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Abstracts tagged "Synovitis"

  • Abstract Number: 0793 • ACR Convergence 2021

    Contributing Factors of Good Outcome in Difficult-to-treat Rheumatoid Arthritis: A Multicenter RA Ultrasound Prospective Observational Cohort Study in Japan

    Shin-ya Kawashiri1, Tohru Michitsuji1, Yushiro Endo1, Ayako Nishino1, Toshimasa Shimizu1, Remi Sumiyoshi1, Tomohiro Koga1, Naoki Iwamoto1, Kunihiro Ichinose2 and Atsushi Kawakami1, 1Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki, Japan

    Background/Purpose: The concept of difficult-to-treat rheumatoid arthritis (D2T RA) has emerged as the greatest unmet need in recent years. We have investigated the clinical characteristics…
  • Abstract Number: 0800 • ACR Convergence 2021

    Digital Spatial Profiling Reveals Distinct Synovial Tissue Transcriptomic Signature of Sustained Disease Remission in Rheumatoid Arthritis Patients at Risk of Disease Flare After Treatment Tapering or Discontinuation

    Stefano Alivernini1, Simone Perniola2, Marco Gessi3, Maria Rita Gigante4, Clara Di Mario5, Luca Petricca4, Dario Bruno5, Laura Bui1, Annamaria Paglionico1, Valentina Varriano1, Maria Antonietta D'Agostino6, Barbara Tolusso1 and Elisa Gremese7, 1Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 2Fondazione Policlinico Universitario A. Gemelli IRCCS - University of Verona, Santeramo in Colle, Italy, 3Fondazione PoliclinicoUniversitario A. Gemelli IRCCS, Rome, Italy, 4Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 5Division of Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy, 6Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, 7Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

    Background/Purpose: Sustained disease remission is the treatment goal for Rheumatoid Arthritis (RA) leading patients to be eligible to treatment tapering or discontinuation. However, disease flare…
  • Abstract Number: 0943 • ACR Convergence 2021

    Metabolomic Profiling of Synovial Tissue of Patients with Osteoarthritis

    Jessica Murillo Saich1, Roxana Coras2, Robert Meyer3 and Monica Guma4, 1University of California San Diego, La Jolla, CA, 2University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 3San Diego VA Healthcare Service, La Jolla, CA, 4University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Increasing evidence indicates that osteoarthritis (OA) progression is mediated not simply by progressive degeneration of cartilage, but also by low-grade synovial inflammation (synovitis) that…
  • Abstract Number: 0945 • ACR Convergence 2021

    A Single-cell Atlas of Human Synovial Endothelial Cells in Inflammatory Arthritis

    Sam Edalat1, Reto Gerber2, Miranda Houtman1, Raphael Micheroli3, Kristina Buerki1, Nadja Izanc1, Blaz Burja4, Tadeja Kuret5, Snežna Sodin-Šemrl5, Adrian Ciurea3, Oliver Distler3, Caroline Ospelt1, Chantal Pauli6, Mark Robinson7 and Mojca Frank-Bertoncelj3, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich and Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland, 3Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland, 4Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich and Department of Rheumatology, University Medical Centre Ljubljana, Zurich, Switzerland, 5Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 6Department of Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 7Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland

    Background/Purpose: Dysregulated endothelial cell (EC) function and altered (lympho)angiogenesis crucially contribute to synovial pathology in inflammatory arthritis. Additionally, endothelium plays a key role in the…
  • Abstract Number: 0968 • ACR Convergence 2021

    Granzyme K+ CD8 T Cells Form the Core Population of Inflamed Human Tissue-associated CD8 T Cells

    Anna Helena Jonsson1, Fan Zhang2, Emma Gomez-Rivas1, Gerald Watts1, Garett Dunlap3, Heather Faust1, Karishma Rupani1, Joseph Mears1, Deepak Rao1, Runci Wang4, Gregory Keras1, Nida Meednu5, Jonathan Coblyn1, Elena Massarotti1, Derrick Todd1, Andrew McDavid6, Jennifer Anolik5, Accelerating Medicines Partnership AMP: RA/SLE Network7, Kevin Wei1, Soumya Raychaudhuri1 and Michael Brenner8, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Harvard University, Somerville, MA, 4Brigham and Women’s Hospital, Boston, MA, 5University of Rochester Medical center, Rochester, NY, 6University of Rochester, Rochester, NY, 7NIH/FNIH, Bethesda, MD, 8Brigham and Women's Hospital, Harvard Medical School, Newton, MA

    Background/Purpose: T cell-derived pro-inflammatory cytokines are a major driver of rheumatoid arthritis (RA) pathogenesis. While CD4 T cells have traditionally been assumed to be the…
  • Abstract Number: 1125 • ACR Convergence 2021

    Synovial Perivascular Edema Is Associated with Altered Knee Loading Patterns During Gait in Patients with Medial Compartment-Dominant Knee Osteoarthritis

