Abstracts tagged "Systemic sclerosis"

Abstract Number: 3011 • 2015 ACR/ARHP Annual Meeting
The Homeoprotein Engrailed-1 Regulates Canonical TGF Beta Signaling in Experimental Systemic Sclerosis
Tatjana Mallano¹, Katrin Palumbo-Zerr¹, Christian Beyer^1,2, Clara Dees¹, Jingang Huang¹, Thomas Wohlfahrt¹, Oliver Distler³, Georg Schett¹ and Jeorg HW Distler^1,2, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Rheumatology, Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is a chronic fibrotic connective disease of unknown etiology that affects the skin and internal organs. Transforming growth factor-β (TGFβ) has…
Abstract Number: 3130 • 2015 ACR/ARHP Annual Meeting
Epstein-Barr Virus Induces Activation of Infammatory Markers Via the TLR8 Transduction Pathway in Infected Scleroderma Monocytes
Antonella Farina¹, Giovanna Peruzzi^2,3, Valentina Lacconi⁴, Edoardo Rosato⁵, Silvia Quarta⁶, Stefania Morrone¹, Alberto Faggioni¹, Maria Trojanowska⁴ and Giuseppina Alessandra Farina⁴, ¹Department of Experimental Medicine, Sapienza University, Department of Experimental Medicine, Rome, Italy, ²Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Rome, Italy, ³Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Viale Regina Elena 291, 00161, Rome, Italy, Rome, Italy, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA, ⁵Department of Clinical Medicine, Clinical Immunology Unit,, Sapienza University,Department of Clinical Medicine, Rome, Italy, ⁶Department of Clinical Medicine, Clinical Immunology Unit., Sapienza University,Department of Clinical Medicine, Rome, Italy
Background/Purpose: Monocytes from patients with systemic sclerosis (Scleroderma, SSc), are characterized by the increased expression of IFN-regulatory genes, implicating dysregulation of the innate immune response…
Abstract Number: 3135 • 2015 ACR/ARHP Annual Meeting
Incidences and Predictors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal Study
Veronika K. Jaeger¹, Elina G. Wirz^2,3, Yannick Allanore⁴, Gabriela Riemekasten⁵, Eric Hachulla⁶, Oliver Distler⁷, Paolo Airo⁸, Patricia E. Carreira⁹, Alexandra Balbir-Gurman¹⁰, Mohammed Tikly¹¹, Serena Vettori¹², Nemanja Damjanov¹³, Ulf Müller-Ladner¹⁴, Jorg HW. Distler¹⁵, Mangtao Li¹⁶, Ulrich A. Walker¹⁷ and EUSTAR collaborators, ¹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ²Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ³Department of Dermatology, University Hospital Basel, Basel, Switzerland, ⁴Department of Rheumatology A, Paris Descartes University, Cochin Hospital, Paris, France, ⁵Clinic of Rheumatology, University of Luebeck, Lübeck, Germany, ⁶Service de Médecine Interne, Hôpital Huriez, Université de Lille, Lille, France, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁸UO Reumatologia ed Immunologia Clinica, Spedali Civili, Brescia, Italy, ⁹Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁰B. Shine Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel, ¹¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, ¹²Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ¹³Institute of Rheumatology, University of Belgrade Medical School, Belgrade, Serbia, ¹⁴Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁵Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁶Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China, ¹⁷Rheumatology, University Hospital, Basel, Basel, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is a rare and clinically heterogeneous autoimmune disorder characterised by fibrosis and microvascular obliteration of the skin and internal organs, particularly…
Abstract Number: 412 • 2015 ACR/ARHP Annual Meeting
Update on the Juvenile Systemic Sclerosis Inception Cohort Project. Characteristics of the First 50 Patients at First Assessment. Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Staņeviča³, Ekaterina Alexeeva⁴, Maria M. Katsicas⁵, Maria Teresa Terreri⁶, Ana Paula Sakamoto⁷, Rolando Cimaz⁸, Mikhail Kostik⁹, Tadey Avcin¹⁰, Maria Jose Santos¹¹, Monika Moll¹², Dana Nemkova¹³, Flavio Sztajnbok¹⁴, Cristina Battagliotti¹⁵, Juergen Brunner¹⁶, Despina Eleftheriou¹⁷, Alberto Sifuentes Giraldo¹⁸, Liora Harel¹⁹, Mahesh Janarthanan²⁰, Tilmann Kallinich²¹, Kirsten Minden²², Susan Mary Nielsen²³, Kathryn S. Torok²⁴, Yosef Uziel²⁵ and Nicola Helmus²⁶, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³Pediatric cathedra, Riga Stradiņš University, Riga, Latvia, ⁴Rheumatology, Scientific Center of Children's Health, Moscow, Russia, ⁵Immunology & Rheumatology., Hospital de Pediatrìa Garrahan, Buenos Aires, Argentina, ⁶Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁷Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁸Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁹State Pediatric Medical University, Saint-Petersburg, Russia, ¹⁰University Children's Hospital, Ljubljana, Slovenia, ¹¹Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹²Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹³Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁴Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁵Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁶Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁷Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁸Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁹Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ²⁰Pediatric Rheumatology, Chennai, India, ²¹Charite, University Medicine Berlin, Berlin, Germany, ²²Chidlrens´ hospital, Charité University Medicine, Berlin, Germany, ²³Rigshospitalet, Copenhagen, Denmark, ²⁴Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁵Meir Medical Center, Kfar Saba, Israel, ²⁶Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Currently just retrospective data exist regarding evolvement of organ involvement. In the previous retrospective studies…
Abstract Number: 413 • 2015 ACR/ARHP Annual Meeting
Is There a Difference in the Presentation of Diffuse and Limited Subtype of Juvenile Systemic Sclerosis in Childhood? Results from the Juvenile Scleroderma Inception Cohort Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Stanevicha³, Maria M. Katsicas⁴, Maria Teresa Terreri⁵, Ana Paula Sakamoto⁶, Rolando Cimaz⁷, Mikhail Kostik⁸, Tadey Avcin⁹, Maria Jose Santos¹⁰, Monika Moll¹¹, Dana Nemkova¹², Flavio Sztajnbok¹³, Cristina Battagliotti¹⁴, Juergen Brunner¹⁵, Despina Eleftheriou¹⁶, Alberto Sifuentes Giraldo¹⁷, Liora Harel¹⁸, Mahesh Janarthanan¹⁹, Tilmann Kallinich²⁰, Kirsten Minden²¹, Susan Mary Nielsen²², Kathryn S. Torok²³, Yosef Uziel²⁴ and Nicola Helmus²⁵, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³Pediatric cathedra, University Childrens Hospital, Riga, Latvia, ⁴Service of Immunology & Rheumatology. Hospital de Pediatrìa Prof Dr.Juan.P. Garrahan, MD, Buenos Aires, Argentina, ⁵Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁶Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁷Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁸State Pediatric Medical University, Saint-Petersburg, Russia, ⁹University Children's Hospital, Ljubljana, Slovenia, ¹⁰Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹¹Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹²Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹³Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ¹⁴Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁵Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁶Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁷Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁸Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ¹⁹Pediatric Rheumatology, Chennai, India, ²⁰Charite, University Medicine Berlin, Berlin, Germany, ²¹Chidlrens´ hospital, Charité University Medicine, Berlin, Germany, ²²Rigshospitalet, Copenhagen, Denmark, ²³Pediatric Rheumatology, Scleroderma Center of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁴Meir Medical Center, Kfar Saba, Israel, ²⁵Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan autoimmune disease. Several publications in adults looked at the differences between limited and diffuse subtypes. There is…
Abstract Number: 414 • 2015 ACR/ARHP Annual Meeting
Performance of the Adult Systemic Sclerosis Classification in Juvenile Systemic Sclerosis Patients. Results from the Juvenile Systemic Sclerosis Inception Cohorte Www.Juvenile-Scleroderma.Com
