ACR Meeting Abstracts

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Abstracts tagged "synovium"

  • Abstract Number: 2830 • 2018 ACR/ARHP Annual Meeting

    Synovitis in Psoriatic Arthritis and Seronegative Rheumatoid Arthritis: Differential Histological Features

    Stefano Alivernini1, Dario Bruno1, Anna Laura Fedele1, Luca Petricca1, Giusy Peluso1, Domenico Birra1, Barbara Tolusso1, Laura Bui2, Francesco Federico2, Gianfranco Ferraccioli1 and Elisa Gremese1, 1Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy, 2Institute of Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: To identify synovial tissue (ST) biomarkers differentially expressed in Psoriatic Arthritis (PsA) and seronegative Rheumatoid Arthritis (Abneg RA) and test their predictive value of…
  • Abstract Number: 2900 • 2018 ACR/ARHP Annual Meeting

    Impaired TCR Signaling Paves the Way for Cytokine Hyper-Responsiveness in Arthritogenic T Cells

    Judith Ashouri1, Lih-Yun Hsu1, Dmitry Rychkov2, Marina Sirota2, Lisa Lattanza3, Eric Hansen3, Julie Zikherman1 and Arthur Weiss1, 1Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, 3Orthopedic Surgery, University of California, San Francisco, San Francisco, CA

    Background/Purpose: The inability to identify relevant arthritogenic CD4 T cells in patients and in murine disease models has limited our understanding of disease initiating events…
  • Abstract Number: 53 • 2018 ACR/ARHP Annual Meeting

    Cyclin-Dependent Kinase 4/6 Inhibitor: A Promising Development Candidate Targeting Synovial Hypertrophy for Rheumatoid Arthritis Treatment

    Shunsuke Tsujimoto, Kyohei Horie, Toshiya Mashiko, Johji Nomura and Tsunefumi Kobayashi, Teijin Institute for Bio-medical Research, TEIJIN PHARMA LIMITED, Tokyo, Japan

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is characterized by the infiltration of immune cells into the synovial tissues and the hypertrophy of synovial fibroblasts,…
  • Abstract Number: 59 • 2018 ACR/ARHP Annual Meeting

    Elucidating the Expression and Role of Heparan Sulfate Proteoglycan Editing Sulfatases in Human Rheumatoid Arthritis Synovium and a Rat Adjuvant-Induced Arthritis Model

    Ruby J. Siegel1, Solomon A. Agere1, Anil K. Singh1 and Salahuddin Ahmed2,3, 1Washington State University, Department of Pharmaceutical Sciences, College of Pharmacy, Spokane, WA, 2Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 3Division of Rheumatology, University of Washington, Division of Rheumatology, School of Medicine, Seattle, WA

    Background/Purpose: Syndecans are cell-surface heparan sulfate proteoglycans (HSPGs) that modulate the receptor/ligand binding of chemokines, cytokines, and growth factors in order to facilitate cellular signaling.…
  • Abstract Number: 171 • 2017 ACR/ARHP Annual Meeting

    Finding Transcriptional Regulators Central to RA with Transcriptomics of IL17 Dose Response, Time Series, and siRNA Silencing in Stromal Cells

    Kamil Slowikowski1, Hung Nguyen2, Gerald Watts2, Fumitaka Mizoguchi3, Erika H. Noss4, Michael Brenner5 and Soumya Raychaudhuri6, 1Harvard University, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 4Division of Rheumatology, University of Washington, Seattle, WA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by immune cell infiltration into the synovial membrane of the joint, where they engage stromal cells such as synovial…
  • Abstract Number: 961 • 2017 ACR/ARHP Annual Meeting

    Adalimumab Reduces CXCR4 Expression during Inflammatory Arthritis and in Fibroblast-like Synoviocytes and Osteoclasts Under Chronic TNF Exposure

    Bohdan P. Harvey1, Li Li1, Mark Konrad1, Heather Knight1, Susan Westmoreland2, Melanie Ruzek1 and Zehra Kaymakcalan1, 1AbbVie Bioresearch Center, Worcester, MA, 2AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA

