Abstracts tagged "SLE"

Abstract Number: 640 • 2019 ACR/ARP Annual Meeting
Elevated Serum Interleukin-23 Level in Patients with Systemic Lupus Erythematosus Is Associated with Disease Activity, Clinical and Immunological Markers
Milena Vukelic¹, Anita Laloo ² and Vasileios Kyttaris ³, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Rheumatology Practice, Fort Lauderdale, FL, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: Systemic lupus erythematosus (SLE) is a autoimmune disease characterized by deregulated cytokine production. IL-23 bridges innate and adaptive immunity by inducing the differentiation of…
Abstract Number: 705 • 2019 ACR/ARP Annual Meeting
A Tale of Three Cohorts: SLE Criteria in Developed vs Developing Countries
Ashira Blazer¹, Allison Guttmann ¹, Ida Dzifa Dey ², Olusola Ayanlowo ³, Uyi Ima-Edomwonyi ³, Hakeem Olasebikan ³, Margaret Reynolds ³, Festus Ankrah ², Jill Buyon ⁴ and Olufemi Adelowo ⁵, ¹NYU School of Medicine, New York, NY, ²Korle bu Teaching Hospital, Accra, Ghana, ³Lagos University Teaching Hospital, Lagos, Nigeria, ⁴NYU School of Medicine, New York, ⁵Lagos State University Teaching Hospital, Lagos, Nigeria
Background/Purpose: SLE diagnostic criteria are important for reliable epidemiologic data. The prevalence of SLE in West Africa is falsely low due to barriers including limited…
Abstract Number: 1191 • 2019 ACR/ARP Annual Meeting
Application of the Systemic Lupus Erythematosus (SLE) Quality Indicators in Patients Attending a Young Adult Transition Program
Aos Aboabat¹, Earl D. Silverman ² and Amanda Steiman ¹, ¹University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada
Background/Purpose: Systemic lupus erythematosus is a multisystemic rheumatic disease affecting 1 in 1000 individuals with a 10:1 female predominance. Childhood-onset SLE (CSLE) constitutes approximately 15%…
Abstract Number: 1732 • 2019 ACR/ARP Annual Meeting
Evaluating the New 2018 ACR/EULAR SLE Classification in Pediatric Patients
Catherine Strahle¹, Angela Merritt ², Xiaoling Niu ³, Arjun Mathur ⁴, Allen Watts ² and Hermine Brunner ⁵, ¹Univeristy of Cincinnati Medical Center, Cincinnati, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Fudan University, Shanghai, Shanghai, China (People's Republic), ⁴Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: The traditional 1997 ACR SLE classification criteria classify a patient as having SLE if 4 of the 11 criteria have been met over time.…
Abstract Number: 2537 • 2019 ACR/ARP Annual Meeting
Influential Factors in Promoting Treat-to-Target for Systemic Lupus Erythematosus via Empowering Patients: A Cohort Study from China by Smart System of Disease Management (SSDM)
Jianlin Huang¹, Yongfu Wang ², Hua Wei ³, Jing Yang ⁴, Tong Xie ⁵, Hongzhi Wang ⁶, Xiaohan Wang ⁷, Yu Zhang ⁴, Cheng Zhao ⁸, Jinmei Zou ⁴, Fang He ⁹, Jinli Ru ¹⁰, Henglian Wu ¹¹, Guosheng Wang ¹², Lingyun Sun ¹³, Shengqian Xu ¹⁴, Yanjie Hao ¹⁵, Xiangpei Li ¹⁶, Zhijun Li ¹⁷, Bing Wu ¹⁸, Yuhua Jia ¹⁹, Yuan Liu ²⁰, Hui Xiao ²⁰, Fei Xiao ²¹ and Chunde Bao ²², ¹The sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China (People's Republic), ²The First Affiliated Hospital of BaoTou Medical College, Baotou, Nei Mongol, China (People's Republic), ³Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, China (People's Republic), ⁴Central Hospital of MianYang, Mianyang, Sichuan, China (People's Republic), ⁵Affiliated hospital of Guangdong medical University, Zhanjiang, Guangdong, China (People's Republic), ⁶JiaXing First Hospital, Jiaxing, Zhejiang, China (People's Republic), ⁷Anyang district hospital, Fuyang, Hainan, China (People's