Abstract Number: 2596 • 2019 ACR/ARP Annual Meeting
The Contribution of Left Heart Disease in Patients with Systemic Sclerosis-associated Pulmonary Hypertension Having Normal Pulmonary Artery Wedge Pressure
Background/Purpose: Patients with systemic sclerosis (SSc) complicates variety of cardiopulmonary diseases which can result in pulmonary hypertension (PH). The types of PH are usually classified…Abstract Number: 2618 • 2019 ACR/ARP Annual Meeting
Anti-RNPC-3 Antibodies Are Associated with Nuclear Speckled Immunofluorescence Pattern and Enriched in Triple Negative Systemic Sclerosis Patients
Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important diagnostic and prognostic role in…Abstract Number: 18 • 2019 ACR/ARP Annual Meeting
Undifferentiated Connective Tissue Disease at Risk for SSc: Potential Role of Circulating CXCL-10, CXCL-11 and IL-33 in Predicting Disease Evolution
Background/Purpose: Higher levels of CXCL10 and CXCL11 in patients with a very early diagnosis of systemic sclerosis (SSc) subsequently shifted to SSc were pointed out…Abstract Number: 726 • 2019 ACR/ARP Annual Meeting
Digital Blood Perfusion Differences Between Black Africans and Caucasians with Systemic Sclerosis
Background/Purpose: Microvascular dysfunction is a prominent feature in SSc. Laser speckle contrast analysis (LASCA) has been shown to be a reliable tool to quantify skin…Abstract Number: 1043 • 2019 ACR/ARP Annual Meeting
The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts
Background/Purpose: Metabolic perturbations are emerging as drivers of fibroblast activation in fibrosis. Transcriptomic analyses have shown the enrichment of glycolysis and suppression of tricarboxylic acid…Abstract Number: 1072 • 2019 ACR/ARP Annual Meeting
CCR2+ Circulating Monocytes Contribute to the Survival of ADSC in Bleomycin-Induced Skin Fibrosis
Background/Purpose: Monocytes and monocyte-derived cells play a crucial role during homeostasis and also during the development of various inflammatory diseases including skin fibrosis. Ly6Chi inflammatory…Abstract Number: 1655 • 2019 ACR/ARP Annual Meeting
Histologic Features Correlate with the Modified Rodnan Skin Score, Serum Inflammatory Markers, and Patient Reported Outcomes in Patients with Early, Diffuse Cutaneous Systemic Sclerosis
Background/Purpose: The association between systemic sclerosis (SSc) skin histology and clinical findings is not fully characterized. In two SSc trials, we developed a scoring system…Abstract Number: 2597 • 2019 ACR/ARP Annual Meeting
Prevalence and Clinical Associations of Degos Lesions in Systemic Sclerosis
Background/Purpose: Degos disease, also known as malignant atrophic papulosis (MAP), is a rare small-vessel vasculopathy that has characteristic cutaneous manifestations consisting of erythematous telangiectatic rims…Abstract Number: 2744 • 2019 ACR/ARP Annual Meeting
Altered Expression of CD52 Facilitates Adhesion of Circulating CD14+ Monocytes in Systemic Sclerosis
Background/Purpose: Infiltration of inflammatory cells, including monocytes, into the organs is a major process leading to fibrosis, remodelling and organ dysfunction in systemic sclerosis (SSc).…Abstract Number: 262 • 2019 ACR/ARP Annual Meeting
Outpatient Healthcare Utilization Among Incident Cases of Systemic Sclerosis: Results from a Population-based Cohort (1988-2016)
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune disorder which results in multi-organ dysfunction and high morbidity and mortality. There is limited data on healthcare…Abstract Number: 727 • 2019 ACR/ARP Annual Meeting
Mortality and Morbidity in Scleroderma Renal Crisis: A Systematic Literature Review
Background/Purpose: The introduction of angiotensin converting enzyme (ACE) inhibitors in the early 1970s resulted in marked improvement in clinical outcomes of scleroderma renal crisis (SRC).Despite…Abstract Number: 1044 • 2019 ACR/ARP Annual Meeting
TGF-β Isoforms Modulate the RNA Cargo of Extracellular Vesicles (Exosomes) Isolated from Cultured Normal Human Lung Microvascular Endothelial Cells: A Mechanistic Link Between Endothelial Cell Dysfunction and the Establishment of a Profibrotic Phenotype in SSc?
Background/Purpose: Extracellular vesicles (EV) are a diverse assortment of lipid bilayer-bound vesicles of various sizes and origin. Exosomes are a subset of EV arising from…Abstract Number: 1629 • 2019 ACR/ARP Annual Meeting
Significance of Abnormal Nailfold Videocapillarscopy Among Patients with Raynaud’s Phenomenon And/or Suspected Connective Tissue Disease: A Cross-Sectional Single-Center US Experience
Background/Purpose: Nailfold videocapillaroscopy (NVC) is a simple, non-invasive & highly sensitive tool to evaluate structural abnormalities of the microcirculation in vivo and considered a key…Abstract Number: 1656 • 2019 ACR/ARP Annual Meeting
Health-Related Quality of Life in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Impact of Lung Function on Patient-Reported Outcomes in a Randomized Phase III Trial
Background/Purpose: SSc-ILD is a major cause of morbidity and mortality in patients with systemic sclerosis. A subset of patients with SSc-ILD show a decline in…Abstract Number: 2598 • 2019 ACR/ARP Annual Meeting
Different Treatment Backgrounds Do Not Influence Aminaphtone Efficacy in Primary and Secondary Raynaud’s Phenomenon
Background/Purpose: Aminaphtone treatment improves clinical symptoms of Raynaud's phenomenon (RP) and increases peripheral blood perfusion (BP) in patients with either primary or secondary RP (1-2).The…
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