Abstracts tagged "Scleroderma"

Abstract Number: 0661 • ACR Convergence 2023
Assessment of Systemic Sclerosis-Associated Myocarditis: A Single Center Case Series Study
Nafsika Gerolymatou¹, NIck Koletsos¹, Aliki Venetsanopoulou², Anastasia Giantsouli³, Sophie Mavrogeni⁴ and PARASKEVI VOULGARI⁵, ¹Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, ²Medical School of Ioannina, Ioannina, Greece, ³Radiology Department, University Hospital of Ioannina, Ioannina, Greece, ⁴Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece, ⁵Rheumatology Clinic, Department of Internal Medicine, University of Ioannina, Ioannina, Greece
Background/Purpose: Myocardial involvement is a significant contributor to mortality in patients with Systemic Sclerosis (SSc). The objective of this study was to analyze the clinical…
Abstract Number: 0961 • ACR Convergence 2023
Transcriptomic Analysis of Scleroderma Monocytes Identifies Distinct Clinically Relevant Clusters and Novel Genes Associated with Disease Complications
Mehmed Dinc¹, Fatima El Adili², Justin Lui³, Giovanni Ligresti³, Robert Lafyatis⁴, Maria Trojanowska³ and Andreea Bujor³, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Revere, MA, ³Boston University, Boston, MA, ⁴University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and internal organ fibrosis, vascular abnormalities, and immunological disturbances. Monocytes play a critical role…
Abstract Number: 1871 • ACR Convergence 2023
Utility of Infrared Thermography in Patients with Digital Gangrene
Nidhish Chandra M, Puneet Kumar, Urmila Dhakad, Shweta Bhardwaj, Sanjay Pruthviraj Buddha, Parag Vijayvergia and Lily Singh, King George Medical University, Lucknow, India
Background/Purpose: Digital gangrene has been described as a complication of several Autoimmune Inflammatory Rheumatic Diseases(AIIRD). Due to multiple underlying mechanisms causing digital gangrene in AIIRD…
Abstract Number: 0622 • ACR Convergence 2023
The Effectiveness of Breath-holding Test to Predict Pulmonary Function in Systemic Sclerosis Patients Using Machine Learning Model
Jina Yeo¹, Min Hyuk Lim², Ju Yeon Kim³, Ji In Jung⁴, Saram Lee² and Eun Bong Lee³, ¹Division of Rheumatology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea, ²Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, South Korea, ³Seoul National University Hospital, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: Pulmonary involvement is major causes of mortality in patients with systemic sclerosis (SSc). The breath-holding test (BHT), rapid bedside test, is a useful surrogate…
Abstract Number: 0665 • ACR Convergence 2023
A Descriptive Study of Disease Characterisics of SSc Patients with the U2RNP Autoantibody
Mridula Dilip¹, Maureen Laffoon², Yongseok Park³, Robert Lafyatis⁴, Thomas Medsger⁵, Virginia Steen⁶, Leigh Freno² and Robyn Domsic⁴, ¹University of Pittsburgh School of Medicine, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA, ³University of Pittsburgh School of Public Health, Pittsburgh, PA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵University of Pittsburgh School of Medicine, Verona, PA, ⁶Georgetown University School of Medicine, Washington, DC
Background/Purpose: U2RNP is a spliceosome-associated autoantibody that has in prior case reports presented with scleroderma with myositis (SSc/PM)and SLE overlap. Autoantibodies are growing in prognostic…
Abstract Number: 0962 • ACR Convergence 2023
Topological Proteomic Differences in Fibrotic and Unaffected Skin in Scleroderma
Irene Choi¹, Courtney Yu², Francesco Boin¹, Elizabeth Volkmann³, Stephanie Stanford² and Nunzio Bottini⁴, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²University of California San Diego, San Diego, CA, ³University of California Los Angeles, Los Angeles, CA, ⁴University of California, San Francisco, CA
Background/Purpose: Scleroderma (SSc) is a chronic autoimmune and rheumatic disease characterized by varying levels of tissue fibrosis in the skin and other internal organs. It…
Abstract Number: 1897 • ACR Convergence 2023
In Pursuit of Excellence: Improving Systemic Sclerosis Quality of Care
Aos Aboabat¹, Samar Aboulenain¹, Zareen Ahmad², Medha Soowamber³ and Sindhu Johnson⁴, ¹University of Toronto, Toronto, ON, Canada, ²Toronto Scleroderma Program, Mount Sinai Hospital, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³Toronto Scleroderma Program, Mount Sinai Hospital, Toronto Western Hospital, University of Toronto, Woodbridge, ON, Canada, ⁴Division of Rheumatology, Department of Medicine, Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western and Mount Sinai Hospitals; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease with significant morbidity and mortality. Quality indicators (QIs) for SSc care, previously published, are essential tools…
Abstract Number: 0623 • ACR Convergence 2023
Nailfold Capillaroscopy in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) Treated with Nintedanib
Vanessa Smith¹, Christopher Denton², Ariane Herrick³, Carina Ittrich⁴, Margarida Alves⁵ and Maurizio Cutolo⁶, ¹Ghent University Hospital, Gent, Belgium, ²University College London, London, United Kingdom, ³University of Manchester, Salford, United Kingdom, ⁴Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Biberach an der Riss, Germany, ⁵Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, ⁶Laboratory of Experimental Rheumatology, Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic, Genova, Italy
