Abstracts tagged "rheumatoid arthritis"

Abstract Number: 0040 • ACR Convergence 2021
M1-M2 Polarization by CTLA4-Ig (Abatacept) on Cultured Circulating Monocytes from Rheumatoid Arthritis Patients and Healthy Subjects
Samuele tardito¹, Stefano Soldano², Emanuele Gotelli², Paola Montagna¹, Rosanna Campitiello², Sabrina Paolino², Carmen Pizzorni¹, Alberto Sulli², Vanessa Smith³ and Maurizio Cutolo², ¹Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Dept. Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, ²Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, ³Department of Rheumatology and Internal Medicine, Ghent University Hospital, Ghent, Belgium
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disorder affecting 1% of the population worldwide [1]. Monocytes/macrophages are known to play a crucial role in…
Abstract Number: 0137 • ACR Convergence 2021
Antiviral Use and Healthcare Resource Utilization Among Patients with Rheumatoid Arthritis and Influenza in Three Influenza Seasons, 2016–2019
Edward Neuberger¹, Tu My To¹, Arpamas Seetasith¹, Stella Arndorfer² and Christopher Wallick¹, ¹Genentech, Inc., South San Francisco, CA, ²Genesis Research, South San Francisco, CA
Background/Purpose: Seasonal influenza poses a large burden on the healthcare system. Patients with certain chronic diseases, such as rheumatoid arthritis (RA), are especially vulnerable to…
Abstract Number: 0227 • ACR Convergence 2021
Work Participation Is Impaired Months Before Clinical Arthritis Is Apparent
Cleo Rogier¹, Pascal de Jong², Annette H.M van der Helm-van Mil³ and Elise van Mulligen⁴, ¹Erasmus MC, Rotterdam, ²Erasmus MC, Hendrik Ido Ambacht, Netherlands, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Work participation is still a major issue for patients with rheumatoid arthritis (RA) despite improved management and outcomes. Work loss can be divided into…
Abstract Number: 0279 • ACR Convergence 2021
Macrophage Cholesterol Loading Associates with Low-density Lipoprotein Structure, Oxidation, Antibodies Against Oxidized Epitopes and Is Modified by Immunomodulatory Treatments in Patients with Rheumatoid Arthritis
George Karpouzas¹, Bianca Papotti², sarah ormseth³, Marcella Palumbo⁴, Elizabeth Hernandez³, Cinzia Marchi⁴, Francesca Zimetti⁴, Franco Bernini⁴ and Nicoletta Ronda⁴, ¹Harbor-UCLA Medical Center, Torrance, CA, ²2. Department of Food and Drug, University of Parma, Italy, Parma, Italy, ³The Lundquist Institute, Harbor-UCLA Medical Center, Torrance, CA, ⁴Department of Food and Drug, University of Parma, Parma, Italy
Background/Purpose: In Rheumatoid arthritis (RA), immune dysregulation, excess inflammation and oxidative stress may alter lipoprotein level and function and promote LDL oxidation and its uptake…
Abstract Number: 0354 • ACR Convergence 2021
A Cross-Sectional Study of Rheumatoid Arthritis Diagnoses in Patients with Systemic Lupus Erythematosus
Kathryn Starzyk¹, Gary Curhan² and Julia Brault², ¹OM1, Inc, Boston, MA, ²OM1, Boston, MA
Background/Purpose: Features of autoimmune conditions may coexist in individual patients, which may represent an overlapping single disease with features of both (i.e., ‘rhupus’), or the…
Abstract Number: 0527 • ACR Convergence 2021
Role of Terminal Uridylyl Transferase 7 in TNF-α-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts In Vitro
Anil singh, farheen Shaikh and Salah-uddin Ahmed, Washington State University, Spokane, WA
Background/Purpose: Terminal uridylyl transferase 7 (TUT7), also known as Zcchc6, is a zinc finger domain-containing protein responsible for terminal uridylation of miRNA, implicated in pre-miRNA…
Abstract Number: 0581 • ACR Convergence 2021
Rheumatoid Arthritis Treatment Patterns in Massachusetts: Informative Findings from Insurance Claims Data
Mark Matza¹, D. Steven Fox², Kay Larholt³, David Fritsche³, Elizabeth Apgar³, Mitesh Puthran³, Gigi Hirsch³ and Marcy Bolster¹, ¹Massachusetts General Hospital, Boston, MA, ²University of Southern California, School of Pharmacy, Los Angeles, CA, ³Massachusetts Institute of Technology (MIT) Center for Biomedical Innovation, Cambridge, MA
