Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2795 • 2019 ACR/ARP Annual Meeting
Patterns of Ambulatory Health Care Utilization and Medication Adherence Among Transition-Age Youth with Systemic Lupus Erythematosus
Joyce Chang¹, Andrea Knight ² and Erica Lawson ³, ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³University of California San Francisco Benioff Children’s Hospital, San Francisco, CA
Background/Purpose: Youth with child-onset systemic lupus erythematosus (SLE) transitioning from pediatric to adult health care systems may be at higher risk for poor outcomes than…
Abstract Number: 76 • 2019 ACR/ARP Annual Meeting
Effect of Ifnα and Costimulatory Blockade on Brain Infiltration in a Model of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’
Hadijat Makinde¹, Chirag Raparia ², Anne Davidson ² and Carla Cuda ³, ¹Northwestern University, Chicago, IL, ²Feinstein Institutes for Medical Research, Manhasset, ³Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
Abstract Number: 646 • 2019 ACR/ARP Annual Meeting
A Meta-Analysis of Anti-Ribosomal P Autoantibodies in Systemic Lupus Erythematosus: A Misunderstood Autoantibody
May Choi¹, Rachael Brown ², Katherine Buhler ³, Michael Mahler ⁴ and Marvin Fritzler ¹, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²University of Victoria, Victoria, Canada, ³University of Calgary, Calgary, Canada, ⁴Inova Diagnostics, San Diego, CA
Background/Purpose: Anti-ribosomal P (Rib-P) antibodies have become known as a highly specific biomarker for the diagnosis of SLE and potentially a biomarker for neuropsychiatric SLE…
Abstract Number: 812 • 2019 ACR/ARP Annual Meeting
Sex Differences in Autoimmunity and Cardiovascular Risk Could Be Associated with Altered Treg Phenotype and Lipoprotein Metabolism
George Robinson¹, Kirsty Waddington ¹, Anna Radziszewska ¹, Hannah Peckham ¹, David A Isenberg ², Yiannis Ioannou ¹, Coziana Ciurtin ³, Ines Pineda-Torra ¹ and Elizabeth Jury ¹, ¹University College London, London, United Kingdom, ²Centre for Rheumatology, London, United Kingdom, ³Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom
Background/Purpose: Males and females have altered immune responses resulting in variation in autoimmune risk. Sex differences exist in the frequency and activity of immune-cell subsets…
Abstract Number: 1023 • 2019 ACR/ARP Annual Meeting
Neutrophils Are an Important Source of Microparticles in Lupus and Asymptomatic ANA+ Individuals
Carolina Muñoz-Grajales¹, Dennisse Bonilla ², Earl D. Silverman ³, Sindhu Johnson ⁴, Arthur Bookman ⁵, Zahi Touma ², Zareen Ahmad ⁶, Linda Hiraki ⁷ and Joan Wither ⁸, ¹University of Toronto, Toronto, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁴Toronto Scleroderma Program, Department of Medicine, Toronto Western and Mount Sinai Hospitals, University of Toronto, Toronto, Canada, Toronto, Canada, ⁵University Health Network - Toronto Western Hospital, Toronto, Canada, ⁶Mount Sinai Hospital, Toronto, Canada, ⁷The Hospital for Sick Children, Toronto, Canada, ⁸University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Apoptotic microparticles (MPs) in the circulation of systemic lupus erythematosus (SLE) patients are enriched for nucleic acids and complexed with IgG (MP-IC), as compared…
Abstract Number: 1158 • 2019 ACR/ARP Annual Meeting
Investigating Health Literacy and Numeracy in an Academic Center Lupus Cohort
Mithu Maheswaranathan¹, Raeann Whitney ², Megan Clowse ², Amanda Eudy ² and Jennifer Rogers ², ¹Duke University Medical Center, Durham, NC, ²Duke University, Durham
Background/Purpose: Up to 50% of American adults have basic or below basic health literacy and numeracy. Low health literacy is associated with increased health care…
Abstract Number: 1585 • 2019 ACR/ARP Annual Meeting
Endothelial Dysfunction and Arterial Stiffness in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis
Claudia Mendoza-Pinto¹, Adriana Rojas-Villarraga ², Nicolás Molano-González ³, Pamela Munguía-Realpozo ⁴, Socorro Méndez-Martínez ⁴, Aurelio López-Colombo ⁴ and Mario García-Carrasco ¹, ¹Systemic Autoimmune Diseases Research Unit, Hospital de Especialidades, UMAE CMNMAC - CIBIOR, Instituto Mexicano del Seguro Social. Department of Rheumatology and Immunology, Medicine School, Benemérita Universidad Autónoma de Puebla, Puebla, Puebla, Mexico, ²FUCS -Fundación Universitaria de Ciencias de la Salud, Bogotá, Distrito Capital de Bogota, Colombia, ³Universidad del Rosario, Bogotá, Distrito Capital de Bogota, Colombia, ⁴Instituto Mexicano del Seguro Social, Puebla, Puebla, Mexico
