Abstracts tagged "Spondylarthritis"

Abstract Number: 1908 • 2019 ACR/ARP Annual Meeting
Preliminary Identification of Arthritis-Associated Microbiota in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran ², Stephen Brooks ³ and Robert Colbert ⁴, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: Gut microbiota are strongly implicated in the pathogenesis of spondyloarthritis (SpA). Previous studies from our lab have documented extensive gut microbial dysbiosis in rats…
Abstract Number: 597 • 2019 ACR/ARP Annual Meeting
High Prevalence of Sacroiliac Bone Marrow Edema on MRI in Post Partum Women: A Temporary Phenomenom
Thomas Renson¹, Ann-Sophie De Craemer ¹, Liselotte Deroo ¹, Anaïs Depicker ¹, Manouk de Hooge ¹, Nele Herregods ¹, Lennart Jans ¹, Kristien Roelens ¹, Isabelle Dehaene ¹, Philippe Carron ¹, Filip Van den Bosch ¹ and Dirk Elewaut ¹, ¹Ghent University Hospital, Ghent, Belgium
Background/Purpose: Magnetic Resonance Imaging (MRI) is a sensitive method for detection of sacroiliitis. However, recently, concerns have been raised about its specificity. In contrast to…
Abstract Number: 1910 • 2019 ACR/ARP Annual Meeting
Inflammatory Processes in Experimental Spondyloarthritis Are Accompanied by Formation of Ectopic Lymphoid Structures and B Cell Lineage Alterations in the Bone Marrow
Merlijn Kaaij¹, Jan Piet van Hamburg ¹, Jasper Rip ², George Kollias ³, Leonie van Duivenvoorde ¹, Martijn Nolte ⁴, Dominique Baeten ¹ and Sander Tas ¹, ¹Amsterdam Rheumatology & immunology Center, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands, ²Department of Pulmonary Medicine, Erasmus MC, Rotterdam, Rotterdam, Netherlands, ³Division of Immunology, Biomedical Sciences Center ”Alexander Fleming”, Vari, Greece, Vari, Greece, ⁴Sanquin Research and Landsteiner Laboratory, Molecular & Cellular Hemostasis, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Tumour necrosis factor a (TNF) is important in immune-mediated inflammatory diseases such as spondyloarthritis (SpA). Transmembrane (tm)TNF-transgenic (tg) mice that overexpress tmTNF develop typical…
Abstract Number: 605 • 2019 ACR/ARP Annual Meeting
Macrophage Migration Inhibitory Factor Is a Critical Regulator in a Mouse Model of Spondyloarthritis
Akihiro Nakamura¹, Fanxing Zeng ¹, Sayaka Nakamura ¹, Richard Bucala ² and Nigil Haroon ³, ¹University Health Network, Toronto, Canada, ²Yale University School of Medicine, New Haven, CT, ³Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: Spondyloarthritis (SpA) is a chronic rheumatic disease characterized by severe inflammation in the spine, peripheral joints, intestine, skin and eyes. Although current treatment modalities…
Abstract Number: 1911 • 2019 ACR/ARP Annual Meeting
Targeting the Oxidative Stress Pathway in Experimental Spondyloarthritis Reduces Pro-inflammatory Response in Rat Macrophages and Modulates Their Metabolic Requirements
Fatemeh Navid¹, Francesca LiCausi ¹, Breanna Nguyen ¹, Antony Cougnoux ², Pierre-Christian Violet ³, Mark Levine ³ and Robert Colbert ¹, ¹NIAMS/NIH, bethesda, ²NICHDR/NIH, Bethesda, ³NIDDK/NIH, Bethesda
Background/Purpose: HLA-B27 is associated with the development of spondyloarthritis (SpA) and has a tendency to generate ER stress due to misfolding which can activate the…
Abstract Number: 632 • 2019 ACR/ARP Annual Meeting
An Observational Analysis of the Co-existence of Brugada Syndrome in Patients with Spondyloarthritis; A Potentially Important Link
