Abstracts tagged "synovium"

Abstract Number: 1959 • 2018 ACR/ARHP Annual Meeting
Stability of DNA Methylation Signature in Primary RA Synovial Fibroblasts Compared with Cultured Fibroblast-like Synoviocytes
Rizi Ai¹, Deepa Hammaker², Wei Wang³ and Gary S. Firestein⁴, ¹University of California San Diego, La Jolla, CA, ²Medicine, UC San Diego, La Jolla, CA, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, ⁴Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) is an aggressive immune-mediated joint disease with synovial inflammation and joint destruction. Fibroblast-like synoviocytes (FLS) play a key role in mediating…
Abstract Number: 2798 • 2018 ACR/ARHP Annual Meeting
Expanded T-Cell Clones Are Present in the Synovium before the Clinical Onset of Rheumatoid Arthritis
Giulia Balzaretti^1,2,3, Paul L. Klarenbeek⁴, Marieke E. Doorenspleet⁵, Maria JH de Hair⁶, Barbera C.D. van Schaik⁷, Rebecca Esveldt², Marleen van de Sande¹, Danielle Gerlag⁸, Antoine H.C. van Kampen⁷, Frank Baas^2,9, Paul-Peter Tak¹⁰ and Niek de Vries^3,5, ¹Clinical Immunology & Rheumatology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Dept. of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Dept. of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Amsterdam Rheumatology and immunology Center | Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands, Utrecht, Netherlands, ⁷Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁸GlaxoSmithKline, Stevenage, United Kingdom, ⁹Dept. of Genome Diagnostics, Leiden University, Leiden, Netherlands, ¹⁰GlaxoSmithKline, Cambridge, United Kingdom
Background/Purpose: In healthy individuals with arthralgia and RA-specific autoantibodies (so called at-risk individuals) the presence of expanded B-cell receptor (BCR) clones in peripheral blood (PB)…
Abstract Number: 2830 • 2018 ACR/ARHP Annual Meeting
Synovitis in Psoriatic Arthritis and Seronegative Rheumatoid Arthritis: Differential Histological Features
Stefano Alivernini¹, Dario Bruno¹, Anna Laura Fedele¹, Luca Petricca¹, Giusy Peluso¹, Domenico Birra¹, Barbara Tolusso¹, Laura Bui², Francesco Federico², Gianfranco Ferraccioli¹ and Elisa Gremese¹, ¹Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy, ²Institute of Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: To identify synovial tissue (ST) biomarkers differentially expressed in Psoriatic Arthritis (PsA) and seronegative Rheumatoid Arthritis (Abneg RA) and test their predictive value of…
Abstract Number: 2900 • 2018 ACR/ARHP Annual Meeting
Impaired TCR Signaling Paves the Way for Cytokine Hyper-Responsiveness in Arthritogenic T Cells
Judith Ashouri¹, Lih-Yun Hsu¹, Dmitry Rychkov², Marina Sirota², Lisa Lattanza³, Eric Hansen³, Julie Zikherman¹ and Arthur Weiss¹, ¹Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, ²Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, ³Orthopedic Surgery, University of California, San Francisco, San Francisco, CA
Background/Purpose: The inability to identify relevant arthritogenic CD4 T cells in patients and in murine disease models has limited our understanding of disease initiating events…
Abstract Number: 1401 • 2017 ACR/ARHP Annual Meeting
Persistence of Mast Cell-Rich Synovitis Is Associated with Lack of Response to Synthetic Disease Modifying Anti-Rheumatic Drugs in Patients with Early Rheumatoid Arthritis
Felice Rivellese, Frances Humby, Sara Pagani, Alessandra Nerviani and Costantino Pitzalis, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: Mast cells (MCs) are immune cells infiltrating the synovial membrane and implicated in the pathogenesis of Rheumatoid Arthritis, but their strict contribution to disease…
Abstract Number: 1940 • 2017 ACR/ARHP Annual Meeting
Immunologic Synovitis Score: A New Score for Synovial Membrane Characterization in Inflammatory and Non-Inflammatory Arthritis
Aurélie Najm^1,2, Benoît Le Goff MD PhD^2,3, Frédéric Blanchard¹, Jérome Amiaud⁴, Céline Charrier⁵ and Veit Krenn⁶, ¹INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France, ³UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁴UMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁵UNMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁶Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany
Background/Purpose: General Synovitis score (GSS) has been developed by Krenn et al in order to discriminate inflammatory arthritis (IA) and non-inflammatory arthritis (NIA) (1). This…
Abstract Number: 171 • 2017 ACR/ARHP Annual Meeting
Finding Transcriptional Regulators Central to RA with Transcriptomics of IL17 Dose Response, Time Series, and siRNA Silencing in Stromal Cells
Kamil Slowikowski¹, Hung Nguyen², Gerald Watts², Fumitaka Mizoguchi³, Erika H. Noss⁴, Michael Brenner⁵ and Soumya Raychaudhuri⁶, ¹Harvard University, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ⁴Division of Rheumatology, University of Washington, Seattle, WA, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is characterized by immune cell infiltration into the synovial membrane of the joint, where they engage stromal cells such as synovial…
Abstract Number: 961 • 2017 ACR/ARHP Annual Meeting
Adalimumab Reduces CXCR4 Expression during Inflammatory Arthritis and in Fibroblast-like Synoviocytes and Osteoclasts Under Chronic TNF Exposure
Bohdan P. Harvey¹, Li Li¹, Mark Konrad¹, Heather Knight¹, Susan Westmoreland², Melanie Ruzek¹ and Zehra Kaymakcalan¹, ¹AbbVie Bioresearch Center, Worcester, MA, ²AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: The CXCL12/CXCR4 chemokine axis has been implicated in the pathogenesis of RA. The expression of this chemokine and receptor has been shown to be…
Abstract Number: 140 • 2016 ACR/ARHP Annual Meeting
Relationship Between the Prevalence of Subclinical Tenosynovitis and Therapy in Patients with RA in Clinical Remission: Results from Italian Society of Rheumatology Study Group
Simone Parisi¹, Greta Carrara², Carlo Alberto Scirè^3,4, Alberto Batticciotto⁵, Emanuela Bellis⁶, Marco Canzoni⁷, Orazio De Lucia⁸, Ilaria Farina⁹, Carlo Venditti¹⁰, Annamaria Iagnocco^11,12 and Georgios Filippou¹³, ¹Department of Rheumatology, University Hospital Città Della Salute e della Scienza di Torino, Turin, Italy, ²Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy, ³Epidemiology Unit -Italian Society for Rheumatology, Milano, Italy, ⁴Epidemiology Unit – Italian Society for Rheumatology (SIR), Milano, Italy, ⁵Rheumatology, L. Sacco University Hospital, Milano, Italy, ⁶Rheumatology, Ospedale Mauriziano, Turin, Italy, ⁷A.O. Sant'Andrea, Rome, Italy, ⁸Rheumatology, Orthopedic Institute Gaetano Pini, Milano, Italy, ⁹Rheumatology Unit AOU S.Anna, Ferrara, Italy, ¹⁰A.O. Rummo, Benevento, Italy, ¹¹Sapienza University of Rome, Rome, Italy, ¹²Sapienza University of Rome, Italy, Roma, Italy, ¹³University of Siena, Siena, Italy
Background/Purpose: This study is a sub-analysis of the data from the patient cohort of STARTER (The Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission)…
Abstract Number: 1036 • 2016 ACR/ARHP Annual Meeting
Dominant B-Cell Receptor Clones in Peripheral Blood Predict Onset of Arthritis in Individuals at Risk for Rheumatoid Arthritis
Paul-Peter Tak^1,2,3, Marieke E. Doorenspleet⁴, Maria de Hair⁵, Paul L. Klarenbeek⁶, Marian van Beers-Tas⁷, Antoine H.C. van Kampen⁸, Dirkjan van Schaardenburg^9,10, Danielle M. Gerlag^11,12, Frank Baas¹³ and Niek de Vries¹⁴, ¹Clinical Immunology & Rheumatology F4.105, Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Currently: GlaxoSmithKline, Stevenage, UK, Stevenage, United Kingdom, ³currently: Ghent University, Ghent, Belgium & Cambridge University, Cambridge, United Kingdom, ⁴Dept. of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Dept. of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and immunology Center | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁷Rheumatology, Amsterdam Rheumatology & Immunology Center, Reade, Amsterdam, Netherlands, ⁸Dept Clin Epidemiology, Biostatistics & Bioinformatics, Academic Medical Center/Univ. of Amsterdam, Amsterdam, Netherlands, ⁹Clinical Immunology & Rheumatology F4.105, Amsterdam Rheumatology and immunology Center | Academic Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ¹⁰Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, Amsterdam, Netherlands, ¹¹Clinical Immunology & Rheumatology, ARC | Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ¹²Current address: GSK,Clinical Unit Cambridge,R&D Projects Clinical Platforms & Sciences, Cambridge, United Kingdom, ¹³Department of Genome Analysis, Academic Medical Center/Univ. of Amsterdam, Amsterdam, Netherlands, ¹⁴Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The onset of seropositive rheumatoid arthritis (RA) is preceded by the presence of specific autoantibodies in the absence of synovial inflammation. Only a subset…
