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Abstracts tagged "Scleroderma"

  • Abstract Number: L09 • ACR Convergence 2020

    A Phase 2a Randomized, Double-blind, Placebo-controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis (NOVESA)

    Dinesh Khanna1, Christopher Denton2, Daniel Furst3, Maureen Mayes4, Marco Matucci-Cerinic5, Vanessa Smith6, Dick de Vries7, Liesbeth Deberdt8, Pieter‑Jan Stiers8, Niyati Prasad8 and Sohail Ahmed9, 1University of Michigan, Ann Arbor, MI, 2Royal Free Hospital, University College London, London, United Kingdom, 3David Geffen School of Medicine at UCLA, Los Angeles, CA, 4University of Texas Health Science Center at Houston, Houston, TX, 5Università degli Studi di Firenze, Firenze, Italy, 6Ghent University Hospital, Ghent, Belgium, 7Galapagos BV, Leiden, Netherlands, 8Galapagos NV, Mechelen, Belgium, 9Ahmed Science Medicine, Basel, Switzerland

    Background/Purpose: There is a high unmet need for systemic sclerosis (SSc) treatments. Ziritaxestat (ziri; GLPG1690) is an autotaxin inhibitor with a novel mechanism of action.…
  • Abstract Number: 0531 • ACR Convergence 2020

    The Prevalence of Systemic Sclerosis, Dermatomyositis/Polymyositis, and Giant Cell Arteritis in the United States by Race and Ethnicity: An Analysis Using Electronic Health Records

    Sunali Goonesekera1, Ankit Bansal1, Swarali Tadwalkar2 and Alison Isherwood3, 1Decision Resources Group, Part of Clarivate, Boston, MA, 2Decision Resources Group, part of Clarivate, Bangolore, India, 3Decision Resources Group, part of Clarivate, London, United Kingdom

    Background/Purpose: Epidemiological studies suggest differences in the prevalence and disease severity of certain autoimmune diseases by race and ethnicity. In this study, we evaluate the…
  • Abstract Number: 1168 • ACR Convergence 2020

    Reliability and Validity of a New Skin Activity Measure for Localized Scleroderma

    Suzanne Li1, Mara Becker2, Sandy Hong3, Polly Ferguson4, Themba Nyrienda1, Tracy Andrews5, Katie Stewart6, C. Egla Rabinovich7, Robert Fuhlbrigge8, Thomas Mason9, Elena Pope10, Maria Ibarra11, Fatma Dedeoglu12, Gloria Higgins13, Ronald Laxer14, Marilynn Punaro6, Kathryn Torok15 and CARRA Investigators16, 1Hackensack University Medical Center, Hackensack, 2Duke University School of Medicine, Durham, NC, 3University of Iowa Stead Family Children's Hospital, Iowa City, IA, 4University of Iowa Carver College of Medicine, Iowa City, IA, 5Rutgers, Newark, 6UT Southwestern, Dallas, TX, 7Duke University Hospital, Durham, NC, 8University of Colorado, Denver, CO, 9Mayo Clinic, Rochester, MN, 10Hospital For Sick Kids, Toronto, ON, Canada, 11Children's Mercy Kansas City, Kansas City, MO, 12Boston Children's Hospital, Boston, MA, 13Nationwide Childrens Hospital/ The Ohio State University, Columbus, OH, 14The Hospital for Sick Children, Toronto, ON, Canada, 15University of Pittsburgh, Pittsburgh, PA, 16CARRA, Durham

    Background/Purpose: Juvenile localized scleroderma (jLS) is a chronic inflammatory and fibrosing disease.  Treatment is directed towards controlling disease activity to minimize risk for functional impairment…
  • Abstract Number: 1914 • ACR Convergence 2020

    Long Non-coding RNA HOTAIR Induces GLI2 Expression Through Notch Signalling in Systemic Sclerosis Dermal Fibroblasts

    Christopher Wasson1, Rebecca Ross1, Rebecca Wells1, Clarissa Corinaldesi1, Ioanna Georgiou2, Natalia Riobo-Del Galdo2 and Francesco Del Galdo3, 11. Leeds Institute of Rheumatic and Musculoskeletal Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom, 22. School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: Systemic sclerosis (SSc) is characterised by tissue fibrosis of the major organs of the body including the skin, lungs and heart. We have previously…
  • Abstract Number: 0912 • ACR Convergence 2020

