Abstracts tagged "Synovitis"

Abstract Number: 1562 • ACR Convergence 2020
Subclinical Joint Inflammation of Hands by Magnetic Resonance Imaging in Patients with Psoriatic Arthritis in Clinical Remission Compared to Active Disease
Victoria Furer¹, Ari Polachek², David Levartovsky¹, Jonathan Wollman³, Mirna Zureik³, Daphna Paran¹, Hagit Sarbagil-Maman⁴, Sara Borok Lev-Ran¹, Mark Berman¹, Ilana Kaufman⁵, Adi Broide³, Valerie Aloush¹, Yael Lahat goldstein¹, Sharon Nevo³, Iris Eshed⁶ and Ori Elkayam³, ¹Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Tel Aviv Sourasky Medical Center, Petah-Tikva, Israel, ³Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel, ⁴Tel-Aviv Sourasky Medical Center, Kiryat Ono, Israel, ⁵Tel Aviv Sourasky Medical Center, Petah-Tiqwa, Israel, ⁶Sheba Medical Center, Tel-Aviv, Israel
Background/Purpose: Assessment of disease activity in psoriatic arthritis (PsA) is based on tender and swollen joint counts (TJC and SJC, respectively). Yet, the prevalence of…
Abstract Number: 0741 • ACR Convergence 2020
Constitutive Inhibitor Kappa B (IκB) Kinase 2 (IKK2) Activation Induces an Inflammatory State in Fibroblast-Like Synoviocytes
Sergio Ramirez-Perez¹, Umesh Gangishetti¹, Kyle Jones¹ and Pallavi Bhattaram², ¹Department of Orthopaedics, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, ²EMORY UNIVERSITY, Atlanta, GA
Background/Purpose: Fibroblast-like synoviocytes (FLS) are key players involved in the production of inflammatory mediators that trigger joint tissue damage in inflammatory arthritis (IA). The most…
Abstract Number: 1608 • ACR Convergence 2020
Survey of Minimally-Invasive Ultrasound-Guided Synovial Biopsy Performed at Rheumatology Centres
Bernard Dyke¹, Mark Maybury², Stefano Alivernini³, Juan Cañete⁴, Orazio De Lucia⁵, João Eurico Fonseca⁶, Nicola Gullick⁷, Søren Just⁸, David Kane⁹, Juhani Koski¹⁰, Antonio Manzo¹¹, Laurent Meric de Bellefon¹², Ronan Mullan⁹, Aurelie Najm¹³, Arthur Pratt¹⁴, Felipe Julio Ramirez Garcia¹⁵, Charlotte Rawlings¹⁶, Fiona Rayner¹⁷, Vasco Romão¹⁸, Ilfita Sahbudin², Darren Tabechian¹⁹ and Andrew Filer², ¹Institute of Inflammation and Ageing, University of Birmingham, Birmingham, England, United Kingdom, ²Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ³Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁴Arthritis Unit, Rheumatology Dpt, Hospital Clinic, Barcelona, Spain and IDIBAPS, Barcelona, Spain, ⁵ASST Gaetano Pini-CTO Orthopedic and Traumatology Specialist Center, Milan, Italy, ⁶Instituto de Medicina Molecular, Faculdade Medicina Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte., Lisboa, Portugal, ⁷University Hospital Coventry & Warwickshire, Knowle, United Kingdom, ⁸Svendborg Hospital - Odense University Hospital, Odense, Denmark, ⁹Tallaght University Hospital, Dublin, Ireland, ¹⁰Mikkeli Central Hospital, Mikkeli, Finland, ¹¹IRCCS Policlinico San Matteo Foundation/University of Pavia, Pavia, Italy, ¹²Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, Belgium, Brussels, Belgium, ¹³Nantes University Hospital, Nantes, France, ¹⁴Newcastle University, Newcastle upon Tyne, United Kingdom, ¹⁵Arthritis Unit, Rheumatology Dpt, Hospital Clinic, Barcelona, Spain, Barcelona, Catalonia, Spain, ¹⁶Cardiff University School of Medicine, Cardiff, United Kingdom, ¹⁷Newcastle University, Newcastle, United Kingdom, ¹⁸Instituto de Medicina Molecular, Faculdade Medicina Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte., Lisbon, Portugal, ¹⁹University of Rochester Medical Center, Rochester, NY
Background/Purpose: Ultrasound-guided synovial biopsy (USGSBx) is a well-established minimally-invasive alternative to arthroscopy for sampling synovial tissue. Adverse event rates in published studies are favourable by…
Abstract Number: 0749 • ACR Convergence 2020
Locating Cellular Subsets in Rheumatoid Arthritis Synovium Using CO-Detection by IndEXing (CODEX)
Isabella Wulur¹, David Boyle², Lin Zhang¹, Andrea Martin¹, Robert Benschop³ and Gary Firestein⁴, ¹Eli Lilly, Indianapolis, IN, ²UC San Diego, San Diego, CA, ³Eli Lilly and Company, Indianapolis, IN, ⁴University of California, San Diego, La Jolla, CA
Background/Purpose: To better understand site-of-disease mechanisms in arthritis, the phenotypes and organization of synovial cells and infiltrates are critical. Conventional histology-based approaches are limited in…
Abstract Number: 1872 • ACR Convergence 2020
