Angeles, Los Angeles, CA, 20University of California San Diego, La Jolla, CA, 21Adjunct Professor of Medicine, Stanford University; Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA, Los Angeles, CA, 22Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 23University of Rochester Medical Center, Rochester, NY, 24Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD

    Background/Purpose: Lupus nephritis (LN) is characterized by considerable variability in its clinical manifestations and histopathological findings. Understanding the cellular and molecular mechanisms underlying this heterogeneity…
  • Abstract Number: 1139 • ACR Convergence 2022

    Molecular Pathways Identified from Risk Alleles Identify Mechanistic Differences in Systemic Lupus Erythematosus Patients of East Asian and European Ancestry

    Katherine Owen1, Kristy Bell2, Andrew Price3, Prathyusha Bachali4, Hannah Ainsworth5, Miranda Marion6, Timothy Howard5, Carl Langefeld7, Nan Shen8, Jinoos Yazdany9, Maria Dall'Era10, Amrie Grammer11 and Peter Lipsky3, 1RILITE, Crozet, VA, 2AMPEL BioSolutions LLC, Charlottesville, VA, 3AMPEL BioSolutions, Charlottesville, VA, 4AMPEL BioSolutions, Redmond, WA, 5Wake Forest School of Medicine, Winston-Salem, NC, 6Wake Forest University, Winston-Salem, NC, 7Wake Forest School of Medicine, Winston Salem, NC, 8Shanghai Jiang Tong University School of Medicine, Shanghai, China, 9UCSF, San Francisco, CA, 10University of California, Division of Rheumatology, San Francisco, CA, 11AMPEL LLC, Charlottesville, VA

    Background/Purpose: SLE is a multi-organ autoimmune disorder with a prominent genetic component. Individuals of Asian-Ancestry (AsA) disproportionately experience more severe SLE compared to individuals of…
  • Abstract Number: 0107 • ACR Convergence 2021

    Acceptability of the COVID-19 Vaccine in Patients with Rheumatic Diseases and Healthcare Professionals in 19 Arab Countries

    Lina El Kibbi1, Mona Metawee1, Ihsane Hmamouchi2, Nizar Abdulateef3, Hussein Halabi4, Mervat Eissa5, Manal El Rakawi6, Basel Masri7, Fatemah Abutiban8, Wafa Hamdi9, Asal Adnan3, Antonella Abi Najm10, Renaud Felten11, Laurent Arnaud11 and Nelly Ziade12, 1Specialized Medical Center, Riyadh, Saudi Arabia, 2Rheumatology Unit, Temara Hospital, Laboratory of Biostatistics, Clinical Research and Epidemiology (LBRCE), Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, 3Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq, 4King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia, 5Cairo University, Cairo, Egypt, Cairo, Egypt, 6Rheumatology Department, Douera Hospital, Faculty of Medicine, Saad Dahlab, Blida, Algeria, 7Jordan Hospital, Amman, Jordan, 8Rheumatology Unit, Department of Medicine, Jaber Alahmed Alsabah Hospital, Kuwait City, Kuwait, 9Rheumatology Department, Kassab Institute of Orthopedics, UR17SP04, Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia, 10Faculty of Medicine, Saint-Joseph University, Beirut, Lebanon, 11Department of Rheumatology, French National Reference Center for Autoimmune Diseases (CRMR RESO), Strasbourg, France, 12Rheumatology Department, Saint-Joseph Medical University and Hotel-Dieu de France Hospital, Beirut, Lebanon

    Background/Purpose: The first COVID-19 vaccines were authorized in December 2020. However, their acceptability remains debated and has never been evaluated in patients with chronic rheumatic…
  • Abstract Number: 0523 • ACR Convergence 2021

    Transcriptional Subsetting of SLE Patient Cohorts Based on Metabolic Pathway Activity

    Diogo Camacho, Jennifer Swantek, Keng Soh, Jurre Kamphorst, Vivek Kaimal, John Monroe and Edward Driggers, Rheos Medicines, Inc, Cambridge, MA

