Abstracts tagged "Scleroderma"

Abstract Number: 1814 • ACR Convergence 2024
Understanding Monocyte Derived Macrophages in the Skin of SSc Patients Through Single Cell Analysis of Blister Fluid Immune Cell Populations
Sandra Lopez Garces¹, Tamara Searle², Siyu Zhang¹, Henry Lopez³, Isra Elhussin⁴, Clayton Yates⁴, David Abraham⁵, Christopher Denton⁶, Bahja Ahmed Abdi¹ and Richard Stratton⁷, ¹University College London, London, United Kingdom, ²Imperial College London, London, United Kingdom, ³Riptide Bioscience Inc, Bethesda, MD, ⁴Johns Hopkins University, Baltimore, MD, ⁵UCL, London, United Kingdom, ⁶University College London, Northwood, United Kingdom, ⁷UCL, London, England, United Kingdom
Background/Purpose: Cells of the monocyte-macrophages (Mφ) are key players in the pathogenesis of systemic sclerosis (SSc), contributing to inflammation and fibrosis. To advance beyond the…
Abstract Number: 1920 • ACR Convergence 2024
Admixture Mapping and Gene-Based Analysis Identifies Rare Variants in Genes in the IL-13 and TGFβ Signaling Pathways in African Americans with Systemic Sclerosis
Jordan Hicks¹, Daniel Shriner², Ami Shah³, Maureen Mayes⁴, Ayo P. Doumatey², Amy R. Bentley¹, Robyn Domsic⁵, Thomas Medsger, Jr⁶, Paula Ramos⁷, Richard Silver⁸, Virginia Steen⁹, John Varga¹⁰, Vivien Hsu¹¹, Lesley Ann Saketkoo¹², Dinesh Khanna¹⁰, Elena Schiopu¹³, Jessica Gordon¹⁴, Lindsey Criswell¹⁵, Heather Gladue¹⁶, Chris Derk¹⁷, Elana Bernstein¹⁸, S. Louis Bridges¹⁴, Victoria Shanmugam¹⁹, Lorinda Chung²⁰, Suzanne Kafaja²¹, Reem Jan²², Marcin Trojanowski²³, Avram Goldberg²⁴, Benjamin Korman²⁵, James W. Thomas²⁶, Elaine Remmers²⁷, Adebowale Adeyemo², Charles Rotimi², Fredrick Wigley²⁸, Francesco Boin²⁹, Daniel Kastner³⁰ and Pravitt Gourh³¹, ¹National institute of Health, Bethesda, MD, ²Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, ⁴UTHealth Houston Division of Rheumatology, Houston, TX, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Verona, PA, ⁷Medical University of South Carolina, Charleston, SC, ⁸Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁹Georgetown University School of Medicine, Washington, DC, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Department of Medicine, Rheumatology Division, Rutgers-RWJ Medical School, South Plainfield, NJ, ¹²New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University and Tulane University Medical Schools, New Orleans, LA, ¹³Division of Rheumatology, Medical College of Georgia at Augusta University, Martinez, GA, ¹⁴Division of Rheumatology, Weill Cornell Medical College, New York, NY, ¹⁵Genomics of Autoimmune Rheumatic Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, Bethesda, MD, ¹⁶Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, ¹⁷Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁸Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, ¹⁹NIH Office of Autoimmune Disease Research in the Office of Research on Women's Health, National Institutes of Health, Bethesda, MD, Bethesda, MD, ²⁰Stanford University, Woodside, CA, ²¹Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, ²²Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, ²³Department of Rheumatology, Boston University School of Medicine, Boston, MA, ²⁴NYU Langone Health - NYU Hospital for Joint Diseases, Lake Success, NY, ²⁵University of Rochester, Rochester, NY, ²⁶NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²⁷Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ²⁸Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, ²⁹Cedars-Sinai Medical Center, Los Angeles, CA, ³⁰National Human Genome Research Institute, Bethesda, MD, ³¹National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD
Background/Purpose: There are significant racial disparities in systemic sclerosis (SSc), with an increased disease burden and worse outcomes among African American (AA) individuals. Reasons for…
Abstract Number: 2469 • ACR Convergence 2024
Machine Learning Identifies Oesophageal Symptoms as a New Red Flag for for Very Early Diagnosis of Systemic Sclerosis (VEDOSS): A EUSTAR Analysis
Stefano Di Donato¹, Vishal Kakkar², Silvia Bellando-Randone³, Marco Matucci-Cerinic⁴ and Francesco Del Galdo², and EUSTAR collaborators, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK, Leeds, United Kingdom, ²University of Leeds, Leeds, United Kingdom, ³University of Florence, Florence, Florence, Italy, ⁴University San Raffaele Milano, Milano, Milan, Italy
