Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 1371 • 2019 ACR/ARP Annual Meeting
Create an Algorithm of Outcome Forecasting and Decision Making for RA Treatment: Data Mining and Machine Learning via the Smart System of Disease Management (SSDM)
Rong Mu¹, Chun Li ², Jing Yang ³, Xiaohan Wang ⁴, Bin Wu ⁵, Fengxiao Zhang ⁶, Yong Wang ⁷, Li Qin ⁸, Cundong Mi ⁹, Huifang Guo ¹⁰, Wei Wei ¹¹, Wei Liu ¹², Qingchun Huang ¹³, Jing Lu ¹⁴, Yang Liu ¹⁵, Huiling Li ¹⁶, Bing Wu ¹⁷, Hui Xiao ¹⁸, Yuhua Jia ¹⁹ and Fei Xiao ²⁰, ¹People's Hospital, Beijing University Medical School, Beijing, China (People's Republic), ²People's Hospital, Beijing University Medical School, Beijing, Beijing, China (People's Republic), ³Central Hospital of MianYang, Mianyang, Sichuan, China (People's Republic), ⁴Anyang district hospital, Fuyang, Hainan, China (People's Republic), ⁵Chongqing Hospital of Traditional Chinese Medicine, Chongqing, Chongqing, China (People's Republic), ⁶Hebei General Hospital, Shijiazhuang, Hebei, China (People's Republic), ⁷The first Hospital Affiliated to AMU (Southernwest Hospital), Chongqing, China (People's Republic), ⁸The No.3 People’s Hospital of HuZhou City, Huzhou, Zhejiang, China (People's Republic), ⁹The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (People's Republic), ¹⁰The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (People's Republic), ¹¹Tianjin Medical University General Hospital, Tianjin, Tianjin, China (People's Republic), ¹²First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China (People's Republic), ¹³The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China (People's Republic), ¹⁴First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (People's Republic), ¹⁵Affiliated Hospital of Inner Mongolia Medical University, Huhehaote, Nei Mongol, China (People's Republic), ¹⁶Hubei Hospital of Traditional Chinese Medicine, Wuhan, Hubei, China (People's Republic), ¹⁷Shanghai Gothic Internet Technology Co., Ltd, Shanghai, China (People's Republic), ¹⁸Shanghai Gothic Internet Technology Co., Ltd, shanghai, Shanghai, China (People's Republic), ¹⁹Shanghai Gothic Internet Technology Co., Ltd., Shanghai, Shanghai, China (People's Republic), ²⁰Shanghai Gothic Internet Technology Co., Ltd., shanghai, China (People's Republic)
Background/Purpose: Daily health care deals with a wide spectrum of RA patients from statuses of remission (R) to disease activities at low (L), moderate (M)…
Abstract Number: 1399 • 2019 ACR/ARP Annual Meeting
Evaluation of Effectiveness and Usage Patterns of Tofacitinib in Treatment of Rheumatoid Arthritis in Australia: An Analysis from the OPAL-QUMI Real World Dataset
Paul Bird¹, Geoffrey Littlejohn ², Belinda Butcher ³, Tegan Smith ⁴, Candida da Fonseca Pereira ⁵, David Witcombe ⁵ and Hedley Griffiths ⁶, ¹Optimus Research, Kogarah, New South Wales, Australia, ²Monash Rheumatology, Clayton, Victoria, Australia, ³WriteSource Medical Pty Ltd, Lane Cove, New South Wales, Australia, ⁴OPAL Rheumatology Ltd, Sydney, New South Wales, Australia, ⁵Pfizer Australia, Sydney, New South Wales, Australia, ⁶Barwon Rheumatology Service, Geelong, Victoria, Australia
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Limited data from large real-world patient populations exist to describe…
Abstract Number: 1436 • 2019 ACR/ARP Annual Meeting
Analysis of Adverse Events of Methotrexate (MTX), bDMARDs and Tofacitinib (TOFA) Reported to Pharmaceuticals and Medical Devices Agency (PMDA), Japan
Naonori Tsuda¹, Shigeko Inokuma ², Kenichi Hiraga ³, Yoshinori Masui ³ and Toshikazu Kano ³, ¹Kohondai Hospital, National Center for Global health and Medicine, Ichikawa, Chiba, Japan, ²Chiba Central Medical Center, Ichikawa, Chiba, Japan, ³Kohnodai Hospital, National Center for Global health and Medicine, Ichikawa, Chiba, Japan
Background/Purpose: Among DMARDs (disease modifying anti-rheumatic drugs), methotrexate (MTX), bDMARDs (biologic DMARDs) and JAK (Janus kinase) inhibitors are the major. Many adverse events of these…
Abstract Number: 1888 • 2019 ACR/ARP Annual Meeting
Serum Calprotectin Is a Prognostic Marker for Drug-Free Remission in RA