Background/Purpose: A real-world current state of RA patients in Massachusetts (MA) is analyzed to provide a novel assessment of demographics, treatment patterns, and clinical settings…
Abstract Number: 0609 • ACR Convergence 2021
Challenges of Caring for Patients with Inflammatory Arthritis Experiencing Homelessness: Preliminary (12- Month) Follow-up Observations and Identification of Certain Barriers to Care
Baljeet Rai¹, Nicole Zagelbaum Ward², Abhimanyu Amarnani², Corinne Feldman², Brett Feldman² and Richard Panush², ¹LAC+USC Medical Center, Modesto, CA, ²LAC+USC Medical Center, Los Angeles, CA
Background/Purpose: Homelessness is a public health crisis. Those with housing insecurity have unique barriers to healthcare that confound their outcomes. Because of the paucity of…
Abstract Number: 0789 • ACR Convergence 2021
Adipokine Levels and Associations with Achievement of Low Disease Activity in Rheumatoid Arthritis
Joshua Baker¹, Bryant England², Michael George¹, Katherine Wysham³, Gail Kerr⁴, Andreas Reimold⁵, Paul Monach⁶, Gary Kunkel⁷, Brian Sauer⁷, Bartlett Hamilton⁸, Carlos Hunter², Michael Duryee², Geoffrey Thiele² and Ted Mikuls², ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³VA Puget Sound/University of Washington, Seattle, WA, ⁴Washington D.C., Veterans Affairs Medical Center (VAMC)/Georgetown and Howard Universities, Washington, DC, ⁵University of Texas – Southwestern Medical Center/Dallas Veterans Affairs Medical Center (VAMC), Dallas, TX, ⁶Brigham and Women's Hospital, Boston, MA, ⁷University of Utah, Salt Lake City, UT, ⁸University of Nebraska, Omaha, NE
Background/Purpose: Adipokines are fat-secreted proteins that serve as metabolic regulators. Prior studies have identified associations between adipokines and disease characteristics such as disease activity and…
Abstract Number: 0805 • ACR Convergence 2021
A Real-world Prospective Observational Study of the Effectiveness of Golimumab in Adult Greek Patients with RA, PsA and Axial SpA and Inadequate Response to Initial TNFα Inhibitor Therapy
Panagiotis Athanassiou¹, Dimitrios Psaltis², Athanasios Georgiadis³, Gkikas Katsifis⁴, Athina Theodoridou⁵, Souzana Gazi⁶, Prodromos Sidiropoulos⁷, Maria Tektonidou⁸, Andreas Bounas⁹, Anna Kandyli¹⁰, Periklis Vounotrypidis⁵, Grigorios Sakellariou⁵, Dimitrios Vassilopoulos¹¹, Zhiping Huang¹², Evangelia Petrikkou¹³ and Dimitrios Boumpas¹⁴, ¹Department of Rheumatology, St. Paul’s Hospital of Thessaloniki, Thessaloniki, Greece, ²Private Practice, Serres, Greece, Athens, Greece, ³Private Practice, Ioannina, Greece, Athens, Greece, ⁴Rheumatology Clinic Naval Hospital of Athens, Athens, Greece, ⁵Private Practice, Thessaloniki, Greece, Athens, Greece, ⁶“KAT” Regional General Hospital, Rheumatology Unit, Athens, Greece, Athens, Greece, ⁷Department of Rheumatology, Clinical Immunology and Allergy, University of Crete, Heraklion, Greece, ⁸Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Joint Rheumatology Program, Laiko Hospital, Athens, Greece, ⁹General Clinic of Patras “Olympion”, Rheumatology, Patras, Greece, ¹⁰Rheumatology Outpatient Clinic, Iaso General Hospital, Athens, Greece, ¹¹2nd University Department of Internal Medicine, General Hospital of Athens "Ippokrateion", Athens, Greece, ¹²Merck & Co., Inc., Pharmacoepidemiology, Center for Observational and Real-world Evidence (CORE), Kenilworth, NJ, ¹³MSD Pharmaceutical, Industrial and Commercial S.A, Athens, Medical Affairs, Athens, Greece, ¹⁴Rheumatology and Clinical Immunology, 4th Department of Internal Medicine, ‘‘Attikon’’ University Hospital, Athens, Greece
Background/Purpose: Patients (pts) with immune-mediated rheumatic diseases and an insufficient response to previous treatment with TNFα inhibitors (TNFαi) are frequently encountered in clinical practice. This…
Abstract Number: 0824 • ACR Convergence 2021
