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Abstracts tagged "risk factors"

  • Abstract Number: 1805 • ACR Convergence 2022

    Effect of Short-Term Fruit Juice and Sugared Beverage Intake on Risk of Recurrent Gout Flares

    Natalie McCormick1, Chio Yokose2, Minna Kohler3, Janeth Yinh1, Clara Chen4, Tuhina Neogi5, Tony Merriman6, kenneth saag7, Yuqing Zhang8 and Hyon Choi9, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Waltham, MA, 3Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Boston University School of Public Health, Boston, MA, 5Boston University School of Medicine, Boston, MA, 6University of Otago, Dunedin, New Zealand, 7University of Alabama at Birmingham, Birmingham, AL, 8Massachusetts General Hospital, Quincy, MA, 9MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA

    Background/Purpose: Habitual fructose-rich beverage intake has been associated with increased serum urate (SU) levels and prevalent and incident gout. This is likely because fructose induces…
  • Abstract Number: 0353 • ACR Convergence 2022

    Steroid-Induced Diabetes in Lupus Nephritis Patients: Classic Risk Factors or a Different Type of Diabetes?

    Cristian Alejandro Dimas Ramírez1, André Fortanell-Meza1, Diego San Agustin-Morales1, Eduardo Brenner Muslera2, Juan Mejia-Vilet3, Paloma Almeda-Valdes4, Paola Vázquez Cárdenas5, F. Javier Merayo-Chalico6 and Ana Barrera-Vargas1, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico, 2School of Medicine of Universidad Panamericana, Ciudad de México, Mexico, 3National Autonomous University of Mexico, Ciudad de México, Mexico, 4Department of Endocrinology and Metabolism, and the Research Unit of Metabolic Diseases. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico, 5Hospital General Dr. Manuel Gea González, Ciudad de México, Mexico, 6Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirn", Ciudad de México, Mexico

    Background/Purpose: Glucocorticoids are frequently employed in the treatment of systemic lupus erythematosus (SLE) patients and play a critical role in the induction therapy of lupus…
  • Abstract Number: 0929 • ACR Convergence 2022

    Severe Low-Dose Methotrexate Toxicity in Elderly Patients with Inflammatory Rheumatic Diseases

    Cara Kumar1, Kristine Herrmann1 and Martin Aringer2, 1Division of Rheumatology, Department of Medicine III, University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany, 2University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany

    Background/Purpose: While mostly remarkably safe, low dose methotrexate (MTX) occasionally causes life-threatening events. We analyzed all patients with rheumatic diseases and severe MTX toxicity between…
  • Abstract Number: 1471 • ACR Convergence 2022

    Trends and Predictors of Hospitalizations Due to Acute Myocardial Infarction in Systemic Lupus Erythematosus Patients

    Izza Bazigh1, Uzair Khan2, Achint Patel3, Aaparna Singh3, Neha Ghalib3, Ghazi Farman4, Salman Muddassir3, Farrukh Zaidi5, Sami Mughni3 and Adam Grunbaum6, 1HCA Florida Oak Hill Hospital, Spring Hill, FL, 2HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Odessa, FL, 3HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Spring Hill, FL, 4Rehman Medical College, Spring Hill, FL, 5HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Port Richey, FL, 6Gulf Coast Rheumatology, Trinity, FL

    Background/Purpose: Cardiovascular events occur more frequently and with earlier onset in patients with Systemic Lupus Erythematosus (SLE) compared with healthy individuals. Several studies have concluded…
  • Abstract Number: 1821 • ACR Convergence 2022

    Colchicine and Other Gout Medications and the Risk of COVID-19 Infection, Hospitalization, and Subsequent Outcomes in People with Gout

    Jasvinder singh1, Timothy Bergquist2, Vithal Madhira3 and Alfred Anzalone4, 1University of Alabama at Birmingham, Birmingham, AL, 2Sage Bionetworks, Seattle, WA, 3Palila Software, L.L.C., Reno, NV, 4University of Nebraska Medical Center, Ohama, NE

    Background/Purpose: To examine whether the use of colchicine and other gout medications is associated with the risk of COVID-19 infection, hospitalization, and subsequent outcomes in…
  • Abstract Number: 0354 • ACR Convergence 2022