Ivan Foeldvari¹, Jens Klotsche², Valda Stanevicha³, Ekaterina Alexeeva⁴, Maria M. Katsicas⁵, Maria Teresa Terreri⁶, Ana Paula Sakamoto⁷, Rolando Cimaz⁸, Mikhail Kostik⁹, Tadey Avcin¹⁰, Maria Jose Santos¹¹, Monika Moll¹², Dana Nemkova¹³, Flavio Sztajnbok¹⁴, Cristina Battagliotti¹⁵, Juergen Brunner¹⁶, Despina Eleftheriou¹⁷, Alberto Sifuentes Giraldo¹⁸, Liora Harel¹⁹, Mahesh Janarthanan²⁰, Tilmann Kallinich²¹, Kirsten Minden²², Susan Mary Nielsen²³, Kathryn S. Torok²⁴, Yosef Uziel²⁵ and Nicola Helmus²⁶, ¹Hamburger Zentrum für Kinder-und Jugendrheumatologie, Hamburg, Germany, ²Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ³University Childrens Hospital, Riga, Latvia, ⁴Rheumatology, Scientific Center of Children's Health, Moscow, Russia, ⁵Hospital de Pediatria, Buenos Aires, Argentina, ⁶Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, ⁷Assistant doctor, Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁸Pediatric Rheumatology, Anna Meyer Children's Hospital, Florence, Italy, ⁹State Pediatric Medical University, Saint-Petersburg, Russia, ¹⁰University Children's Hospital, Ljubljana, Slovenia, ¹¹Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ¹²Pediatric Rheumatology, University Childrenhospital, Tübingen, Germany, ¹³Pediatric Rheumatology Unit, Department of Pediatrics and Adolescent Medicine, General University Hospital in Prague, Prague, Czech Republic, ¹⁴Pediatric Rheumatology Division, Adolescent Health Care Unit, Universida de do Estado do Rio de Janeiro., Rio de Janeiro, Brazil, ¹⁵Hospital de Niños Dr Orlando Alasia, Santa Fé, Argentina, ¹⁶Universitätsklinik für Kinder- u. Jugendheilkunde, Innsbruck, Austria, ¹⁷Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹⁸Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁹Pediatric Rheumatology Unit, Schneider Children's Medical Center,Tel Aviv University, Petach Tikvah, Israel, ²⁰Pediatric Rheumatology, Chennai, India, ²¹Charite, University Medicine Berlin, Berlin, Germany, ²²Epidemiology, Charite, DRFZ, Berlin, Germany, ²³Rigshospitalet, Copenhagen, Denmark, ²⁴Pediatric Rheumatology, Scleroderma Center of Pittsburgh, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²⁵Meir Medical Center, Kfar Saba, Israel, ²⁶Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany
Background/Purpose: The new adult classifiction criteria (1) for Systemic Sclerosis (SSc) were recently published and the pediatric criteria were published in 2007 (2). None of…
Abstract Number: 824 • 2015 ACR/ARHP Annual Meeting
Familial Risk of Systemic Sclerosis and Co-Aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study
Chang-Fu Kuo¹, Matthew J. Grainge², Ana Valdes³, Shue-Fen Luo⁴, Lai-Chu See⁵, Kuang-Hui Yu⁶, Weiya Zhang⁷ and Michael Doherty⁸, ¹Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memorial Hospital, Tayuan, Taiwan, ²Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom, ³Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, United Kingdom, ⁴Rheumatology, Chang Gung Memorial Hosp, Taipei, Taiwan, ⁵Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, ⁶Division of Rheumatoplogy, Allergy and Immunology, Chang Gung Memoria Hospital, Tayuan, Taiwan, ⁷Academic Rheumatology, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom, ⁸Academic Rheumatology, City Hospital, Nottingham, United Kingdom
Background/Purpose: To investigate familial aggregation of systemic sclerosis and the relative risks (RRs) of other autoimmune disease in relatives of affected patients. Methods: We identified…
Abstract Number: 2708 • 2014 ACR/ARHP Annual Meeting
Post-Occlusive Reactive Hyperemia (PORH) Test Mirrors Vascular Changes in Systemic Sclerosis (SSc):a Laser Speckle Contrast (LASCA) Study
Alessandra Della Rossa¹, Anna d'Ascanio², Massimo Cagnoni¹, Chiara Stagnaro³, Alice Parma⁴, Marta Mosca⁵ and Stefano Bombardieri⁶, ¹malattie muscoloscheletriche e cutanee, Rheumatology Unit, Pisa, Italy, ²Malattie muscolo-scheletriche e cutanee, Rheumatology Unit, Pisa, Italy, ³Malattie scheletriche e muscolocutanee, Rheumatology Unit, Pisa, Italy, ⁴University of Pisa, Rheumatology Unit, Pisa, Italy, ⁵Rheumatology Unit, University of Pisa, Pisa, Italy, ⁶Rheumatology Unit, Pisa, Italy
Background/Purpose Vascular involvement is a key feature of Systemic sclerosis (SSc) and involves both the micro and macrovasculature. Vascular changes are central in the disease’s…
Abstract Number: 2706 • 2014 ACR/ARHP Annual Meeting
Ulnar and Radial Stenosis in Systemic Sclerosis