Background/Purpose: Microvascular damage is part of the pathogenesis of systemic sclerosis and is associated with internal organ involvement. Nintedanib is a tyrosine kinase inhibitor approved…
Abstract Number: 0670 • ACR Convergence 2023
Title: Patient Characteristics and Outcomes of Scleroderma Renal Crisis versus Hypertensive Emergencies: A Nationwide Comparative Study
Husam el Sharu¹, Sukhvir Singh¹, Omar Alwahadneh² and Mohammad Alqaisieh³, ¹East Carolina University, Greenville, NC, ²Carle Foundation Hospital, Urbana, IL, ³Hamilton Medical Center, Dalton, GA
Background/Purpose: Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis. It presents with sudden onset of severe hypertension, a rise in serum creatinine…
Abstract Number: 0964 • ACR Convergence 2023
Systemic Sclerosis (SSc) Dermal Fibroblasts Show Shortened Primary Cilia Due to Aberrant Aurora a Kinase Activation Independently of Transforming Growth Factor β Signalling
Rebecca Wells¹, Rebecca Ross², Alex Timmis¹, Ioanna Georgiou¹, Colin Johnson¹, Natalia Riobo-Del Galdo¹ and Francesco Del Galdo³, ¹University of Leeds, Leeds, United Kingdom, ²Medicine and Health, University of Leeds, Leeds, United Kingdom, ³University of Leeds - Leeds Institute of Rheumatic and Muskuloskeletal Medicine, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterised by abnormal activation of tissue fibroblasts, resulting in tissue and vascular fibrosis of the skin and…
Abstract Number: 2094 • ACR Convergence 2023
Increasing Collaboration, Education, and Awareness of Scleroderma Through an Interprofessional Education Program: Emphasizing the Importance of a Multidisciplinary Team and the Patient as the Primary Educator
Corey Fellon¹, Hannah Bowen² and Lee Shapiro³, ¹Albany Medical College, Albany, NY, ²Steffens Scleroderma Foundation, Batavia, NY, ³Albany Medical College, Stillwater, NY
Background/Purpose: Scleroderma is a condition that can affect almost every organ system and thus requires an interprofessional team to optimally manage symptoms and improve patient…
Abstract Number: 0624 • ACR Convergence 2023
Outcomes in Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) Based on Serological Profiles: Focus on Anti-Centromere Antibody (ACA) and Anti-RNA Polymerase III (ARA) Antibodies
Elizabeth Volkmann¹, Shervin Assassi², Christopher Denton³, Rozeta Simonovska⁴, Steven Sambevski⁵ and Elana Bernstein⁶, ¹University of California Los Angeles, Los Angeles, CA, ²University of Texas McGovern Medical School at Houston, Houston, TX, ³University College London, London, United Kingdom, ⁴Mainanalytics GmbH, Sulzbach (Taunus), Sulzbach, Germany, ⁵Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, ⁶Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY
Background/Purpose: Autoantibody profiles are associated with organ involvement and outcomes in patients with SSc. Anti-topoisomerase I antibody (ATA) positivity has been associated with a greater…
Abstract Number: 0787 • ACR Convergence 2023
Understanding Distinct Resident and Migratory Fibroblast Populations in Systemic Sclerosis Skin Through Single-cell RNAseq and Immunohistochemistry
Kristina Clark¹, Shiwen Xu², Voon Ong³, Christopher Buckley⁴ and Christopher Denton², ¹Barts Health NHS Trust, London, United Kingdom, ²University College London, London, United Kingdom, ³UCL Medical School Royal Free Campus, London, United Kingdom, ⁴University of Oxford, Oxford, United Kingdom
Background/Purpose: We previously described distinct migratory and resident fibroblast populations from lesional skin biopsies in SSc patients. Both populations are profibrotic compared with those from…
Abstract Number: 1034 • ACR Convergence 2023
The Relationship Between the Extent of Ground Glass to Fibrosis Ratio and Treatment Response to Immunomodulatory Therapy in Three Separate Autoimmune Interstitial Lung Disease Cohorts
Scott Matson¹, Stephen Humphries², joyce Lee³, Michael Roth⁴, Donald Tashkin⁴, Grace Kim⁴, Jonathan Goldin⁴, Mei Leng⁴ and Elizabeth Volkmann⁴, ¹University of Kansas School of Medicine, Kansas City, MO, ²National Jewish Health, Denver, CO, ³University of Colorado Anschutz Campus, Denver, CO, ⁴University of California Los Angeles, Los Angeles, CA
Background/Purpose: For patients with autoimmune interstitial lung disease (ILD), the clinician's interpretation of the extent of ground glass relative to fibrosis on imaging often influences…
Abstract Number: 2353 • ACR Convergence 2023
Role of Insulin-like Growth Factor Binding Protein-7 (IGFBP7) in Pulmonary Hypertension Pathogenesis and as a Biomarker Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
Ye Jin Jeong¹, Soumyaroop Bhattacharya¹, Maria de la Luz Garcia-Hernandez², Javier Rangel-Moreno¹, Qingfu Xu³ and Benjamin Korman¹, ¹University of Rochester, Rochester, NY, ²University of Rochester, West Henrietta, NY, ³CanSino Biologic Inc., Tianjin, China
Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune connective tissue disease that causes autoimmunity, vascular dysfunction, and fibrosis of the skin, lungs, and other organs.…

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