Abstracts tagged "Scleroderma, Systemic"

Abstract Number: 0548 • ACR Convergence 2021
Rapamycin Blocks the Profibrotic Effects of Fli1 Downregulation in Scleroderma Myeloid Cells
Fatima El-adili, Grace Marden, Maria Trojanowska and Andreea Bujor, Boston University School of Medicine, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune fibrotic disease with unclear pathogenesis and no effective therapies. Increased proportion of CD163-positive, profibrotic macrophages has been described…
Abstract Number: 1836 • ACR Convergence 2021
Outcomes Linked to Eligibility for Stem Cell Transplantation Trials in Diffuse Cutaneous Systemic Sclerosis
Julia Spierings¹, Svetlana Nihtyanova², Emma Derrett-Smith³, Kristina Clark², Jacob van Laar⁴, Voon Ong⁵ and Christopher Denton⁶, ¹University Medical Center Utrecht, Utrecht, Netherlands, ²University College London, Royal Free Campus, London, United Kingdom, ³University College London Division of Medicine, London, United Kingdom, ⁴University Medical Centre Utrecht, Utrecht, Netherlands, ⁵University College London Medical School Royal Free Campus, London, United Kingdom, ⁶University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom
Background/Purpose: Autologous haematopoietic stem cell transplantation (SCT) has emerged as an effective treatment for patients with severe diffuse systemic sclerosis (dcSSc) based upon the results…
Abstract Number: 0552 • ACR Convergence 2021
Long Non-coding RNA H19X as a Regulator of Endothelial Adhesion Molecules in Systemic Sclerosis
Francesca Tirelli¹, Elena Pachera¹, Robert Lafyatis², Menqi Huang³, Francesco Zulian⁴, Gabriela Kania¹ and Oliver Distler⁵, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ²University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology Unit, Department of Woman and Child Health - University of Padova, Padova, Italy, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland
Background/Purpose: Long non-coding RNAs (lncRNAs) are non-coding transcripts involved in the regulation of gene expression; their role in disease development, to date, remains largely under…
Abstract Number: 1843 • ACR Convergence 2021
Perceptions and Concerns Regarding COVID-19 Vaccination in Patients with Systemic Sclerosis in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort
Jessica Gordon¹, Kimberly Showalter¹, Yin Wu², Linda Kwakkenbos³, Marie-Eve Carrier⁴, Richard Henry², Nora Østbø², Julia Nordlund², Angelica Bourgeault², Mara Canedo Ayala², Marie-Nicole Discepola², Andrea Carboni Jiménez², Christopher Denton⁵, Luc Mouthon⁶, Brett Thombs⁷ and Robert Spiera¹, ¹Hospital for Special Surgery, New York, NY, ²Lady Davis Institute of the Jewish General Hospital, Montréal, QC, Canada, ³Department of Clinical Psychology, Radboud University Behavioural Science Institute, Nijmegen, Netherlands, ⁴Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada, ⁵University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ⁶Hopital Cochin - Paris University, Paris, France, ⁷Lady Davis Institute for Medical Research, Jewish General Hospital; Department of Psychiatry, McGill University, Montréal, QC, Canada
Background/Purpose: Hesitancy about COVID-19 vaccination exists among patients with rheumatic and musculoskeletal diseases, but previous studies have not assessed this specifically in patients with systemic…
Abstract Number: 0553 • ACR Convergence 2021
IgG from Systemic Sclerosis Patients Induce a Profibrosing and Serotype-dependent Phenotype in Normal Dermal Fibroblast: A Multi-omics Study