Background/Purpose: The analysis of the EUSTAR Very Early Diagnosis of Systemic Sclerosis (VEDOSS) study has identified the risk of progression to fulfil 2013 ACR/EULAR classification…
Abstract Number: 0371 • ACR Convergence 2024
This Is Caring: Enhancing Patient Education Materials for Individuals with Morphea Through Qualitative Inquiry
Jennifer Foster¹, Robin Higashi², Priya Sarlashkar¹ and Heidi Jacobe¹, ¹The University of Texas Southwestern Medical Center, Department of Dermatology, Dallas, TX, ²2UT Southwestern Medical Center, Peter O’Donnell Jr School of Public Health, Dallas, TX
Background/Purpose: Patient education materials (PEMs) are essential for conveying disease and treatment information, empowering patients to actively participate in their care. However, PEMs for rare…
Abstract Number: 0712 • ACR Convergence 2024
Efficacy of Sacubitril/Valsartan in Patients with Systemic Sclerosis and Heart Failure: A Retrospective Analysis
Nouran Eshak¹, Mahmoud Abdelnabi², Jaxon Quillen¹, Michael Pham¹, Joseph Hentz¹ and Vivek Nagaraja¹, ¹Mayo Clinic Arizona, Scottsdale, AZ, ²Mayo Clinic Arizona, Phoenix, AZ
Background/Purpose: Cardiac involvement in systemic sclerosis (SSc) is common, underdiagnosed, and manifests variably. Myocardial involvement can manifest as left heart failure with preserved or reduced…
Abstract Number: 1563 • ACR Convergence 2024
Prevalence, Risk Factors and Associations for Osteoporosis in Postmenopausal Women with Scleroderma
Gayane Matusov¹, Jon Giles² and Francesco Boin³, ¹Scripps Clinic, San Diego, CA, ²Cedars Sinai Medical Center, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Case-control studies have shown that systemic sclerosis (SSc) patients exhibit higher prevalence of osteoporosis (OP) compared to subjects in the general population. The pathophysiology…
Abstract Number: 1816 • ACR Convergence 2024
Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages
Emily Morris¹, Helen Jarnagin², Heetaek Yang³, Alexandra Turnquist², Michael Whitfield⁴ and Patricia Pioli⁵, ¹Dartmouth College, Enfield, NH, ²Dartmouth College, Lebanon, NH, ³Dartmouth College, West Lebanon, NH, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: While we have shown that systemic sclerosis (SSc) dermal fibroblasts and macrophages (MØs) engage in reciprocal activation mediated by exosomes via paracrine signaling, the…
Abstract Number: 1957 • ACR Convergence 2024
Assessing Left Ventricular Hemodynamic Forces in Systemic Sclerosis Patients: Pilot Study
Aïcha Kante¹, Andreea Afana², Damien Sène³, Valérie Bousson⁴, Trecy Goncalves⁵, Edouard Ballout⁵, Solenn Toupin⁵, Jean-Guillaume Dillinger⁶, William Bigot³, Valentin Pagis⁷, Karine Champion³, Ruxandra burlacu⁷, stephane mouly³, Patrick Henry⁶, Theo Pezel⁶ and Cloé Comarmond³, ¹Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Université Paris Cité, Paris, Ile-de-France, France, ²Department of Cardiology, University of Medicine and Pharmacy Craiova, Craiova, Romania, ³Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Lariboisière Hospital, Université Paris Cité, Paris, Ile-de-France, France, ⁴Department of Radiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, Ile-de-France, France, ⁵Department of Cardiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, France, ⁶Department of Cardiology, Lariboisiere Hospital, (Assistance Publique des Hôpitaux de Paris, AP-HP), Paris, Ile-de-France, France, ⁷Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Lariboisière Hospital, Université Paris Cité, Paris, France
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease marked by inflammation, microvascular changes and fibrosis. Cardiac comorbidities are the leading cause of mortality. Early…
Abstract Number: 2471 • ACR Convergence 2024
Association of Telangiectasias with Autoantibodies and Clinical Manifestations in Systemic Sclerosis
Namitha Nair¹, Thomas Medsger, Jr², Robert Lafyatis³, Maureen Laffoon⁴, Leigh Freno⁴ and Robyn Domsic⁵, ¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Verona, PA, ³University of Pittsburgh, Pittsburgh, PA, ⁴UPMC, Pittsburgh, PA, ⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
Background/Purpose: Telangiectasias (Tel) are visibly dilated cutaneous post-capillary venules reported to occur in about 75% of patients with systemic sclerosis (SSc), making them a common…