Background/Purpose: Studies have reported increased cardiovascular (CV) morbidity and mortality in patients with SLE. In recent years, several non-invasive surrogates of CV disease risk have…
Abstract Number: 1623 • 2019 ACR/ARP Annual Meeting
Mortality in a SLE Inception Cohort of Hispanic Patients
Maria del Carmen Zamora Medina¹, Jessica Roldan Ortega ², Mario Cesar Ocampo Torres ³, Pilar Lara Reyes ¹, Ivon Bautista Mejia ¹, Alba Cicero Casarrubias ¹ and Juanita Romero-Diaz ⁴, ¹Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, MEXICO CITY, Mexico, ²Monterrey Institute of Technology and Higher Education, MEXICO CITY, Mexico, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, MEXICO CITY, ⁴Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico
Background/Purpose: To determine mortality and identify risk factors for mortality at 10 years in a mexican-mestizo SLE inception cohort at a tertiary care center in…
Abstract Number: 1897 • 2019 ACR/ARP Annual Meeting
Sexual Function and Health-related Quality of Life in Male Patients with Systemic Lupus Erythematosus, the Untold Story
Martín Valdez-López¹, Jonathan Campos-Guzmán ¹, Ana Barrera-Vargas ², Samuel Govea-Peláez ¹, Diana Gómez-Martín ¹, Jorge Alcocer-Varela ¹, Eduardo Aguirre-Aguilar ¹, Diana Padilla-Ortíz ³ and Javier Merayo-Chalico ¹, ¹Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Distrito Federal, Mexico, ²Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico, ³Universidad De La Sabana, Bogotá, Cundinamarca, Colombia
Background/Purpose: Although SLE is uncommon in men, the disease is usually more severe and requires more aggressive immunosuppression in male patients. There are multiple studies…
Abstract Number: 2116 • 2019 ACR/ARP Annual Meeting
Serious Infection in Patients with Systemic Lupus Erythematosus, Lupus Nephritis and Rheumatoid Arthritis Compared to the General Population: Incidence Rates Using Real-World Claims Data
Lisa Lindsay¹, Ching-Yi Chuo ², Nicholas Jones ², Joshua Galanter ², Anna McGregor ² and Katie Tuckwell ², ¹Genentech Inc, SOUTH SAN FRANCISCO, CA, ²Genentech Inc, SOUTH SAN FRANCISCO
Background/Purpose: Patients with systemic lupus erythematosus (SLE), lupus nephritis (LN) and rheumatoid arthritis (RA) are at risk of serious infections (SIs) due to the impact…
Abstract Number: 2527 • 2019 ACR/ARP Annual Meeting
Cytokine and Autoantibody Profiles During Treatment with Belimumab in Patients with Systemic Lupus Erythematosus
Ioannis Parodis¹, Emil Åkerström ¹, Christopher Sjöwall ², Azita Sohrabian ³, Andreas Jönsen ⁴, Alvaro Gomez ¹, Martina Frodlund ², Agneta Zickert ¹, Anders Bengtsson ⁴, Johan Rönnelid ³ and Iva Gunnarsson ¹, ¹Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, ³Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁴Lund University, Lund, Sweden
Background/Purpose: The anti-BAFF monoclonal belimumab is approved for the treatment of systemic lupus erythematosus (SLE) since 2011. Effects of belimumab on anti-double stranded (ds)DNA levels,…
Abstract Number: 2562 • 2019 ACR/ARP Annual Meeting
Glucocorticosteroid Usage and Major Organ Damage in Patients with Systemic Lupus Erythematosus – Meta-analyses of Observational Studies Published Between 1979 and 2018
Anselm Mak¹, Mike W.L.- Cheung ¹, Wai Yee Joanna Leong ², Bhushan Dharmadhikari ³, Nien Yee Kow ³, Michelle Petri ⁴, Susan Manzi ⁵, Ann Clarke ⁶, Cynthia Aranow ⁷, Laurent Arnaud ⁸, Anca Askanase ⁹, Sang-Cheol Bae ¹⁰, Sasha Bernatsky ¹¹, Ian Bruce ¹², Jill Buyon ¹³, W. Winn Chatham ¹⁴, Nathalie Costedoat-Chalumeau ¹⁵, MA Dooley ¹⁶, Paul Fortin ¹⁷, Ellen M Ginzler ¹⁸, Dafna Gladman ¹⁹, Caroline Gordon ²⁰, John G Hanly ²¹, Murat Inanc ²², David A Isenberg ²³, Soren Jacobsen ²⁴, Judith James ²⁵, Andreas Jönsen ²⁶, Kenneth C Kalunian ²⁷, Diane Kamen ²⁸, S Sam Lim ²⁹, Eric Morand ³⁰, Christine Peschken ³¹, Bernardo A. Pons-Estel ³², Anisur Rahman ³³, Rosalind Ramsey-Goldman ³⁴, Juanita Romero-Diaz ³⁵, Guillermo Ruiz-Irastorza ³⁶, Jorge Sanchez-Guerrero ³⁷, Kristjan Steinsson ³⁸, Elisabet Svenungsson ³⁹, Murray Urowitz ⁴⁰, Ronald van Vollenhoven ⁴¹, Evelyne Vinet ⁴², Alexandre Voskuyl ⁴³, Daniel J Wallace ⁴⁴ and Graciela Alarcón ⁴⁵, ¹National University of Singapore, Singapore, Singapore, ²Changi General Hospital, Singapore, Singapore, ³National University of Singapore, Singapore, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Allegheny Health Network, Pittsburg, PA, ⁶University of Calgary, Calgary, AB, Canada, ⁷Feinstein Institute for