Abstracts tagged "Systemic sclerosis"

Abstract Number: 413 • 2015 ACR/ARHP Annual Meeting
Is There a Difference in the Presentation of Diffuse and Limited Subtype of Juvenile Systemic Sclerosis in Childhood? Results from the Juvenile Scleroderma Inception Cohort Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Stanevicha³, Maria M. Katsicas⁴, Maria Teresa Terreri⁵, Ana Paula Sakamoto⁶, Rolando Cimaz⁷, Mikhail Kostik⁸, Tadey Avcin⁹, Maria Jose Santos¹⁰, Monika Moll¹¹, Dana Nemkova¹², Flavio Sztajnbok¹³, Cristina Battagliotti¹⁴, Juergen Brunner¹⁵, Despina Eleftheriou¹⁶, Alberto Sifuentes Giraldo¹⁷, Liora Harel¹⁸, Mahesh Janarthanan¹⁹, Tilmann Kallinich²⁰, Kirsten Minden²¹, Susan Mary Nielsen²², Kathryn S. Torok²³, Yosef Uziel²⁴ and Nicola Helmus²⁵, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³Pediatric cathedra, University Childrens Hospital, Riga, Latvia, ⁴Service of Immunology & Rheumatology. Hospital de Pediatrìa Prof Dr.Juan.P. Garrahan, MD, Buenos Aires, Argentina, ⁵Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁶Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁷Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁸State Pediatric Medical University, Saint-Petersburg, Russia, ⁹University Children's Hospital, Ljubljana, Slovenia, ¹⁰Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹¹Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹²Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹³Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁴Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁵Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁶Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁷Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁸Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ¹⁹Pediatric Rheumatology, Chennai, India, ²⁰Charite, University Medicine Berlin, Berlin, Germany, ²¹Chidlrens´ hospital, Charité University Medicine, Berlin, Germany, ²²Rigshospitalet, Copenhagen, Denmark, ²³Pediatric Rheumatology, Scleroderma Center of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁴Meir Medical Center, Kfar Saba, Israel, ²⁵Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Several publications in adults looked at the differences between limited and diffuse subtypes. There is…
Abstract Number: 414 • 2015 ACR/ARHP Annual Meeting
Performance of the Adult Systemic Sclerosis Classification in Juvenile Systemic Sclerosis Patients. Results from the Juvenile Systemic Sclerosis Inception Cohorte Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Stanevicha³, Ekaterina Alexeeva⁴, Maria M. Katsicas⁵, Maria Teresa Terreri⁶, Ana Paula Sakamoto⁷, Rolando Cimaz⁸, Mikhail Kostik⁹, Tadey Avcin¹⁰, Maria Jose Santos¹¹, Monika Moll¹², Dana Nemkova¹³, Flavio Sztajnbok¹⁴, Cristina Battagliotti¹⁵, Juergen Brunner¹⁶, Despina Eleftheriou¹⁷, Alberto Sifuentes Giraldo¹⁸, Liora Harel¹⁹, Mahesh Janarthanan²⁰, Tilmann Kallinich²¹, Kirsten Minden²², Susan Mary Nielsen²³, Kathryn S. Torok²⁴, Yosef Uziel²⁵ and Nicola Helmus²⁶, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³University Childrens Hospital, Riga, Latvia, ⁴Rheumatology, Scientific Center of Children's Health, Moscow, Russia, ⁵Hospital de Pediatria, Buenos Aires, Argentina, ⁶Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁷Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁸Pediatric Rheumatology, Anna Meyer Children's Hospital, Florence, Italy, ⁹State Pediatric Medical University, Saint-Petersburg, Russia, ¹⁰University Children's Hospital, Ljubljana, Slovenia, ¹¹Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹²Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹³Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁴Pediatric Rheumatology Division, Adolescent Health Care Unit, Universida de do Estado do Rio de Janeiro., Rio de Janeiro, Brazil, ¹⁵Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁶Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁷Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁸Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁹Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ²⁰Pediatric Rheumatology, Chennai, India, ²¹Charite, University Medicine Berlin, Berlin, Germany, ²²Epidemiology, Charite, DRFZ, Berlin, Germany, ²³Rigshospitalet, Copenhagen, Denmark, ²⁴Pediatric Rheumatology, Scleroderma Center of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁵Meir Medical Center, Kfar Saba, Israel, ²⁶Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: The new adult classifiction criteria (1) for Systemic Sclerosis (SSc) were recently published and the pediatric criteria were published in 2007 (2). None of…
Abstract Number: 824 • 2015 ACR/ARHP Annual Meeting
Familial Risk of Systemic Sclerosis and Co-Aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study
