ACR Meeting Abstracts

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Abstracts tagged "Scleroderma"

  • Abstract Number: 1814 • ACR Convergence 2024

    Understanding Monocyte Derived Macrophages in the Skin of SSc Patients Through Single Cell Analysis of Blister Fluid Immune Cell Populations

    Sandra Lopez Garces1, Tamara Searle2, Siyu Zhang1, Henry Lopez3, Isra Elhussin4, Clayton Yates4, David Abraham5, Christopher Denton6, Bahja Ahmed Abdi1 and Richard Stratton7, 1University College London, London, United Kingdom, 2Imperial College London, London, United Kingdom, 3Riptide Bioscience Inc, Bethesda, MD, 4Johns Hopkins University, Baltimore, MD, 5UCL, London, United Kingdom, 6University College London, Northwood, United Kingdom, 7UCL, London, England, United Kingdom

    Background/Purpose: Cells of the monocyte-macrophages (Mφ) are key players in the pathogenesis of systemic sclerosis (SSc), contributing to inflammation and fibrosis. To advance beyond the…
  • Abstract Number: 1920 • ACR Convergence 2024

    Admixture Mapping and Gene-Based Analysis Identifies Rare Variants in Genes in the IL-13 and TGFβ Signaling Pathways in African Americans with Systemic Sclerosis

    Jordan Hicks1, Daniel Shriner2, Ami Shah3, Maureen Mayes4, Ayo P. Doumatey2, Amy R. Bentley1, Robyn Domsic5, Thomas Medsger, Jr6, Paula Ramos7, Richard Silver8, Virginia Steen9, John Varga10, Vivien Hsu11, Lesley Ann Saketkoo12, Dinesh Khanna10, Elena Schiopu13, Jessica Gordon14, Lindsey Criswell15, Heather Gladue16, Chris Derk17, Elana Bernstein18, S. Louis Bridges14, Victoria Shanmugam19, Lorinda Chung20, Suzanne Kafaja21, Reem Jan22, Marcin Trojanowski23, Avram Goldberg24, Benjamin Korman25, James W. Thomas26, Elaine Remmers27, Adebowale Adeyemo2, Charles Rotimi2, Fredrick Wigley28, Francesco Boin29, Daniel Kastner30 and Pravitt Gourh31, 1National institute of Health, Bethesda, MD, 2Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 3Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 4UTHealth Houston Division of Rheumatology, Houston, TX, 5Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 6Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Verona, PA, 7Medical University of South Carolina, Charleston, SC, 8Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 9Georgetown University School of Medicine, Washington, DC, 10University of Michigan, Ann Arbor, MI, 11Department of Medicine, Rheumatology Division, Rutgers-RWJ Medical School, South Plainfield, NJ, 12New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University and Tulane University Medical Schools, New Orleans, LA, 13Division of Rheumatology, Medical College of Georgia at Augusta University, Martinez, GA, 14Division of Rheumatology, Weill Cornell Medical College, New York, NY, 15Genomics of Autoimmune Rheumatic Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, Bethesda, MD, 16Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 17Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 18Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 19NIH Office of Autoimmune Disease Research in the Office of Research on Women's Health, National Institutes of Health, Bethesda, MD, Bethesda, MD, 20Stanford University, Woodside, CA, 21Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, 22Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, 23Department of Rheumatology, Boston University School of Medicine, Boston, MA, 24NYU Langone Health - NYU Hospital for Joint Diseases, Lake Success, NY, 25University of Rochester, Rochester, NY, 26NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 27Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 28Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, 29Cedars-Sinai Medical Center, Los Angeles, CA, 30National Human Genome Research Institute, Bethesda, MD, 31National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD

    Background/Purpose: There are significant racial disparities in systemic sclerosis (SSc), with an increased disease burden and worse outcomes among African American (AA) individuals. Reasons for…
  • Abstract Number: 2469 • ACR Convergence 2024

    Machine Learning Identifies Oesophageal Symptoms as a New Red Flag for for Very Early Diagnosis of Systemic Sclerosis (VEDOSS): A EUSTAR Analysis

    Stefano Di Donato1, Vishal Kakkar2, Silvia Bellando-Randone3, Marco Matucci-Cerinic4 and Francesco Del Galdo2, and EUSTAR collaborators, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK, Leeds, United Kingdom, 2University of Leeds, Leeds, United Kingdom, 3University of Florence, Florence, Florence, Italy, 4University San Raffaele Milano, Milano, Milan, Italy

