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Abstracts tagged "Scleroderma, Systemic"

  • Abstract Number: 0383 • ACR Convergence 2020

    Sex Differences in Severity and Progression of Interstitial Lung Disease in Systemic Sclerosis: What We Have Learned from Clinical Trials

    Elizabeth Volkmann1, Ning Li2, Michael Roth2, Carol Feghali-Bostwick3, Richard Silver4, DeAnna Baker Frost5, Shervin Assassi6, Grace Kim2, Jonathan Goldin2 and Donald Tashkin2, 1University of California, Los Angeles, Los Angeles, CA, 2University of California, Los Angeles, Los Angeles, 3The Medical University of South Carolina, Charleston, SC, 4Medical University of South Carolina, Charleston, 5The Medical University of South Carolina, Charleston, 6University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX

    Background/Purpose: Although systemic sclerosis (SSc) disproportionately affects females compared with males [1], observational studies have demonstrated higher mortality rates in males with SSc [2]. This…
  • Abstract Number: 1172 • ACR Convergence 2020

    Cardiovascular involvement as a clue for diagnosis of Juvenile Systemic Sclerosis sine scleroderma

    Gloria Lanzoni1, Giorgia Martini1, Alessandra Meneghel1, Fabio Vittadello2, Biagio Castaldi1, Elisabetta Zanatta3 and Francesco Zulian1, 1Department of Woman's and Child's Health, University of Padova, Padua, Italy, 2Centro Studi Statistici Explora, Padua, Italy, 3Department of Medicine-DIMED, University of Padova, Padua, Italy

    Background/Purpose: Juvenile Systemic Sclerosis (JSSc) is a rare condition in childhood and its variety with no skin involvement, systemic sclerosis sine scleroderma (JSSSS) is anecdotal…
  • Abstract Number: 0384 • ACR Convergence 2020

    Serum Neutrophil Count Predicts Progression of Interstitial Lung Disease and Mortality in Patients with Systemic Sclerosis Related Interstitial Lung Disease

    Nancy Wareing1, Ning Li2, Elizabeth Volkmann3, Marka Lyons4, Michael Roth2, Donald Tashkin2 and Shervin Assassi1, 1University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, 2University of California, Los Angeles, Los Angeles, 3University of California, Los Angeles, Los Angeles, CA, 4University of Texas Houston, McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX

    Background/Purpose: Systemic sclerosis (SSc) patients have a prominent neutrophil gene expression signature.  However, investigations into the pathophysiologic role of neutrophils in SSc are lacking. This…
  • Abstract Number: 1173 • ACR Convergence 2020

    No Disease Progression After 36 Months Follow up in the Juvenile Systemic Scleroderma Inception Cohort

    Ivan Foeldvari1, Jens Klotsche2, Ozgur Kasapcopur3, Amra Adrovic4, Maria Teresa Terreri5, Edoardo Marrani6, Tadej Avcin7, Maria Katsicas8, Dana Nemcova9, Maria Jose Santos10, Jürgen Brunner11, Tilmann Kallinich12, Mikhail Kostik13, Kirsten Minden14, Anjali Patwardhan15, Kathryn Torok16 and Nicola Helmus17, 1Head of the Hamburg Centre for Pediatric and Adolescence Rheumatology, Budapest, Hungary, 2German Rheumatism Research Center, Berlin, Germany, 3PRINTO, Istituto Giannina Gaslini, Genova, Italy, 4Cerrahpaşa Tıp Fakültesi, Istanbul, Turkey, 5Federal University of São Paulo, São Paulo, Brazil, 6University of Florence, Firenze, Italy, 7Ljubljana University Medical Centre, Ljubljana, Slovenia, 8Hospital de Pediatria, Buenos Aires, Argentina, 9General University Hospital, Prague, Czech Republic, 10Hospital Garcia de Orta, Almada, Portugal, 11Tirol Kliniken, Innsbruck, Innsbruck, Austria, 12Charite, Berlin, Germany, 13Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 14Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, 15University of Missouri, Columbia, 16University of Pittsburgh, Pittsburgh, PA, 17Hamburg Centre for Pediatric and Adolescence Rheumatology, Hamburg, Germany

    Background/Purpose: Juvenile systemic scleroderma (jSSc) is an orphan disease with a prevalence of 3 in 1 000 000 children. Longitudinal prospective follow up data of…
  • Abstract Number: 0392 • ACR Convergence 2020

