ACR Meeting Abstracts

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Abstracts tagged "Scleroderma, Systemic"

  • Abstract Number: 2472 • ACR Convergence 2024

    Are Anti-centromere Antibodies (aCENP) Predictive of Systemic Sclerosis Development in Patients Without Raynaud´s Phenomenon?

    Andrea Alvear-Torres1, María José Martínez-Becerra2, María Carmen Vegas-Sánchez3, Sheila Recuero-Díaz1, María Pérez-ferro4 and Olga Sánchez-Pernaute5, 1Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD, Madrid, Spain, 2Department of Immunology. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD, Madrid, Spain, 3Hospital Universitario Fundación Jiménez Díaz and IIS-FJD, Madrid, Spain, 4Department of Rheumatology. Hospital Universitario Rey Juan Carlos, Madrid, Spain, 5Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain

    Background/Purpose: Anti-centromere (aCENP) antibodies are considered highly specific of systemic sclerosis (SSc), typically defining a limited cutaneous phenotype, usually associated to Raynaud´s phenomenon (RP). It…
  • Abstract Number: L06 • ACR Convergence 2023

    Improvement in Clinical and Patient-Reported Outcomes for Refractory Juvenile-Onset Systemic Sclerosis (jSSc) 6 Months to 2 Years After Autologous Stem Cell Transplantation (ASCT)

    Kathryn Torok1, Paulina Horvei1, Franziska Rosser1, Kirsten Rose-felker2, Vibha Sood2, Adam Olsen2, Nicole Hogue2, Vickie Vandergrift2, Lauren Farver2, Devin Mcguire2, Jonathan Li3, Haley Havrilla2, Jessie Alexander4, Shawna McIntyre2 and Paul Szabolcs1, 1University of Pittsburgh; UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 2UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, 3University of Pittsburgh Medical Center, Pittsburgh, PA, 4Stanford Children's Hospital, Palo Alto, CA

    Background/Purpose: Juvenile-onset systemic sclerosis (jSSc) is an inflammatory, fibrotic, and vasculopathic disease that causes severe multi-organ dysfunction leading to significant morbidity and early mortality.When patients…
  • Abstract Number: 0638 • ACR Convergence 2023

    Application of the 2022 European Society of Cardiology (ESC) Risk Assessment Model in Australian and Singaporean Systemic Sclerosis Patients with Newly Diagnosed Pulmonary Arterial Hypertension (PAH)

    Zoe Brown1, Dylan Hansen2, Wendy Stevens3, Nava Ferdowsi4, laura ross5, Alannah Quinlivan6, Joanne Sahhar7, Gene-Siew Ngian7, Diane Apostolopoulos7, Jennifer G Walker8, Susanna Proudman9, Gim Gee Teng10, Andrea Hsiu Ling Low11, Kathleen Morrisroe12 and Mandana Nikpour13, 1The University of Melbourne, Armadale, Australia, 2Department of Rheumatology, St Vincent’s Hospital Melbourne, Fitzroy, Australia, 3Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Australia, 4St Vincents Hospital, Kew, Australia, 5St. Vincent's Hospital Melbourne, Fitzroy, Australia, 6St Vincent's Hospital Melbourne, Highett, Australia, 7Monash Health and Monash University, Clayton, Australia, 8Royal Adelaide Hospital, Adelaide, Australia, 9Royal Adelaide Hospital and University of Adelaide, Adelaide, Australia, 10Alexandra Hospital, Department of Medicine, Division of Rheumatology, National University Health System, Singapore, Singapore, 11Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, 12The University of Melbourne at St Vincent’s Hospital Melbourne, Fitzroy, Australia, 13The University of Melbourne at St. Vincent’s Hospital Melbourne, Departments of Medicine and Rheumatology, Melbourne, Australia

    Background/Purpose: Pulmonary arterial hypertension (PAH) patients can be stratified as low, intermediate, or high risk of 1-year mortality based on clinical, biochemical and haemodynamic prognostic…
  • Abstract Number: 1702 • ACR Convergence 2023

    Outcomes in Systemic Sclerosis Patients Treated with Rituximab and Mycophenolate Mofetil Combination Therapy Compared to Autologous Hematological Stem Cell Transplantation

    shiri keret1, Lisa Kaly2, Aniela Shouval2, Tsila Zuckerman3, Israel Henig4, Abid Awisat5, Itzhak Rosner6, Michel Rozenbaum2, Nina Boulman2, Yair Molad7, ariela Dortort Lazar8, Gleb Slobodin2 and Doron Rimar2, 1Bnai Zion, Atlit, Israel, 2Bnai Zion Medical Center, Haifa, Israel, 3Hematology department, Rambam Medical Center, Haifa, Israel, 4Stem cell transplantation unit, Hematology department, Rambam Medical Center, Haifa, Israel, 5Bney-Zion Medical Center, Baqa Elgharbiya, Israel, 6Bnai Zion Medical Center/Technion, Haifa, Israel, 7Rabin Medical Center, Beilinson Hospital, and Tel Aviv University, Petah-Tikva, Israel, 8Rabin Medical Center and Tel Aviv university, Tel Aviv, Israel