Relative Associations of Sociodemographic, Clinical and HLA-B Alleles with Enthesitis and Peripheral Arthritis in Patients with Ankylosing Spondylitis
Benjamin Naovarat¹, Lianne Gensler², Michael Ward³, Mark Hwang⁴, Matthew Brown⁵, Amirali Tahanan⁶, Mohammad Rahbar⁶, Mariko Ishimori⁷, Michael Weisman⁸ and John Reveille⁹, ¹The University of Texas McGovern Medical School, Houston, TX, ²University of California San Francisco, San Francisco, CA, ³National Institutes of Health, Bethesda, MD, ⁴McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ⁵Guy's and St Thomas, NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom, London, United Kingdom, ⁶McGovern Medical School at UTHealth, Houston, ⁷Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁹Department of Internal Medicine, University of Texas, Houston, TX
Background/Purpose: Previous studies from Latin America have shown an association with peripheral arthritis in patients with spondyloarthritis with HLA-B*15 (as opposed to HLA-B27). We aimed…
Abstract Number: 0753 • ACR Convergence 2020
Synovial Tissue Histopathology Findings in Early RA. Is It Useful? Analysis of the Belgian CAP48 Cohort
Stéphanie de Montjoye¹, Tatiana Sokolova¹, Emilie Sapart¹, Bernard Lauwerys², Stéphanie Dierckx³, Christine Galant⁴, Laurent Meric de Bellefon¹, Adrien Nzeusseu Toukap⁵, Clément Triaille⁶ and Patrick Durez⁷, ¹Rheumatology, Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCL) – Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ³Rheumatology, CHU Mont-Godinne, Mont Godinne, Belgium, ⁴3Pathology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Brussels, Belgium, ⁵1Department of Rheumatology, Cliniques Universitaires Saint Luc, 2Institut de recherche expérimentale et clinique (IREC), Brussels, Belgium, ⁶Rheumatology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Brussels, Belgium, ⁷Division of Rheumatology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium
Background/Purpose: Rheumatoid arthritis is a heterogeneous disease with different clinical presentation and prognostic factors including the immune process in the synovium. The development of ultrasound-guided…
Abstract Number: 2005 • ACR Convergence 2020
Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis
Felice Rivellese¹, Frances Humby², Giovanni Giorli², Alessandra Nerviani¹, Rebecca Hands², Liliane Fossati-Jimack², Georgina Thorborn², Myles Lewis¹ and Costantino Pitzalis², ¹Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom
Background/Purpose: The results of the R4RA trial, the first biopsy-based RCT in TNF-i inadequate responders patients with Rheumatoid Arthritis (RA), showed that molecular stratification of…
Abstract Number: 0787 • ACR Convergence 2020
MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients
Alessandra Nerviani¹, Marie-Astrid Boutet¹, Giulia Maria Ghirardi², Gloria Lliso-Ribera², Felice Rivellese¹, Myles Lewis¹, Michele Bombardieri², Frances Humby² and Costantino Pitzalis², ¹Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ²Queen Mary University of London, London, United Kingdom
Background/Purpose: Despite valuable improvements in long-term clinical outcomes, a significant portion of rheumatoid arthritis (RA) patients still do not adequately respond to available treatments, and…
Abstract Number: 2045 • ACR Convergence 2020
Resident Memory T Cells in Synovial Tissue Mediate Arthritis Flares
Margaret Chang¹, Anais Levescot², Nathan Nelson-Maney², Rachel Blaustein², Kellen Winden¹, Allyn Morris³, Spoorthi Balu³, Alexandra Wactor², Ricardo Grieshaber-Bouyer⁴, Kevin Wei⁵, Lauren Henderson⁶, Rachael Clark³, Deepak Rao², Robert Fuhlbrigge⁷ and Peter Nigrovic⁸, ¹Boston Children's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, ⁴Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Heidelberg, Germany, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Boston Children's Hospital, Watertown, MA, ⁷University of Colorado, Denver, CO, ⁸Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston
Background/Purpose: Resident memory T cells (TRM) are site-specific memory T cells that take up long-term residence in peripheral tissues and aid in local immune defense.…
Abstract Number: 1164 • 2019 ACR/ARP Annual Meeting
Novel Computer Assisted Methodology for Quantitative Assessment of MRI Treatment Responses to Apremilast in Patients with Psoriatic Arthritis