    Background/Purpose: The analysis of the EUSTAR Very Early Diagnosis of Systemic Sclerosis (VEDOSS) study has identified the risk of progression to fulfil 2013 ACR/EULAR classification…
  • Abstract Number: 0371 • ACR Convergence 2024

    This Is Caring: Enhancing Patient Education Materials for Individuals with Morphea Through Qualitative Inquiry

    Jennifer Foster1, Robin Higashi2, Priya Sarlashkar1 and Heidi Jacobe1, 1The University of Texas Southwestern Medical Center, Department of Dermatology, Dallas, TX, 22UT Southwestern Medical Center, Peter O’Donnell Jr School of Public Health, Dallas, TX

    Background/Purpose: Patient education materials (PEMs) are essential for conveying disease and treatment information, empowering patients to actively participate in their care. However, PEMs for rare…
  • Abstract Number: 0712 • ACR Convergence 2024

    Efficacy of Sacubitril/Valsartan in Patients with Systemic Sclerosis and Heart Failure: A Retrospective Analysis

    Nouran Eshak1, Mahmoud Abdelnabi2, Jaxon Quillen1, Michael Pham1, Joseph Hentz1 and Vivek Nagaraja1, 1Mayo Clinic Arizona, Scottsdale, AZ, 2Mayo Clinic Arizona, Phoenix, AZ

    Background/Purpose: Cardiac involvement in systemic sclerosis (SSc) is common, underdiagnosed, and manifests variably. Myocardial involvement can manifest as left heart failure with preserved or reduced…
  • Abstract Number: 1563 • ACR Convergence 2024

    Prevalence, Risk Factors and Associations for Osteoporosis in Postmenopausal Women with Scleroderma

    Gayane Matusov1, Jon Giles2 and Francesco Boin3, 1Scripps Clinic, San Diego, CA, 2Cedars Sinai Medical Center, Los Angeles, CA, 3Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Case-control studies have shown that systemic sclerosis (SSc) patients exhibit higher prevalence of osteoporosis (OP) compared to subjects in the general population. The pathophysiology…
  • Abstract Number: 1816 • ACR Convergence 2024

    Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages

    Emily Morris1, Helen Jarnagin2, Heetaek Yang3, Alexandra Turnquist2, Michael Whitfield4 and Patricia Pioli5, 1Dartmouth College, Enfield, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth College, West Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: While we have shown that systemic sclerosis (SSc) dermal fibroblasts and macrophages (MØs) engage in reciprocal activation mediated by exosomes via paracrine signaling, the…
  • Abstract Number: 1957 • ACR Convergence 2024

    Assessing Left Ventricular Hemodynamic Forces in Systemic Sclerosis Patients: Pilot Study

    Aïcha Kante1, Andreea Afana2, Damien Sène3, Valérie Bousson4, Trecy Goncalves5, Edouard Ballout5, Solenn Toupin5, Jean-Guillaume Dillinger6, William Bigot3, Valentin Pagis7, Karine Champion3, Ruxandra burlacu7, stephane mouly3, Patrick Henry6, Theo Pezel6 and Cloé Comarmond3, 1Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Université Paris Cité, Paris, Ile-de-France, France, 2Department of Cardiology, University of Medicine and Pharmacy Craiova, Craiova, Romania, 3Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Lariboisière Hospital, Université Paris Cité, Paris, Ile-de-France, France, 4Department of Radiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, Ile-de-France, France, 5Department of Cardiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, France, 6Department of Cardiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, Ile-de-France, France, 7Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Lariboisière Hospital, Université Paris Cité, Paris, France

    Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease marked by inflammation, microvascular changes and fibrosis. Cardiac comorbidities are the leading cause of mortality. Early…
  • Abstract Number: 2471 • ACR Convergence 2024

    Association of Telangiectasias with Autoantibodies and Clinical Manifestations in Systemic Sclerosis

    Namitha Nair1, Thomas Medsger, Jr2, Robert Lafyatis3, Maureen Laffoon4, Leigh Freno4 and Robyn Domsic5, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Verona, PA, 3University of Pittsburgh, Pittsburgh, PA, 4UPMC, Pittsburgh, PA, 5Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Background/Purpose: Telangiectasias (Tel) are visibly dilated cutaneous post-capillary venules reported to occur in about 75% of patients with systemic sclerosis (SSc), making them a common…
  • Abstract Number: 0568 • ACR Convergence 2024