    Background/Purpose: Autologous hematological stem cell transplantation (AHSCT) is a grade A therapy for early diffuse progressive systemic sclerosis (SSc), that has been validated in three…
  • Abstract Number: 0639 • ACR Convergence 2023

    Evaluating Esophageal Dysmotility by Scintigraphy in Systemic Sclerosis: Subsets and Phenotypes

    Antonio Salas1, Lisa Yanek2 and Zsuzsanna McMahan3, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine Department of Medicine, Baltimore, MD, 3Johns Hopkins Rheumatology, Lutherville, MD

    Background/Purpose: Gastrointestinal (GI) dysmotility affects most patients with systemic sclerosis (SSc), and the esophagus is the most commonly affected region. While most SSc patients are…
  • Abstract Number: 1703 • ACR Convergence 2023

    Increased Mortality and Cardiovascular Events in Male Patients with Systemic Sclerosis: Left Ventricular Global Longitudinal Strain as Possible Screening Tool

    Jeska de Vries-Bouwstra1, Tea Gegenava2, Federico Fortuni3, Nina Van Leeuwen4, Anders Tennoe5, Anna Maria Hoffmann-Vold6, Ruxandra Jurcut7, Adrian Giuca7, Laura Groseanu8, Felix Tanner9, Oliver Distler10, Jeroen Bax11 and Nina Ajmone Marsan11, 1Leiden University Medical Center, Leiden, Netherlands, 2Department of Cardiology, Heart Lung Centre, Leiden University Medical Centre; Department of Internal Medicine,Tbilisi State Medical University, Tbilisi, Georgia, 3Department of Cardiology, San Giovanni Battista Hospital, Foligno, Italy, 4Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 5Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 6Oslo University Hospital, Department of Rheumatology, Oslo, Norway, 7Department of Cardiology, Emergency Institute for Cardiovascular Diseases “Prof .Dr. C. C. Iliescu”, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania, 8University of Medicine and Pharmacy "Carol Davila", Department of Internal Medicine -Rheumatology; Santa Maria Clinical Hospital, Internal Medicine and Rheumatology, Bucharest, Romania, 9Department of Cardiology, University Heart Centre, University Hospital Zurich, Zurich, Switzerland, 10Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 11Department of Cardiology, Heart Lung Centre, Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: Systemic sclerosis (SSc) is less frequent in males, but the risk of severe outcomes is higher in males than in females(1). Seven to 30%…
  • Abstract Number: 0646 • ACR Convergence 2023

    Racial Variability in Immune Responses Only Partially Explains Differential Systemic Sclerosis Disease Severity

    Kamini Kuchinad1, Ji Soo Kim1, Adrianne Woods1, Gwen Leatherman1, Laura Gutierrez2, Maureen Mayes3, Robyn Domsic4, Paula Ramos5, Richard Silver5, John Varga6, Lesley Ann Saketkoo7, Suzanne Kafaja8, Victoria Shanmugam9, Jessica Gordon10, Lorinda Chung11, Elana Bernstein12, Pravitt Gourh13, Francesco Boin14, Daniel Kastner15, Scott Zeger16, Livia Casciola-Rosen1, Fred Wigley1 and Ami Shah17, 1Department of Rheumatology, Johns Hopkins Medicine, Baltimore, MD, 2Johns Hopkins Medicine, Baltimore, MD, 3Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX, 4University of Pittsburgh, Pittsburgh, PA, 5Medical University of South Carolina, Charleston, SC, 6University of Michigan, Ann Arbor, MI, 7University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 8UCLA Department of Medicine, Division of Rheumatology, Los Angeles, CA, 9Victoria Shanmugam, MD, Great Falls, VA, 10Hospital for Special Surgery, New York, NY, 11Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA, 12Columbia University, New York, NY, 13National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 14Cedars-Sinai Medical Center, Los Angeles, CA, 15National Human Genome Research Institute, Bethesda, MD, 16Johns Hopkins University, Baltimore, MD, 17Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Ellicott City, MD

    Background/Purpose: Individuals with self-identified Black race have a higher incidence of systemic sclerosis (SSc), develop SSc at a younger age, and have a more severe…
  • Abstract Number: 1714 • ACR Convergence 2023

    Aberrant Myeloid Populations in the TNF-Transgenic Model of Pulmonary Hypertension Overexpress Interferon Pathways and Are Driven by TNFR1 Signaling

    Gaochan Wang1, Qingfu Xu2, Stacey Duemmel1 and Benjamin Korman1, 1University of Rochester, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Pulmonary hypertension (PH) is a severe, progressive disorder characterized by elevated pulmonary artery pressures, right ventricular hypertrophy, and increased mortality. We previously demonstrated that…
  • Abstract Number: 0654 • ACR Convergence 2023

    Comparison of Cardiovascular Risk in Patients with Systemic Sclerosis and the General Population