    Background/Purpose: The CXCL12/CXCR4 chemokine axis has been implicated in the pathogenesis of RA. The expression of this chemokine and receptor has been shown to be…
  • Abstract Number: 1401 • 2017 ACR/ARHP Annual Meeting

    Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis

    Felice Rivellese, Frances Humby, Sara Pagani, Alessandra Nerviani and Costantino Pitzalis, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    Background/Purpose: Mast cells (MCs) are immune cells infiltrating the synovial membrane and implicated in the pathogenesis of Rheumatoid Arthritis, but their strict contribution to disease…
  • Abstract Number: 1940 • 2017 ACR/ARHP Annual Meeting

    Immunologic Synovitis Score: A New Score for Synovial Membrane Characterization in Inflammatory and Non-Inflammatory Arthritis

    Aurélie Najm1,2, Benoît Le Goff MD PhD2,3, Frédéric Blanchard1, Jérome Amiaud4, Céline Charrier5 and Veit Krenn6, 1INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, 2Rheumatology, Nantes University Hospital, Nantes, France, 3UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 4UMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 5UNMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 6Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany

    Background/Purpose: General Synovitis score (GSS) has been developed by Krenn et al in order to discriminate inflammatory arthritis (IA) and non-inflammatory arthritis (NIA) (1). This…
  • Abstract Number: 140 • 2016 ACR/ARHP Annual Meeting

    Relationship Between the Prevalence of Subclinical Tenosynovitis and Therapy in Patients with RA in Clinical Remission: Results from Italian Society of Rheumatology Study Group

    Simone Parisi1, Greta Carrara2, Carlo Alberto Scirè3,4, Alberto Batticciotto5, Emanuela Bellis6, Marco Canzoni7, Orazio De Lucia8, Ilaria Farina9, Carlo Venditti10, Annamaria Iagnocco11,12 and Georgios Filippou13, 1Department of Rheumatology, University Hospital Città Della Salute e della Scienza di Torino, Turin, Italy, 2Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy, 3Epidemiology Unit -Italian Society for Rheumatology, Milano, Italy, 4Epidemiology Unit – Italian Society for Rheumatology (SIR), Milano, Italy, 5Rheumatology, L. Sacco University Hospital, Milano, Italy, 6Rheumatology, Ospedale Mauriziano, Turin, Italy, 7A.O. Sant'Andrea, Rome, Italy, 8Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, 9Rheumatology Unit AOU S.Anna, Ferrara, Italy, 10A.O. Rummo, Benevento, Italy, 11Sapienza University of Rome, Rome, Italy, 12Sapienza University of Rome, Italy, Roma, Italy, 13University of Siena, Siena, Italy

    Background/Purpose: This study is a sub-analysis of the data from the patient cohort of STARTER (The Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission)…
  • Abstract Number: 1036 • 2016 ACR/ARHP Annual Meeting

    Dominant B-Cell Receptor Clones in Peripheral Blood Predict Onset of Arthritis in Individuals at Risk for Rheumatoid Arthritis

    Paul-Peter Tak1,2,3, Marieke E. Doorenspleet4, Maria de Hair5, Paul L. Klarenbeek6, Marian van Beers-Tas7, Antoine H.C. van Kampen8, Dirkjan van Schaardenburg9,10, Danielle M. Gerlag11,12, Frank Baas13 and Niek de Vries14, 1Clinical Immunology & Rheumatology F4.105, Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Currently: GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, 3currently: Ghent University, Ghent, Belgium & Cambridge University, Cambridge, United Kingdom, 4Dept. of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 6Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 7Rheumatology, Amsterdam Rheumatology & Immunology Center, Reade, Amsterdam, Netherlands, 8Dept Clin Epidemiology, Biostatistics & Bioinformatics, Academic Medical Center/Univ. of Amsterdam, Amsterdam, Netherlands, 9Clinical Immunology & Rheumatology F4.105, Amsterdam Rheumatology and immunology Center | Academic Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, 10Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, Amsterdam, Netherlands, 11Clinical Immunology & Rheumatology, ARC | Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 12Current address: GSK,Clinical Unit Cambridge,R&D Projects Clinical Platforms & Sciences, Cambridge, United Kingdom, 13Department of Genome Analysis, Academic Medical Center/Univ. of Amsterdam, Amsterdam, Netherlands, 14Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: The onset of seropositive rheumatoid arthritis (RA) is preceded by the presence of specific autoantibodies in the absence of synovial inflammation. Only a subset…
  • Abstract Number: 1451 • 2016 ACR/ARHP Annual Meeting