Aurélien Chepy¹, Solange Vivier², Fabrice Bray³, Martin Figeac⁴, Jean-Pascal Meneboo⁴, Camille Ternynck⁵, Lucile Guilbert², Manel Jendoubi², Christian Rolando³, David Launay¹, Sylvain Dubucquoi⁶, Guillemette Marot⁵ and Vincent Sobanski¹, ¹Univ. Lille, Inserm, CHU Lille, Service de Médecine Interne, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France, Lille, France, ²Univ. Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F59000 Lille, France, Lille, France, ³Univ. Lille, CNRS, USR 3290 - MSAP - Miniaturisation pour la Synthèse, l'Analyse et la Protéomique, F-59000 Lille, France, Lille, France, ⁴Université de Lille, Functional Genomics Platform, Lille, France., Lille, France, ⁵ULR 2694 – METRICS : évaluation des technologies de santé et des pratiques médicales, université de Lille, CHU de Lille, 59000 Lille, France, Lille, France, ⁶Univ. Lille, U1286 – INFINITE – Institute for Translational Research in Inflammation, F59000 Lille, France, Lille
Background/Purpose: Antinuclear antibodies are frequent in systemic sclerosis (SSc). While recognized as potent biomarkers, their pathogenic role is much more debated. This study explored the…
Abstract Number: 1847 • ACR Convergence 2021
Severity of Gastroesophageal Reflux, but Not the Use of Proton Pump Inhibitors, Is Associated with Radiographic Progression of Interstitial Lung Disease in Systemic Sclerosis
Elizabeth Volkmann¹, Donald Tashkin², Mei Leng², Grace Kim², Jonathan Goldin² and Michael Roth², ¹Department of Medicine, Division of Rheumatology, University of California, David Geffen School of Medicine, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, CA
Background/Purpose: Esophageal dysmotility is a common feature of systemic sclerosis (SSc) and aspiration of gastric contents may serve as an inciting and/or exacerbating factor in…
Abstract Number: 0179 • ACR Convergence 2021
Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging Predicts Adverse Events in Patients with Autoimmune Rheumatic Disease
Attila Feher¹, Nabil Boutagy¹, Evangelos Oikonomou¹, Yi-Hwa Liu¹, Edward Miller¹, Albert Sinusas¹ and Monique Hinchcliff², ¹Yale School of Medicine, New Haven, CT, ²Yale School of Medicine, Westport, CT
Background/Purpose: Coronary microvascular dysfunction (CMVD) has been described in patients with autoimmune rheumatic disease (ARD). By noninvasive evaluation of myocardial blood flow (MBF) and myocardial…
Abstract Number: 0555 • ACR Convergence 2021
Pathway-Driven Drug Repositioning in Systemic Sclerosis from Omics Data
Dillon Popovich¹, Tamar Abel¹, Noelle Kosarek², Monica Espinoza³, Rezvan Parvizi⁴, Jonathan Garlick⁵ and Michael Whitfield⁴, ¹Geisel School of Medicine, West Lebanon, NH, ²Dartmouth Geisel School of Medicine, Hartford, VT, ³Geisel School of Medicine, Hanover, NH, ⁴Geisel School of Medicine, Lebanon, NH, ⁵Tufts University School of Dental Medicine, Boston, MA
Background/Purpose: Omic analyses of systemic sclerosis (SSc) skin biopsy datasets identified distinct sets of patients that respond differently to treatment. The goal of this study…
Abstract Number: 1852 • ACR Convergence 2021
Healthcare Utilization and Economic Burden in Systemic Sclerosis
Leonardo Martin Calderon¹, Mitali Chaudhary¹ and Janet Pope², ¹Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada
Background/Purpose: Systemic Sclerosis (SSc) is a multi-system autoimmune disease, characterized by vasculopathy, fibrosis of the skin and internal organs, and autoimmunity with distinct antibodies. SSc…
Abstract Number: 0180 • ACR Convergence 2021
Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Computed Tomography in Patients with Systemic Sclerosis
Attila Feher¹, Nabil Boutagy¹, Evangelos Oikonomou¹, Stephanie Thorn¹, Yi-Hwa Liu¹, Edward Miller¹, Albert Sinusas¹ and Monique Hinchcliff², ¹Yale School of Medicine, New Haven, CT, ²Yale School of Medicine, Westport, CT
Background/Purpose: To investigate the association between Raynaud phenomenon (RP) and coronary microvascular dysfunction, we measured myocardial flow reserve (MFR) using positron emission tomography/computed tomography (PET/CT)…