    Prevalence and Survival of Systemic Sclerosis (SSc) and Associated Interstitial Lung Disease (ILD) in Ontario, Canada over 10 Years

    Janet Pope1, Kobina Quansah2, Martin Kolb3, Jason Flavin4, Hassan Shazia5 and Soo Jin Seung5, 1Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, 2Boehringer Ingelheim (Canada) Limited, Burlington, ON, Canada, 3McMaster University and Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamliton, ON, Canada, 4Boehringer Ingelheim, Corporate Headquarters, Burlington, ON, Canada, 5HOPE Research Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by skin thickening, vascular lesions and fibrotic changes in various organs, mainly the lungs, heart, intestinal…
  • Abstract Number: 1384 • ACR Convergence 2020

    Usage, Needs and Preferences Regarding Physical Therapy in Patients with Systemic Sclerosis

    Sophie Liem1, Nina van Leeuwen2, Thea Vliet Vlieland3, Lian de Pundert4, Rita Schriemer5, Julia Spierings6, Madelon Vonk7 and Jeska de Vries-Bouwstra1, 1Leiden University Medical Center, Leiden, Netherlands, 2LUMC, Leiden, Netherlands, 3Leiden University Medical Center, 2300 RC Leiden, Netherlands, 4HAGA Hospital, The Hague, Netherlands, 5NVLE, Utrecht, 6University Medical Center Utrecht, Maastricht, Netherlands, 7Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen, Netherlands

    Background/Purpose: The importance of non-pharmacologic interventions in systemic sclerosis (SSc) is increasingly recognized. Physical therapy is among the most frequently used interventions, but knowledge on…
  • Abstract Number: 0394 • ACR Convergence 2020

    Prevalence of a Diagnosis of Osteopenia/Osteoporosis Amongst Patients with Systemic Sclerosis and Identification of Associated Clinical Factors

    Guanying Wang1, Diane Mar2, Joy Wu3, Julia Simard4, Rita Popat1 and Lorinda Chung5, 1Department of Epidemiology & Population Health, Stanford University School of Medicine, Palo Alto, CA, 2Stanford Department of Immunology/Rheumatology, Palo Alto, CA, 3Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Palo Alto, CA, 4Stanford Medicine, Stanford, CA, 5Stanford University School of Medicine and Palo Alto VA Health Care System, Palo Alto, CA

    Background/Purpose: This study aims to determine the prevalence of a diagnosis of osteopenia/osteoporosis (OP) in systemic sclerosis (SSc) patients and to identify the clinical and…
  • Abstract Number: 1385 • ACR Convergence 2020

    Physical Therapy in Patients with Systemic Sclerosis: The Perspective of Physical Therapists on Current Delivery and Educational Needs

    Sophie Liem1, Nina van Leeuwen2, Thea Vliet Vlieland3, Lian de Pundert4, Rita Schriemer5, Julia Spierings6, Madelon Vonk7 and Jeska de Vries-Bouwstra1, 1Leiden University Medical Center, Leiden, Netherlands, 2LUMC, Leiden, Netherlands, 3Leiden University Medical Center, 2300 RC Leiden, Netherlands, 4HAGA Hospital, The Hague, Netherlands, 5NVLE, Utrecht, 6University Medical Center Utrecht, Maastricht, Netherlands, 7Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen, Netherlands

    Background/Purpose: As there is currently no cure available for systemic sclerosis (SSc), nonpharmacologic care is an essential element in the management of the disease. Physical…
  • Abstract Number: 0402 • ACR Convergence 2020

    Optical Coherence Tomography of the Skin Detects Scleroderma Changes in Clinically Unaffected Skin: An Opportunity for Early Detection of Systemic Sclerosis

    Giuseppina Abignano1, Duygu Temiz Karadag2, Ozcan Gundogdu3, Giovanni Lettieri4, Maria Carmela Padula5, Angela A Padula5, Paul Emery6, Salvatore D'Angelo5 and Francesco Del Galdo6, 1Rheumatology Institute of Lucania (IReL), Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Potenza, Italy, 2Rheumatology Institute of Lucania (IReL), Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy and Department of Rheumatology, Kocaeli University, Kocaeli, Turkey, Kocaeli, Turkey, 3Department of Biomedical Engineering, Kocaeli University, Kocaeli,Turkey, Kocaeli, Turkey, 4Radiology Department, San Carlo Hospital, Potenza, Italy, Potenza, Italy, 5Rheumatology Institute of Lucania (IReL), Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy, Potenza, Italy, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: The Very Early Diagnosis Of Systemic Sclerosis (VEDOSS) study has shown that more than 80% of patients with Raynaud’s Phenomenon, specific ANA positivity and…
  • Abstract Number: 1389 • ACR Convergence 2020