Republic), ⁸The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (People's Republic), ⁹Suining Central Hospital, suining, China (People's Republic), ¹⁰The Second Hospital of Shanxi Medical University, Shanxi, Shanxi, China (People's Republic), ¹¹Dongguan donghua hospital, Dongguan, Guangdong, China (People's Republic), ¹²Anhui Provincial Hospital, Hefei, Anhui, China (People's Republic), ¹³The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (People's Republic), ¹⁴First Affiliated Hospital of Medical University Of Anhui, Hefei, Anhui, China (People's Republic), ¹⁵Peking University First Hospital; Department of Rheumatology and Clinical Immunology, Beijing, Beijing, China (People's Republic), ¹⁶Anhui Provincial Hospital, Heifei, Anhui, China (People's Republic), ¹⁷The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (People's Republic), ¹⁸Shanghai Gothic Internet Technology Co., Ltd, Shanghai, China (People's Republic), ¹⁹Shanghai Gothic Internet Technology Co., Ltd., Shanghai, Shanghai, China (People's Republic), ²⁰Shanghai Gothic Internet Technology Co., Ltd, Shanghai, Shanghai, China (People's Republic), ²¹Shanghai Gothic Internet Technology Co., Ltd., shanghai, China (People's Republic), ²²Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of medicine, Shanghai, Shanghai, China (People's Republic)
Background/Purpose: Treating to target is routine in rheumatoid arthritis, but no comparable standard has been defined for SLE. In 2015, the definition of Lupus Low Disease Activity State (LLDAS) was…
Abstract Number: 647 • 2019 ACR/ARP Annual Meeting
Is ANA-status at Disease Inception Associated with Long-term Damage Accrual and Direct and Indirect Health Care Costs in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort?
May Choi¹, Megan Barber ², Marvin Fritzler ¹, John G Hanly ³, Murray Urowitz ⁴, Yvan St-Pierre ⁵, Juanita Romero-Diaz ⁶, Caroline Gordon ⁷, Sang-Cheol Bae ⁸, Sasha Bernatsky ⁹, Daniel J Wallace ¹⁰, David A Isenberg ¹¹, Anisur Rahman ¹², Ellen M Ginzler ¹³, Michelle Petri ¹⁴, Ian Bruce ¹⁵, Paul Fortin ¹⁶, Dafna Gladman ¹⁷, Jorge Sanchez-Guerrero ¹⁸, Rosalind Ramsey-Goldman ¹⁹, Munther A Khamashta ²⁰, Cynthia Aranow ²¹, Meggan Mackay ²², Graciela Alarcón ²³, Susan Manzi ²⁴, Ola Nived ²⁵, Andreas Jönsen ²⁵, Asad Zoma ²⁶, Ronald van Vollenhoven ²⁷, Manuel Ramos-Casals ²⁸, Guillermo Ruiz-Irastorza ²⁹, S Sam Lim ³⁰, Kenneth C Kalunian ³¹, Murat Inanc ³², Diane Kamen ³³, Christine Peschken ³⁴, Soren Jacobsen ³⁵, Anca Askanase ³⁶, Vernon Farewell ³⁷ and Ann E Clarke ³⁸, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²University of Calgary, Calgary, Canada, ³Dalhousie University, Halifax, NS, Canada, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵McGill University Health Centre, Montreal, QC, Canada, ⁶Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico, ⁷University of Birmingham, Birmingham, United Kingdom, ⁸Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ¹⁰Cedars-Sinai Medical Centre, Beverly Hills, CA, ¹¹Centre for Rheumatology, London, United Kingdom, ¹²University College London, London, United Kingdom, ¹³State University of New York Downstate Medical Center, Brooklyn, NY, ¹⁴Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁵University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom, ¹⁶Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada, ¹⁷University of Toronto, Toronto, ON, Canada, ¹⁸Toronto Western Hospital, Toronto, ON, Canada, ¹⁹Northwestern University, Chicago, IL, ²⁰King's College London School of Medicine, London, United Kingdom, ²¹Feinstein Institute for Medical Research, Manhasset, NY, ²²Feinstein Institute for