    Clinical and Economic Characterization of Systemic Lupus Erythematosus Patients by Cumulative Corticosteroid Dose over 1 Year: Real-World Observation of Commercially Insured Adults in the United States

    Sandra Sze-jung Wu1, Allison Perry2, Helen Varker3, Rich Bizier3, Liisa Palmer3 and Gary Bryant4, 1AstraZeneca, Hockessin, DE, 2IBM Watson Health, New York, NY, 3Merative, Cambridge, MA, 4AstraZeneca, New Castle, DE

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, heterogeneous disease associated with periods of flares. Identifying patients at risk of severe disease and associated resource…
  • Abstract Number: 0991 • ACR Convergence 2022

    Prior Use of Autoimmune Disease Treatments Among Patients with Systemic Lupus Erythematosus, Rheumatoid Arthritis, or Myositis Hospitalized with COVID-19

    Cassandra Calabrese1, Gelareh Atefi2, Kristin Evans3, Meghan Moynihan3, Liisa Palmer3 and Sandra Sze-jung Wu4, 1Cleveland Clinic Foundation, Cleveland Heights, OH, 2AstraZeneca, Wilmington, DE, 3Merative, Cambridge, MA, 4AstraZeneca, Hockessin, DE

    Background/Purpose: To compare use of autoimmune disease treatments between patients with and without severe COVID-19 (COVID) in cohorts of patients with systemic lupus erythematosus (SLE),…
  • Abstract Number: 1475 • ACR Convergence 2022

    Epidemiology of Acute Ischemic Stroke in Patients with Systemic Lupus Erythematosus

    Uzair Khan1, Izza Bazigh2, Achint Patel3, Aaparna Singh3, Neha Ghalib3, Ghazi Farman4, Salman Muddassir3, Farrukh Zaidi5, Sami Mughni3 and Adam Grunbaum6, 1HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Odessa, FL, 2HCA Florida Oak Hill Hospital, Spring Hill, FL, 3HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Spring Hill, FL, 4Rehman Medical College, Spring Hill, FL, 5HCA Healthcare Florida / USF Morsani College of Medicine GME Consortium / Oak Hill Hospital, Port Richey, FL, 6Gulf Coast Rheumatology, Trinity, FL

    Background/Purpose: Vascular events, including cerebrovascular accidents (CVA) occur earlier and more frequently in patients with Systemic Lupus Erythematosus (SLE) compared with healthy individuals. Several studies…
  • Abstract Number: 1942 • ACR Convergence 2022

    Maybe Silent: Spine Disease in Chronic Recurrent Multifocal Osteomyelitis, Clinical Features, Risk Factors, and Red Flags

    Shima Yasin1, T. Shawn Sato2, Emma Leisinger2, Aleksander Lenert2, Yongdong (Dan) Zhao3 and Polly Ferguson1, 1University of Iowa Carver College of Medicine, Iowa City, IA, 2University of Iowa, Iowa City, IA, 3University of Washington, Redmond, WA

    Background/Purpose: Chronic recurrent multifocal osteomyelitis (CRMO) is a female predominant autoinflammatory bone disease. The average age at disease onset is 9-10 years. The majority have…
  • Abstract Number: 0372 • ACR Convergence 2022

    Incidence and Risk of Overall Infections in Patients with Ankylosing Spondylitis Receiving Biologic Therapies: A Real-world Prospective Observational Study Using KOBIO Registry

    Kyung Min Ko1 and Su-Jin Moon2, 1International St. Mary's Hospital, Incheon, Republic of Korea, 2Catholic University of Korea, Seoul, Republic of Korea

    Background/Purpose: Infection is a perpetual concern in patients treated with biological therapy. However, long-term real-world data on infectious profile of AS patients are lacking The…
  • Abstract Number: 1055 • ACR Convergence 2022

    Associations of Potential Risk Factors with Severe Outcomes in Scleroderma Renal Crisis: Results from a Single Center Study

    Alex Luta1, Saloni Godbole1 and Virginia Steen2, 1Medstar Georgetown University Hospital, Washington, DC, 2Georgetown University School of Medicine, Washington, DC

    Background/Purpose: Scleroderma Renal Crisis (SRC) is a severe and life-threatening complication of Systemic Sclerosis (SSc). Given the rare nature of SSc, it is challenging to…
  • Abstract Number: 1484 • ACR Convergence 2022

