Abstracts tagged "SLE"

Abstract Number: 2064 • 2016 ACR/ARHP Annual Meeting
Blood and Kidney Molecular Profiles Distinguish Subjects with Lupus Nephritis from Other Kidney Disorders
Matteo Cesaroni¹, Jarrat Jordan¹, Marc Chevrier², Alan Perlman³, James M. Chevalier⁴, Thomas Parker³, Daniel Levine³, Surya V. Seshan⁵, Anna Gong⁶, Takahiro Sato¹ and Jacqueline Benson¹, ¹Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ²Janssen Research and Development, LLC, Collegeville, PA, ³The Rogosin Institute,New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY, ⁴Nephrology, The Rogosin Institute New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, ⁵Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁶The Rogosin Institute,New York Presbyterian Hospital-Weill Medical College of Cornell University, new york, NY
Background/Purpose: Kidney biopsy remains the gold standard for diagnosis and staging of Lupus Nephritis (LN). Although kidney biopsies are commonly performed in the clinical setting,…
Abstract Number: 2869 • 2016 ACR/ARHP Annual Meeting
Critical Roles of IRAK4 Kinase Activity in Inflammation but Not B Cell Response in SLE
Chia Chi Sun¹, Gang Chen², Nuruddeen Lewis¹, Andrew T Bender¹, Changling Sia³, Ling Zhang², Catherine Jorand Lebrun⁴, Herbert Y Lin⁵, Ravi I Thadhani⁶, Harsukh Parmar¹ and Julie A DeMartino¹, ¹TIP Immunology, EMD Serono, Inc, Billerica, MA, ²EMD Serono, Inc, Billerica, MA, ³TIP Immunology, EMD Serono, Inc, Billeria, MA, ⁴Discovery Technology, EMD Serono, Inc, Billerica, MA, ⁵Division of Nephrology, Massachusetts General Hospital, Boston, MA, ⁶Divison of Nephrology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Interleukin-1 receptor (IL-1R)-associated kinase 4 (IRAK4) is a key component of the Myddosome complex, which is essential for signalling downstream of IL-1R and most…
Abstract Number: 3241 • 2016 ACR/ARHP Annual Meeting
Genetic Variation and Tobacco Smoke Exposure in Systemic Lupus Erythematosus: A Case Control Study Among African Americans
Bethany Wolf¹, Paula S. Ramos², Paul Nietert³, J. Madison Hyer¹, Viswanathan Ramakrishnan¹, Gary S. Gilkeson⁴, Gerard Hardiman² and Diane L. Kamen⁵, ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects African Americans, and the development of SLE is believed to be triggered by exposure to one or more…
Abstract Number: 770 • 2016 ACR/ARHP Annual Meeting
Introducing a Novel SLE-Specific IFN-I Inhibitor CNTO 6358: Laying the Groundwork for Precision Medicine in Lupus
Jarrat Jordan¹, Matteo Cesaroni¹, Jessica Schreiter¹, Chichi Huang², Tanesha Cash-Mason³, Marc Chevrier¹ and Jacqueline Benson¹, ¹Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ²Biologics Research, Janssen Research and Development, LLC., Spring House, PA, ³Cardiovascular and Metabolism Research, Janssen Research and Development, LLC., Spring House, PA
Background/Purpose: The type I interferon (IFN-I) family of cytokines signal through a ubiquitously expressed heterodimeric receptor (IFNAR) composed of IFNAR1 and the high-affinity binding chain…
Abstract Number: 1171 • 2016 ACR/ARHP Annual Meeting
Obesity and the Risk of Systemic Lupus Erythematosus in the Nurses’ Health Studies
Sara K. Tedeschi¹, Medha Barbhaiya¹, Bing Lu¹, Susan Malspeis², Jeffrey A. Sparks², Elizabeth W. Karlson¹, Walter C. Willett³ and Karen H. Costenbader¹, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Obesity has become alarmingly common over the past four decades in the U.S., with a notable rise in obesity prevalence starting in the late…
Abstract Number: 1775 • 2016 ACR/ARHP Annual Meeting
Smoking As a Predictor of Cutaneous Activity in Systemic Lupus Erythematosus
Shawn Kwatra¹, Michelle Petri² and Wei Fu³, ¹Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
ACR Abstract Authors: Shawn G. Kwatra1, Wei Fu2, Michelle Petri2 1Department of Dermatology, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD Title:…
Abstract Number: 2451 • 2016 ACR/ARHP Annual Meeting
Evaluation of Ovarian Reserve and Function in Adolescent Females with Systemic Lupus Erythematosus
Yonit Sterba¹, Tamara Tanner² and Dawn Wahezi¹, ¹Pediatric Rheumatology, The Children's Hospital at Montefiore, Bronx, NY, ²Pediatrics, The Children's Hospital at Montefiore, Bronx, NY
Background/Purpose: The onset of childhood systemic lupus erythematosus (cSLE) most frequently occurs after age 12. Studies in adolescents with cSLE suggest that ovarian dysfunction may…
Abstract Number: 2871 • 2016 ACR/ARHP Annual Meeting
Unaffected Lupus Relatives Are Distinguished from SLE Patients and Unaffected Individuals Not Related to SLE Patients By Lupus-Specific Connective Tissue Disease Questionnaire Scores, Autoantibodies, and Distinct Soluble Mediators
Melissa E. Munroe¹, Kendra A. Young², Jill M. Norris², Teresa Aberle¹, Virginia C. Roberts¹, Joel M. Guthridge³, Diane L. Kamen⁴, Gary S. Gilkeson⁵, Michael Weisman⁶, Mariko Ishimori⁶, Daniel J Wallace⁷, David Karp⁸, Kathy L. Sivils¹, John B. Harley^9,10 and Judith A. James^11,12, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Internal Medicine/Division of Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹⁰Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ¹¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Identifying populations at risk of SLE is essential to curtail inflammatory damage and select individuals for prevention trials. Blood relatives (Rel) of lupus patients…