    McKenzie Carter1, Holly Philpott1, Trevor Birmingham2, Ryan Pinto3, Codie Primeau1, J. Robert Giffin1, Brent Lanting2 and Tom Appleton2, 1Western University, London, ON, Canada, 2University of Western Ontario, London, ON, Canada, 3Western University, Kitchener, ON, Canada

    Background/Purpose: Synovial inflammation and aberrant joint loads are independent risk factors for knee osteoarthritis (OA) incidence and progression. Perivascular edema, the accumulation of fluid around…
  • Abstract Number: 1221 • ACR Convergence 2021

    Association of Neutrophil Lymphocyte and Platelet Lymphocyte Ratios with Joint Inflammation in Rheumatoid Arthritis

    Diyu Pearce-Fisher1, Dana Orange2, Bella Mehta3, Deanna Jannat-Khah1 and Susan Goodman1, 1Hospital for Special Surgery, New York, NY, 2The Rockefeller University, New York, NY, 3Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: It can be challenging to determine whether rheumatoid arthritis (RA) patients who require arthroplasty have ongoing inflammation, in addition to damage in the affected…
  • Abstract Number: 1358 • ACR Convergence 2021

    Clusters of Psoriatic Arthritis Patients at Baseline Based on Different Ultrasound Detected Synovitis: Exploratory Analysis from a Phase III Study

    Maria Antonietta D'Agostino1, Georg Schett2, Corine Gaillez3, Philip Conaghan4, Esperanza Naredo5, Philippe Carron6, Ruben Burgos-Vargas7, Peter Mandl8, Javier Rosa9, Maarten Boers10, Punit Goyanka11, Weibin Bao12 and David Demanse3, 1Rheumatology, Fondazione Policlinico Universitario “Gemelli”, IRCCS, Rome, Italy, 2Universitätsklinikum Erlangen, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany, Erlangen, Germany, 3Novartis Pharma AG, Basel, Switzerland, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Department of Rheumatology and Joint and Bone Research Unit, Hospital Fundación Jiménez Díaz and Autónoma University, Madrid, Spain, 6Department of Rheumatology, University Hospital Ghent, University of Ghent, Ghent, Belgium, 7Department of Rheumatology, General Hospital of Mexico, Ciudad de Mxico, Mexico, 8Medical University of Vienna, Vienna, Austria, 9Rheumatology Unit, Internal Medical Services, and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 10Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 11Novartis Healthcare Pvt Ltd, Hyderabad, India, Hyderabad, India, 12Novartis, East Hanover, NJ

    Background/Purpose: Psoriatic arthritis (PsA) is characterized by inflammation of synovial membranes and entheseal sites leading to pain, structural damage, impairment of physical function and quality…
  • Abstract Number: 1360 • ACR Convergence 2021

    Ultrasound Demonstrates Continued Improvement in Psoriatic Arthritis Synovitis and Enthesitis with Secukinumab: 52-week Results from a Phase III Study

    Maria Antonietta D'Agostino1, Georg Schett2, Corine Gaillez3, Carlos Guerrero4, PETRA HANOVA5, Tomas Cazenave6, Maria S. Stoenoiu7, Marina Backhaus8, Gael Mouterde9, Maarten Boers10, Anne-Marie Duggan11, Punit Goyanka12 and Philip Conaghan13, 1Rheumatology, Fondazione Policlinico Universitario “Gemelli”, IRCCS, Rome, Italy, 2Universitätsklinikum Erlangen, Department of Internal Medicine 3 – Rheumatology and Immunology, Erlangen, Germany, Erlangen, Germany, 3Novartis Pharma AG, Basel, Switzerland, 4Dermatologico Country, Jalisco, Mexico, 5Department of Rheumatology, Institute of Rheumatology, Prague, Czech Republic, 6Instituto de Rehabilitación Psicofisica, Buenos Aires, Argentina, Buenos Aires, Argentina, 7Rheumatology department, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 8Department of Internal Medicine, Rheumatology and Clinical Immunology, Park-Klinik Weissensee Academic Hospital of the Charité, Berlin, Germany, Berlin, Germany, 9Rheumatology department, CHU Montpellier, Montpellier, France, 10Department of Epidemiology and Data Science, and Amsterdam Rheumatology and Immunology Center, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, 11Novartis Ireland Limited, Dublin, Ireland, Dublin, Ireland, 12Novartis Healthcare Pvt Ltd, Hyderabad, India, Hyderabad, India, 13Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Power Doppler ultrasound (PDUS) is a sensitive non-invasive imaging tool to visualize a wide range of articular and periarticular inflammation in psoriatic arthritis (PsA).1,2…
  • Abstract Number: 0029 • ACR Convergence 2021

    JAK1 Regulates Autophagy and Reinforces the Inflammatory and Autoimmune Potentials in Rheumatoid Arthritis Synovial Fibroblasts

