Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 45 • 2016 ACR/ARHP Annual Meeting
Small Fiber Neuropathy in Rheumatology Clinics
Samy Metyas¹, Ramy Messiah², Tina Gettas², Christina Chen³ and Daniel Arkfeld⁴, ¹University of Southern California, Keck School of Medicine, Covina, CA, ²Research Associate, Covina Arthritis Clinic, covina, CA, ³Department of medicine, University of Southern California , Keck School of Medicine, Los Angeles, CA, ⁴Div of Rheumatology, Keck School of Medicine, University of Southern California-Los Angeles County Medical Center, Los Angeles, CA
Background/Purpose: , Small Fiber Neuropathy (SFN) is a condition prevalent in patients with rheumatic diseases, particularly Fibromyalgia. The presence of neuropathic pain with normal nerve…
Abstract Number: 1075 • 2016 ACR/ARHP Annual Meeting
CD40-Pathway Activation in Ectopic Lymphoid Structure (ELS)-Resident B Cells Contributes to Disease Pathology in Primary SjöGren’s Syndrome
Grazyna Wieczorek, Marc Bigaud, Sabina Pfister, Sebastian Hoersch, Katriona McMichael, Catherine Afatsawo, Meike Hamburger, Celine Texier, Celine Cojean, Maurane Henry and James S. Rush, Novartis Institutes for Biomedical Research, Basel, Switzerland
Background/Purpose: T cell-dependent activation of B lymphocytes is a key effector arm of the adaptive immune system, resulting in protective antibody responses and long-lived humoral…
Abstract Number: 2672 • 2016 ACR/ARHP Annual Meeting
Elderly Patients Risk a False Positive Diagnosis of Primary Sjogren’s Syndrome If a Positive Labial Gland Biopsy Is Solely Based on Focus Score
Erlin A. Haacke^1,2, Jolien F. van Nimwegen¹, Martha S. van Ginkel¹, Suzanne Arends¹, Fred K.L. Spijkervet³, Gwenny M. Verstappen¹, Nicole Sillevis Smitt-Kamminga⁴, Arjan Vissink⁵, Frans G.M. Kroese¹, Bert van der Vegt⁶ and Hendrika Bootsma⁷, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Opthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁶Pathology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁷Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic auto-immune disease affecting the exocrine glands leading to sicca complaints. For the diagnosis of pSS, a positive…
Abstract Number: 3227 • 2016 ACR/ARHP Annual Meeting
Modelling Primary Sjögren’s Syndrome Using Salivary Gland Stem Cells
Sarah Pringle¹, Hendrika Bootsma², Arjan Vissink³, Fred K.L. Spijkervet⁴, Robert Coppes⁵ and Frans G.M. Kroese⁶, ¹Rheumatology and Clinical Immunology, University Medical Centrum Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands, ³Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Radiation Oncology and Cell Biology, University Medical Centrum Groningen, Groningen, Netherlands, ⁶Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is characterized by lymphocytic infiltration of salivary glands. Unclear interactions between infiltrating cells and salivary gland ductal cells cause reduced…
Abstract Number: 66 • 2016 ACR/ARHP Annual Meeting
Very Rare X Chromosome Abnormalities in SLE and SjöGren’s May Localize X Gene Dose Effect
Rohan Sharma¹, Valerie M Harris², Joshua Cavett³, Biji T Kurien³, Ke Liu⁴, Kristi A. Koelsch⁵, Lida Radfar⁶, David M. Lewis⁷, Donald U. Stone⁸, C. Erick Kaufman⁹, Shibo Li¹⁰, Barbara M. Segal¹¹, Daniel J Wallace¹², Michael Weisman¹³, Jennifer A. Kelly¹⁴, Bernado Pons-Estel¹⁵, Roland Jonsson¹⁶, Jacques-Eric Gottenberg¹⁷, Juan-Manuel Anaya¹⁸, Deborah S. Cunninghame-Graham¹⁹, Vivian P. Bykerk²⁰, Gideon Hirschfield²¹, Gang Xie²², Wan-Fai Ng²³, Gunnel Nordmark²⁴, Per Eriksson²⁵, Roald Omdal²⁶, Nelson L. Rhodus²⁷, Maureen Rischmueller²⁸, Michael D. Rohrer²⁹, Marie Wahren-Herlenius³⁰, Torsten Witte³¹, Xavier Mariette³², Christopher J. Lessard³³, John B. Harley³⁴, Kathy L. Sivils³³, Astrid Rasmussen³⁵, R. Hal Scofield³³, Swamy