ACR Meeting Abstracts

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Abstracts tagged "Scleroderma"

  • Abstract Number: 0624 • ACR Convergence 2023

    Outcomes in Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) Based on Serological Profiles: Focus on Anti-Centromere Antibody (ACA) and Anti-RNA Polymerase III (ARA) Antibodies

    Elizabeth Volkmann1, Shervin Assassi2, Christopher Denton3, Rozeta Simonovska4, Steven Sambevski5 and Elana Bernstein6, 1University of California Los Angeles, Los Angeles, CA, 2University of Texas McGovern Medical School at Houston, Houston, TX, 3University College London, London, United Kingdom, 4Mainanalytics GmbH, Sulzbach (Taunus), Sulzbach, Germany, 5Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, 6Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY

    Background/Purpose: Autoantibody profiles are associated with organ involvement and outcomes in patients with SSc. Anti-topoisomerase I antibody (ATA) positivity has been associated with a greater…
  • Abstract Number: 0787 • ACR Convergence 2023

    Understanding Distinct Resident and Migratory Fibroblast Populations in Systemic Sclerosis Skin Through Single-cell RNAseq and Immunohistochemistry

    Kristina Clark1, Shiwen Xu2, Voon Ong3, Christopher Buckley4 and Christopher Denton2, 1Barts Health NHS Trust, London, United Kingdom, 2University College London, London, United Kingdom, 3UCL Medical School Royal Free Campus, London, United Kingdom, 4University of Oxford, Oxford, United Kingdom

    Background/Purpose: We previously described distinct migratory and resident fibroblast populations from lesional skin biopsies in SSc patients. Both populations are profibrotic compared with those from…
  • Abstract Number: 1034 • ACR Convergence 2023

    The Relationship Between the Extent of Ground Glass to Fibrosis Ratio and Treatment Response to Immunomodulatory Therapy in Three Separate Autoimmune Interstitial Lung Disease Cohorts

    Scott Matson1, Stephen Humphries2, joyce Lee3, Michael Roth4, Donald Tashkin4, Grace Kim4, Jonathan Goldin4, Mei Leng4 and Elizabeth Volkmann4, 1University of Kansas School of Medicine, Kansas City, MO, 2National Jewish Health, Denver, CO, 3University of Colorado Anschutz Campus, Denver, CO, 4University of California Los Angeles, Los Angeles, CA

    Background/Purpose: For patients with autoimmune interstitial lung disease (ILD), the clinician's interpretation of the extent of ground glass relative to fibrosis on imaging often influences…
  • Abstract Number: 2353 • ACR Convergence 2023

    Role of Insulin-like Growth Factor Binding Protein-7 (IGFBP7) in Pulmonary Hypertension Pathogenesis and as a Biomarker Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)

    Ye Jin Jeong1, Soumyaroop Bhattacharya1, Maria de la Luz Garcia-Hernandez2, Javier Rangel-Moreno1, Qingfu Xu3 and Benjamin Korman1, 1University of Rochester, Rochester, NY, 2University of Rochester, West Henrietta, NY, 3CanSino Biologic Inc., Tianjin, China

    Background/Purpose: Systemic sclerosis (SSc, scleroderma) is an autoimmune connective tissue disease that causes autoimmunity, vascular dysfunction, and fibrosis of the skin, lungs, and other organs.…
  • Abstract Number: 0625 • ACR Convergence 2023

    Use of Heated Gloves for Raynaud’s Phenomenon in Systemic Sclerosis

    Kimti Kumar1, Nor Hashimah Abu Mansor Matardiah2, Kim Griggs3, Aline Kunnel4, Jennifer Walker5 and Susanna Proudman6, 1SA Health and University of Adelaide, Millswood, Australia, 2Tuanku Fauziah Hospital, Kangar, Malaysia, 3Royal Adelaide Hospital, Adelaide, Australia, 4South Australian Health and Medical Research Institute, Adelaide, Australia, 5Flinders Medical Centre and Royal Adelaide Hospital, Bedford Park, Australia, 6Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia

    Background/Purpose: RP and its ischaemic complications are a major cause of morbidity in SSc. Non-pharmacological measures to minimise cold exposure can play a vital role…
  • Abstract Number: 0788 • ACR Convergence 2023

    Whole Exome Sequencing and Evolutionary Action Missense Mutation Analysis Identifies MICB as a New SSc Susceptibility Locus and the Interferon Pathway as Contributors to SSc Pathogenesis

    Shamika Ketkar1, Hongzheng Dai1, Brian Dawson1, Lindsay Burrage1, David Murdock1, Jennifer Asmussen1, Kevin Wilhelm1, Olivier Lichtarge1, Martin Kerick2, Javier Martin3, Shervin Assassi4, Brendan Lee1 and Maureen Mayes5, 1Baylor College of Medicine, Houston, TX, 2Spanish National Research Council, Granada, Spain, 3Instituto de Parasitologia y Biomedicina Lopez-Neyra - CSIC, Granada, Spain, 4University of Texas McGovern Medical School at Houston, Houston, TX, 5Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by fibrosis of the skin and internal organs associated with vasculopathy and autoantibodies and exhibiting wide clinical heterogeneity. Contributors…
  • Abstract Number: 1216 • ACR Convergence 2023

    “I Call It Zombie Hands and Feet, That’s Actually How I Found out I Had This Disease”: Disease Symptoms and Treatment Side Effects in a Diverse Sample of Patients with Early Limited Cutaneous and Diffuse Cutaneous Systemic Sclerosis

    Chelsea Perschon1, Emilie Jaeger1, George Greene1, Alain Lescoat2, Yen Chen3, Susan Murphy3, Sara Shaunfield1, David Cella1 and Dinesh Khanna3, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2University Rennes, Rennes, France, 3University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune rheumatic disease with heterogeneous manifestations, including common symptoms such as pain, fatigue, dyspnea, and Raynaud's phenomenon. It…
  • Abstract Number: 2354 • ACR Convergence 2023

    Is Midkine a Novel Biomarker for Acro-osteolysis in Systemic Sclerosis?