Physicians’ Reasons for Prescribing Janus Kinase Inhibitors (JAKi) in Patients with Rheumatoid Arthritis, and Associated Alignment Between Physicians and Patients in a Real-world Clinical Setting
Peter C Taylor¹, Bruno Fautrel², Yves Piette³, Susana Romero-Yuste⁴, Jasper Broen⁵, Martin Welcker⁶, Elizabeth Holdsworth⁷, Monia Zignani⁸, Katrien Van Beneden⁸, Roberto Caporali⁹ and Rieke Alten¹⁰, ¹University of Oxford, Oxford, United Kingdom, ²Pitié Salpêtrière Hospital, APHP, Sorbonne Université, Paris, France, ³AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium, ⁴Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Spain, ⁵Maxima Medical Centre, Veldhoven, Netherlands, ⁶MVZ für Rheumatologie, Planegg, Germany, ⁷Adelphi Real World, Bollington, United Kingdom, ⁸Galapagos, NV, Mechelen, Belgium, ⁹Policlinico S. Matteo University, Pavia, Italy, ¹⁰Schlosspark-Klinik University, Berlin, Germany
Background/Purpose: Shared decision making, a cornerstone of rheumatoid arthritis (RA) management1, allows physicians and their patients to make informed decisions about their treatment goals and…
Abstract Number: 0840 • ACR Convergence 2021
Modelling of Disease Activity in Patients with Inflammatory Arthropathies Treated with Etanercept Originator or Biosimilar as First-Line Biologic: A Real-World Observational Study Using the OPAL Dataset
Claire Deakin¹, Geoffrey Littlejohn², Hedley Griffiths³, Tegan Smith⁴, Catherine OSullivan⁵ and Paul Bird⁶, ¹OPAL Rheumatology Ltd, Sydney, Australia, ²Monash University, Melbourne, Australia, ³Barwon Rheumatology Service, Geelong, Australia, ⁴OPAL Rheumatology Ltd, Kogarah, Australia, ⁵OPAL Rheumatology Ltd, Queenscliff, Australia, ⁶University of New South Wales, Sydney, Australia
Background/Purpose: The availability of biosimilars as non-proprietary versions of established biologic disease-modifying anti-rheumatic drugs (bDMARDs) has increased around the world. Since April 2017 both the…
Abstract Number: 0990 • ACR Convergence 2021
Lower Incidence of COVID-19 but Higher Mortality in Patients with Inflammatory Arthritis Compared to Controls in Wales, United Kingdom: A Population Epidemiological Study
Roxanne Cooksey¹, Mark Atkinson² and Ernest Choy³, ¹Cardiff University, Cardiff, Wales, United Kingdom, ²Swansea University, Swansea, Wales, United Kingdom, ³CREATE Centre, Cardiff University, Cardiff, Wales, United Kingdom
Background/Purpose: The COVID-19 pandemic has caused over 3 million deaths. Having inflammatory arthritis (IA) and anti-rheumatic medications increase the risk of infections. Comorbidities, common in…
Abstract Number: 1073 • ACR Convergence 2021
In Favor of the Subspecialty Clinic Model for Rheumatoid Arthritis
Jasmine Thai¹, Roshan Patel¹, Yeohan Song¹ and Sheryl Mascarenhas², ¹Ohio State University, Columbus, OH, ²Ohio State University Hospital, Columbus, OH
Background/Purpose: The Subspecialty Clinic Model (SCM) which seeks to allow for collaborative care and services by stratifying patients with a particular disease or need to…
Abstract Number: 1200 • ACR Convergence 2021
Predicting Progression to RA in Patients with Seropositive Arthralgia
Aine Gorman¹, Keelin Flynn², Matthew Turk¹, Candice Low³, Kieran Murray⁴, Carl Orr⁵, Phil Gallagher⁵, Lorna Freeman², Edel Meaney², Eamonn Molloy⁶, Lorraine O Neill⁷, Ursula Fearon⁸ and Douglas Veale⁹, ¹St Vincents Hospital, Dublin, Ireland, ²The Centre for Arthritis and Rheumatic Disease, EULAR Centre of Excellence, St. Vincent’s University Hospital and University College Dublin, Ireland, Dublin, Ireland, ³St. Vincent's University Hospital, Dublin, Ireland, ⁴Saint Vincent's University Hospital, Dublin, Ireland, ⁵St Vincent's Hospital, Dublin, Ireland, ⁶St Vincent's Healthcare Group, Dublin, Ireland, ⁷St. Vincent's Hospital, Dublin, Ireland, ⁸Trinity College Dublin, Dublin, Ireland, ⁹University College Dublin, Dublin, Ireland
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory condition often associated with joint destruction, disability, and reduced life expectancy. Before RA diagnosis, some patients may…

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