Venturopalli³⁶, Xianglan Lu¹⁰, Pamela Hughes³⁷, Andrew J.W. Huang³⁸ and Corinnine Miceli-Richard³⁹, ¹Medical Service, US Department of Veterans Affaris Medical Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴3333 Burnet Ave., University of Cincinnati & Cincinnati Childre, Cincinnati, OH, ⁵U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁸King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁹Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ¹⁰Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹¹Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ¹²Cedars-Sinai Medical Center, West Hollywood, CA, ¹³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Sanatorio Parque, Rosario, Argentina, ¹⁶Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ¹⁷Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹⁸Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogotá, Colombia, ¹⁹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ²⁰Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ²¹Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²²Mount Sinai Hospital, Toronto, ON, Canada, ²³Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²⁴Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ²⁵University Hospital, Rheumatology clinic, Linköping, Sweden, ²⁶Department of internal medicine, Clinical Immunology unit, Stavanger, Norway, ²⁷Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁸Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ²⁹Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁰Department of Medicine, Experimental Rheumatology Unit, Solna, Sweden, ³¹Hannover Medical School, Hanover, Germany, ³²Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France, ³³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³⁴Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ³⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ³⁶Rheumatology, Cedars Syani Medical Center, Los Angeles, CA, ³⁷Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁸Washington University,, St Louis, MO, ³⁹Rheumatology, Université Paris-Sud, Paris, France
Background/Purpose: Sjögren’s syndrome and systemic lupus erythematosus (SLE) are chronic, autoimmune diseases that are related by clinical and serological manifestations as well as genetic risks.…
Abstract Number: 1079 • 2016 ACR/ARHP Annual Meeting
Discovery of Novel Autoantigens in Sjogren’s Syndrome with Potential for Subgrouping of Disease
Peter Schulz-Knappe¹, Petra Budde¹, Hans-Dieter Zucht¹, Heike Göhler¹, Klaus Marquart¹, Prof. Dr. Matthias Schneider² and Torsten Witte³, ¹Protagen AG, Dortmund, Germany, ²Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany, ³Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a common autoimmune disease with exocrine gland dysfunction and multi-organ involvement. With the growing interest in conducting clinical trials…
Abstract Number: 2673 • 2016 ACR/ARHP Annual Meeting
Glandular Ultrasonography in Primary SjöGren Syndrome: Clinical and Laboratory Correlation
Tania Fidelix¹, Virginia Trevisani², Adagmar Andriolo³ and Adriano Czapkowski⁴, ¹Evidence Based Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil, ²Health Evidence Based, Escola Paulista de Medicina, São Paulo, Brazil, ³Clinical Laboratories, Escola Paulista de Medicina, Sao Paulo, Brazil, ⁴Radiology, Radiology Department- Escola Paulista de Medicina, Sao Paulo, Brazil
Background/Purpose: Primary SjogrenÕs syndrome (pSS) is a chronic autoimmune disorder that is characterized clinically by dryness of the eyes (xerophthalmia) and mouth (xerostomia). The assayÕs…
Abstract Number: 3228 • 2016 ACR/ARHP Annual Meeting
Specific T Cell and B Cell Distributions Characterize Subgroups of Patients with Primary Sjögren’s Syndrome and Are Associated with Disease Activity and Pro-Inflammatory Cytokine Expression
