Abstracts tagged "Systemic sclerosis"

Abstract Number: 1070 • 2019 ACR/ARP Annual Meeting
Cytokine Signatures Differentiate Systemic Sclerosis Patients at High versus Low Risk for Pulmonary Arterial Hypertension
Kathleen Kolstad¹, Avani Khatri ², Michele Donato ³, Sarah Chang ⁴, Shufeng Li ⁵, Virginia Steen ⁶, Paul Utz ⁴, Purvesh Khatri ³ and Lorinda Chung ⁷, ¹Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, ²Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, ³Institute for Immunity, Transplantation and Infection, Stanford University, Palo Alto, ⁴Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, ⁵Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA, ⁶Georgetown University, Washington, D.C., USA, Georgetown, ⁷Stanford University, Palo Alto, CA
Background/Purpose: Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. Screening algorithms using clinical…
Abstract Number: 1654 • 2019 ACR/ARP Annual Meeting
Esophageal Dilation and Other Clinical Factors Associated with Pulmonary Function Decline in Patients with Systemic Sclerosis
Kimberly Showalter¹, Aileen Hoffmann ², Carrie Richardson ³, Kimberly Koloms ², Gerald Rouleau ², David Aaby ², Julia (Jungwha) Lee ⁴, Jane Dematte ², Rishi Agrawal ², Xiaoping Wu ⁵, Rowland Chang ⁴ and Monique Hinchcliff ⁶, ¹Hospital for Special Surgery, New York, NY, ²Northwestern University Feinberg School of Medicine, Chicago, ³Rush University, Chicago, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵New York Presbyterian/Weill Cornell, New York, ⁶Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT
Background/Purpose: Prior work has shown that Scl-70 positive autoantibody status and baseline c-reactive protein (CRP) are associated with more rapid pulmonary function decline in patients…
Abstract Number: 2596 • 2019 ACR/ARP Annual Meeting
The Contribution of Left Heart Disease in Patients with Systemic Sclerosis-associated Pulmonary Hypertension Having Normal Pulmonary Artery Wedge Pressure
Yoshioki Yamasaki¹, Kanako Suzuki ¹, Keiichi Sakurai ², Yusa Asari ¹, Hidehiro Yamada ³ and Kimito Kawahata ², ¹Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki, Japan, ²Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, ³Center for Rheumatic diseases, Seirei Yokohama Hospital, Kawasaki, Japan
Background/Purpose: Patients with systemic sclerosis (SSc) complicates variety of cardiopulmonary diseases which can result in pulmonary hypertension (PH). The types of PH are usually classified…
Abstract Number: 2618 • 2019 ACR/ARP Annual Meeting
Anti-RNPC-3 Antibodies Are Associated with Nuclear Speckled Immunofluorescence Pattern and Enriched in Triple Negative Systemic Sclerosis Patients
Michael Mahler¹, Fabrece Roup ¹, Chelsea Bentow ¹, Marie Hudson ², Murray Baron ³, May Choi ⁴ and Marvin Fritzler ⁵, ¹Inova Diagnostics, San Diego, CA, ²Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada, ³Jewish General Hospital, McGill University, Montreal, Canada, ⁴Cumming School of Medicine, University of Calgary, Calgary, Canada, ⁵Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important diagnostic and prognostic role in…
Abstract Number: 18 • 2019 ACR/ARP Annual Meeting
Undifferentiated Connective Tissue Disease at Risk for SSc: Potential Role of Circulating CXCL-10, CXCL-11 and IL-33 in Predicting Disease Evolution
Antonella Riccardi¹, Alessia Borgia ², Serena Fasano ¹, Valentina Messiniti ³, Rosaria Irace ³ and Gabriele Valentini ⁴, ¹Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, Italy, ²University of Campania L. Vanvitelli, Naples, Italy, ³Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, ⁴Dipartimento di Medicina di Precisione, II Policlinico U.O. Reumatologia, Napoli, Italy, Napoli, Italy
Background/Purpose: Higher levels of CXCL10 and CXCL11 in patients with a very early diagnosis of systemic sclerosis (SSc) subsequently shifted to SSc were pointed out…
Abstract Number: 726 • 2019 ACR/ARP Annual Meeting
Digital Blood Perfusion Differences Between Black Africans and Caucasians with Systemic Sclerosis
Claudia Ickinger¹, Valerie Lambrecht ², Eustasius Musenge ³, Mohammed Tikly ¹, Maurizio Cutolo ⁴ and Vanessa Smith ⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Joahnnesburg, South Africa, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, ⁵Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium; Dept. of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium, Gent, Belgium
Background/Purpose: Microvascular dysfunction is a prominent feature in SSc. Laser speckle contrast analysis (LASCA) has been shown to be a reliable tool to quantify skin…
Abstract Number: 1043 • 2019 ACR/ARP Annual Meeting
The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts
Blaž Burja¹, Gabriela Kania ², Matija Tomšič ³, Tea Janko ³, Snezna Sodin-Semrl ³, Oliver Distler ⁴, Katja Lakota ³ and Mojca Frank-Bertoncelj ⁵, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, LJUBLJANA, Slovenia, ⁴Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁵University Hospital Zürich, Zürich, Switzerland
Background/Purpose: Metabolic perturbations are emerging as drivers of fibroblast activation in fibrosis. Transcriptomic analyses have shown the enrichment of glycolysis and suppression of tricarboxylic acid…
Abstract Number: 1072 • 2019 ACR/ARP Annual Meeting
CCR2+ Circulating Monocytes Contribute to the Survival of ADSC in Bleomycin-Induced Skin Fibrosis
Madhavi Latha Chalasani¹, Liyoung Kim ¹ and Theresa Lu ², ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York
