Abstract Number: 1992 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor (A2AR) Stimulation Mitigates Mitochondrial Inflammaging, Enhances Mitochondrial Metabolism and Reduces Reactive Oxygen Species-Mediated Mitochondrial Injury In Vitro and In Vivo in Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 10% of the US population and one of the contributing factors in OA…Abstract Number: 1999 • 2019 ACR/ARP Annual Meeting
NADPH Oxidase 4 Regulates the Migration and Invasion of Synoviocytes in Rheumatoid Arthritis Through Pro-angiogenic Factor Secretion
Background/Purpose: Fibroblast-like synoviocytes (FLS) are key effector cells in the pathogenesis of rheumatoid arthritis (RA) through the increased cell migration, degradation of extracellular matrix, and…Abstract Number: 1988 • 2018 ACR/ARHP Annual Meeting
Effect of Different Fucoidans on Pathological Pathways Activated in Osteoarthritic Chondrocytes and Synoviocytes
Background/Purpose: Osteoarthritis (OA) is a disease managed rather than cured, with a focus on alleviating its pain. Recent studies show that fucoidans, one of the…Abstract Number: 3107 • 2016 ACR/ARHP Annual Meeting
Switching from Anabolic to Catabolic Metabolism – a Novel Immunomodulatory Therapy in RA
Background/Purpose: Inflammatory activity in RA relies on numerous anabolic processes; including cellular proliferation, cell trafficking, secretion of proinflammatory cytokines and release of antibodies. Lasting reversal…Abstract Number: 1660 • 2016 ACR/ARHP Annual Meeting
Role of Immune System Cells and Induction of Netosis-Mediated Cell Death in the Development of Atherosclerosis in Ankylosing Spondylitis
Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disease associated with the development of atherosclerosis. Our aims were: 1) To evaluate the involvement of immune…Abstract Number: 1845 • 2016 ACR/ARHP Annual Meeting
TGF-β-Induced Tissue Fibrosis Is Abrogated in Mice Containing a Constitutive Genetic Deletion of Nox4 (Nox4 knockout)
Background/Purpose: Excessive deposition of collagen and other connective tissue components in the skin and multiple internal organs is characteristic of Systemic Sclerosis (SSc). Besides the…Abstract Number: 15 • 2015 ACR/ARHP Annual Meeting
Regulation of Neutrophil Extravasation By Interleukin-8-Induced Intravascular Reactive Oxygen Species Production during the Inflammatory Response
Background/Purpose: The extravasation and recruitment of leukocytes in damaged tissues is an essential component of the inflammatory response. Once in the inflammatory foci, neutrophils destroy…Abstract Number: 1144 • 2015 ACR/ARHP Annual Meeting
Effect of PEP-1-Glrx-1 on Catabolic Gene Expression in Human Articular Chondrocytes and in Mouse Carrageenan-Induced Paw Edema Model
Background/Purpose: Excessive production of reactive oxygen species (ROS) of the chondrocyte plays an important role of cartilage degradation, inflammation, and increased chondrocyte death in the…Abstract Number: 1164 • 2015 ACR/ARHP Annual Meeting
Four Types of Calcium Pyrophosphate Crystals Differentially Induce IL-1beta Production By Monocytes through ATP/Potassium Efflux/ROS Dependent Pathways
Background/Purpose: Monoclinic and triclinic calcium pyrophosphate (m- and t-CPP) crystals are the 2 types of CPP crystals observed in human joints. Frequently asymptomatic, it can…Abstract Number: 1854 • 2015 ACR/ARHP Annual Meeting
Identification and Characterization of microRNAs Related to the Pathogenesis of Cardiovascular Disease in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus. Role of Specific Autoantibodies
Background/Purpose: 1) To identify and characterize miRNAs related to the pathogenesis of CVD in antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) patients; 2) To…Abstract Number: 2199 • 2015 ACR/ARHP Annual Meeting
in Vivo Ubiquinol Supplementation Reduces the Pro-Atherothrombotic Status in Antiphospholipid Syndrome Patients. Preliminary Results of a Clinical Trial
Background/Purpose: To investigate the beneficial effects of in vivoubiquinol (Q, reduced form of CoQ10) supplementation on athero-thrombosis prevention in APS patients, through the implementation of…Abstract Number: 2832 • 2015 ACR/ARHP Annual Meeting
Characterization of Leukocyte Subsets in Ankylosing Spondylitis Patients
Background/Purpose: AS is a chronic inflammatory disease, of unknown aetiology, characterized by pathological ossification. We aimed: 1) To analyze the profile of inflammation, oxidative status…Abstract Number: 2342 • 2014 ACR/ARHP Annual Meeting
Redox Regulation of a New Autoimmune Mouse Model, Glucose-6-Phosphate Isomerase Peptide Induced Arthritis in Mice
Background/Purpose Rheumatoid arthritis (RA) is a perpetuating disease, which affects approximately 1% of the population. Until now, the pathogenic mechanisms of RA remain elusive and…Abstract Number: 1742 • 2014 ACR/ARHP Annual Meeting
Depletion of Reactive Oxygen Species Biases T Cells to Proinflammatory Cytokine Production in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease, genetically associated with polymorphisms in HLA class II molecules. CD4 cells produce proinflammatory cytokines and orchestrate…Abstract Number: 1707 • 2014 ACR/ARHP Annual Meeting
High Oxidative Stress in Fibrotic and Non-Fibrotic Skin of Patients with Systemic Sclerosis
Background/Purpose Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil…
ACR Meeting Abstracts