ACR Meeting Abstracts

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Abstracts tagged "Scleroderma, Systemic"

  • Abstract Number: 0548 • ACR Convergence 2021

    Rapamycin Blocks the Profibrotic Effects of Fli1 Downregulation in Scleroderma Myeloid Cells

    Fatima El-adili, Grace Marden, Maria Trojanowska and Andreea Bujor, Boston University School of Medicine, Boston, MA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune fibrotic disease with unclear pathogenesis and no effective therapies. Increased proportion of CD163-positive, profibrotic macrophages has been described…
  • Abstract Number: 1836 • ACR Convergence 2021

    Outcomes Linked to Eligibility for Stem Cell Transplantation Trials in Diffuse Cutaneous Systemic Sclerosis

    Julia Spierings1, Svetlana Nihtyanova2, Emma Derrett-Smith3, Kristina Clark2, Jacob van Laar4, Voon Ong5 and Christopher Denton6, 1University Medical Center Utrecht, Utrecht, Netherlands, 2University College London, Royal Free Campus, London, United Kingdom, 3University College London Division of Medicine, London, United Kingdom, 4University Medical Centre Utrecht, Utrecht, Netherlands, 5University College London Medical School Royal Free Campus, London, United Kingdom, 6University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom

    Background/Purpose: Autologous haematopoietic stem cell transplantation (SCT) has emerged as an effective treatment for patients with severe diffuse systemic sclerosis (dcSSc) based upon the results…
  • Abstract Number: 0552 • ACR Convergence 2021

    Long Non-coding RNA H19X as a Regulator of Endothelial Adhesion Molecules in Systemic Sclerosis

    Francesca Tirelli1, Elena Pachera1, Robert Lafyatis2, Menqi Huang3, Francesco Zulian4, Gabriela Kania1 and Oliver Distler5, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2University of Pittsburgh, Pittsburgh, PA, 3Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 4Rheumatology Unit, Department of Woman and Child Health - University of Padova, Padova, Italy, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland

    Background/Purpose: Long non-coding RNAs (lncRNAs) are non-coding transcripts involved in the regulation of gene expression; their role in disease development, to date, remains largely under…
  • Abstract Number: 1843 • ACR Convergence 2021

    Perceptions and Concerns Regarding COVID-19 Vaccination in Patients with Systemic Sclerosis in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort

    Jessica Gordon1, Kimberly Showalter1, Yin Wu2, Linda Kwakkenbos3, Marie-Eve Carrier4, Richard Henry2, Nora Østbø2, Julia Nordlund2, Angelica Bourgeault2, Mara Canedo Ayala2, Marie-Nicole Discepola2, Andrea Carboni Jiménez2, Christopher Denton5, Luc Mouthon6, Brett Thombs7 and Robert Spiera1, 1Hospital for Special Surgery, New York, NY, 2Lady Davis Institute of the Jewish General Hospital, Montréal, QC, Canada, 3Department of Clinical Psychology, Radboud University Behavioural Science Institute, Nijmegen, Netherlands, 4Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada, 5University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 6Hopital Cochin - Paris University, Paris, France, 7Lady Davis Institute for Medical Research, Jewish General Hospital; Department of Psychiatry, McGill University, Montréal, QC, Canada

    Background/Purpose: Hesitancy about COVID-19 vaccination exists among patients with rheumatic and musculoskeletal diseases, but previous studies have not assessed this specifically in patients with systemic…
  • Abstract Number: 0553 • ACR Convergence 2021

    IgG from Systemic Sclerosis Patients Induce a Profibrosing and Serotype-dependent Phenotype in Normal Dermal Fibroblast: A Multi-omics Study

