Date: Sunday, November 8, 2015
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
To investigate familial aggregation of systemic sclerosis and the relative risks (RRs) of other autoimmune disease in relatives of affected patients.
We identified 23,658,577 beneficiaries registered with the National Health Insurance in 2010, of whom 1,891 individuals had systemic sclerosis. We identified 21,009,551 parent-child relationships and 17,168,340 full sibling pairs. The familial risks of systemic sclerosis, rheumatoid arthritis and systemic lupus erythematosus, familial transmission and expected proportion of sporadic cases were estimated.
The prevalence of systemic sclerosis was 7.99 (95% confidence interval [CI], 7.64–8.36) per 100,000 people in the general population of Taiwan in 2010; in comparison, the prevalence was 387.60 (95% CI, 46.97–1393.06) per 100,000 people. The adjusted RR (95% CI) for systemic sclerosis was 81.21 (11.40–579.72) for siblings of systemic sclerosis patients. The familial transmission (heritability plus shared environmental contribution) was 0.72; despite this, 84.1% of patients was expected to be sporadic cases. The RR (95% CI) in first-degree relatives of systemic sclerosis patients was 7.43 (2.42–22.86) for rheumatoid arthritis; 9.82 (3.76–25.70) for systemic lupus erythematosus.
The risk of systemic sclerosis and other autoimmune diseases is increased in relatives of people with systemic sclerosis and family factors explain over two-thirds the phenotypic variance of the disease. Despite this, the majority of patients were expected to be sporadic cases.
To cite this abstract in AMA style:Kuo CF, Grainge MJ, Valdes A, Luo SF, See LC, Yu KH, Zhang W, Doherty M. Familial Risk of Systemic Sclerosis and Co-Aggregation of Autoimmune Diseases in Affected Families: A Nationwide Population Study [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/familial-risk-of-systemic-sclerosis-and-co-aggregation-of-autoimmune-diseases-in-affected-families-a-nationwide-population-study/. Accessed October 27, 2021.
« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/familial-risk-of-systemic-sclerosis-and-co-aggregation-of-autoimmune-diseases-in-affected-families-a-nationwide-population-study/