Abstracts tagged "SLE"

Abstract Number: 1813 • 2015 ACR/ARHP Annual Meeting
Novel Mechanism of Action of Anti-Malarial Drugs in the Inhibition of Type I Interferon Production
Jie An¹, Joshua Woodward², Mark Minie³, YuFeng Peng⁴, Tomikazu Sasaki⁵ and Keith B. Elkon⁶, ¹Division of Rheumatology, Department of Medicine & Immunology, University of Washington, Seattle, WA, ²Department of Microbiology, University of Washington, Seattle, WA, ³Department of Bioengineering, University of Washington, Seattle, WA, ⁴Rheumatology, University of Washington, Seattle, WA, ⁵Department of Chemistry, University of Washington, Seattle, WA, ⁶Department of Medicine & Immunology, University of Washington, Seattle, WA
Background/Purpose: Anti-malarial drugs (AMD) such as Hydroxychloroquine (HCQ) and Quinacrine (QC) are effective in the treatment of skin rash and arthritis in systemic lupus erythematosus…
Abstract Number: 2125 • 2015 ACR/ARHP Annual Meeting
Rheumatic and Non-Rheumatic Autoimmune Diseases in SLE Offspring
Julie Couture¹, Sasha Bernatsky², Susan Scott³, Christian A. Pineau² and Evelyne Vinet², ¹McGill University Health Centre, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Autoimmune diseases (AID) have familial aggregation and frequently share a common genetic predisposition. Only few small uncontrolled studies have evaluated the risk of AID…
Abstract Number: 3127 • 2015 ACR/ARHP Annual Meeting
Serologic Diagnosis of Human Neuropsychiatric Lupus Using the Immunarray ICHIP®
Chaim Putterman¹, D. Scott Batty², I.R. Cohen³, Nicole Jordan⁴, Debbie Rybak¹, Tamar Rubinstein¹, Keren Jakobi⁵, Rachel Sorek⁵, Anat Reiner-Benaim⁵, Yakov Blumenstein⁵ and Pennina Safer⁵, ¹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ²ImmunArray Inc., Richmond, VA, ³Weizmann Institute of Science, Rehovot, Israel, ⁴Montefiore Medical Center, New York, NY, ⁵ImmunArray LTD, Rehovot, Israel
Background/Purpose: Peripheral neurologic syndromes and central nervous system (CNS) manifestations are recognized as primary disease manifestations in systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) involves…
Abstract Number: 146 • 2015 ACR/ARHP Annual Meeting
Rates of Lipid Testing and Statin Prescription Filling Among U.S. Medicaid Recipients with SLE, 2007-2010
Sarah Chen¹, Michael A. Fischer², Hongshu Guan³, Medha Barbhaiya⁴ and Karen H. Costenbader⁵, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴Internal Medicine, Weill Cornell Medical College, New York, NY, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Given high cardiovascular disease (CVD) risks in SLE patients, lipid testing and statin prescription are widely advocated for those with elevated risks. We examined…
Abstract Number: 788 • 2015 ACR/ARHP Annual Meeting
Identification of Molecular Biomarkers to Distinguish Systemic Lupus Erythematosus with Skin Involvement from Discoid Lupus Erythematosus and Subacute Cutaneous Erythematosus: Provisional Results from Cross-Sectional Studies
Matteo Cesaroni¹, Jarrat Jordan¹, Jessica Schreiter¹, Marc Chevrier¹, Grace Wang², Cesar Calderon³, Alexa Piantone², Ian Gourley⁴, Stanley Cohen⁵, Scott Fretzin⁶, Anna Wozniacka⁷, Victoria P. Werth⁸ and Jacqueline Benson¹, ¹Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ²Janssen Research and Development, Spring House, PA, ³37 Derwen Dr., Janssen Research and Development, Havertown, PA, ⁴1329 Anthony Wayne drive, Janssen Research and Development, Wayne, PA, ⁵Metroplex Clinical Research Center, LLC, Dallas, TX, ⁶Dawes Fretzin Clinical Research Group, LLCC, Indianapolis, IN, ⁷Medical University of Lodz, Lodz, Poland, ⁸Philadelphia VA Medical Center, Philadelphia, PA
Background/Purpose: Sub-classification of Lupus Erythematosus (LE) patients is largely based on defined clinical criteria while biological factors associating with or contributing to these clinical features…
Abstract Number: 1116 • 2015 ACR/ARHP Annual Meeting
Decreased Expression of Negative Regulators of Toll-like Receptor Signaling and Increased TLR7 Responsiveness in Expanded IgD- CD27- B Cells from Systemic Lupus Erythematosus Patients
Scott Jenks¹, Benjamin Barwick² and Ignacio Sanz³, ¹Allergy, Immunology, and Rheumatology, Emory University School of Medicine, Atlanta, GA, ²Emory University, Altanta, GA, ³Medicine, Emory University, Atlanta, GA
Background/Purpose: B cell homeostasis is perturbed in SLE patients; in particular many patients with active disease have a large expansion of IgD- CD27- B cells…
Abstract Number: 1835 • 2015 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Does Not Increase Risk of Adverse Events in the First 6 Months after Total Knee Replacement
Arielle Fein¹, Caroline Figgie¹, Taylor Dodds², Joshua Wright-Chisem³, Michael Parks⁴, Lisa Mandl⁵, Edwin Su⁶, Jane E. Salmon^5,7, David J. Mayman⁴, Yuo-Yu Lee⁸, Mark P. Figgie² and Susan M. Goodman⁷, ¹Research, Hospital for Special Surgery, New York, NY, ²Orthopaedics, Hospital for Special Surgery, New York, NY, ³University of Illinois at Chicago College of Medicine, Chicago, IL, ⁴Orthopedics, Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, New York, NY, ⁶Orthopedic Surgery, Hospital for Special Surgery, New York, NY, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY
Background/Purpose: More Systemic Lupus Erythematosus (SLE) patients are undergoing total knee arthroplasty (TKA) with equivalent benefits to osteoarthritis (OA) patients. While post-surgical adverse events (AEs)…
Abstract Number: 2536 • 2015 ACR/ARHP Annual Meeting
The Role of Race/Ethnicity and SES in Adverse Pregnancy Outcome in SLE and Apl
Sancia Ferguson¹, Elianna Kaplowitz², Laura Trupin³, Edward H. Yelin⁴, Patricia P. Katz^3,5 and Jane E. Salmon⁶, ¹Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, ²Hospital for Special Surgery, New York, NY, ³Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ⁴Medicine/Rheumatology, UC San Francisco, San Francisco, CA, ⁵Arthritis Research Group, University of California San Francisco, San Francisco, CA, ⁶Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Women with Systemic Lupus Erythematosus (SLE) and Anti-Phospholipid Antibodies (aPL) have pregnancies with higher rates of preterm labor, preeclampsia, and fetal loss than healthy…
Abstract Number: 3157 • 2015 ACR/ARHP Annual Meeting
B Cell Profile As a Biomarker of Disease Segmentation and Flare Prognosis in SLE
Chungwen Wei¹, Bridget Neary², Jamie Biear³, Jennifer Barnard^3,4, Michelle Petri⁵, Alex Rosenberg⁶, Jennifer H. Anolik⁷ and Ignacio Sanz¹, ¹Rheumatology, Emory University, Atlanta, GA, ²Emory University, Atlanta, GA, ³Rheumatology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁶University of Rochester, Rochester, NY, ⁷University of Rochester Medical Center, Rochester, NY
Background/Purpose: B cell abnormalities in SLE are well-established contributors to disease pathogenesis. Perturbation of B cell homeostasis in SLE is often described separately for each…
Abstract Number: 197 • 2015 ACR/ARHP Annual Meeting
Synergy Between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of Dnase II Deficient Mice
Rebecca Baum¹, Kerstin Nundel¹, Sudesh Pawaria^1,2, Shruti Sharma¹, Patricia Busto¹, Tara Robidoux¹, Katherine A. Fitzgerald¹, Ellen M. Gravallese³ and Ann Marshak-Rothstein¹, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ³Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Toll-like receptors (TLRs) dependent on Unc93b1 and cytosolic sensors dependent on STING detect microbial and endogenous nucleic acids to initiate inflammatory responses that resolve…
Abstract Number: 796 • 2015 ACR/ARHP Annual Meeting
Single Cell Gene Expression Studies in Lupus Patient Monocytes Reveal a Unique Anti-Inflammatory Population of Non-Classical Monocytes Associated with Clinical Quiescence
Zhongbo Jin¹, Wei Fan^2,3, Mark A. Jensen⁴, Jessica M. Dorschner¹, Danielle Vsetecka¹, Shreyasee Amin⁵, Ashima Makol⁶, Floranne C. Ernste⁷, Thomas Osborn⁷, Kevin G. Moder⁵, Vaidehi Chowdhary⁵ and Timothy B. Niewold¹, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China, ³Mayo Clinic, Rochester, MN, ⁴Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Our previous gene expression studies in sorted immune cell populations in SLE has shown that different cell types from the same blood sample demonstrate…
Abstract Number: 1120 • 2015 ACR/ARHP Annual Meeting
Analysis of SLE Plasmablasts By High Throughput Pairing of the Immunoglobulin Heavy and Light Chain (VH-VL)
Deepak Tomar¹, Christopher Tipton¹ and Ignacio Sanz², ¹Medicine/Rheumatology, Emory University School of Medicine, Atlanta, GA, ²Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: In-depth analysis of the molecular and antigenic properties of antibody secreting cells (ASC) is critical for our understanding of autoimmune diseases. This goal however…
Abstract Number: 1837 • 2015 ACR/ARHP Annual Meeting
Predictability of Musculoskeletal Flares and Hand Deformities in Systemic Lupus Erythematosus By High Resolution Ultrasound : 5-Year Clinical and Imaging Prospective Follow-up Study
Matteo Piga¹, Alessandra Gabba¹, Mattia Congia¹, Fabiana Figus¹, Alberto Floris^1,2, Alberto Cauli¹ and Alessandro Mathieu¹, ¹University of Cagliari, Cagliari, Italy, ²University of Oxford, Oxford, United Kingdom
Background/Purpose: SLE patients develop non-deforming non-erosive (NDNE) arthritis in 70-80%, but 5-15% of cases progresses into Jaccoud's arthropathy (JA) a non-erosive deforming arthritis. This study…
Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting
Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome
Yoshiyuki Arinuma^1,2, Yuko Sakuma³, Eisuke Ogawa², Tatsuhiko Wada⁴, Tatsuo Nagai², Sumiaki Tanaka² and Shunsei Hirohata², ¹Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ³Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ⁴Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…
Abstract Number: 3212 • 2015 ACR/ARHP Annual Meeting
Characterizing the Effects of the G-CSF-R Coding rs13377964 SNP Located within Murine Lupus Susceptibility Locus Sle2c2
Ramya Sivakumar¹ and Laurence Morel², ¹Pathology, University of Florida, Gainesville, FL, ²Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL
Background/Purpose: The genetic analysis of the lupus prone NZM2410 mouse has identified a suppressor locus, Sle2c2, which confers resistance to both spontaneous and chronic graft-vs.-host…

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