María Eugenia Lara¹, Mariano Rivero¹, Julia Romero¹, Guadalupe Palacios², Ignacio Carrillo³, Claudia L. Giraldo⁴, Amalia Schiel⁵, Hugo Armando Laborde¹, Marina Khoury⁶, Saez Diego⁷, Gustavo Citera⁸, Oscar L. Rillo⁹ and Juan C. Barreira¹, ¹Rheumatology, British Hospital, Buenos Aires, Argentina, ²British Hospital, Buenos Aires, Argentina, ³Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁴Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁵Central Laboratory, British Hospital, Buenos Aires, Argentina, ⁶Teaching and Research, British Hospital, Buenos Aires, Argentina, ⁷Imaging, British Hospital, Buenos Aires, Argentina, ⁸Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁹Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina
Background/Purpose: Systemic sclerosis (SSc) is a chronic, autoimmune disease. Endothelial damage has been recognized as the initial pathogenic factor. The involvement of the microvasculature is…
Abstract Number: 1724 • 2014 ACR/ARHP Annual Meeting
Loss of IRF5 Ameliorates Tissue Fibrosis in a Murine Model of Systemic Sclerosis
Ryosuke Saigusa¹, Yoshihide Asano¹, Takashi Taniguchi¹, Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Ayumi Yoshizaki¹, Tadatsugu Taniguchi² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations that result from fibrosis development, immune activation and vascular injuries. A genome-wide association…
Abstract Number: 1715 • 2014 ACR/ARHP Annual Meeting
Serum Levels of CD163/Tweak Predict Risk of Digital Ulcers in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Marek Bielecki², Beata Trzcinska-Butkiewicz³, Malgorzata Michalska-Jakubus⁴, Marek Brzosko³, Dorota Krasowska⁴ and Krzysztof Kowal⁵, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ³Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, ⁴Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁵Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK) regulates inflammation, angiogenesis and tissue remodeling. CD163 molecule, a scavenger receptor and marker of alternatively activated macrophages, modulates…
Abstract Number: 766 • 2014 ACR/ARHP Annual Meeting
Endothelial Fli1 Deficiency Delays Wound Healing Due to Impaired Anastomosis of Newly Formed Vessels – a Possible Mechanism of Refractory Skin Ulcers in Systemic Sclerosis
Yoshihide Asano¹ and Maria Trojanowska², ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Arthritis Center, Boston University, Boston, MA
Background/Purpose Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in fibrosis of the skin and certain internal organs. Although the pathogenesis of…
Abstract Number: 740 • 2014 ACR/ARHP Annual Meeting
Right Ventricular Diastolic Impairment Is Common in Systemic Sclerosis and Is a Marker of Several Organ-Target Damage of the Disease
Christophe Meune¹, Dinesh Khanna², Jamil Aboulhosn³, Jerome Avouac⁴, Andre Kahan⁵, Daniel E. Furst⁶ and Yannick Allanore⁴, ¹Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Cardiology Department, Bobigny, France, ²University of Michigan Health System, Ann Arbor, MI, ³Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁶University of California, Los Angeles, Department of Medicine, Los Angeles, CA
Background/Purpose Heart failure and cardiac dysfunctions both of intrinsic or secondary origin and targeting LV (left ventricule) and/or RV (right ventricule) are critical complications promoting…
Abstract Number: 748 • 2014 ACR/ARHP Annual Meeting
Increased Expression of Chemerin in Endothelial Cells Due to Fli1 Deficiency May Contribute to the Development of Digital Ulcers in Systemic Sclerosis
Kaname Akamata, Yoshihide Asano, Takashi Taniguchi, Hayakazu Sumida, Naohiko Aozasa, Shinji Noda, Tetsuo Toyama, Takehiro Takahashi, Yohei Ichimura, Ayumi Yoshizaki and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder characterized by vascular injuries and fibrosis development. In SSc lesional skin, transcription factor Friend leukemia virus…
Abstract Number: 721 • 2014 ACR/ARHP Annual Meeting
Muscle Disease in Systemic Sclerosis Is Associated with an Increased Risk for Cardiac Involvement
Jison Hong¹, Antonia Valenzuela², David Fiorentino³ and Lorinda Chung⁴, ¹Medicine- Immunology & Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ³Dermatology, Stanford University, Redwood City, CA, ⁴Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose Patients with systemic sclerosis (SSc) and muscle involvement (myopathy/myositis) have more severe disease and worse outcomes. We sought to determine the prevalence of muscle…

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