Abstract Number: 0556 • ACR Convergence 2021
Investigating the Heterogeneity of Skin Macrophages in Systemic Scleroderma
Hadijat Makinde¹, Salina Dominguez¹, Monique Hinchcliff², Deborah Winter³ and Harris Perlman¹, ¹Northwestern University, Chicago, IL, ²Yale School of Medicine, Westport, CT, ³Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: The etiology and pathogenesis of systemic sclerosis (SSc) are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes…
Abstract Number: 1854 • ACR Convergence 2021
Disease Characteristics and Social Determinants in African Americans with Systemic Sclerosis: A Single Center Experience
Sarah Compton, DeAnna Baker Frost, Richard Silver and Diane Kamen, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease categorized on the basis of skin involvement as either limited or diffuse cutaneous SSc, the latter…
Abstract Number: 0388 • ACR Convergence 2021
Prediction Tool for Damage Accrual Trajectory in Incident Systemic Sclerosis
Ariane Barbacki¹, Ada Man², Mianbo Wang³, Dylan Johnson⁴, Yuqing Zhang⁵, Mandana Nikpour⁶ and Murray Baron⁷, ¹McGill University, Montral, Montréal, QC, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³Lady Davis institute for Medical Research, Montréal, QC, Canada, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Massachusetts General Hospital, Quincy, MA, ⁶University of Melbourne at St Vincent's Hospital, Melbourne, Australia, ⁷Jewish General Hospital, Montréal, QC, Canada
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease associated with the accrual of organ damage over time, which can be measured using the Scleroderma…
Abstract Number: 0979 • ACR Convergence 2021
Autoantibody Testing in Juvenile Localized Scleroderma and Systemic Sclerosis: Comparing Antibody Profiles and Clinical Correlations
Jonathan Li¹, Emily Mirizio¹, Katherine Buhler², May Choi³, Haiyan Hou², Giffin Werner¹, Anwesha Sanyal¹, Kaila Schollaert-Fitch¹, Marvin Fritzler² and Kathryn Torok¹, ¹University of Pittsburgh, Pittsburgh, PA, ²University of Calgary, Calgary, AB, Canada, ³Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada
Background/Purpose: Pediatric scleroderma encompasses juvenile onset localized scleroderma (jLS) and juvenile onset systemic sclerosis (jSSc), both of which present with varied cutaneous fibrosis and systemic…
Abstract Number: 1858 • ACR Convergence 2021
Serum Interferon Score Is a Biomarker of Active Disease in Patients with Early Diffuse Cutaneous Systemic Sclerosis Enrolled in the Prospective Registry of Early Systemic Sclerosis (PRESS) Cohort
Monique Hinchcliff¹, Suiyuan Huang², Shervin Assassi³, Elana Bernstein⁴, Flavia Castelino⁵, Robyn Domsic⁶, Tracy Frech⁷, Jessica Gordon⁸, Faye Hant⁹, Ami Shah¹⁰, Victoria Shanmugam¹¹, Virginia Steen¹², Dinesh Khanna² and Francesco Del Galdo¹³, ¹Yale School of Medicine, Westport, CT, ²University of Michigan, Ann Arbor, MI, ³University of Texas McGovern Medical School at Houston, Houston, TX, ⁴Columbia University, New York, NY, ⁵Massachusetts General Hospital, Boston, MA, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of Utah, Salt Lake City, UT, ⁸Hospital for Special Surgery, New York, NY, ⁹Medical University of South Carolina, Charleston, SC, ¹⁰Johns Hopkins Rheumatology, Baltimore, MD, ¹¹The George Washington University, Great Falls, VA, ¹²Division of Rheumatology, Georgetown University, Washington, DC, ¹³University of Leeds, Leeds, United Kingdom
Background/Purpose: Several published studies have demonstrated activation of the interferon type 1 (IFN) pathway in sera from patients with systemic sclerosis (SSc). Specifically, levels of…

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