    Aurélien Chepy1, Solange Vivier2, Fabrice Bray3, Martin Figeac4, Jean-Pascal Meneboo4, Camille Ternynck5, Lucile Guilbert2, Manel Jendoubi2, Christian Rolando3, David Launay1, Sylvain Dubucquoi6, Guillemette Marot5 and Vincent Sobanski1, 1Univ. Lille, Inserm, CHU Lille, Service de Médecine Interne, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France, Lille, France, 2Univ. Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F59000 Lille, France, Lille, France, 3Univ. Lille, CNRS, USR 3290 - MSAP - Miniaturisation pour la Synthèse, l'Analyse et la Protéomique, F-59000 Lille, France, Lille, France, 4Université de Lille, Functional Genomics Platform, Lille, France., Lille, France, 5ULR 2694 – METRICS : évaluation des technologies de santé et des pratiques médicales, université de Lille, CHU de Lille, 59000 Lille, France, Lille, France, 6Univ. Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F59000 Lille, France, Lille

    Background/Purpose: Antinuclear antibodies are frequent in systemic sclerosis (SSc). While recognized as potent biomarkers, their pathogenic role is much more debated. This study explored the…
  • Abstract Number: 1847 • ACR Convergence 2021

    Severity of Gastroesophageal Reflux, but Not the Use of Proton Pump Inhibitors, Is Associated with Radiographic Progression of Interstitial Lung Disease in Systemic Sclerosis

    Elizabeth Volkmann1, Donald Tashkin2, Mei Leng2, Grace Kim2, Jonathan Goldin2 and Michael Roth2, 1Department of Medicine, Division of Rheumatology, University of California, David Geffen School of Medicine, Los Angeles, CA, 2University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Esophageal dysmotility is a common feature of systemic sclerosis (SSc) and aspiration of gastric contents may serve as an inciting and/or exacerbating factor in…
  • Abstract Number: 0179 • ACR Convergence 2021

    Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging Predicts Adverse Events in Patients with Autoimmune Rheumatic Disease

    Attila Feher1, Nabil Boutagy1, Evangelos Oikonomou1, Yi-Hwa Liu1, Edward Miller1, Albert Sinusas1 and Monique Hinchcliff2, 1Yale School of Medicine, New Haven, CT, 2Yale School of Medicine, Westport, CT

    Background/Purpose: Coronary microvascular dysfunction (CMVD) has been described in patients with autoimmune rheumatic disease (ARD). By noninvasive evaluation of myocardial blood flow (MBF) and myocardial…
  • Abstract Number: 0555 • ACR Convergence 2021

    Pathway-Driven Drug Repositioning in Systemic Sclerosis from Omics Data

    Dillon Popovich1, Tamar Abel1, Noelle Kosarek2, Monica Espinoza3, Rezvan Parvizi4, Jonathan Garlick5 and Michael Whitfield4, 1Geisel School of Medicine, West Lebanon, NH, 2Dartmouth Geisel School of Medicine, Hartford, VT, 3Geisel School of Medicine, Hanover, NH, 4Geisel School of Medicine, Lebanon, NH, 5Tufts University School of Dental Medicine, Boston, MA

    Background/Purpose: Omic analyses of systemic sclerosis (SSc) skin biopsy datasets identified distinct sets of patients that respond differently to treatment. The goal of this study…
  • Abstract Number: 1852 • ACR Convergence 2021

    Healthcare Utilization and Economic Burden in Systemic Sclerosis

    Leonardo Martin Calderon1, Mitali Chaudhary1 and Janet Pope2, 1Western University, London, ON, Canada, 2University of Western Ontario, London, ON, Canada

    Background/Purpose: Systemic Sclerosis (SSc) is a multi-system autoimmune disease, characterized by vasculopathy, fibrosis of the skin and internal organs, and autoimmunity with distinct antibodies. SSc…
  • Abstract Number: 0180 • ACR Convergence 2021

    Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Computed Tomography in Patients with Systemic Sclerosis

    Attila Feher1, Nabil Boutagy1, Evangelos Oikonomou1, Stephanie Thorn1, Yi-Hwa Liu1, Edward Miller1, Albert Sinusas1 and Monique Hinchcliff2, 1Yale School of Medicine, New Haven, CT, 2Yale School of Medicine, Westport, CT

