Abstracts tagged "Synovitis"

Abstract Number: 0029 • ACR Convergence 2021
JAK1 Regulates Autophagy and Reinforces the Inflammatory and Autoimmune Potentials in Rheumatoid Arthritis Synovial Fibroblasts
Keita Ninagawa¹, Masaru Kato¹, Yuki Kudo², Masaru Yoshimura², Michihito Kono², Yuichiro Fujieda¹, Kenji Oku² and Tatsuya Atsumi³, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²1. Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ³Hokkaido University, Sapporo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is pathologically characterized by autoimmunity against citrullinated proteins, proliferative synovitis, and ultimately joint destruction. Synovial fibroblasts (SFs) are, when activated, capable…
Abstract Number: 1522 • ACR Convergence 2021
Potential Predictors of Persistence in Immune Check Point Inhibitor Induced Arthritis
Anu Desai¹, Lakshmi Priya Shadananan¹, Adam Croft², Lalit Pallan¹, Neil Steven³ and Benjamin Fisher⁴, ¹University of Birmingham, Birmingham, United Kingdom, ²University of Birmingham, Halesowen, United Kingdom, ³Institute of Immunology and Immunotherapy/University of Birmingham, Birmingham, United Kingdom, ⁴Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Background/Purpose: Immune Check Point Inhibitors (ICIs) are widely used in Oncology and are associated with multiple autoimmune and systemic inflammatory reactions called immune-related adverse events.…
Abstract Number: 0060 • ACR Convergence 2021
Lipidomic Profiling Identifies Different Expression of Oxylipins Between Synovial Tissue and Plasma of Patients with Rheumatoid and Psoriatic Arthritis
Abha Singh¹, Jessica Murillo Saich², Roxana Coras³, Julio Ramirez⁴, Eric Chang², Raquel Celis⁵, Aaron Armando², Oswald Quehenberger², Arthur Kavanaugh², Juan D Cañete⁶ and Monica Guma⁷, ¹University of California San Diego, San Diego, CA, ²University of California San Diego, La Jolla, CA, ³University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ⁴Arthritis Unit, Rheumatology Department, Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁵Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁶Rheumatology Department, Hospital Clinic, Barcelona, Spain, ⁷University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFAs) that modulate inflammation. Oxylipins derived from n-6 PUFA precursors, such as arachidonic acid (AA),…
Abstract Number: 1786 • ACR Convergence 2021
Association of the Improvement of Synovitis and Enthesitis with Quality of Life/Patient Reported Outcomes in Patients with PsA Treated with Ixekizumab
Lars Erik Kristensen¹, Dennis McGonagle², Martin Rudwaleit³, Hideto Kameda⁴, Thorsten Holzkaemper⁵, Celine El Baou⁶ and Josef Smolen⁷, ¹Bispebjerg-Frederiksberg Hospital, Copenhagen,, Denmark, ²University of Leeds, Leeds, United Kingdom, ³Bielefeld University, Rheumatology, Klinikum Bielefeld, Berlin, Germany, ⁴Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan, ⁵Eli Lilly and Company, Bad Homburg, Germany, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷Medical University of Vienna, Vienna, Austria
Background/Purpose: PsA is an inflammatory rheumatic disease with manifestations including synovitis and enthesitis. During extensive study programs, IXE has shown a treatment effect across domains…
Abstract Number: 0153 • ACR Convergence 2021
Echogenic and Hypervascular Synovium Detected on Ultrasound Are Predictive of a Favorable Response After Intra-articular Corticosteroid Injection in Patients with Knee Osteoarthritis
Robert Dima¹, Trevor Birmingham², Ryan Pinto³, Holly Philpott¹, McKenzie Carter¹ and Tom Appleton², ¹Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³Western University, Kitchener, ON, Canada
Background/Purpose: Intra-articular corticosteroids (IACS) are commonly used for symptom management in knee osteoarthritis (KOA) patients, despite the fact that many patients do not respond to…
Abstract Number: 0217 • ACR Convergence 2021
The OMERACT Knee Inflammation MRI Scoring System: Validation of Quantitative Methodologies and Tri-compartmental Overlays by Comparison with the MRI Osteoarthritis Knee Score