    Background/Purpose: Systemic lupus erythematosus is a highly complex, heterogeneous, autoimmune disorder, with diverse clinical presentation and innate and adaptive immune system involvement. There is a…
  • Abstract Number: 1061 • ACR Convergence 2021

    Comparing Consultation Patterns Across Telehealth Platforms and Face-to-Face Clinic in the Military Health System

    Michael Loncharich, David DeSena, Angelique Collamer and Jess Edison, Walter Reed National Military Medical Center, Bethesda, MD

    Background/Purpose: Rheumatic diseases are often diagnostically challenging not only due to rarity, but also because symptoms can develop piecemeal before the diagnosis is clear. Access…
  • Abstract Number: 0596 • ACR Convergence 2020

    Clinical Academic Rheumatology: A Boon for Health Systems

    Kathleena D'Anna1, Karina Torralba2, Christina Downey3 and Carlos Silva Lynch4, 1Loma Linda University Medical Center, Moreno Valley, CA, 2Loma Linda University School of Medicine, Redlands, CA, 3Loma Linda University Medical Center, Redlands, CA, 4Loma Linda University Medical Center, Loma Linda

    Background/Purpose: Finding a balance between clinical and scholarly productivity is a challenge for many academic clinician-educator (CE) rheumatologists. An examination of workload and practice-generated downstream…
  • Abstract Number: 1481 • ACR Convergence 2020

    A Systematic Review to Quantify the Extent of Pharmaceutical Company Involvement in Rheumatology Consensus-Based Recommendations

    Dominique Feterman Jimenez1, Garret Duron2, Ali Duarte-Garcia3, Paul Sufka4, Samuel Whittle5, Philip Robinson6, Larry Prokop3 and Michael Putman7, 1UConn Health Center, Farmington, CT, 2HCA Memorial Health University Medical Center, Savannah, GA, 3Mayo Clinic, Rochester, MN, 4Healthpartners, St Paul, 5Rheumatology Unit, The Queen Elizabeth Hospital, Springfield, South Australia, Australia, 6University of Queensland, Herston, Queensland, Australia, 7Northwestern University, Chicago, IL

    Background/Purpose: Consensus-based recommendations guide standards of care for clinical practice. Pharmaceutical-industry involvement in producing such recommendations may undermine their objectivity. We performed a systematic review…
  • Abstract Number: 1564 • ACR Convergence 2020

    Feasibility of Ultra-low-dose, Short-duration, Total-body Evaluation of Inflammatory Arthritis Using uEXPLORER 18F-FDG PET/CT

    Soumajyoti Sarkar1, Siba Raychaudhuri2, Lorenzo Nardo3, Heather Hunt3, Denise Caudle4, Mike Nguyen4, Simon Cherry4, Ramsey Badawi4, Abhijit Chaudhari5 and Yasser Abdelhafez3, 1University of California, Davis, Davis, 2Division of Rheumatology, Allergy & Clinical Immunology, University of California School of Medicine, Davis, and VA Medical Center Sacramento, Sacramento, CA, 3University of California Davis, Sacramento, CA, 4University of California Davis, Sacramento, 5University of California, Davis, Sacramento, CA

    Background/Purpose: The uEXPLORER system enables the unique, simultaneous acquisition of PET data over the entire adult human body with a high-sensitivity, alongside concurrent CT data.…
  • Abstract Number: 1613 • ACR Convergence 2020

    Improving Transition Policy Dissemination and Care Team Communication in Pediatric Rheumatology Clinic Through Standardization of Workflow and Electronic Health Record Documentation

    Rosemary Peterson1, Emily Liebling1, Beth Rutstein2, Julie Chase1, Atiye Bilgic Dagci3, Melissa Argraves3, Jon Burnham1, Lisa Wiater3, Deborah Bieniakowski3, Danielle Dodson3, Jane Kennedy3, Cora Sears3 and Joyce Chang1, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2The Children's Hospital of Philadelphia, Philadelphia, PA, 3Children's Hospital of Philadelphia, Philadelphia

    Background/Purpose: Morbidity and mortality increase when young adults with chronic disease transfer from pediatric to adult care.  Structured healthcare transition processes improve outcomes, yet are…
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