Abstracts tagged "Spondylarthritis"

Abstract Number: 1005 • 2019 ACR/ARP Annual Meeting
Tendon T-cell Interactions as Drivers of Chronicity in Spondyloarthritis
Emma Garcia-Melchor ¹, Giacomo Cafaro ¹, Hanna Johnsson¹, Lindsay Crowe ², Michael McLean ², James Reilly ², Iain McInnes ³, Moeed Akbar ² and Neal Millar ³, ¹University of Glasgow, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, ³Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Emerging evidence supports the concept that stromal cell functions extend beyond maintenance of tissue architecture, exerting a key role in choreographing immune responses and…
Abstract Number: 1007 • 2019 ACR/ARP Annual Meeting
Memory ex-Th17 Cells Contribute to Synovial Inflammation in Spondyloarthritis
SO-HEE JIN ¹, Pu-Reum PARK ¹, Ji Hyun KANG ¹, DONG-JIN PARK ¹ and TAE-JONG KIM¹, ¹Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: Spondyloarthritis (SpA) is characterized by inflammation of the synovium. An increase in the number of Th17cells in SpA has been reported. However, it is…
Abstract Number: 1167 • 2019 ACR/ARP Annual Meeting
To Evaluate Spine Ankylosis, Vertebral Fractures and Bone Fragility on a Single Imaging Exam in Patients with Ankylosing Spondylitis: Myth or Reality?
caroline Morizot¹, Marine Fauny ², Edem Allado ³, Frank Verhoeven ⁴, Eliane Albuisson ⁵, Astrid Pinzano-Watrin ⁶, Isabelle Chary-Valckenaere ⁵ and Damien Loeuille ⁷, ¹Department Of rheumatology, Vandoeuvre les Nancy, Lorraine, France, ²CHU Nancy, Vandoeuvre, France, ³CHRU Nancy, VANDOEUVRE, France, ⁴Univeristy of Franche comté, Besancon, France, ⁵Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ⁶IMoPA. UMR 7365 CNRS, Vandoeuvre, France, ⁷Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France
Background/Purpose: Spine ankylosis is a risk factor of osteoporosis and mortality in ankylosing spondylitis (AS). Recently, thoracic-abdomino-pelvic CT (TAP-CT) has demonstrated its ability to screen…
Abstract Number: 1179 • 2019 ACR/ARP Annual Meeting
Resting-State Functional Connectivity of Pain Processing Brain Region Associated with Therapeutic Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis
Nobuya Abe¹, Yuichiro Fujieda ¹, Kuniyuki Asou ¹, Kohei Karino ², Michihito Kono ³, Hisashi Narita ⁴, Masaru Kato ¹, Khin Tha ⁵, Kenji Oku ¹, Olga Amengual ¹, Shinsuke Yasuda ¹ and Tatsuya Atsumi ⁶, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ³Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, ⁴Department of Psychiatry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ⁵Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ⁶Hokkaido University, Sapporo, Japan
Background/Purpose: Background/Purpose: Discriminating inflammatory pain from non-inflammatory pain is critical to determine therapeutic strategy in inflammatory arthritis (IA) such as rheumatoid arthritis (RA) and spondyloarthritis…
Abstract Number: 1247 • 2019 ACR/ARP Annual Meeting
Adult-Onset Still’s Disease and Spondyloarthritis: Overlapping Syndrome or Incidental Association? A Series of 5 Cases
Aly Kamissoko ¹, Nolan Hassold ², Alexis Mathian ³, Edouard Pertuiset ⁴, Gaetane Nocturne ², Bruno Fautrel ⁵ and Stéphane Mitrovic⁶, ¹AP-HP, Department of Rheumatology, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, ²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ³AP-HP, Service de Médecine Interne 2, Hôpital Universitaire Pitié-Salpêtrière, Paris, France, Paris, France, ⁴Rheumatology Department, Pontoise Hospital, Pontoise, France, Pontoise, France, ⁵Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, ⁶AP-HP, Department of Rheumatology, Pitié-Salpêtrière University Hospital, Sorbonne Université, GRC 08, Pierre Louis Institute of Epidemiology and Public Health, Paris, France - Centre d’Etude et de Référence sur les Maladies AutoInflammatoires et les Amyloses (CEREMAIA), FAI2R network, Paris, France - Institut Mutualiste Montsouris, Paris, France, Paris, France