    Effectiveness of DETECT Algorithm in Japanese Systemic Sclerosis Patients with Old or New Hemodynamic Definition of Pulmonary Arterial Hypertension

    Takanori Ito1, Takehiro Nakai2, Genki Kidoguchi2, Sho Fukui2, Hiroki Ozawa2, Satoshi Kawaai2, Yukihiko Ikeda2, Hisanori Shimizu2, Yasuhiro Suyama3, Atsushi Nomura2, Hiromichi Tamaki1, Kenichi Yamaguchi2 and Masato Okada1, 1St. Luke's International Hospital, Tokyo, Japan, 2St. Luke's International Hospital, Chuo-ku, Tokyo, Japan, 3JR Tokyo General Hospital, Tokyo, Japan

    Background/Purpose: Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) has been known as a life-threatening manifestation in SSc. Earlier detection and subsequent interventions are important to improve…
  • Abstract Number: 1169 • ACR Convergence 2020

    Three-Dimensional Analysis of Facial Asymmetry in Craniofacial Scleroderma

    Daniel Glaser1, Christopher Liu2 and Kathryn Torok3, 1UPMC Children's Hospital of Pittsburgh, Piitsburgh, PA, 2Children's Hospital of Pittsburgh, Pittsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Localized scleroderma (LS) is a rare, progressive autoimmune disease of the skin and underlying connective tissue that can result in devastating functional impairment and cosmetic damage in children. …
  • Abstract Number: 1915 • ACR Convergence 2020

    Leptin Plays a Critical Role in Modulating Dermal Adipose Tissue, Inflammation and Skin Fibrosis

    Roberta Goncalves Marangoni1, Stacey Duemmel2, Marc Nuzzo2, Christopher Ritchlin3 and Benjamin Korman3, 1University of Rochester Medical Center, Rochester, NY, 2Department of Medicine, University of Rochester Medical Center, Rochester, 3Department of Medicine, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: We previously demonstrated that systemic sclerosis (SSc) patients have substantial reduction in dermal white adipose tissue (dWAT) which correlates with skin fibrosis. In animal…
  • Abstract Number: 0913 • ACR Convergence 2020

    Systemic Sclerosis Portends a Higher Risk of Conduction and Rhythm Disorders at Diagnosis and During Disease Course: Results from a US Population Based Study

    Yasser Radwan1, Reto Kurmann2, Avneek Singh Sandhu3, Edward El-Am4, Cynthia Crowson2, Eric Matteson5, Thomas Osborn2, Kenneth Warrington6, Rekha Mankad2 and Ashima Makol2, 1Mayo Clinic, Rochester, Minnesota, USA, Lansing, MI, 2Mayo Clinic, Rochester, Minnesota, USA, Rochester, MN, 3Mayo Clinic, Rochester, Minnesota, USA, Dayton, OH, 4Indiana University School of Medicine, Indianapolis, IN, 5Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA, Rochester, MN, 6Mayo Clinic, Rochester, MN

    Background/Purpose: Cardiac involvement, including electrocardiogram (ECG) abnormalities, is associated with worse prognosis in systemic sclerosis (SSc). We studied the incidence, risk factors and outcomes of…
  • Abstract Number: 1170 • ACR Convergence 2020

    Exploring the Use of Von Willebrand Factor as a Disease Biomarker in a Cohort of Patients with Juvenile Scleroderma: A Pilot Study

    Natalia Vasquez-Canizares1, Beamon Agarwal2, Tamar Rubinstein3, Dawn Wahezi1 and Morayma Reyes-Gil1, 1Albert Einstein College of Medicine, Bronx, NY, 2GenomeRxUS LLC, Clifton Heights, PA, 3Albert Einstein College of Medicine / Montefiore Medical Center, White Plains, NY

    Background/Purpose: Juvenile Scleroderma (JScl) is a heterogenous disease characterized by autoimmunity, vasculopathy, and fibrosis. Morbidity and mortality remain high in part due to the continuing…
  • Abstract Number: 1991 • ACR Convergence 2020