Chang-Fu Kuo¹, Matthew J. Grainge², Ana Valdes³, Shue-Fen Luo⁴, Lai-Chu See⁵, Kuang-Hui Yu⁶, Weiya Zhang⁷ and Michael Doherty⁸, ¹Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memorial Hospital, Tayuan, Taiwan, ²Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, ³Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, ⁴Rheumatology, Chang Gung Memorial Hosp, Taipei, Taiwan, ⁵Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ⁶Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memoria Hospital, Tayuan, Taiwan, ⁷Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ⁸Academic Rheumatology, City Hospital, Nottingham, United Kingdom
Background/Purpose: To investigate familial aggregation of systemic sclerosis and the relative risks (RRs) of other autoimmune disease in relatives of affected patients. Methods: We identified…
Abstract Number: 827 • 2015 ACR/ARHP Annual Meeting
Reliability of the Quantitative Assessment of Peripheral Blood Perfusion By Laser Speckle Contrast Analysis in a Systemic Sclerosis Cohort
Valérie Lambrecht¹, Maurizio Cutolo², Filip De Keyser³, Saskia Decuman⁴, Barbara Ruaro², Alberto Sulli⁵, Ellen Deschepper⁶ and Vanessa Smith⁷, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Department of Rheumatology, UGent, Ghent, Belgium, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, Genova, Italy, ⁶Biostatistics Unit, Biostatistics Unit, Ghent University, Ghent, Belgium, ⁷Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
Background/Purpose: Laser speckle contrast analysis (LASCA) is an innovative technique to quantify peripheral blood perfusion (PBP) over a given area. Quantification of blood flow might…
Abstract Number: 1875 • 2015 ACR/ARHP Annual Meeting
Deep Vein Thrombosis and Pulmonary Embolism in Systemic Sclerois
Nabil Hakami^1,2 and Sindhu R. Johnson³, ¹Rheumatology, Toronto Scleroderma Program,Toronto Western Hospital, Mount Sinai Hospital,, Toronto, ON, Canada, ²King Fahad Central Hospital, Riyad, Saudi Arabia, ³Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada
Background/Purpose: In systemic sclerosis (SSc) vasculopathy causes frequent episodes of reperfusion injury and free radical mediated endothelial dysfunction, which may influence the onset of local…
Abstract Number: 1876 • 2015 ACR/ARHP Annual Meeting
Caveolin 1 Gene Variants May Effect Disease Progression in Systemic Sclerosis Related Interstitial Lung Disease
Sule Yavuz¹, Elena Lopez-Isac², Ahmet Mesut Onat³, Neslihan Yilmaz⁴, Levent Kilic⁵, Ali Akdogan⁵ and Javier Martín⁶, ¹Rheumatology, Istanbul Bilim University, Faculty of Medicine,Department of Rheumatology, Istanbul, Turkey, ²Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ³Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁴Istanbul Bilim University, Faculty of Medicine, Rheumatology Department, Istanbul, Turkey, ⁵Hacettepe University Vasculitis Center (HUVAC), Ankara, Turkey, ⁶Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain
Background/Purpose: To determine possible association of Cav-1 genetic variants: rs926198, rs959173 and rs9920 with SSc and/or SSc-related ILD progression. Methods: Three Cav-1 single nucleotide polymorphisms…
Abstract Number: 1878 • 2015 ACR/ARHP Annual Meeting
Diagnostic Performance of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis: Results from a Brazilian Validation Cohort
Farley Carvalho¹, Cintia Camargo², Bruna Fernandez¹ and Cristiane Kayser², ¹Universidade Federal de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: New classification criteria for systemic sclerosis (SSc) were proposed by the ACR/EULAR in 2013, due to the low sensitivity of the 1980 ACR classification…
Abstract Number: 1724 • 2014 ACR/ARHP Annual Meeting
Loss of IRF5 Ameliorates Tissue Fibrosis in a Murine Model of Systemic Sclerosis
Ryosuke Saigusa¹, Yoshihide Asano¹, Takashi Taniguchi¹, Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Ayumi Yoshizaki¹, Tadatsugu Taniguchi² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations that result from fibrosis development, immune activation and vascular injuries. A genome-wide association…
Abstract Number: 1715 • 2014 ACR/ARHP Annual Meeting
Serum Levels of CD163/Tweak Predict Risk of Digital Ulcers in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Marek Bielecki², Beata Trzcinska-Butkiewicz³, Malgorzata Michalska-Jakubus⁴, Marek Brzosko³, Dorota Krasowska⁴ and Krzysztof Kowal⁵, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ³Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, ⁴Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁵Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK) regulates inflammation, angiogenesis and tissue remodeling. CD163 molecule, a scavenger receptor and marker of alternatively activated macrophages, modulates…
