Session Title: Sjögren's Syndrome - Poster I: Translational Science
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To analyse the influence of geolocation (North-to-South gradient) on the clinical presentation of primary Sjögren syndrome (SjS) at diagnosis.
Methods: The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Patients were classified according to the geolocation of the country of the diagnosing hospital. Patients were first classified by continent, with an additional north-south sub-classification according to latitude in continents including patients from > 1 country (latitude > or < 50’N in Europe, equator > or < in America and latitude > or < 30’N in Asia).
Results: We included 7748 (93%) women and 562 (7%) men, with a mean age at diagnosis of primary SjS of 53 years. Multivariate analysis adjusted by age and gender showed that northern European patients (latitude > 50´N) had a lower frequency of ocular dryness (OR=0.39, 95%CI 0.29-0.53), abnormal ocular tests (OR=0.51, 95%CI 0.40-0.65), ANA (OR=0.59, 95%CI 0.47-0.73) and Ro/La autoantibodies (OR=0.71, 95%CI 0.58-0.88) and a higher frequency of abnormal oral tests (OR=1.62, 95%CI 1.26-2.11) and RF (OR=1.86, 95%CI 1.55-2.23) compared with southern European patients. North American patients had a lower frequency of abnormal oral tests (OR=0.55, 95%CI 0.35-0.84) and positive salivary biopsy (OR=0.43, 95%CI 0.18-0.91), and a higher frequency of ANA (OR=1.56, 95%CI 1.03-2.35), Ro/La autoantibodies (OR=2.92, 95%CI 1.95-4.41) and low C4 levels (OR=6.02, 95%CI 1.78-37.63) compared with South American patients. Northern Asian patients had a lower frequency of dry mouth (OR=0.47, 95%CI 0.26-0.83), dry eyes (OR=0.35, 95%CI 0.20-0.59), abnormal ocular tests (OR=0.34, 95%CI 0.19-0.60) and positive salivary biopsy (OR=0.43, 95%CI 0.25-0.74), and a higher frequency of ANA (OR=2.95, 95%CI 1.78-4.97) compared with southern Asian patients.
Conclusion: These results suggest, for the first time, that geolocation may influence the phenotypic expression of primary SjS at diagnosis, including significant geoepidemiological variations in the prevalence of dryness, the frequency of abnormal diagnostic tests and the positivity of the main immunological markers. Geoepidemiology and ethnicity should be considered as key variables that should be analysed in multi-ethnic studies of patients with primary SjS.
To cite this abstract in AMA style:Brito-Zerón P, Retamozo S, Zeher M, Rasmussen A, Seror R, Theander E, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Kruize AA, Valim V, Kvarnström M, Sene D, Gerli R, Praprotnik S, Isenberg DA, Solans R, Rischmueller M, Kwok SK, Nordmark G, Suzuki Y, Giacomelli R, Devauchelle V, Bombardieri M, Hofauer B, Bootsma H, Brun JG, Fraile G, Carsons SE, Gheita T, Morel J, Vollenweider CF, Atzeni F, Acar-Denizli N, Horvath IF, Sivils K, Mandl T, Sandhya P, De Vita S, Sánchez-Guerrero J, van der Heijden E, Moça Trevisano V, Wahren-Herlenius M, Mariette X, Ramos-Casals M. Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient) [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/sjogren-big-data-project-influence-of-geolocation-on-the-phenotypic-expression-at-diagnosis-in-8310-patients-north-to-south-gradient/. Accessed December 2, 2020.
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