Kunal Lall ¹, Robbie Ramsden ², Elijah R. Behr ³ and Virinderjit Sandhu², ¹St.George's University Medical School, London, United Kingdom, ²Department of Rheumatology, St.George's Hospital NHS Foundation Trust, London, United Kingdom, ³Department of Cardiology, St.George's Hospital NHS Foundation Trust, London, United Kingdom
Background/Purpose: Cardiac involvement in Spondyloarthritis (SpA) has been recognised as an important determinant of increased comorbidity and mortality due to atherosclerosis, aortitis, aortic regurgitation and…
Abstract Number: 2321 • 2019 ACR/ARP Annual Meeting
Subclinical Myocardial Dysfunction Assessed by Strain Imaging in Patients with Rheumatoid Arthritis and Spondyloarthritis
Guillaume CLERFOND ¹, Marc VILLEDON DE NAIDE ², Clara ALLEMAND ³, Lucie ULMANN ³, Romain ESCHALIER ³, Martin SOUBRIER ⁴, Bruno Pereira ⁵ and Anne TOURNADRE⁶, ¹CHU de Clermont Ferrand, Clermont Ferrand, ²CHU de Clermont Ferrand, Clermont -Ferrand, France, ³CHU de Clermont Ferrand, Clermont Ferrand, France, ⁴CHU Gabriel Montpied, Clermont Ferrand, Auvergne, France, ⁵CHU CLERMONT-FERRAND, CLERMONT-FERRAND, France, ⁶CHU de Clermont-Ferrand, Clermont-Ferrand, France
Background/Purpose: Although cardiovascular (CV) risk and mortality are increased in rheumatoid arthritis (RA) and spondyloarthritis (SpA), mechanisms resulting in CV risk excess and stratification are…
Abstract Number: 633 • 2019 ACR/ARP Annual Meeting
Diagnostic Delay in Spondyloarthritis
Santiago Scarafia¹, Maria Paula Girard Bosch ², Mariana Benegas ³, Vanesa Cosentino ⁴, Josefina Marin ⁵, Vanesa Duarte ⁶, Juan Bande ⁷, Maria Julieta Gamba ⁸, Fernando Sommerfleck ⁹, Paula Gonzalez ⁸, Diego Vila ¹⁰, Marina Oliver ¹¹, Maria Mercedes Piovesan ¹², Rodrigo Aguila ¹³, Velozo Edson Javier ¹⁴, Eduardo Kerzberg ¹⁵, Maria Janina Tapia Moreira ¹⁶, Micaela Cosatti ¹⁷, Carla Airoldi ¹⁸, Mercedes Garcia ¹⁹ and Maria Victoria Martire ²⁰, ¹Hospital Municipal "San Cayetano", Buenos Aires, Buenos Aires, Argentina, ²Instituto Médico Platense, La Plata, ³Sanatorio Mendez, Buenos Aires, ⁴Federación de Asociaciones de Trabajadores de la Sanidad Argentina Buenos Aires, Buenos Aires, Argentina, ⁵Hospital Italiano de Buenos Aires, buenos aires, Ciudad Autonoma de Buenos Aires, Argentina, ⁶Clínica Monte Grande, Monte Grande, Buenos Aires, Argentina, ⁷Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ⁸Hospital Nacional Posadas, Buenos Aires, Buenos Aires, Argentina, ⁹Sanatorio Mendez, Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ¹⁰Centro Médico Ginecológico Zárate, Zárate, Buenos Aires, Argentina, ¹¹Hospital Privado de Comunidad de Mar del Plata, Mar del Plata, Buenos Aires, Argentina, ¹²Sanatorio Finochietto, Buenos AIres, Ciudad Autonoma de Buenos Aires, Argentina, ¹³HIZGA "San Martin", La Plata, Buenos Aires, Argentina, ¹⁴Sanatorio Adventista del Plata, Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ¹⁵Hospital Ramos Mejia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ¹⁶Hospital Ramos Mejia, Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ¹⁷CEMIC, Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ¹⁸Hospital Provincial de Rosario, Rosario, Santa Fe, Argentina, ¹⁹Hospital San Martín, La Plata, Argentina, ²⁰Hospital San Martín. Instituto Médico Platense, La Plata
Background/Purpose: Spondyloarthritis (Spa) is an heterogeneous group of diseases. Diagnostic delay contributes to poor patient outcome. Prompt diagnosis of Spa is the first step towards…