    Coexistence of Raynaud’s Phenomenon, Morphea or Scleroderma in Spondyloarthritis Patients: Insights from a Retrospective Cohort Study Highlighting a Unique Phenotype

    Ameesh Dev, Cary Roy, Deepak Jagannath, Alexandra Cloutet and Sarah Kazzaz, Houston Methodist Hospital, Houston, TX

    Background/Purpose: Spondyloarthritis (SpA) is a heterogeneous group of inflammatory arthritides that includes ankylosing spondylitis (AS), psoriatic arthritis (PsA), enteropathic-related arthritis, reactive arthritis, and undifferentiated SpA.…
  • Abstract Number: 0713 • ACR Convergence 2024

    Anti-muscarinic 3 Antibodies in SSc Associate with a More Significant GI and Extraintestinal Clinical Phenotype

    Naveen Kalavar1, Michael Hughes2, Walter Morales3, Ami Shah4, Elizabeth Volkmann5, Roshan Dongre6, Mark Pimentel7, Laura Hummers8 and Zsuzsanna McMahan9, 1University of Texas Health Science Center, Houston, TX, 2University of Manchester, Manchester, United Kingdom, 3Cedars-Sinai, Los Angeles, CA, 4Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 5University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles, 6Methodist Hospital, Houston, TX, 7Cedars-Sinai, Los Angeles, 8Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, 9UTHealth Houston Division of Rheumatology, Houston, TX

    Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease that negatively impacts internal organ function, including the gastrointestinal tract. While the etiology of…
  • Abstract Number: 1564 • ACR Convergence 2024

    Incidence of Posttraumatic Stress Disorder Secondary to the Diagnosis of Systemic Sclerosis

    Camille Zander1, Sébastien De Almeida Chaves1, Eva Bories2, Martin MICHAUD Martin3, Grégoire Prevot1, Antoine Yrondi1 and Grégory Pugnet4, 1CHU Toulouse, Toulouse, France, 2Clinique Monie, Toulouse, France, 3Clinique St Exupery, Toulouse, France, 4Toulouse Rangueil University Hospital, Toulouse, France

    Background/Purpose: Systemic sclerosis (SSc) is a severe autoimmune connective-tissue disease characterized by vasculopathy, immune activation, and subsequent fibrosis of skin, lungs, heart, kidney or gastrointestinal…
  • Abstract Number: 1817 • ACR Convergence 2024

    Activated Macrophages Mediate Loss of Dermal White Adipose Tissue in Fibrotic Skin

    Chanhyuk Park1, Helen Jarnagin2, Asmaa Mohamed3, Yina Huang3, Michael Whitfield4 and Patricia Pioli1, 1Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth, Lebanon, 4Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: Autoimmune systemic sclerosis (SSc) is characterized by inflammation, vasculopathy, and dermal and internal organ fibrosis. A widely-reported but poorly understood aspect of SSc skin…
  • Abstract Number: 1965 • ACR Convergence 2024

    Artificial Intelligence Assisted Interpretation of Lung Ultrasound Imaging for the Detection of Interstitial Lung Disease

    Robert Fairchild1, Diane Mar2, Mariani Deluna3, Matthew Baker4, suzanne Tamang5, Henry Guo3, David Fiorentino4 and Lorinda Chung6, 1Stanford University, San Francisco, CA, 2VA Palo Alto / Stanford, Palo Alto, CA, 3Stanford University, Palo Alto, CA, 4Stanford University, Menlo Park, CA, 5Stanford University, Atherton, CA, 6Stanford University, Woodside, CA

    Background/Purpose: Interstitial lung disease (ILD) is a serious complication of SSc and inflammatory myopathy (IM), necessitating accurate and early detection for improved outcomes.  Lung ultrasound…
  • Abstract Number: 2477 • ACR Convergence 2024

    Quantifying Tissue Microstructural Changes in Scleroderma Skin Using a Novel, Point-of-care, High-frequency-ultrasound Instrument

    Kimberly Lakin1, Cameron Hoerig2, Jessica Gordon3, Elmira Ghahramani2, Mia Diaz1, Robert Spiera4, dana Orange5 and Jonathan Mamou2, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medical College, New York, NY, 3Division of Rheumatology, Weill Cornell Medical College, New York, NY, 4Scleroderma, Vasculitis, and Myositis Center, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, 5Rockefeller University, New York, NY

    Background/Purpose: A highly reproducible, quantitative method of measuring skin severity in systemic sclerosis (SSc) trials and patient care is needed. While conventional skin US, operating…
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