Abstract Number: 766 • 2014 ACR/ARHP Annual Meeting
Endothelial Fli1 Deficiency Delays Wound Healing Due to Impaired Anastomosis of Newly Formed Vessels – a Possible Mechanism of Refractory Skin Ulcers in Systemic Sclerosis
Yoshihide Asano¹ and Maria Trojanowska², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Arthritis Center, Boston University, Boston, MA
Background/Purpose Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in fibrosis of the skin and certain internal organs. Although the pathogenesis of…
Abstract Number: 740 • 2014 ACR/ARHP Annual Meeting
Right Ventricular Diastolic Impairment Is Common in Systemic Sclerosis and Is a Marker of Several Organ-Target Damage of the Disease
Christophe Meune¹, Dinesh Khanna², Jamil Aboulhosn³, Jerome Avouac⁴, Andre Kahan⁵, Daniel E. Furst⁶ and Yannick Allanore⁴, ¹Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Cardiology Department, Bobigny, France, ²University of Michigan Health System, Ann Arbor, MI, ³Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁶University of California, Los Angeles, Department of Medicine, Los Angeles, CA
Background/Purpose Heart failure and cardiac dysfunctions both of intrinsic or secondary origin and targeting LV (left ventricule) and/or RV (right ventricule) are critical complications promoting…
Abstract Number: 748 • 2014 ACR/ARHP Annual Meeting
Increased Expression of Chemerin in Endothelial Cells Due to Fli1 Deficiency May Contribute to the Development of Digital Ulcers in Systemic Sclerosis
Kaname Akamata, Yoshihide Asano, Takashi Taniguchi, Hayakazu Sumida, Naohiko Aozasa, Shinji Noda, Tetsuo Toyama, Takehiro Takahashi, Yohei Ichimura, Ayumi Yoshizaki and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder characterized by vascular injuries and fibrosis development. In SSc lesional skin, transcription factor Friend leukemia virus…
Abstract Number: 721 • 2014 ACR/ARHP Annual Meeting
Muscle Disease in Systemic Sclerosis Is Associated with an Increased Risk for Cardiac Involvement
Jison Hong¹, Antonia Valenzuela², David Fiorentino³ and Lorinda Chung⁴, ¹Medicine- Immunology & Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ³Dermatology, Stanford University, Redwood City, CA, ⁴Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose Patients with systemic sclerosis (SSc) and muscle involvement (myopathy/myositis) have more severe disease and worse outcomes. We sought to determine the prevalence of muscle…
Abstract Number: 739 • 2014 ACR/ARHP Annual Meeting
Lack of Association Between Esophageal Symptoms and Abnormal Findings in High-Resolution Manometry in a Mexican Mestizo Cohort with Systemic Sclerosis (SSc)
Ana Arana-Guajardo¹, Miguel Villarreal-Alarcón², Gustavo Torres-Barrera³, David Vega-Morales⁴, Hector Maldonado-Garza³ and Mario Garza-Elizondo², ¹Departamento de Medicina Interna del Hospital Universitario, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ²Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ³Departamento de Medicina Interna del Hospital Universitario, Servicio de Gastroenterología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ⁴Rheumatology, Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose . Esophageal involvement is present in 50-70% of SSc patients and it is the most common visceral organ complication. The impact of the esophageal…
Abstract Number: 733 • 2014 ACR/ARHP Annual Meeting
Impact of Geographic Variation on the Risk of Digital Ulcers Development in Systemic Sclerosis: A Brazilian Multicenter Registry
Eduardo José do Rosário e Souza¹, Carolina de Souza Muller², Andrea Tavares Dantas³, Henrique A. Mariz³, Alex Magno Coelho Horimoto⁴, Renato Alvarenga Rezende¹, Isabela Guimarães², Izaias Pereira da Costa⁴, Glauce Rejane Leonardi Bertazzi⁵, Luiza Paiola⁵, Eutília Andrade Medeiros Freire⁶, Roberta Ismael⁶, Ana Paula Toledo Del-Rio⁷, Juliana Sekiyama⁷, Carolina Barros Kahwage⁸ and Cristiane Kayser⁹, ¹Serviço de Reumatologia, Hospital Santa Casa, Minas Gerais, Belo Horizonte, Brazil, ²Universidade Federal do Paraná, Curitiba, Brazil, ³Disciplina de Reumatologia, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, ⁴Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil, ⁵Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil, ⁶Universidade Federal da Paraíba, João Pessoa, Brazil, ⁷Universidade Estadual de Campinas, Campinas, Brazil, ⁸Universidade Federal de São Paulo, São Paulo, Brazil, ⁹Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Digital ulcers (DU) and Raynaud’s phenomenon (RP) are a frequent complication in patients with Systemic Sclerosis (SSc). The present study aimed to evaluate the…

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