Medical Research, New York, ²³University of Alabama at Birmingham, Birmingham, ²⁴Allegheny Health Network, Pittsburg, PA, ²⁵Lund University, Lund, Sweden, ²⁶Hairmyres Hospital, East Kilbride, United Kingdom, ²⁷Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, the Netherlands, Amsterdam, Netherlands, ²⁸Josep Font Autoimmune Diseases Laboratory, Barcelona, Spain, ²⁹Autoimmune Diseases Unit, Hospital Universitario Cruces, Barakaldo, Spain, Barakaldo, Spain, ³⁰Emory University, Atlanta, GA, ³¹UC San Diego School of Medicine, LaJolla, CA, ³²Istanbul University, Istanbul, Turkey, ³³Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, ³⁴University of Manitoba, Winnipeg, Canada, ³⁵Copenhagen Lupus and Vasculitis Clinic, Copenhagen, Denmark, ³⁶Columbia University Medical Center, New York, NY, ³⁷University of Cambridge, Cambridge, United Kingdom, ³⁸University of Calgary, Calgary, AB, Canada
Background/Purpose: We reported that 7.7% (88/1137) of patients in an international inception cohort were ANA-negative at enrolment (Arthritis Care Res 2018 doi:1002/acr23712). There are no…
Abstract Number: 857 • 2019 ACR/ARP Annual Meeting
Mesenchymal Stem Cell Therapy Induces FLT3L and CD1c+ Dendritic Cells in Systemic Lupus Erythematosus Patients
Xinran Yuan ¹, Dandan Wang ¹ and Lingyun Sun², ¹Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (People's Republic), ²The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (People's Republic)
Background/Purpose: Allogeneic mesenchymal stem cells (MSCs) exhibit immunoregulatory function in human autoimmune diseases such as systemic lupus erythematosus (SLE), but the underlying mechanisms remain incompletely…
Abstract Number: 1200 • 2019 ACR/ARP Annual Meeting
Influenza Vaccination Rates Among Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis on Immunosuppressive Therapy: Findings from a Large Public Hospital
Judith Aniekwena¹, Titilope Olanipekun ² and Valery Effoe ², ¹Morehouse School of Medicine, Atlanta, GA, ²Morehouse School of Medicine, Atlanta
Background/Purpose: Influenza infection constitutes a significant cause of morbidity and mortality in patients living with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). The risk…
Abstract Number: 1787 • 2019 ACR/ARP Annual Meeting
The Glucocorticoid-Induced Protein GILZ Represent a Checkpoint in the IFN Program in SLE
Eric Morand¹, Champa Nataraja ¹, Melissa Northcott ¹, Wendy Dankers ¹, Jacqueline Flynn ¹, Wendy Zhu ¹, Taylah Bennett ¹, Mehnaz Pervin ¹, Brendan Russ ¹, James Harris ¹ and Sarah Jones ¹, ¹Monash University, Melbourne, Victoria, Australia
Background/Purpose: Given the primacy of Type I interferon (IFN) pathways in SLE pathogenesis, and the near-ubiquity of glucocorticoid (GC) use in SLE treatment, clarifying the…
Abstract Number: 2540 • 2019 ACR/ARP Annual Meeting
Impact of IL34, IFN-α and IFN-λ1 on Disease Activity of SLE Patients in Egypt
Yasmin Hussein¹ and Yousra Sadeq ¹, ¹Mansoura University Hospital, Mansoura, Egypt
Background/Purpose: SLE is a systemic inflammatory and autoimmune disease. IL-34 plays pivotal roles in the proliferation and differentiation of mononuclear phagocyte cells, osteoclastogenesis and inflammation.…
Abstract Number: 649 • 2019 ACR/ARP Annual Meeting
Potentially Reversible Associations with Fatigue in SLE Patients – Results from a Single-centre Study