Paul Bird ¹, Mikael Boesen ², Mark Hinton ³, Eser Sanverdi ³, Romiesa Hagoug ³, Chrisotpher Sabin ³, Priscila Nakasato ⁴, Benoit Guerette ⁴ and Olga Kubassova⁵, ¹Optimus Research, Kogarah, New South Wales, Australia, ²Dept. of Radiology, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark, Copenhagen, Denmark, ³Image Analysis Ltd, London, United Kingdom, ⁴Celgene Corporation, Summit, ⁵Image Analysis Group, London, United Kingdom
Background/Purpose: Response to treatment in Psoriatic Arthritis (PsA) can be captured using the OMERACT PsA Magnetic Resonance Imaging Score (PsAMRIS). While reliable and valid, PsAMRIS…
Abstract Number: 1982 • 2019 ACR/ARP Annual Meeting
Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain
Christopher Yohn ¹, Robert O'Brien ¹, Stephanie Lussier ¹, Casey Berridge ¹, Rathi Ryan ¹, Ali Guermazi ², Mahru An ¹, Remi-Martin Laberge ¹, Benjamin Hsu¹, Carl Millward ¹, Kate Doherty ¹ and Jamie Dananberg ¹, ¹Unity Biotechnology, Brisbane, CA, ²Boston Medical Center, Boston
Background/Purpose: Background/Purpose: Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A…
Abstract Number: 1993 • 2019 ACR/ARP Annual Meeting
Inhibition of Choline Kinase Alpha Improves Synovitis and Cartilage Damage in Animal Models of Osteoarthritis
Roxana Coras¹, Leening P Liu ², Serena Z Shi ², Anyan Cheng ³, Alexandra Stubelius ⁴, Elsa Sanchez-Lopez ⁵, Robert Sah ⁶, Ru Liu-Bryan ⁷ and Monica Guma ⁸, ¹Department of Medicine, University of California San Diego, La Jolla, San Diego, CA, ²Department of Bioengineering, University of California San Diego, La Jolla, San Diego, ³Department of Medicine, University of California San Diego, La Jolla, San Diego, ⁴Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, San Diego, ⁵Department of Pharmacology, University of California San Diego, La Jolla, San Diego, ⁶Department of Bioengineering and Medicine, University of California San Diego, La Jolla, San Diego, ⁷San Diego VA/UCSD, La Jolla, CA, ⁸Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Osteoarthritis (OA) is a disease of the whole joint, affecting cartilage, ligaments, menisci, bone and synovial tissue. We previously found that choline kinase alpha…
Abstract Number: 1201 • 2018 ACR/ARHP Annual Meeting
Finger Extensor Tendon Involvement Is Frequent in Early Rheumatoid Arthritis
Mihaela Maruseac¹, Patrick Durez^2,3, Adrien Nzeusseu Toukap⁴ and Maria Stoenoiu⁵, ¹Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ²Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ³Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, ⁴Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ⁵Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium
Background/Purpose: Finger extensor involvement (FET) at ultrasound examination (US) was previously described in patients suffering from early psoriatic arthritis. Contradictory results were published in patients…
Abstract Number: 2868 • 2018 ACR/ARHP Annual Meeting
Tender Joint Count May Not Reflect Inflammatory Activity in Established Rheumatoid Arthritis Patients; Results from a Longitudinal Study of Tocilizumab
Hilde B Hammer¹, Inger Marie Jensen Hansen², Pentti Järvinen³, Marjatta Leirisalo-Repo⁴, Michael Ziegelasch⁵, Birte Agular⁶ and Lene Terslev⁷, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Svendborg Hospital, Svendborg, Denmark, ³Rheumatology, Kiljava Medical Research, Kiljavan, Finland, ⁴Rheumatology, University of Helsinki, Helsinki, Finland, ⁵Rheumatology, University Hospital, Linköping, Linköping, Sweden, ⁶Roche, Copenhagen, Denmark, ⁷Rheumatology, Rigshospitalet Glostrup, Copenhagen, Denmark
Background/Purpose: Tender joints may be caused by non-inflammatory pathologies but are still included in composite scores like CDAI. The present objective was to explore the…
Abstract Number: 2012 • 2017 ACR/ARHP Annual Meeting
First Description of Tenosynovitis Prevalence in a Large Cohort of ACPA-Positive Patients
Gisela Eugénio^1,2,3, Kulveer Mankia^3,4, Peta Pentony^2,3, Jackie L. Nam^2,3, Laura Hunt^2,3, Hanna Gul^2,3, Richard J. Wakefield^2,3 and Paul Emery^3,5, ¹Rheumatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ²Leeds Teaching Hospitals NHS Trust, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, ⁴Rheumatology, Leeds Teaching Hospitals NHS Trust, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁵NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Tenosynovitis has been regarded as a feature of RA, although its true prevalence in early stages has not been firmly established. The aim of…

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