Abstract Number: 0568 • ACR Convergence 2024
Coexistence of Raynaud’s Phenomenon, Morphea or Scleroderma in Spondyloarthritis Patients: Insights from a Retrospective Cohort Study Highlighting a Unique Phenotype
Ameesh Dev, Cary Roy, Deepak Jagannath, Alexandra Cloutet and Sarah Kazzaz, Houston Methodist Hospital, Houston, TX
Background/Purpose: Spondyloarthritis (SpA) is a heterogeneous group of inflammatory arthritides that includes ankylosing spondylitis (AS), psoriatic arthritis (PsA), enteropathic-related arthritis, reactive arthritis, and undifferentiated SpA.…
Abstract Number: 0713 • ACR Convergence 2024
Anti-muscarinic 3 Antibodies in SSc Associate with a More Significant GI and Extraintestinal Clinical Phenotype
Naveen Kalavar¹, Michael Hughes², Walter Morales³, Ami Shah⁴, Elizabeth Volkmann⁵, Roshan Dongre⁶, Mark Pimentel⁷, Laura Hummers⁸ and Zsuzsanna McMahan⁹, ¹University of Texas Health Science Center, Houston, TX, ²University of Manchester, Manchester, United Kingdom, ³Cedars-Sinai, Los Angeles, CA, ⁴Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, ⁵University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles, ⁶Methodist Hospital, Houston, TX, ⁷Cedars-Sinai, Los Angeles, ⁸Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Ellicott City, MD, ⁹UTHealth Houston Division of Rheumatology, Houston, TX
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease that negatively impacts internal organ function, including the gastrointestinal tract. While the etiology of…
Abstract Number: 1564 • ACR Convergence 2024
Incidence of Posttraumatic Stress Disorder Secondary to the Diagnosis of Systemic Sclerosis
Camille Zander¹, Sébastien De Almeida Chaves¹, Eva Bories², Martin MICHAUD Martin³, Grégoire Prevot¹, Antoine Yrondi¹ and Grégory Pugnet⁴, ¹CHU Toulouse, Toulouse, France, ²Clinique Monie, Toulouse, France, ³Clinique St Exupery, Toulouse, France, ⁴Toulouse Rangueil University Hospital, Toulouse, France
Background/Purpose: Systemic sclerosis (SSc) is a severe autoimmune connective-tissue disease characterized by vasculopathy, immune activation, and subsequent fibrosis of skin, lungs, heart, kidney or gastrointestinal…
Abstract Number: 1817 • ACR Convergence 2024
Activated Macrophages Mediate Loss of Dermal White Adipose Tissue in Fibrotic Skin
Chanhyuk Park¹, Helen Jarnagin², Asmaa Mohamed³, Yina Huang³, Michael Whitfield⁴ and Patricia Pioli¹, ¹Geisel School of Medicine at Dartmouth, Lebanon, NH, ²Dartmouth College, Lebanon, NH, ³Dartmouth, Lebanon, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Autoimmune systemic sclerosis (SSc) is characterized by inflammation, vasculopathy, and dermal and internal organ fibrosis. A widely-reported but poorly understood aspect of SSc skin…
Abstract Number: 1965 • ACR Convergence 2024
Artificial Intelligence Assisted Interpretation of Lung Ultrasound Imaging for the Detection of Interstitial Lung Disease
Robert Fairchild¹, Diane Mar², Mariani Deluna³, Matthew Baker⁴, suzanne Tamang⁵, Henry Guo³, David Fiorentino⁴ and Lorinda Chung⁶, ¹Stanford University, San Francisco, CA, ²VA Palo Alto / Stanford, Palo Alto, CA, ³Stanford University, Palo Alto, CA, ⁴Stanford University, Menlo Park, CA, ⁵Stanford University, Atherton, CA, ⁶Stanford University, Woodside, CA
Background/Purpose: Interstitial lung disease (ILD) is a serious complication of SSc and inflammatory myopathy (IM), necessitating accurate and early detection for improved outcomes. Lung ultrasound…
Abstract Number: 2477 • ACR Convergence 2024
Quantifying Tissue Microstructural Changes in Scleroderma Skin Using a Novel, Point-of-care, High-frequency-ultrasound Instrument
Kimberly Lakin¹, Cameron Hoerig², Jessica Gordon³, Elmira Ghahramani², Mia Diaz¹, Robert Spiera⁴, dana Orange⁵ and Jonathan Mamou², ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medical College, New York, NY, ³Division of Rheumatology, Weill Cornell Medical College, New York, NY, ⁴Scleroderma, Vasculitis, and Myositis Center, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁵Rockefeller University, New York, NY
Background/Purpose: A highly reproducible, quantitative method of measuring skin severity in systemic sclerosis (SSc) trials and patient care is needed. While conventional skin US, operating…

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