Christina Duesing¹, Gamal Chehab ², Jutta Richter ³, Oliver Sander ⁴, Rebecca Fischer-Betz ⁵, Benedikt Ostendorf ¹, Hasan Acar ¹, Ralph Brinks ⁶ and Matthias Schneider ⁵, ¹Policlinic of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, Duesseldorf, Nordrhein-Westfalen, Germany, ²Policlinic of Rheumatology and Hiller Research Unit Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ³Department and Hiller Research Unit of Rheumatology, Heinrich-Heine University Duesseldorf, Duesseldorf, Nordrhein-Westfalen, Germany, ⁴Department and Hiller Research Unit of Rheumatology, Heinrich-Heine University Duesseldorf, Duesseldorf, ⁵Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany, ⁶Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
Background/Purpose: Fatigue is the most common symptom in SLE patients with a strong impact on patients’ reported quality of life. The cause of fatigue is…
Abstract Number: 884 • 2019 ACR/ARP Annual Meeting
Interferon-Alpha Disrupts Multiple B Cell Tolerance Mechanisms in 3H9 Mice
Dario Ferri ¹, Yuriy Baglaenko ², Kieran Manion ³, Carolina Munoz-Grajales ⁴ and Joan Wither⁵, ¹University Health Network, Toronto, ON, Canada, ²Brigham Woman's Hospital, Boston, ³Krembil Research Institute, Toronto, ON, Canada, ⁴University Health Network, Toronto, Canada, ⁵University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Interferon-alpha (IFNα) is elevated in Systemic Lupus Erythematosus (SLE) and is thought to play a central role in its pathogenesis. Amongst IFNα’s many effects…
Abstract Number: 1560 • 2019 ACR/ARP Annual Meeting
Imbalance Between Th17 and Regulatory T Cells in Patients with Systemic Lupus Erythematosus Combined EBV/CMV Viremia
Rui Su¹, Yue Liu ¹, Xinyu Zheng ¹, Xiao-feng Li ² and Cai-hong Wang ³, ¹Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan , Shanxi, China, Tai Yuan, China (People's Republic), ²Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan , Shanxi, China, TaiYuan, China (People's Republic), ³The Second Hospital of Shanxi Medical University, Tai Yuan, China (People's Republic)
Background/Purpose: Infection is common and is one of the leading causes of morbidity and mortality in Systemic Lupus Erythematosus (SLE) patients . Excessive using glucocorticoid…
Abstract Number: 1829 • 2019 ACR/ARP Annual Meeting
Ability of Inflammatory and Regulatory Soluble Mediators to Forecast Impending Clinical Disease Flare and Inform a Refined Lupus Flare Prediction Index in a Confirmatory Cohort of SLE Patients
Melissa E. Munroe¹, Sarah Kleckner ¹, Wade DeJager ¹, Susan R. Macwana ¹, Joel Guthridge ², Eldon Jupe ³, Mohan Purushothaman ³, Sanjiv Sharma ³, Nancy Redinger ¹, Teresa Aberle ¹, Stan Kamp ¹, Cristina Arriens ², Eliza F. Chakravarty ², Joan T. Merrill ⁴ and Judith James ², ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Progentec Diagnostics, Inc., Oklahoma City, OK, ⁴Okalahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: SLE is marked by altered immune regulation linked to waxing and waning clinical disease activity. This study seeks to verify the alteration of inflammatory…
Abstract Number: 2547 • 2019 ACR/ARP Annual Meeting
Safety Results of 50% Enrollment from a Multicenter, Randomized, Double‑blind, Placebo‑controlled Study to Assess the Efficacy and Safety of Repository Corticotropin Injection in Patients with Systemic Lupus Erythematosus Despite Moderate‑dose Corticosteroid Use
Anca Askanase¹, Dharani Munirathinam ², Enxu Zhao ², Julie Zhu ², Erin Connolly-Strong ² and Richard Furie ³, ¹Columbia University Medical Center, New York, NY, ²Mallinckrodt Pharmaceuticals, ARD, LLC, Bedminster, NJ, ³Northwell Health, Great Neck, NY
Background/Purpose: Repository corticotropin injection (RCI) is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH1-39) analogues and other pituitary peptides that stimulates endogenous corticosteroid (CS)…

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