    Management of the Heightened Risk for Clinical Events from Atherosclerotic Cardiovascular Disease (ASCVD) in an Established Cohort of Lupus Erythematosus Patients

    Megan Zhao1, Kevin Williams2, Douglas Jacoby3, Rui Feng4 and Victoria Werth5, 1Perelman School of Medicine, Philadelphia, 2Temple University Hospital System, Philadelphia, 3University of Pennsylvania Health System, Philadelphia, 4University of Pennsylvania, Philadelphia, 5Philadelphia VAMC, Philadelphia, PA, USA and Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia

    Background/Purpose: Lupus erythematosus (LE) patients are at heightened risk of clinical events, chiefly heart attacks and strokes, caused by ASCVD. To address this problem, we…
  • Abstract Number: 1958 • ACR Convergence 2022

    The Increased Risk of Staphylococcus Aureus Bacteremia in Rheumatoid Arthritis – What Is the Impact of Glucocorticoids, Biologic Disease-Modifying Anti-Rheumatic Drugs and Disease Activity: A Danish Nationwide Nested Case-Control Study in the DANBIO Registry

    Sabine Dieperink1, Bente Glintborg2, Frank Mehnert3, Mette Nørgaard3, Louise Bruun Oestergaard4, Thomas Benfield5, Christian Torp-Pedersen6, Andreas Petersen7 and Merete Lund Hetland1, 1Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark, 2Rigshospitalet, Glostrup, Virum, Denmark, 3Aarhus University Hospital, Aarhus, Denmark, 4Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark, 5Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark, 6Copenhagen University Hospital - North Zealand, Copenhagen, Denmark, 7Statens Serum Institut, Copenhagen, Denmark

    Background/Purpose: Staphylococcus aureus bacteremia (SAB) has high mortality.[1] We have previously identified an approximately doubled risk in patients with rheumatoid arthritis (RA),[2] but the role…
  • Abstract Number: 0541 • ACR Convergence 2022

    Prevalence of Venous Thrombo-Embolism in Lupus Nephritis and Associated Risk Factors

    Tara Tofighi, Jiandong Su and Zahi Touma, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with SLE have an increased risk of developing venous thrombo-embolism (VTE) based on several cohort studies, accounting for significant morbidity and mortality. Lupus…
  • Abstract Number: 1121 • ACR Convergence 2022

    Intricate Roles of Low Gene Copy Numbers for Complement C4, C4A Deficiency and HLA-DRB1*03 as Genetic Risk Factors for Myositis, Its Subgroups and Autoantibodies

    Danlei Zhou1, Emily H King1, Simon Rothwell2, Olga Kryštůfková3, Antonella Notarnicola4, Samantha Coss1, Rabheh Abdul Aziz5, Katherine E Miller1, Amanda Dang1, G. Richard Yu1, Joanne Drew6, Emeli Lundstrom4, Lauren Pachman7, Gulnara Mamyrova8, Rodolfo V Curiel8, Boel De Paepe9, Jan De Bleecker9, Antony Payton10, William Ollier11, Terrance P O'Hanlon12, Ira Targoff12, Willy Flegel12, Vidya Sivaraman6, Edward Oberle6, Shoghik Akoghlanian6, Kyla Driest6, Charles H Spencer13, Yee Ling Wu14, Haikady N Nagaraja15, Stacy P Ardoin6, Hector Chinoy16, Lisa G Rider12, Frederick Miller12, Ingrid Lundberg17, Leonid Padyukov18, Jiří Vencovský3, Janine A Lamb2 and Chack-Yung Yu1, 1Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH, 2National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, United Kingdom, 3Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 4Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 5Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, 6Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, 7Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL, 8Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, 9Department of Neurology, Ghent University Hospital, Ghent, Belgium, 10Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, 11Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, United Kingdom, 12Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, 13Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, The Ohio State University, Columbus, MS, 14Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, 15Division of Biostatistics, The Ohio State University, Columbus, OH, 16The University of Manchester, Sale, United Kingdom, 17Karolinska Universitetssjukhuset, Karolinska Institutet, Stockholm, Sweden, 18Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterized by autoantibodies plus infiltration of leukocytes into muscles and/or the skin, leading to…
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