Medical Research, Manhasset, NY, ⁸Service de Rhumatologie, Centre National de Référence des Maladies Autoimmunes Systemiques Rares (RESO), Hôpitaux Universitaires de Strasbourg, Strasbourg, France, Strasbourg, France, ⁹Columbia University Medical Center, New York, NY, ¹⁰Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ¹¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ¹²University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom, ¹³NYU School of Medicine, New York, ¹⁴University of Alabama Medical Center, Birmingham, AL, ¹⁵Cochin University Hospital, Paris, France, ¹⁶UnC Kidney Centre, Chapel Hill, NC, ¹⁷Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada, ¹⁸State University of New York Downstate Medical Center, Brooklyn, NY, ¹⁹Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, ²⁰University of Birmingham, Birmingham, United Kingdom, ²¹Dalhousie University, Halifax, NS, Canada, ²²Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ²³Centre for Rheumatology, London, United Kingdom, ²⁴Copenhagen Lupus and Vasculitis Clinic, Copenhagen, Denmark, ²⁵Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁶Lund University, Lund, Sweden, ²⁷UC San Diego School of Medicine, LaJolla, CA, ²⁸Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, ²⁹Emory University, Atlanta, GA, ³⁰Monash University, Melbourne, Victoria, Australia, ³¹University of Manitoba, Winnipeg, Canada, ³²Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Grupo Oroño, Rosario, Rosario, Argentina, ³³University College London, London, United Kingdom, ³⁴Northwestern University, Chicago, IL, ³⁵Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico, ³⁶Autoimmune Diseases Unit, Hospital Universitario Cruces, Barakaldo, Spain, Barakaldo, Spain, ³⁷Toronto Western Hospital, Toronto, ON, Canada, ³⁸Landspitali, University Hospital, Reykjavik, Iceland, ³⁹Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁴⁰University Health Network, University of Toronto, Toronto, ON, Canada, ⁴¹Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁴²McGill University Health Centre, Montreal, QC, Canada, ⁴³Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ⁴⁴Cedars-Sinai Medical Centre, Beverly Hills, CA, ⁴⁵University of Alabama at Birmingham, Birmingham
Background/Purpose: The impact of glucocorticoid (GC) use on major organ damage in SLE patients has not been formally studied by amalgamating the relevant data published…
Abstract Number: 2811 • 2019 ACR/ARP Annual Meeting
The IRE1α Pathway Mediates Neutrophil Stress and NETosis in Lupus
Gautam Sule¹, Basel Abuaita ¹, Paul Steffes ¹, Kristen Gilley ¹, Andrew Fernandes ¹, Mary O’Riordan ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Immune complex (IC)-activated neutrophils appear to amplify inflammation in lupus through the release of neutrophil extracellular traps (NETosis). There is presently no consensus as…
Abstract Number: 2045 • 2019 ACR/ARP Annual Meeting
RNA Sequencing of Plasma and Urine-derived Extracellular Vesicles from Lupus Nephritis Patients Identifies Disease-associated Small RNA Signatures and Putative Therapeutic Targets
Taylor Koenig¹, Nicholas Young ², Giancarlo Valiente ³, Ifeoma Okafor ⁴, Emily Schwarz ⁵, Peter Harb ⁵, Caitlin Henry ¹, Kyle Jablonski ⁶, Lai-Chu Wu ⁴, Eli Roberson ⁷ and Wael Jarjour ⁸, ¹Division of Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, ²The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, OH, ³The Ohio State University, Columbus, ⁴Ohio State College of Medicine, Columbus, ⁵The Ohio State University Wexner Medical Center, Columbus, OH, ⁶The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, ⁷Washington University at St.Louis, St.Louis, MO, ⁸Ohio State College of Medicine, Columbus, OH
Background/Purpose: Systemic lupus erythematosus is an autoimmune disease characterized by chronic inflammation. We have previously shown that TLR7 and TLR8 are significantly upregulated in PBMCs…
Abstract Number: 77 • 2019 ACR/ARP Annual Meeting
Flux Analysis Reveals Influence of Rab4 Expression on Mitochondrial and Pentose Phosphate Pathway Metabolism of Lupus T Cells
Tamas Faludi¹, Nick Huang ¹, Manuel Duarte ², Joshua Lewis ² and Andras Perl ³, ¹Upstate Medical University, Syracuse, NY, ²Upstate Medical University, Syracuse, ³SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: HRES-1/Rab4 is a small GTPase enzyme which regulates endosomal trafficking. The protein is overexpressed in T cells of SLE patients (J Immunol. February 15,…

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