    Sabina Oreska1, Hana Storkanova1, Jaroslav Kudlicka2, Vladimir Tuka2, Ondrej Mikes2, Zdislava Krupickova2, Martin Satny2, Eva Chytilova2, Jan Kvasnicka2, Maja Spiritovic3, Barbora Hermankova4, Petr Cesak5, Marian Rybar6, Karel Pavelka7, Ladislav Senolt8, Radim Becvar9, Jiri Vencovsky1, Michal Vrablik2 and Michal Tomcik1, 1Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 23rd Department of Internal Medicine, General University Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic, Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, 4Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, 5Department of Human Movement Laboratory, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, 6Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic, 7Institut of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Praha, Czech Republic, 8Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Praha, Czech Republic, 9Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Praha, Czech Republic

    Background/Purpose: Patients with systemic sclerosis (SSc) may be burdened by increased cardiovascular (CV) risk due to accelerated atherosclerosis (ATS) due to systemic inflammation, and vascular…
  • Abstract Number: 2037 • ACR Convergence 2023

    Assessing Risk of Depression in Common Rheumatologic Disorders Using Diagnostic Codes, Survey Scores, and Propensity Score Matching Methodology

    COMFORT ANIM-KORANTENG1, YONG EUN2, Okeoghene Akpoigbe2 and AMANDA SAMMUT2, 1Harlem Hospital Center, New York, NY, 2NYCHH- HARLEM, New York, NY

    Background/Purpose: Many studies have shown that rheumatologic conditions are associated with a higher risk of depression. The two most common methods to detect depression in…
  • Abstract Number: 0664 • ACR Convergence 2023

    Quantitative Hand Held Dynamometry to Assess Muscle Strength in Scleroderma Associated Myopathy

    Julie Paik1, Christopher Mecoli2, Anshula Nallapati1, Ami Shah3, Fred Wigley4, Zsuzsanna McMahan5 and Laura Hummers1, 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Ellicott City, MD, 4Department of Rheumatology, Johns Hopkins Medicine, Baltimore, MD, 5Johns Hopkins Rheumatology, Lutherville, MD

    Background/Purpose: Manual muscle strength testing can be challenging in SSc associated myopathy (SSc-AM) due to contractures or skin tightening. Since there is currently no validated…
  • Abstract Number: 2090 • ACR Convergence 2023

    Adaptation of the Making it WorkTM for People with Systemic Sclerosis

    Janet Poole1, Kristine Carandang2, Mary Thelander Hill1, Anna Koch3, Pamela Rogers4 and Diane Lacaille5, 1University of New Mexico, Albuquerque, NM, 2University of Wisconsin, San Diego, CA, 3New Mexico Highlands University, Rio Rancho, NM, 4Arthritis Research Canada, Richmond, BC, Canada, 5Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Systemic sclerosis (SSc) limits participation in paid employment, threatening well-being. Few resources exist to help people with SSc remain in the work force despite…
  • Abstract Number: 0127 • ACR Convergence 2023

    Time Trends, Cumulative Incidence, and Impact on Survival of Interstitial Lung Disease in Systemic Sclerosis: Results from a Population-based Cohort Study

    Anukul Karn1, Sara Achenbach2, Alicia Hinze3, Cynthia Crowson1 and Ashima Makol2, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, MN, Rochester, MN, 3Mayo Clinic - Rochester, MN, Rochester, MN

    Background/Purpose: Cardiopulmonary complications are the number one cause of mortality in Systemic sclerosis (SSc). We studied the prevalence, cumulative incidence, predictors and impact of interstitial…
  • Abstract Number: 0792 • ACR Convergence 2023

    Single Cell RNA-seq of Myeloid Cells from Systemic Sclerosis Patients Identifies Circulating Monocyte Population with Interferon Signature Associated with Interstitial Lung Disease

    Richard Ainsworth1, Kim Taylor2, Ye Cao3, Takanori Sasaki4, Deepak Rao5, Nunzio Bottini6 and Francesco Boin1, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2University of California San Francisco, San Francisco, CA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Brigham and Women's Hospital, Boston, MA, 6University of California, San Francisco, CA

    Background/Purpose: Growing evidence supports a critical role for innate immunity in systemic sclerosis (SSc) pathogenesis. Altered myeloid cell numbers and functions have been implicated in…
  • Abstract Number: 2352 • ACR Convergence 2023

    High Serum C-X-C Motif Chemokine Ligand 10 (CXCL10) Potentially Predicts New Onset of Systemic Sclerosis-Interstitial Lung Disease

    Yehya Al-Adwi, Isabella Atzeni, Berber Doornbos-van der Meer, Marcel J van der Leij, Bart-Jan Kroesen, Alja Stel, Wim Timens, C.Tji Gan, Harry van Goor, Johanna Westra and Douwe J Mulder, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Systemic sclerosis-interstitial lung disease (SSc-ILD) is the leading cause of death in SSc patients. There is an unmet need for predictive biomarkers of ILD…
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