Background/Purpose: Monocytes and monocyte-derived cells play a crucial role during homeostasis and also during the development of various inflammatory diseases including skin fibrosis. Ly6Chi inflammatory…
Abstract Number: 1655 • 2019 ACR/ARP Annual Meeting
Histologic Features Correlate with the Modified Rodnan Skin Score, Serum Inflammatory Markers, and Patient Reported Outcomes in Patients with Early, Diffuse Cutaneous Systemic Sclerosis
Kimberly Showalter¹, Cynthia Magro ², Dana Orange ³, Yaxia Zhang ⁴, Phaedra Agius ⁵, Jackie Finik ⁶, Robert Spiera ¹ and Jessica Gordon ¹, ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, ³Rockefeller University, New York, ⁴Hospital for Special Surgery, New York, ⁵New York Genome Center, New York City, ⁶Hospital for Special Surgery, New York, NY, New York, NY
Background/Purpose: The association between systemic sclerosis (SSc) skin histology and clinical findings is not fully characterized. In two SSc trials, we developed a scoring system…
Abstract Number: 2597 • 2019 ACR/ARP Annual Meeting
Prevalence and Clinical Associations of Degos Lesions in Systemic Sclerosis
Paula Song¹, Melody Chung ², Shufeng Li ³, David Fiorentino ⁴ and Lorinda Chung ², ¹Department of Medicine, Santa Clara Valley Medical Center, Palo Alto, CA, ²Stanford University, Palo Alto, CA, ³Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA, ⁴Department of Dermatology, Stanford University School of Medicine, Redwood City, CA
Background/Purpose: Degos disease, also known as malignant atrophic papulosis (MAP), is a rare small-vessel vasculopathy that has characteristic cutaneous manifestations consisting of erythematous telangiectatic rims…
Abstract Number: 2744 • 2019 ACR/ARP Annual Meeting
Altered Expression of CD52 Facilitates Adhesion of Circulating CD14+ Monocytes in Systemic Sclerosis
Michal Rudnik¹, Mara Stellato ¹, Filip Rolski ², Przemyslaw Blyszczuk ³, Karin Klingel ⁴, Joerg Henes ⁵, Carol Feghali-Bostwick ⁶, Oliver Distler ⁷ and Gabriela Kania ³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland, ³Centre of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Institute for Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵University Hospital Tuebingen, Department of Internal Medicine II (Oncology, Haematology, Immunology and Rheumatology), Tuebingen, Germany, ⁶Division of Rheumatology & Immunology, Medical University of South Carolina, Charlston, SC, ⁷Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Infiltration of inflammatory cells, including monocytes, into the organs is a major process leading to fibrosis, remodelling and organ dysfunction in systemic sclerosis (SSc).…
Abstract Number: 262 • 2019 ACR/ARP Annual Meeting
Outpatient Healthcare Utilization Among Incident Cases of Systemic Sclerosis: Results from a Population-based Cohort (1988-2016)
Caitrin Coffey¹, Avneek Singh Sandhu ², Cynthia Crowson ³, Dennis Asante ¹, Eric Matteson ⁴, Thomas Osborn ⁵, Kenneth Warrington ⁶ and Ashima Makol ⁵, ¹Mayo Clinic, Rochester, MN, ²kettering health, dayton, OH, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA, Rochester, ⁵Mayo Clinic Minnesota, rochester, MN, ⁶Mayo Clinic Rochester, Rochester, MN
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disorder which results in multi-organ dysfunction and high morbidity and mortality. There is limited data on healthcare…
Abstract Number: 727 • 2019 ACR/ARP Annual Meeting
Mortality and Morbidity in Scleroderma Renal Crisis: A Systematic Literature Review
Hyein Kim¹, Frédéric Lefebvre ², Sabrina Hoa ³ and Marie Hudson ⁴, ¹The University of British Columbia, Vancouver, Canada, ²University of Montreal, Montreal, Canada, ³University of Montreal, Montreal, QC, Canada, ⁴Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada
Background/Purpose: The introduction of angiotensin converting enzyme (ACE) inhibitors in the early 1970s resulted in marked improvement in clinical outcomes of scleroderma renal crisis (SRC).Despite…
Abstract Number: 1044 • 2019 ACR/ARP Annual Meeting
TGF-β Isoforms Modulate the RNA Cargo of Extracellular Vesicles (Exosomes) Isolated from Cultured Normal Human Lung Microvascular Endothelial Cells: A Mechanistic Link Between Endothelial Cell Dysfunction and the Establishment of a Profibrotic Phenotype in SSc?
Peter Wermuth¹ and Sergio Jimenez ¹, ¹Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, Philadelphia, PA
Background/Purpose: Extracellular vesicles (EV) are a diverse assortment of lipid bilayer-bound vesicles of various sizes and origin. Exosomes are a subset of EV arising from…
Abstract Number: 1629 • 2019 ACR/ARP Annual Meeting
Significance of Abnormal Nailfold Videocapillarscopy Among Patients with Raynaud’s Phenomenon And/or Suspected Connective Tissue Disease: A Cross-Sectional Single-Center US Experience
Yasser Radwan¹, Tina Gunderson ², Cynthia Crowson ³, Alicia Hinze ¹, Kevin Moder ⁴, Floranne Ernste ⁴, Shreyasee Amin ⁴, Uma Thanarajasingam ², Thomas Osborn ¹, Kenneth Warrington ⁴, Paul Wennberg ⁴ and Ashima Makol ¹, ¹Mayo Clinic Minnesota, rochester, MN, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic Rochester, rochester, MN
Background/Purpose: Nailfold videocapillaroscopy (NVC) is a simple, non-invasive & highly sensitive tool to evaluate structural abnormalities of the microcirculation in vivo and considered a key…

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