Walter Maksymowych¹, Jacob Jaremko², Susanne Pedersen³, Iris Eshed⁴, Ulrich Weber⁵, Paul Bird⁶, Andrew McReynolds², Stephanie Wichuk², Joel Paschke⁷ and Robert Lambert², ¹Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³Rigshospitalet, Center for Arthritis Research, Glostrup, Denmark, ⁴Sheba Medical Center, Ramat Gan, Israel, ⁵Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, ⁶University of New South Wales, Sydney, Australia, ⁷CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: Bone marrow lesions (BML) and synovitis on MRI are independently associated with the severity and progression of osteoarthritis (OA) and randomized controlled trials have…
Abstract Number: 0218 • ACR Convergence 2021
Synovitis Does Not Mediate the Relationship Between Body Mass Index and Progression of Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Marina Bañuls¹, Alecio Lombardi¹, Eric Chang¹, Aladdin H Shadyab¹, Nancy Lane² and Monica Guma³, ¹University of California San Diego, San Diego, CA, ²University of California Davis, Hillsborough, CA, ³University of California San Diego, La Jolla, CA
Background/Purpose: Synovial inflammation is associated with knee osteoarthritis (KOA) progression. Body mass index (BMI) has also been associated with KOA progression. Yet, it is unclear…
Abstract Number: 0468 • ACR Convergence 2021
During Development of Rheumatoid Arthritis, Intermetatarsal Bursitis May Occur Before Clinical Joint Swelling: A Large MRI Study in Patients with Clinically Suspect Arthralgia
Bastiaan van Dijk¹, Fenne Wouters¹, Elise van Mulligen², Monique Reijnierse¹ and Annette H.M van der Helm-van Mil¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Inflammation of the synovial lining is a hallmark of rheumatoid arthritis (RA). A synovial lining is not only present at synovial joints and tendon…
Abstract Number: 0731 • ACR Convergence 2021
An Open-Label Study to Evaluate the Effect of Intra-articular Triamcinolone Acetonide Extended Release on Patients with Baseline Synovitis and Osteoarthritis of the Knee
Kim Huffman¹, Alan Kivitz², Philip Conaghan³, Michael Bowes⁴, Alan Brett⁴, Virginia Kraus¹, William Maloney⁵, Javad Parvizi⁶, Amy Cinar⁷, Neil Bodick⁷ and Scott Kelley⁷, ¹Duke University School of Medicine, Durham, NC, ²Altoona Center for Clinical Research, Duncansville, PA, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Imorphics Ltd, Manchester, United Kingdom, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Thomas Jefferson University Hospital, Philadelphia, PA, ⁷Flexion Therapeutics Inc., Burlington, MA
Background/Purpose: Synovial inflammation is common in knee osteoarthritis (OA) and is associated with pain and disease severity. Previous studies have suggested short-term (approximately 2 weeks)…
Abstract Number: 0793 • ACR Convergence 2021
Contributing Factors of Good Outcome in Difficult-to-treat Rheumatoid Arthritis: A Multicenter RA Ultrasound Prospective Observational Cohort Study in Japan
Shin-ya Kawashiri¹, Tohru Michitsuji¹, Yushiro Endo¹, Ayako Nishino¹, Toshimasa Shimizu¹, Remi Sumiyoshi¹, Tomohiro Koga¹, Naoki Iwamoto¹, Kunihiro Ichinose² and Atsushi Kawakami¹, ¹Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki, Japan
Background/Purpose: The concept of difficult-to-treat rheumatoid arthritis (D2T RA) has emerged as the greatest unmet need in recent years. We have investigated the clinical characteristics…
Abstract Number: 0800 • ACR Convergence 2021
Digital Spatial Profiling Reveals Distinct Synovial Tissue Transcriptomic Signature of Sustained Disease Remission in Rheumatoid Arthritis Patients at Risk of Disease Flare After Treatment Tapering or Discontinuation
Stefano Alivernini¹, Simone Perniola², Marco Gessi³, Maria Rita Gigante⁴, Clara Di Mario⁵, Luca Petricca⁴, Dario Bruno⁵, Laura Bui¹, Annamaria Paglionico¹, Valentina Varriano¹, Maria Antonietta D'Agostino⁶, Barbara Tolusso¹ and Elisa Gremese⁷, ¹Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ²Fondazione Policlinico Universitario A. Gemelli IRCCS - University of Verona, Santeramo in Colle, Italy, ³Fondazione PoliclinicoUniversitario A. Gemelli IRCCS, Rome, Italy, ⁴Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁵Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy, ⁶Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, ⁷Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
Background/Purpose: Sustained disease remission is the treatment goal for Rheumatoid Arthritis (RA) leading patients to be eligible to treatment tapering or discontinuation. However, disease flare…
Abstract Number: 0943 • ACR Convergence 2021
Metabolomic Profiling of Synovial Tissue of Patients with Osteoarthritis