Abstract Number: 2494 • 2019 ACR/ARP Annual Meeting
Comparison of Comorbidity in Spondyloarthritis: Influence on Inflammatory Activity in Patients with Psoriatic Arthritis
Luis Gomez-Lechon¹, Maria Elisa Acosta ¹, Guadalupe Manzano Canabal ¹, Olga Compan ¹, Cristina Hidalgo ², Olga Martinez ¹, Ana Turrión ¹, Javier del Pino ¹ and Carlos Montilla ¹, ¹Hospital Clínico Universitario de Salamanca, Salamanca, Spain, ²Hospital Clínico Universitario de Salamanca, Salamanca, Castilla y Leon, Spain
Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease that is included in the group of spondyloarthritis. Although PsA has its own clinical characteristics, it has…
Abstract Number: 634 • 2019 ACR/ARP Annual Meeting
Targeted 1H NMR Based Metabolomics Analysis Revealed Significantly Higher Synovial Phe/Tyr Ratio in Reactive Arthritis and Undifferentiated Spondyloarthropathy
Hafis Muhammed¹, Dinesh Kumar ², Durgesh Dubey ², Sandeep Kumar ³, Smriti Chaurasia ³, Anupam Guleria ², Sanjukta Majumder ³, Rajeev Singh ³, Vikas Agarwal ¹ and Ramnath Misra ⁴, ¹SGPGI, Lucknow, Uttar Pradesh, India, ²Centre for Biomedical Research, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh, India, ³Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, Uttar Pradesh, India, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India
Background/Purpose: Elevated phenylalanine-to-tyrosine ratio (Phe/Tyr) is a marker of oxidative stress. We hypothesized that the synovial Phe/Tyr in reactive arthritis is higher than Rheumatoid arthritis(RA)…
Abstract Number: 934 • 2019 ACR/ARP Annual Meeting
Predictors of Survival of Secukinumab Treatment in a Multicenter Cohort of 556 Spondylarthritis
Benoit Flachaire¹, Jean-Guillaume Letarouilly ², Céline Labadie ³, Nicolas Cohen ⁴, Vincent Pradel ⁵, Jérémie Sellam ⁶, Pascal Richette ⁷, Philippe Dieudé ⁸, Pascal Claudepierre ⁹, Bruno Fautrel ¹⁰, Eric Houvenagel ¹¹, Chi Duc Nguyen ¹², Marie-Hélène Guyot ¹³, Nicolas Segaud ¹⁴, Frédéric Maury ¹⁵, Laurent Marguerie ¹⁶, Xavier Deprez ¹⁷, Jean-Hugues Salmon ¹⁸, Guy Baudens ¹⁹, Elisabeth Gervais ²⁰, Corinne Miceli-Richard ²¹, Isabelle Chary-Valckenaere ²², Pierre Lafforgue ²³, Damien Loeuille ²⁴, Christophe Richez ²⁵, René-Marc Flipo ²⁶ and Thao Pham ²³, ¹Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, Provence-Alpes-Cote d'Azur, France, ²University of Lille, CHU Lille, department of rheumatology, 59,000 Lille, France, Lille, Nord-Pas-de-Calais, France, ³Bordeaux University, CHU Bordeaux, department of Rheumatology, 33,000 Bordeaux, France, Bordeaux, Aquitaine, France, ⁴APHM -Assistance publique des hôpitaux de Marseille, Marseille, France, ⁵APHM -Assistance publique des hôpitaux de Marseille, Marseille, Finland, ⁶Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ⁷Department of Rheumatology, AP-HP Lariboisiere Hospital, Paris, France, ⁸Rheumatology, Bichat Hospital, APHP, Paris;, Paris, France, ⁹Rheumatology, CHU Henri Mondor Créteil, Paris, France, ¹⁰Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, ¹¹Rheumatology, Saint Philibert Hospital, Lille Cathololic Institute, Lomme, Lomme, France, ¹²Rheumatology, Hospital of Béthune, Béthune, Béthune, France, ¹³Rheumatology, Hospital of Roubaix, Roubaix, Roubaix, France, ¹⁴Internal Medicine, Hospital of Armentières, Armentières, Armentières, France, ¹⁵Rheumatology, Private Practice, Beuvry, Beuvry, France, ¹⁶Rheumatology, Calot