Lucas Le Lann¹, Quentin Simon¹, Christophe Jamin¹, Maria Orietta Borghi², Lorenzo Beretta³, Ricard Cervera⁴, Alain Saraux⁵, Divi Cornec¹, Rik Lories⁶, Carlo Chizzolini⁷, Marta E. Alarcon Riquelme⁸, Jacques-Olivier Pers¹ and on behalf of the PRECISESADS Consortium, ¹INSERM ERI29, EA2216, Université de Brest, Labex IGO, CHRU Morvan, Brest, France, ²University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ³Rheumatology, Milan, Italy, ⁴Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic de Barcelona, Barcelona, Spain, ⁵Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ⁶Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, ⁷University hospital of Geneva, Geneva, Switzerland, ⁸Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Background/Purpose : The goal of the IMI PRECISESADS project is to reclassify individuals affected by systemic autoimmune diseases (SADs) into clusters of molecular, instead of…
Abstract Number: 184 • 2016 ACR/ARHP Annual Meeting
Upregulation and Activation of the IFI16-Sting-IRF3-IFN Pathway in Sjogren’s Salivary Glands
Brendan Antiochos¹, Livia Casciola-Rosen² and Antony Rosen³, ¹Rheumatology, Johns Hopkins University School of Medicine, Maltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Type I IFN expression is known to be upregulated in the salivary glands of patients with SjogrenÕs syndrome, but the upstream stimuli responsible for…
Abstract Number: 1080 • 2016 ACR/ARHP Annual Meeting
B-Cell Clonal Expansions in Parotid Glands of Sjogren’s Patients Are Associated with Increased Numbers of N-Glycosylation Motifs in the Immunoglobulin Heavy Chain Genes
Annie Visser¹, Marieke E. Doorenspleet², Niek de Vries³, Fred K.L. Spijkervet⁴, Arjan Vissink⁵, Hendrika Bootsma⁶, Frans G.M. Kroese¹ and Nicolaas A Bos¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁶Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by chronic inflammation of salivary and lacrimal glands. Patients with pSS have increased clonal…
Abstract Number: 2676 • 2016 ACR/ARHP Annual Meeting
Changes in Salivary Gland Echostructure in Patients with Primary SjöGren’s Syndrome over the Time: A Four-Year Longitudinal Study
Chiara Baldini¹, Nicoletta Luciano², Francesco Ferro³, Elena Elefante³, Stefano Bombardieri³ and Marta Mosca⁴, ¹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ²Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴Clinical and Experimental Medicine, University of Pisa, Rheumatology Unit, Pisa, Italy
Background/Purpose: Salivary gland ultrasonography (SGUS) has recently appeared as a promising tool for a non-invasive diagnosis of primary Sjögren’s syndrome (pSS). However, it is still…
Abstract Number: 3229 • 2016 ACR/ARHP Annual Meeting
Bone Morphogenetic Protein 6 Receptor Inhibition Restores Salivary Gland Function in a Mouse Model of Primary Sjögren’s Syndrome
Hongen Yin¹, Lovika Kalra¹, Arif Karim¹, Zhennan Lai¹, Maria Guimaro¹, Lauren Aber¹, Bill Swaim¹, Sandra Afione¹, Alexandria Voigt², Cuong Nguyen³, Paul Yu⁴, Donald Bloch⁵ and John A. Chiorini¹, ¹Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ²Department of Pathology and Infectious Diseases, University of Florida, Gainesville, FL, ³Department of Pathology and Infectious Diseases, University of Florida, Bethesda, MD, ⁴Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁵Center for Immunology and Inflammatory Diseases and the Division of Rheumatology, Allergy, and Immunology of the Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Methods: Results: Elevated BMP6 was found in 63/80 (78.8%) of pSS patients examined in this study. In humans, ALK2 and ALK3 receptors…
Abstract Number: 340 • 2016 ACR/ARHP Annual Meeting
Hydroxychloroquine: A Potential Treatment for Osteoporosis By Osteoclast Inhibition!