Background/Purpose: Some forms of spondyloarthritis (SpA) such as SAPHO syndrome are classified as auto-inflammatory disorders. Association with adult onset Still’s disease (AoSD) has never been…
Abstract Number: 1486 • 2019 ACR/ARP Annual Meeting
Infliximab Serum Trough Levels Predict Non-clinical Response in Patients with Axial Spondyloarthritis
Chamaida Plasencia¹, Ana Martínez-Feito ², Borja Hernández-Breijo ³, Victoria Navarro-Compán ⁴, Eva Olariaga-Mérida ³, Diana Peiteado ⁵, Alejandro Villalba ⁶, Irene Monjo ⁷, Laura Nuño ³, Cristina Diego ⁸, Dora Pascual-Salcedo ⁹ and Alejandro Balsa ¹, ¹Immuno-Rheumatology Research Group, IdiPaz & Rheumatology Department. La Paz University Hospital, Madrid, Spain, ²Immuno-Rheumatology Research Group, IdiPAZ & Immunology Department. La Paz University Hospital, MADRID, Spain, ³Immuno-Rheumatology research group , Institute for Health Research (IdiPAZ), Madrid, Spain, MADRID, Spain, ⁴University Hospital La Paz, IdiPaz, Madrid, Spain, ⁵Hospital Universitario La Paz, Madrid, ⁶FIBHULP-IdiPAZ-Hospital La Paz-Rheumatology, Madrid, ⁷FIBHULP-IdiPAZ-Hospital La Paz-Rheumatology, Madrid, Spain, ⁸Immunology Unit, La Paz University Hospital, Madrid, Spain, MADRID, Spain, ⁹Immuno-Rheumatology Research Group, IdiPAZ. La Paz University Hospital, MADRID, Spain
Background/Purpose: Infliximab (Ifx) has proven to be efficacious for improving symptoms in patients with axial SpA(axSpA). Several factors may influence the pharmacokinetic-pharmacodynamic of Ifx and…
Abstract Number: 1504 • 2019 ACR/ARP Annual Meeting
Subcutaneous Secukinumab 150 Mg Provides Rapid and Sustained Relief in Total and Nocturnal Back Pains, Morning Stiffness, and Fatigue in Patients with Active Ankylosing Spondylitis over 4 Years
Helena Marzo-Ortega¹, Corinne Miceli-Richard ², Sonja Gill ³, Marina Magrey ⁴, Paula Machado ⁵, Abhijit Shete ⁶, Jianyuan Wang ⁶, Susanne Rohrer ⁶ and Atul Deodhar ⁷, ¹NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, Leeds, United Kingdom, ²Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, ³412 – 3075 Hospital Gate, Oakville, Canada, ⁴Division of Rheumatology, The MetroHealth System and School of Medicine, Case Western Reserve University, Cleveland, OH, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Oregon Health & Science University, Portland, OR
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory condition. Pain, stiffness, and fatigue are reported as the most troubling symptoms by 70–80%, 20–40%, and 50–60%…
Abstract Number: 1781 • 2019 ACR/ARP Annual Meeting
Cytokine Dependence of Enthesis-resident Lymphocytes in Murine Spondyloarthritis
Mederbek Matmusaev ¹, Emma Haley¹, Imtiyaz Hossain ¹ and Joerg Ermann ¹, ¹Brigham and Women's Hospital, Boston
Background/Purpose: Enthesis-resident CD4-CD8- double-negative (DN) T cells have been implicated in the pathogenesis of spondyloarthritis. Overexpression of IL-23 in adult mice activates these cells to…
Abstract Number: 1908 • 2019 ACR/ARP Annual Meeting
Preliminary Identification of Arthritis-Associated Microbiota in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran ², Stephen Brooks ³ and Robert Colbert ⁴, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: Gut microbiota are strongly implicated in the pathogenesis of spondyloarthritis (SpA). Previous studies from our lab have documented extensive gut microbial dysbiosis in rats…
Abstract Number: 1910 • 2019 ACR/ARP Annual Meeting