Institute, Berck, Berck-sur-Mer, ¹⁷Rheumatology, Hospital of Valenciennes, Valenciennes, Valenciennes, France, ¹⁸Rheumatology, Reims University Hospital, Reims, Reims, France, ¹⁹Rheumatology, Private Practice, Valenciennes, Valenciennes, France, ²⁰CHU de Poitiers, Rheumatology, Poitiers, France, ²¹Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, ²²Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ²³Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, ²⁴Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France, ²⁵Pellegrin Hospital, University Hospital of Bordeaux, Bordeaux, France, ²⁶University of Lille, CHU Lille, department of rheumatology, 59,000 Lille, France, Lille, France
Background/Purpose: Secukinumab (SEC) is an interleukin-17 inhibitor used to treat patients with axial spondylarthritis (axSpA) and psoriatic arthritis (PsA). Drug survival is often used as…
Abstract Number: 1002 • 2019 ACR/ARP Annual Meeting
Beneficial Effect of Angiotensin Receptor Blocker in a Spondyloarthritis Animal Model
Seung-Cheol Shim¹, Jin-Sun Choi ², Ji-Young Kim ² and Chan-Geol Park ², ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, Republic of Korea, ²Chungnam National University Hospital, Daejeon, Republic of Korea
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to be efficacious in the treatment of the signs and symptoms of spondyloarthritis (SpA). However, NSAIDs have…
Abstract Number: 1005 • 2019 ACR/ARP Annual Meeting
Tendon T-cell Interactions as Drivers of Chronicity in Spondyloarthritis
Emma Garcia-Melchor ¹, Giacomo Cafaro ¹, Hanna Johnsson¹, Lindsay Crowe ², Michael McLean ², James Reilly ², Iain McInnes ³, Moeed Akbar ² and Neal Millar ³, ¹University of Glasgow, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, ³Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Emerging evidence supports the concept that stromal cell functions extend beyond maintenance of tissue architecture, exerting a key role in choreographing immune responses and…
Abstract Number: 1007 • 2019 ACR/ARP Annual Meeting
Memory ex-Th17 Cells Contribute to Synovial Inflammation in Spondyloarthritis
SO-HEE JIN ¹, Pu-Reum PARK ¹, Ji Hyun KANG ¹, DONG-JIN PARK ¹ and TAE-JONG KIM¹, ¹Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea
Background/Purpose: Spondyloarthritis (SpA) is characterized by inflammation of the synovium. An increase in the number of Th17cells in SpA has been reported. However, it is…
Abstract Number: 1167 • 2019 ACR/ARP Annual Meeting
To Evaluate Spine Ankylosis, Vertebral Fractures and Bone Fragility on a Single Imaging Exam in Patients with Ankylosing Spondylitis: Myth or Reality?
caroline Morizot¹, Marine Fauny ², Edem Allado ³, Frank Verhoeven ⁴, Eliane Albuisson ⁵, Astrid Pinzano-Watrin ⁶, Isabelle Chary-Valckenaere ⁵ and Damien Loeuille ⁷, ¹Department Of rheumatology, Vandoeuvre les Nancy, Lorraine, France, ²CHU Nancy, Vandoeuvre, France, ³CHRU Nancy, VANDOEUVRE, France, ⁴Univeristy of Franche comté, Besancon, France, ⁵Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, ⁶IMoPA. UMR 7365 CNRS, Vandoeuvre, France, ⁷Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France
Background/Purpose: Spine ankylosis is a risk factor of osteoporosis and mortality in ankylosing spondylitis (AS). Recently, thoracic-abdomino-pelvic CT (TAP-CT) has demonstrated its ability to screen…

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