Jessica Murillo Saich¹, Roxana Coras², Robert Meyer³ and Monica Guma⁴, ¹University of California San Diego, La Jolla, CA, ²University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, ³San Diego VA Healthcare Service, La Jolla, CA, ⁴University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: Increasing evidence indicates that osteoarthritis (OA) progression is mediated not simply by progressive degeneration of cartilage, but also by low-grade synovial inflammation (synovitis) that…
Abstract Number: 0945 • ACR Convergence 2021
A Single-cell Atlas of Human Synovial Endothelial Cells in Inflammatory Arthritis
Sam Edalat¹, Reto Gerber², Miranda Houtman¹, Raphael Micheroli³, Kristina Buerki¹, Nadja Izanc¹, Blaz Burja⁴, Tadeja Kuret⁵, Snežna Sodin-Šemrl⁵, Adrian Ciurea³, Oliver Distler³, Caroline Ospelt¹, Chantal Pauli⁶, Mark Robinson⁷ and Mojca Frank-Bertoncelj³, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich and Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland, ³Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich and Department of Rheumatology, University Medical Centre Ljubljana, Zurich, Switzerland, ⁵Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ⁶Department of Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁷Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland
Background/Purpose: Dysregulated endothelial cell (EC) function and altered (lympho)angiogenesis crucially contribute to synovial pathology in inflammatory arthritis. Additionally, endothelium plays a key role in the…
Abstract Number: 0741 • ACR Convergence 2020
Constitutive Inhibitor Kappa B (IκB) Kinase 2 (IKK2) Activation Induces an Inflammatory State in Fibroblast-Like Synoviocytes
Sergio Ramirez-Perez¹, Umesh Gangishetti¹, Kyle Jones¹ and Pallavi Bhattaram², ¹Department of Orthopaedics, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, ²EMORY UNIVERSITY, Atlanta, GA
Background/Purpose: Fibroblast-like synoviocytes (FLS) are key players involved in the production of inflammatory mediators that trigger joint tissue damage in inflammatory arthritis (IA). The most…
Abstract Number: 1608 • ACR Convergence 2020
Survey of Minimally-Invasive Ultrasound-Guided Synovial Biopsy Performed at Rheumatology Centres
Bernard Dyke¹, Mark Maybury², Stefano Alivernini³, Juan Cañete⁴, Orazio De Lucia⁵, João Eurico Fonseca⁶, Nicola Gullick⁷, Søren Just⁸, David Kane⁹, Juhani Koski¹⁰, Antonio Manzo¹¹, Laurent Meric de Bellefon¹², Ronan Mullan⁹, Aurelie Najm¹³, Arthur Pratt¹⁴, Felipe Julio Ramirez Garcia¹⁵, Charlotte Rawlings¹⁶, Fiona Rayner¹⁷, Vasco Romão¹⁸, Ilfita Sahbudin², Darren Tabechian¹⁹ and Andrew Filer², ¹Institute of Inflammation and Ageing, University of Birmingham, Birmingham, England, United Kingdom, ²Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ³Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁴Arthritis Unit, Rheumatology Dpt, Hospital Clinic, Barcelona, Spain and IDIBAPS, Barcelona, Spain, ⁵ASST Gaetano Pini-CTO Orthopedic and Traumatology Specialist Center, Milan, Italy, ⁶Instituto de Medicina Molecular, Faculdade Medicina Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte., Lisboa, Portugal, ⁷University Hospital Coventry & Warwickshire, Knowle, United Kingdom, ⁸Svendborg Hospital - Odense University Hospital, Odense, Denmark, ⁹Tallaght University Hospital, Dublin, Ireland, ¹⁰Mikkeli Central Hospital, Mikkeli, Finland, ¹¹IRCCS Policlinico San Matteo Foundation/University of Pavia, Pavia, Italy, ¹²Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, Belgium, Brussels, Belgium, ¹³Nantes University Hospital, Nantes, France, ¹⁴Newcastle University, Newcastle upon Tyne, United Kingdom, ¹⁵Arthritis Unit, Rheumatology Dpt, Hospital Clinic, Barcelona, Spain, Barcelona, Catalonia, Spain, ¹⁶Cardiff University School of Medicine, Cardiff, United Kingdom, ¹⁷Newcastle University, Newcastle, United Kingdom, ¹⁸Instituto de Medicina Molecular, Faculdade Medicina Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte., Lisbon, Portugal, ¹⁹University of Rochester Medical Center, Rochester, NY
Background/Purpose: Ultrasound-guided synovial biopsy (USGSBx) is a well-established minimally-invasive alternative to arthroscopy for sampling synovial tissue. Adverse event rates in published studies are favourable by…

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