Tim Both¹, Paul L. van Daele² and Bram Van der Eerden¹, ¹Internal Medicine, Erasmus MC, Rotterdam, Netherlands, ²Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: We recently showed that patients with primary Sjögren Syndrome (pSS) have significantly higher bone mineral density (BMD) in the lumbar spine and femoral neck…
Abstract Number: 1216 • 2016 ACR/ARHP Annual Meeting
Sjogren’s Syndrome-Associated Transcripts Show Correlation with Objective Measures of Dryness
John A. Ice¹, Indra Adrianto¹, Astrid Rasmussen¹, Kiely Grundahl², Michelle L. Joachims³, Graham B. Wiley¹, Jennifer A. Kelly¹, Glen D. Houston⁴, David M. Lewis⁴, Lida Radfar⁵, Donald U. Stone^6,7, Barbara M. Segal⁸, Nelson L. Rhodus⁹, Joel M. Guthridge³, James Chodosh^10,11, Raj Gopalakrishnan¹², Andrew J.W. Huang¹³, Pamela J Hughes¹⁴, Michael D. Rohrer¹⁵, Judith A. James^1,16,17, Courtney G. Montgomery¹, R. Hal Scofield^1,17,18, Patrick Gaffney¹, Kathy L. Sivils³ and Christopher J. Lessard¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁷Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁸Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ⁹Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁰Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹¹Harvard Medical School, Boston, MA, ¹²Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota School of Dentistry, Minneapolis, MN, ¹³Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, MO, ¹⁴Department of Oral and Maxillofacial Surgery, Oregon Health & Science University School of Dentistry, Portland, OR, ¹⁵Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ¹⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disorder in which exocrine dysfunction can lead to chronic, debilitating dryness. Expression studies in SS have identified…
Abstract Number: 2681 • 2016 ACR/ARHP Annual Meeting
Clinical and Immunological Characteristics of Primary Sjogren´s Syndrome in Men
Rebeca Belmonte¹, Carlos Sánchez-Piedra², Monica Fernandez Castro³, Jose Luis Andreu⁴, Victor Martinez Taboada⁵, Alejandro Olivé⁶, José Rosas⁷, Jorge González Martín⁸, Esther Ruiz Lucea⁹, Antonio Naranjo¹⁰, Oscar Illera¹¹, Lurdes Romani¹², Sheila Melchor¹³, Begoña Moreira¹⁴, Enrique Raya¹⁵, Marina Rodriguez¹⁶, Natalia Cid¹⁷ and on behalf of SJOGRENSER project (GEEAS-SER), ¹Rheumatoloy, Hospital Virgen de la Salud, Toledo, Spain, ²Research Unit, Spanish Society of Rheumatology, Madrid, Spain, ³Rheumatology, Hospital Infanta Sofía, Madrid, Spain, ⁴Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, ⁵Hospital Marqués de Valdecilla., Santander, Spain, ⁶Rheumatology, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, ⁷Rheumatology, Hospital Marina Baixa, Villajoyosa (Alicante), Spain, ⁸Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid, Spain, ⁹Rheumatology, Hospital de Basurto, Bilbao, Spain, ¹⁰Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, ¹¹Rheumatology, Hospital Universitario Infanta Sofía, Madrid, Spain, ¹²Hospital Virgen de las Nieves., Granada, Spain, ¹³Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹⁴Rheumatology, Hospital de Sierrallana, Torrelavega, Spain, ¹⁵Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain, ¹⁶Rheumatology, University Hospital Complex of Vigo, Vigo, Spain, ¹⁷Rheumatology, Hospital de Valme, Sevilla, Spain
Background/Purpose: Primary Sjögren syndrome (pSS) is a systemic autoimmune disease involving primarily the exocrine glandular system. pSS in men is uncommon. Data of pSS in…

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