    Clinical Characteristics and Treatment Outcome of a Cohort of Patients with Joint and Fascial Involvement in the Context of Chronic Graft versus Host Disease

    Cristina Hidalgo Calleja1, Concepción Román Curto2, Luis Gómez-Lechón3, Maria Elisa Acosta2, Olga Compán4, Sonia Pastor2, Carlos Montilla Morales2, Lucía Pantoja Zarza5, María Dolores Sánchez González6 and Lucía López Corral2, 1Hospital Universitario Salamanca, Salamanca, Spain, 2Hospital Universitario de Salamanca, Salamanca, Spain, 3Hospital Francesc de Borga de Gandía, Valencia, Spain, 4Hospital Universitario de Salamanca, ´Salamanca, Spain, 5Complejo Asistencial Hospital General de Segovia, Segovia, Spain, 6Hospital Clínico Universitario de Valladolid, Valladolid, Spain

    Background/Purpose: Chronic graft-vs-host disease (cGVHD) is a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT), typically occurring within three years post-transplant and affecting…
  • Abstract Number: 0916 • ACR Convergence 2020

    Validating Autoantibody Associations and Clinical Impact of Severe Gastrointestinal Involvement in Systemic Sclerosis

    Fiza Ahmed1, Svetlana Nihtyanova1, Stamatia Chatzinikolaou2, Voon Ong1, Charles Murray2 and Christopher Denton3, 1Centre for Rheumatology, Royal Free Campus, UCL Division of Medicine, UK, London, United Kingdom, 2Department of Gastroenterology, Royal Free London Foundation Trust, UK, London, United Kingdom, 3University College London, London, United Kingdom

    Background/Purpose: Patients with systemic sclerosis (SSc) frequently experience gastrointestinal (GI) symptoms, ranging from mild to debilitating in severity. Better prediction of those most at risk…
  • Abstract Number: 1390 • ACR Convergence 2020

    Outcomes of Systemic Sclerosis Patients Who Were Primarily Admitted for Acute Myocardial Infarction from 2016 to 2017: Insights from the National Inpatient Sample

    Atefeh Vafa1, Omid Behnamfar2 and Yih Chang Lin3, 1University of South Florida, Tampa, FL, 2University of California San Diego, La Jolla, CA, 3University of South Florida, Morsani College of Medicine, Tampa, FL

    Background/Purpose: Several systemic autoimmune rheumatic diseases have been shown to increase coronary artery disease (CAD) risk, notable rheumatoid arthritis and systemic lupus erythematosus.  However, data…
  • Abstract Number: 0919 • ACR Convergence 2020

    Determinants of Health-related Quality of Life in Systemic Sclerosis

    Nina van Leeuwen1, Jacopo Ciaffi2, Sophie Liem2, Thomas Huizinga2 and Jeska de Vries-Bouwstra2, 1LUMC, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Systemic Sclerosis (SSc) is a heterogeneous disease, in which multiple manifestations are associated with considerable morbidity and mortality. Cross sectional studies have shown that…
  • Abstract Number: 1391 • ACR Convergence 2020

    Associations Between Autoantibodies in Systemic Sclerosis and Cancer in a National Registry

    Selma Lazizi1, Marie Hudson2, Murray Baron3, Marvin Fritzler4 and Sabrina Hoa5, 1Université de Montréal, Montreal, QC, Canada, 2Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, 3Jewish General Hospital, Montreal, QC, Canada, 4Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 5Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada

    Background/Purpose: Autoantibodies are useful in systemic sclerosis (SSc) for predicting disease course. Some autoantibodies have been associated with a close temporal relationship with cancer. We…
  • Abstract Number: 0920 • ACR Convergence 2020

    Machine Learning Assisted Prediction of Progression in Systemic Sclerosis Patients: An Approach to Concise, Tailored Model Construction Using Outpatient Clinical Data

    Nina van Leeuwen1, Marc Maurits2, Sophie Liem2, Jacopo Ciaffi2, Nina Ajmone Marsan2, Maarten Ninaber2, Thomas Huizinga2 and Jeska de Vries-Bouwstra2, 1LUMC, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Systemic Sclerosis (SSc) disease course can range from mild, to very severe with progressive organ involvement within months. Guidelines for follow-up are mainly based…
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ACR Pediatric Rheumatology Symposium 2020

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