    Keita Ninagawa1, Masaru Kato1, Yuki Kudo2, Masaru Yoshimura2, Michihito Kono2, Yuichiro Fujieda1, Kenji Oku2 and Tatsuya Atsumi3, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 21. Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 3Hokkaido University, Sapporo, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is pathologically characterized by autoimmunity against citrullinated proteins, proliferative synovitis, and ultimately joint destruction. Synovial fibroblasts (SFs) are, when activated, capable…
  • Abstract Number: 1522 • ACR Convergence 2021

    Potential Predictors of Persistence in Immune Check Point Inhibitor Induced Arthritis

    Anu Desai1, Lakshmi Priya Shadananan1, Adam Croft2, Lalit Pallan1, Neil Steven3 and Benjamin Fisher4, 1University of Birmingham, Birmingham, United Kingdom, 2University of Birmingham, Halesowen, United Kingdom, 3Institute of Immunology and Immunotherapy/University of Birmingham, Birmingham, United Kingdom, 4Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

    Background/Purpose: Immune Check Point Inhibitors (ICIs) are widely used in Oncology and are associated with multiple autoimmune and systemic inflammatory reactions called immune-related adverse events.…
  • Abstract Number: 0060 • ACR Convergence 2021

    Lipidomic Profiling Identifies Different Expression of Oxylipins Between Synovial Tissue and Plasma of Patients with Rheumatoid and Psoriatic Arthritis

    Abha Singh1, Jessica Murillo Saich2, Roxana Coras3, Julio Ramirez4, Eric Chang2, Raquel Celis5, Aaron Armando2, Oswald Quehenberger2, Arthur Kavanaugh2, Juan D Cañete6 and Monica Guma7, 1University of California San Diego, San Diego, CA, 2University of California San Diego, La Jolla, CA, 3University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 4Arthritis Unit, Rheumatology Department, Hospital Clinic and IDIBAPS, Barcelona, Spain, 5Hospital Clinic and IDIBAPS, Barcelona, Spain, 6Rheumatology Department, Hospital Clinic, Barcelona, Spain, 7University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFAs) that modulate inflammation. Oxylipins derived from n-6 PUFA precursors, such as arachidonic acid (AA),…
  • Abstract Number: 1786 • ACR Convergence 2021

    Association of the Improvement of Synovitis and Enthesitis with Quality of Life/Patient Reported Outcomes in Patients with PsA Treated with Ixekizumab

    Lars Erik Kristensen1, Dennis McGonagle2, Martin Rudwaleit3, Hideto Kameda4, Thorsten Holzkaemper5, Celine El Baou6 and Josef Smolen7, 1Bispebjerg-Frederiksberg Hospital, Copenhagen,, Denmark, 2University of Leeds, Leeds, United Kingdom, 3Bielefeld University, Rheumatology, Klinikum Bielefeld, Berlin, Germany, 4Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan, 5Eli Lilly and Company, Bad Homburg, Germany, 6Eli Lilly and Company, Indianapolis, IN, 7Medical University of Vienna, Vienna, Austria

    Background/Purpose: PsA is an inflammatory rheumatic disease with manifestations including synovitis and enthesitis. During extensive study programs, IXE has shown a treatment effect across domains…
  • Abstract Number: 0153 • ACR Convergence 2021

    Echogenic and Hypervascular Synovium Detected on Ultrasound Are Predictive of a Favorable Response After Intra-articular Corticosteroid Injection in Patients with Knee Osteoarthritis

    Robert Dima1, Trevor Birmingham2, Ryan Pinto3, Holly Philpott1, McKenzie Carter1 and Tom Appleton2, 1Western University, London, ON, Canada, 2University of Western Ontario, London, ON, Canada, 3Western University, Kitchener, ON, Canada

    Background/Purpose: Intra-articular corticosteroids (IACS) are commonly used for symptom management in knee osteoarthritis (KOA) patients, despite the fact that many patients do not respond to…
  • Abstract Number: 0217 • ACR Convergence 2021

    The OMERACT Knee Inflammation MRI Scoring System: Validation of Quantitative Methodologies and Tri-compartmental Overlays by Comparison with the MRI Osteoarthritis Knee Score

    Walter Maksymowych1, Jacob Jaremko2, Susanne Pedersen3, Iris Eshed4, Ulrich Weber5, Paul Bird6, Andrew McReynolds2, Stephanie Wichuk2, Joel Paschke7 and Robert Lambert2, 1Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada, 2University of Alberta, Edmonton, AB, Canada, 3Rigshospitalet, Center for Arthritis Research, Glostrup, Denmark, 4Sheba Medical Center, Ramat Gan, Israel, 5Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, 6University of New South Wales, Sydney, Australia, 7CARE Arthritis, Edmonton, AB, Canada

    Background/Purpose: Bone marrow lesions (BML) and synovitis on MRI are independently associated with the severity and progression of osteoarthritis (OA) and randomized controlled trials have…
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