    Abatacept Treatment Reduces Cutaneous and Joint Activity in Juvenile Localized Scleroderma

    Suzanne Li1, Sarah Ishaq2, Mary Buckley3, Kathryn Torok4, Barbara Edelheit5, Kaleo Ede6, Christopher Liu7 and C. Egla Rabinovich8, 1Hackensack University Medical Center, Hackensack, 2Montclair State University, Montclair, 3Duke University, Durham, NC, 4University of Pittsburgh, Pittsburgh, PA, 5Conneticut Children's Medical Center, Hartford, 6Phoenix Children's Hospital, Phoenix, AZ, 7U Pittsburgh, Pittsburgh, 8Duke University Hospital, Durham, NC

    Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease commonly associated with damage. Damage includes dyspigmentation, tissue atrophy, arthropathy, hemiatrophy, vision loss, and seizures. To…
  • Abstract Number: 0175 • ACR Convergence 2020

    Identifying Immuno-phenotypes in Juvenile Localized Scleroderma with RNA Sequencing

    Christina Schutt1, Emily Mirizio2, Kaila Schollaert-Fitch2, Claudia Salgado3, Miguel Reyes-Mugica3 and Kathryn Torok2, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3University of Pittsburgh Medical Center, Pittsburgh

    Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue characterized by an early inflammatory infiltrate followed by fibrosis and…
  • Abstract Number: 0915 • ACR Convergence 2020

    Clinical Bedside Tools to Assess Systemic Sclerosis Vasculopathy: Can Digital Thermal Monitoring and Sublingual Microscopy Identify Patients with Current or past Digital Ulcers?

    Tracy Frech1, Zhining Ou2, Julie Thomas2 and Angela Presson2, 1University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT

    Background/Purpose: Sublingual microscopy is reported as a useful tool for vasculopathy assessment in SSc.  Digital thermal monitoring (DTM) correlates with flow-mediated dilatation, and may identify…
  • Abstract Number: 1378 • ACR Convergence 2020

    Understanding Diagnostic Pathways in Systemic Sclerosis and Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)

    Shervin Assassi1, Nan Shao2, Ziwei Yin2, Elizabeth Volkmann3, Donald Zoz2 and Thomas Leonard2, 1University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, 2Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, 3University of California, Los Angeles, Los Angeles, CA

    Background/Purpose: Interstitial lung disease (ILD) is a common manifestation of SSc. SSc-ILD is usually detected in a patient known to have SSc, but ILD may…
  • Abstract Number: 2018 • ACR Convergence 2020

    Development and Validation of an Artificial Intelligence Approach for the Detection of Radiographic Sacroiliitis

    Keno-Kyrill Bressem1, Janis Vahldiek1, Lisa Adams1, Stefan Niehues1, Hildrun Haibel1, Valeria Rios Rodriguez1, Murat Torgutalp1, Mikhail Protopopov1, Fabian Proft1, Judith Rademacher1, Joachim Sieper1, Martin Rudwaleit2, Bernd Hamm1, Markus Makowski1, Kay-Geert Hermann1 and Denis Poddubnyy3, 1Charité Universitätsmedizin Berlin, Berlin, Germany, 2Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, 3Charité – Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: Conventional radiography of the sacroiliac joints is still recommended as the first imaging method if axial spondyloarthritis (axSpA) is suspected. Furthermore, radiographic sacroiliitis is…
  • Abstract Number: 0384 • ACR Convergence 2020

    Serum Neutrophil Count Predicts Progression of Interstitial Lung Disease and Mortality in Patients with Systemic Sclerosis Related Interstitial Lung Disease

    Nancy Wareing1, Ning Li2, Elizabeth Volkmann3, Marka Lyons4, Michael Roth2, Donald Tashkin2 and Shervin Assassi1, 1University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, 2University of California, Los Angeles, Los Angeles, 3University of California, Los Angeles, Los Angeles, CA, 4University of Texas Houston, McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX

    Background/Purpose: Systemic sclerosis (SSc) patients have a prominent neutrophil gene expression signature.  However, investigations into the pathophysiologic role of neutrophils in SSc are lacking. This…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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