Abstract Number: 3242 • 2016 ACR/ARHP Annual Meeting
Identification and Functional Characterization of TNIP1 Causal Variants Associated with Systemic Lupus Erythematosus
Satish Pasula¹, Mandi Wiley¹, Ying-yu Wu¹, Ajay Nair¹, Jaanam Gopalakrishnan² and Patrick M. Gaffney¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by autoantibody production and dysregulated interferon responses. Genome-wide association studies (GWAS) have identified more…
Abstract Number: 771 • 2016 ACR/ARHP Annual Meeting
Preventive Effects of Glucocorticoids on Progression of Atherosclerosis in Japanese Patients with SLE
Hisaji Oshima¹, Masaki Iwasaki¹, Ikuko Tanaka², Misako Higashida³, Mari Ushikubo⁴, Eriko Takei⁵, Kumiko Akiya³ and Keisuke Izumi⁶, ¹Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ²NAGOYA Rheumatology Clinic, Nagoya, Japan, ³Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ⁴Department of Connective Tissue Disease, National Tokyo Medical Center, Tokyo, Japan, ⁵Connective tissue disease, National Tokyo Medical Center, Tokyo, Japan, ⁶Connective Tissue Dseases, National Tokyo Medical Center, Tokyo, Japan
Background/Purpose: Several cross-sectional studies have shown a progression of atherosclerosis in SLE was associated with activities of SLE but not with glucocorticoid therapy. However, a…
Abstract Number: 1182 • 2016 ACR/ARHP Annual Meeting
Opiod Use and Death in Chronic Pain Patients with Systemic Lupus Erythematosis
Romy Cabacungan¹, Clifford Qualls², Wilmer Sibbitt Jr.¹, Timothy Moore¹, Luis Salayandia¹, Roderick Fields³, Suzanne Emil¹, Monthida Fangtham¹, Konstantin Konstantinov⁴, Tej Bhavsar¹ and Arthur Bankhurst⁵, ¹Rheumatology, University of New Mexico, Albuquerque, NM, ²Biostatistics, UNM, Albuquerque, NM, ³Internal Medicine/ Rheumatology, University of New Mexico School of Medicine, Albuquerque, NM, ⁴1 University Of New Mexico, University of New Mexico, Albuquerque, NM, ⁵Rheumatology, University of NM Medical Center, Albuquerque, NM
Background/Purpose: Chronic pain is one of the most common symptoms reported in patients with SLE. Treating pain in these individuals can be complex and…
Abstract Number: 1789 • 2016 ACR/ARHP Annual Meeting
Herpetic Viruses in Lupus
Teja Kapoor¹, Pooja Mahadeshwar², Barkha Bhandari³, Jianhua Li⁴, Joan Bathon⁵, Samantha Nguyen⁶ and Anca D. Askanase⁷, ¹Medicine, Division of Rheumatology, Columbia University Medical Center, New York, NY, ²George Washington University Hospital, Washington, DC, ³American University of Antigua, Antigua Guatemala, Antigua and Barbuda, ⁴Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, ⁵Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁶Columbia University Medical Center, NY, NY, ⁷Medicine, Rheumatology, Columbia University Medical Center, New York, NY
Background/Purpose: This is a retrospective cohort study evaluating the prevalence of VZV and HSV in SLE patients hospitalized at Columbia University Medical Center-New York…
Abstract Number: 2782 • 2016 ACR/ARHP Annual Meeting
Bortezomib Treatment Prevents Glomerulosclerosis Associated with Lupus Nephritis in a Murine Model through Suppressive Effects on the Immune and Renin-Angiotensin Systems
Kazuhisa Nozawa¹, Yuko Matsuki², Ken Yamaji³, Naoto Tamura⁴ and Yoshinari Takasaki³, ¹2-1-1 Hongo Bunkyo-ku, Juntendo University, Tokyo, Japan, ²Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Rheumatology, Juntendo University, Tokyo, Japan
Background/Purpose: Lupus nephritis (LN) is one of the main causes of morbidity and mortality in SLE. Although a combination therapy using steroids and immunosuppressant…
Abstract Number: 2872 • 2016 ACR/ARHP Annual Meeting
SLE Subjects Express High Levels of Intracellular Interferon-β That Acts in an Autocrine Fashion to Promote Survival of Transitional Stage B Cells
Jennie Hamilton¹, Qi Wu², PingAr Yang³, Bao Luo⁴, Shanrun Liu⁵, Jun Li⁶, Ignacio Sanz⁷, W. Winn Chatham⁸, Hui-Chen Hsu² and John D. Mountz⁹, ¹Medicine/Division of Clinical Immunology and Rhematology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA, ⁸Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁹Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL
Background/Purpose: Upregulation of interferon-β (IFNβ) is an important step in promoting maturation and survival of B cells. Secretion and autocrine action of IFNβ requires assembly…
Abstract Number: 3243 • 2016 ACR/ARHP Annual Meeting
Intestinal Microbial Dysbiosis in SLE Is Linked to Elevated IgA and Induction of Autoimmunity
Doua F. Azzouz¹, Lelise Getu², Celine Anquetil¹, Jill P. Buyon³ and Gregg J. Silverman³, ¹Medicine, NYU School of Medicine, New York, NY, ²Department of Medicine, New York University School of Medicine, New York, NY, ³Medicine, New York University School of Medicine, New York, NY
Background/Purpose: SLE is a complex multifactorial systemic autoimmune disease, which has been attributed to poorly understood interactions between genetic and environmental factors. Recent reports have…

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