    Ganiat Adeogun1, Venkateswara Gogulamudi2, Meridith Balbach1, Anthony Donato2 and Tracy Frech1, 1Vanderbilt University Medical Center, Nashville, TN, 2Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT

    Background/Purpose: Acro-osteolysis is a hand complication in systemic sclerosis (SSc) characterized by the destruction of distal digital bone possibly related to repetitive ischemia-reperfusion injury. Diagnosis…
  • Abstract Number: 0629 • ACR Convergence 2023

    Negative Affect, Anxiety and Fatigue Moderate the Association Between Pain Intensity and Physical Function in People with Systemic Sclerosis

    Daniel Whibley1, Yen Chen1, Anna Kratz1, Dinesh Khanna1 and Susan Murphy2, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Plymouth, MI

    Background/Purpose: Pain is a common symptom of systemic sclerosis (SSc), affecting over 80% of those living with the condition, with over a third experiencing pain…
  • Abstract Number: 0790 • ACR Convergence 2023

    Transcriptomic Analyses of Lung Tissues Reveals Potential Key Genes Associated with Progression of Systemic Sclerosis-Interstitial Lung Disease (SSc-ILD)

    Yehya Al-Adwi1, Johanna Westra1, Harry van Goor1, Leon.C.L.T van Kempen2, Wim Timens1, C.Tji Gan1 and Douwe J Mulder1, 1University Medical Center Groningen, Groningen, Netherlands, 2UMCG and University of Antwerp, Groningen, Netherlands

    Background/Purpose: SSc-ILD is the leading cause of death in SSc affecting around 50% of the patients. Lung tissue of patients with early-stage SSc-ILD is characterized…
  • Abstract Number: 1225 • ACR Convergence 2023

    Nailfold Video Capillaroscopy and Its Association with Autoantibodies and Rheumatic Diseases in Pediatric Patients

    Yazmin Espinosa1, Sara Concha1, Clara Schulze1 and Antonia Valenzuela2, 1Pontificia Universidad Católica de Chile, Santiago de Chile, Chile, 2Pontificia Universidad Católica de Chile, Santiago, Chile

    Background/Purpose: Nailfold video capillaroscopy (NVC) is useful in diagnosing secondary Raynaud's phenomenon (RP) and predicting systemic sclerosis (SSc) and other CTD in adults. Recent studies…
  • Abstract Number: 2357 • ACR Convergence 2023

    The Involvement of CCR3-CCL24 Axis in Endothelial to Mesenchymal Transition Process and Pulmonary Arterial Hypertension in Systemic Sclerosis Patients

    Itzchak Amoyal1, Tzipi Hornik-Lurie2, Tali Zitman-Gal1, Hilit Levy3, Ilan Vaknin3, Liat Drucker4, Ishai Heusler5, Yair Levy1 and Shelly Tartakover Matalon1, 1Meir Medical Center, Autoimmune Research Laboratory, Kfar-Saba, Israel, 2Meir Medical Center, Data Research Department, Kfar-Saba, Israel, 3Chemomab Ltd, Tel Aviv, Israel, 4Meir Medical Center, Oncogenetics Laboratory, Kfar Saba, Israel, 5Meir Medical Center, Department of Obstetric and Genecology, Kfar-Saba, Israel

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury and extensive tissue fibrosis of the skin and internal organs. Endothelial cells (ECs),…
  • Abstract Number: 123 • 2023 Pediatric Rheumatology Symposium

    Development of Specific Classification Criteria for Juvenile System Sclerosis Patients: A Scoping Review

    Ioana Dobre1, Suzanne Li2, Natalia Vasquez Canizares3, Barbara Reich4, Xurong Zhao5, Quinn McCormick6 and Marinka Twilt5, 1Alberta Children's Hospital/University of Calgary, Calgary, AB, Canada, 2Hackensack Meridian School of Medicine, Joseph M. Sanzari Children's Hospital, Hackensack, NJ, 3Children's Hospital at Montefiore, New York, NY, 4Hackensack University Medical Center, Hackensack, NJ, 5Alberta Children's Hospital, Calgary, AB, Canada, 6Hackensack Medical Hospital Network, Hackensack, NJ

    Background/Purpose: Juvenile systemic sclerosis (jSSc) is associated with one of the highest morbidity and mortality rate in pediatric rheumatology, yet care recommendations are based upon…
  • Abstract Number: 029 • 2023 Pediatric Rheumatology Symposium

    Cardiac Magnetic Resonance Imaging in Children with Systemic Lupus Erythematosus and Scleroderma Spectrum Disorders: A Single Center Experience

    Meredith Rae, Tam Doan and Eyal Muscal, Baylor College of Medicine, Houston, TX

    Background/Purpose: Cardiac disease is a major cause of morbidity and mortality in children with SLE and SSc. Various studies have demonstrated an association between duration…
  • Abstract Number: 086 • 2023 Pediatric Rheumatology Symposium

    Systemic Sclerosis Overlap Syndrome: A Case Series from a Single Large Pediatric Center

    Jessica Nguyen1, Miriah Gillispie-Taylor1, Eyal Muscal1 and Marietta Deguzman2, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: Childhood-onset systemic sclerosis (SSc) is a rare but potentially life-threatening autoimmune condition with features including immune, fibrotic, and vascular manifestations affecting the skin and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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