    Background/Purpose: To investigate the association between Raynaud phenomenon (RP) and coronary microvascular dysfunction, we measured myocardial flow reserve (MFR) using positron emission tomography/computed tomography (PET/CT)…
  • Abstract Number: 0556 • ACR Convergence 2021

    Investigating the Heterogeneity of Skin Macrophages in Systemic Scleroderma

    Hadijat Makinde1, Salina Dominguez1, Monique Hinchcliff2, Deborah Winter3 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Yale School of Medicine, Westport, CT, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: The etiology and pathogenesis of systemic sclerosis (SSc) are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes…
  • Abstract Number: 1854 • ACR Convergence 2021

    Disease Characteristics and Social Determinants in African Americans with Systemic Sclerosis: A Single Center Experience

    Sarah Compton, DeAnna Baker Frost, Richard Silver and Diane Kamen, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease categorized on the basis of skin involvement as either limited or diffuse cutaneous SSc, the latter…
  • Abstract Number: 0388 • ACR Convergence 2021

    Prediction Tool for Damage Accrual Trajectory in Incident Systemic Sclerosis

    Ariane Barbacki1, Ada Man2, Mianbo Wang3, Dylan Johnson4, Yuqing Zhang5, Mandana Nikpour6 and Murray Baron7, 1McGill University, Montral, Montréal, QC, Canada, 2University of Manitoba, Winnipeg, MB, Canada, 3Lady Davis institute for Medical Research, Montréal, QC, Canada, 4University of Alberta, Edmonton, AB, Canada, 5Massachusetts General Hospital, Quincy, MA, 6University of Melbourne at St Vincent's Hospital, Melbourne, Australia, 7Jewish General Hospital, Montréal, QC, Canada

    Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease associated with the accrual of organ damage over time, which can be measured using the Scleroderma…
  • Abstract Number: 0979 • ACR Convergence 2021

    Autoantibody Testing in Juvenile Localized Scleroderma and Systemic Sclerosis: Comparing Antibody Profiles and Clinical Correlations

    Jonathan Li1, Emily Mirizio1, Katherine Buhler2, May Choi3, Haiyan Hou2, Giffin Werner1, Anwesha Sanyal1, Kaila Schollaert-Fitch1, Marvin Fritzler2 and Kathryn Torok1, 1University of Pittsburgh, Pittsburgh, PA, 2University of Calgary, Calgary, AB, Canada, 3Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada

    Background/Purpose: Pediatric scleroderma encompasses juvenile onset localized scleroderma (jLS) and juvenile onset systemic sclerosis (jSSc), both of which present with varied cutaneous fibrosis and systemic…
  • Abstract Number: 1858 • ACR Convergence 2021

    Serum Interferon Score Is a Biomarker of Active Disease in Patients with Early Diffuse Cutaneous Systemic Sclerosis Enrolled in the Prospective Registry of Early Systemic Sclerosis (PRESS) Cohort

    Monique Hinchcliff1, Suiyuan Huang2, Shervin Assassi3, Elana Bernstein4, Flavia Castelino5, Robyn Domsic6, Tracy Frech7, Jessica Gordon8, Faye Hant9, Ami Shah10, Victoria Shanmugam11, Virginia Steen12, Dinesh Khanna2 and Francesco Del Galdo13, 1Yale School of Medicine, Westport, CT, 2University of Michigan, Ann Arbor, MI, 3University of Texas McGovern Medical School at Houston, Houston, TX, 4Columbia University, New York, NY, 5Massachusetts General Hospital, Boston, MA, 6University of Pittsburgh, Pittsburgh, PA, 7University of Utah, Salt Lake City, UT, 8Hospital for Special Surgery, New York, NY, 9Medical University of South Carolina, Charleston, SC, 10Johns Hopkins Rheumatology, Baltimore, MD, 11The George Washington University, Great Falls, VA, 12Division of Rheumatology, Georgetown University, Washington, DC, 13University of Leeds, Leeds, United Kingdom

    Background/Purpose: Several published studies have demonstrated activation of the interferon type 1 (IFN) pathway in sera from patients with systemic sclerosis (SSc). Specifically, levels of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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