Abstract Number: 1451 • 2016 ACR/ARHP Annual Meeting
Glutamine Metabolism Plays a Crucial Role in the Pathogenesis of Rheumatoid Arthritis
Soshi Takahashi¹, Jun Saegusa², Ikuko Naka³, Kosaku Tsuda³, Takaichi Okano⁴, Kengo Akashi³, Sho Sendo², Yo Ueda³, Akira Onishi⁵, Yoshinori Kogata² and Akio Morinobu², ¹Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Many signaling pathways activated under inflammatory and hypoxic conditions have profound effects on intracellular metabolism to support cell growth and survival. Cancer cells consume…
Abstract Number: 175 • 2015 ACR/ARHP Annual Meeting
Correlating Semiquantitative Ultrasound Scores with Measured Synovial Thickness
Ralf G. Thiele¹, Darren Tabechian¹, Laura C Coates² and Jennifer H. Anolik¹, ¹University of Rochester Medical Center, Rochester, NY, ²Medicine, University of Rochester, Rochester, NY
Background/Purpose: In studies of rheumatoid arthritis using ultrasonography (US), findings of synovial thickening are often reported in semiquantitative scores. For synovial biopsies of small joints,…
Abstract Number: 510 • 2015 ACR/ARHP Annual Meeting
Histologic Scoring of Arthroplasty Synovial Samples May Predict RA Flare
Susan M. Goodman¹, Rivka Friedlander², Caroline Figgie², Alessandra B. Pernis³, Cristina T. Rozo⁴, Ellen M. Gravallese⁵, Edward F. DiCarlo⁶, Laura T. Donlin⁷, Mark P. Figgie⁸, Reena Khianey⁹, Anh Hoang¹, Kathleen Andersen¹⁰, Luvana Chowdhury¹¹ and VP Bykerk¹², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Research, Hospital for Special Surgery, New York, NY, ³Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, ⁴535 East 70th Street, Hospital for Special Surgery, New York, NY, ⁵Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, ⁶Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁷Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁸Orthopaedics, Hospital for Special Surgery, New York, NY, ⁹Medicine, Hospital for Special Surgery, New York, NY, ¹⁰Hospital for Special Surgery, New York, NY, ¹¹Autoimmunity and Inflammation Program/Research, Hospital for Special Surgery, New York, NY, ¹²Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Patients with established RA undergoing total joint arthroplasty (TJA) frequently experience a disease flare within 6 weeks of surgery. This study aims to determine…
Abstract Number: 1166 • 2015 ACR/ARHP Annual Meeting
Expression and Function of Proviral Integration Site for Moloney Murine Leukemia Virus 1 (PIM-1) Kinase in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Yong Seok Choi¹, You Jung Ha², Jaehyung Hur³, Eun Ha Kang⁴, Yeong Wook Song⁵ and Yun Jong Lee², ¹Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ²Division of Rheumatology, Department of Internal Medicine,Seoul National University Bundang Hospital, Seongnam, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ⁴Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: The Proviral Integration site of Moloney murine leukemia virus (PIM) kinases are important mediators of cell survival and considered as attractive targets in cancer…
Abstract Number: 1622 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Analysis and Whole Genome Sequencing Identify Variants Associated with Radiographic Severity of Rheumatoid Arthritis in African Americans
Vincent A. Laufer¹, Richard J. Reynolds², Maria I. Danila³, R. Curtis Hendrickson⁴, Elliot J. Lefkowitz⁵, Devin Absher⁶, Robert P. Kimberly⁷ and S. Louis Bridges Jr.⁸, ¹Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, ²Medicine, University of Alabama at Birmingham, Birmingham, AL, ³AL, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Microbiology, University of Alabama at Birmingham, Birmingham, AL, ⁶Hudson Alpha Institute for Biotechnology, Huntsville, AL, ⁷Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Joint damage manifested by bony erosions and joint space narrowing is a major contributor to the morbidity and mortality of RA. Reports in Caucasians…

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