    Glutamine Metabolism Plays a Crucial Role in the Pathogenesis of Rheumatoid Arthritis

    Soshi Takahashi1, Jun Saegusa2, Ikuko Naka3, Kosaku Tsuda3, Takaichi Okano4, Kengo Akashi3, Sho Sendo2, Yo Ueda3, Akira Onishi5, Yoshinori Kogata2 and Akio Morinobu2, 1Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Kobe University Graduate School of Medicine, Kobe, Japan, 4Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 5Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Many signaling pathways activated under inflammatory and hypoxic conditions have profound effects on intracellular metabolism to support cell growth and survival. Cancer cells consume…
  • Abstract Number: 175 • 2015 ACR/ARHP Annual Meeting

    Correlating Semiquantitative Ultrasound Scores with Measured Synovial Thickness

    Ralf G. Thiele1, Darren Tabechian1, Laura C Coates2 and Jennifer H. Anolik1, 1University of Rochester Medical Center, Rochester, NY, 2Medicine, University of Rochester, Rochester, NY

    Background/Purpose: In studies of rheumatoid arthritis using ultrasonography (US), findings of synovial thickening are often reported in semiquantitative scores. For synovial biopsies of small joints,…
  • Abstract Number: 510 • 2015 ACR/ARHP Annual Meeting

    Histologic Scoring of Arthroplasty Synovial Samples May Predict RA Flare

    Susan M. Goodman1, Rivka Friedlander2, Caroline Figgie2, Alessandra B. Pernis3, Cristina T. Rozo4, Ellen M. Gravallese5, Edward F. DiCarlo6, Laura T. Donlin7, Mark P. Figgie8, Reena Khianey9, Anh Hoang1, Kathleen Andersen10, Luvana Chowdhury11 and VP Bykerk12, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Research, Hospital for Special Surgery, New York, NY, 3Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, 4535 East 70th Street, Hospital for Special Surgery, New York, NY, 5Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 8Orthopaedics, Hospital for Special Surgery, New York, NY, 9Medicine, Hospital for Special Surgery, New York, NY, 10Hospital for Special Surgery, New York, NY, 11Autoimmunity and Inflammation Program/Research, Hospital for Special Surgery, New York, NY, 12Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with established RA undergoing total joint arthroplasty (TJA) frequently experience a disease flare within 6 weeks of surgery. This study aims to determine…
  • Abstract Number: 1166 • 2015 ACR/ARHP Annual Meeting

    Expression and Function of Proviral Integration Site for Moloney Murine Leukemia Virus 1 (PIM-1) Kinase in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Yong Seok Choi1, You Jung Ha2, Jaehyung Hur3, Eun Ha Kang4, Yeong Wook Song5 and Yun Jong Lee2, 1Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 2Division of Rheumatology, Department of Internal Medicine,Seoul National University Bundang Hospital, Seongnam, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 4Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

    Background/Purpose: The Proviral Integration site of Moloney murine leukemia virus (PIM) kinases are important mediators of cell survival and considered as attractive targets in cancer…
  • Abstract Number: 1622 • 2015 ACR/ARHP Annual Meeting

    Genome-Wide Association Analysis and Whole Genome Sequencing Identify Variants Associated with Radiographic Severity of Rheumatoid Arthritis in African Americans

    Vincent A. Laufer1, Richard J. Reynolds2, Maria I. Danila3, R. Curtis Hendrickson4, Elliot J. Lefkowitz5, Devin Absher6, Robert P. Kimberly7 and S. Louis Bridges Jr.8, 1Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, 2Medicine, University of Alabama at Birmingham, Birmingham, AL, 3AL, 4University of Alabama at Birmingham, Birmingham, AL, 5Microbiology, University of Alabama at Birmingham, Birmingham, AL, 6Hudson Alpha Institute for Biotechnology, Huntsville, AL, 7Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 8Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Joint damage manifested by bony erosions and joint space narrowing is a major contributor to the morbidity and mortality of RA. Reports in Caucasians…
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