Inflammatory Processes in Experimental Spondyloarthritis Are Accompanied by Formation of Ectopic Lymphoid Structures and B Cell Lineage Alterations in the Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg ¹, Jasper Rip ², George Kollias ³, Leonie van Duivenvoorde ¹, Martijn Nolte ⁴, Dominique Baeten ¹ and Sander Tas ¹, ¹Amsterdam Rheumatology & immunology Center, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands, ²Department of Pulmonary Medicine, Erasmus MC, Rotterdam, Rotterdam, Netherlands, ³Division of Immunology, Biomedical Sciences Center ”Alexander Fleming”, Vari, Greece, Vari, Greece, ⁴Sanquin Research and Landsteiner Laboratory, Molecular & Cellular Hemostasis, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Tumour necrosis factor a (TNF) is important in immune-mediated inflammatory diseases such as spondyloarthritis (SpA). Transmembrane (tm)TNF-transgenic (tg) mice that overexpress tmTNF develop typical…
Abstract Number: 597 • 2019 ACR/ARP Annual Meeting
High Prevalence of Sacroiliac Bone Marrow Edema on MRI in Post Partum Women: A Temporary Phenomenom
Thomas Renson¹, Ann-Sophie De Craemer ¹, Liselotte Deroo ¹, Anaïs Depicker ¹, Manouk de Hooge ¹, Nele Herregods ¹, Lennart Jans ¹, Kristien Roelens ¹, Isabelle Dehaene ¹, Philippe Carron ¹, Filip Van den Bosch ¹ and Dirk Elewaut ¹, ¹Ghent University Hospital, Ghent, Belgium
Background/Purpose: Magnetic Resonance Imaging (MRI) is a sensitive method for detection of sacroiliitis. However, recently, concerns have been raised about its specificity. In contrast to…
Abstract Number: 1911 • 2019 ACR/ARP Annual Meeting
Targeting the Oxidative Stress Pathway in Experimental Spondyloarthritis Reduces Pro-inflammatory Response in Rat Macrophages and Modulates Their Metabolic Requirements
Fatemeh Navid¹, Francesca LiCausi ¹, Breanna Nguyen ¹, Antony Cougnoux ², Pierre-Christian Violet ³, Mark Levine ³ and Robert Colbert ¹, ¹NIAMS/NIH, bethesda, ²NICHDR/NIH, Bethesda, ³NIDDK/NIH, Bethesda
Background/Purpose: HLA-B27 is associated with the development of spondyloarthritis (SpA) and has a tendency to generate ER stress due to misfolding which can activate the…
Abstract Number: 605 • 2019 ACR/ARP Annual Meeting
Macrophage Migration Inhibitory Factor Is a Critical Regulator in a Mouse Model of Spondyloarthritis
Akihiro Nakamura¹, Fanxing Zeng ¹, Sayaka Nakamura ¹, Richard Bucala ² and Nigil Haroon ³, ¹University Health Network, Toronto, Canada, ²Yale University School of Medicine, New Haven, CT, ³Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: Spondyloarthritis (SpA) is a chronic rheumatic disease characterized by severe inflammation in the spine, peripheral joints, intestine, skin and eyes. Although current treatment modalities…
Abstract Number: 2321 • 2019 ACR/ARP Annual Meeting
Subclinical Myocardial Dysfunction Assessed by Strain Imaging in Patients with Rheumatoid Arthritis and Spondyloarthritis
Guillaume CLERFOND ¹, Marc VILLEDON DE NAIDE ², Clara ALLEMAND ³, Lucie ULMANN ³, Romain ESCHALIER ³, Martin SOUBRIER ⁴, Bruno Pereira ⁵ and Anne TOURNADRE⁶, ¹CHU de Clermont Ferrand, Clermont Ferrand, ²CHU de Clermont Ferrand, Clermont -Ferrand, France, ³CHU de Clermont Ferrand, Clermont Ferrand, France, ⁴CHU Gabriel Montpied, Clermont Ferrand, Auvergne, France, ⁵CHU CLERMONT-FERRAND, CLERMONT-FERRAND, France, ⁶CHU de Clermont-Ferrand, Clermont-Ferrand, France
Background/Purpose: Although cardiovascular (CV) risk and mortality are increased in rheumatoid arthritis (RA) and spondyloarthritis (SpA), mechanisms resulting in CV risk excess and stratification are…
Abstract Number: 632 • 2019 ACR/ARP Annual Meeting
An Observational Analysis of the Co-existence of Brugada Syndrome in Patients with Spondyloarthritis; A Potentially Important Link
Kunal Lall ¹, Robbie Ramsden ², Elijah R. Behr ³ and Virinderjit Sandhu², ¹St.George's University Medical School, London, United Kingdom, ²Department of Rheumatology, St.George's Hospital NHS Foundation Trust, London, United Kingdom, ³Department of Cardiology, St.George's Hospital NHS Foundation Trust, London, United Kingdom
Background/Purpose: Cardiac involvement in Spondyloarthritis (SpA) has been recognised as an important determinant of increased comorbidity and mortality due to atherosclerosis, aortitis, aortic regurgitation and…

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