Emma de Moel¹, Jürgen Rech ², Michael Mahler ³, Johannes Roth ⁴, Anne Schouffoer ⁵, Karel Ronday ⁶, Thomas Huizinga ⁵, CF Allaart ⁷, René Toes ⁵, Georg Schett ⁸ and Diane van der Woude ¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, ³Inova Diagnostics, San Diego, CA, ⁴University of Muenster, Muenster, Germany, ⁵Leiden University Medical Center, Leiden, Netherlands, ⁶Haga Ziekenhuis, The Hague, Netherlands, ⁷Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ⁸Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: The ability to accurately predict whether RA patients will flare following DMARD-tapering would open doors in clinical decision-making for achieving drug-free remission (DFR). Calprotectin…
Abstract Number: 2003 • 2019 ACR/ARP Annual Meeting
Anti-Polygalacturonic Acid Antibody (PGA-Ab) Induced Bone Destruction in Rheumatoid Arthritis by Promoting Osteoclastogenesis via Integrin Beta 5
JIAWEI XIE¹ and HUI DAI ¹, ¹Peking University, Beijing, China (People's Republic)
Background/Purpose: Anti-polygalacturonic acid antibody (PGA-Ab) is a new rheumatoid arthritis (RA)-related autoantibody first identified by our group. The sensitivity and specificity of PGA-Ab is even…
Abstract Number: 2159 • 2019 ACR/ARP Annual Meeting
Pachymeningitis in Rheumatic Disease
Rachel Kneeland¹, John Berry ², Sydney Brandwein ² and Monika Starosta ², ¹Department of Internal Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, ²Advocate Lutheran General Hospital, Park Ridge, IL
Background/Purpose: Pachymeningitis is a rare complication of rheumatic disease. Patients present with hearing loss or other neurologic complications. Diagnosis is made by thickening of dura…
Abstract Number: 2300 • 2019 ACR/ARP Annual Meeting
Risk Factors for Transfusion and Use of Tranexemic Acid in Patients with Rheumatoid Arthritis Undergoing Total Hip Arthroplasty and Total Knee Arthroplasty
Kyle Morse ¹, Jeremy Abolade ¹, Nicole Heinz ¹, Meng Zhang ², Linda Russell ¹, Serene Mirza ¹, Dana Orange ³, Joshua Wright-Chisem ¹, Mark Figgie ⁴, Peter Sculco ¹ and Susan Goodman⁵, ¹Hospital for Special Surgery, New York, ²The Feinstein Institute for Medical Research, Northwell Health, Manhasset, ³Rockefeller University, New York, ⁴Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, ⁵Hospital For Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: Utilization of total hip (THA) and total knee arthroplasty (THA) remains high for patients with RA, and most patients have moderate to high disease…
Abstract Number: 2322 • 2019 ACR/ARP Annual Meeting
Toward Cardiovascular Risk Stratification in Rheumatoid Arthritis: Use of Regression Tree Analyses to Evaluate Impact of Serum Biomarkers and Cardiovascular Risk Factors on Carotid Intima Media Thickness
Kimberly Liang¹, Yaming Li ¹, Suresh Mulukutla ¹, Steven Reis ¹, Marc Levesque ¹, Donald Jones ¹, Rachel Gartland ¹, Jennifer Avolio ¹, Ali Hakim Shoushtari ¹, Flordeliza Villanueva ¹, Larry Moreland ¹ and Douglas Landsittel ², ¹University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, RI
Background/Purpose: Both traditional cardiovascular (CV) risk factors and disease-related factors contribute to the increased risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA). Mechanisms of…
Abstract Number: 2341 • 2019 ACR/ARP Annual Meeting
Findings of Pulmonary Abnormalities on High Resolution Computed Tomography in a Cohort of Rheumatoid Arthritis Patients Without Known Lung Disease
Scott Matson¹, Kevin Deane ², Christopher Collora ¹, Xi Zheng ¹, Marie Fester ¹, Joyce Lee ¹ and M. Kristen Demoruelle ³, ¹University of Colorado, Denver, ²University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ³University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora
Background/Purpose: Pulmonary manifestations of rheumatoid arthritis (RA) lead to significant morbidity and mortality. Lung manifestations in RA are myriad, however little is known about how…
Abstract Number: 2366 • 2019 ACR/ARP Annual Meeting
Comparison of Healthcare Resource Utilization (HCRU) and Costs of Type 2 Diabetes Mellitus (T2DM)-Related Complications in TNFi-Experienced Medicare Beneficiaries with Rheumatoid Arthritis (RA) and T2DM Who Switch to Abatacept or Other Targeted Disease-Modifying Anti-Rheumatic Drugs
Vardhaman Patel¹, Zulkarnain Pulungan ², Anne Shah ², Barton Jones ², Allison Petrilla ², Leticia Ferri ³, Xue Han ³ and Kaleb Michaud ⁴, ¹Bristol-Myers Squibb, New York City, NY, ²Avalere, washington, DC, ³Bristol-Myers Squibb Company, Princeton, NJ, ⁴University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with RA experienced an increase in the whole-body insulin sensitivity and a reduction in HbA1c levels from treatment with abatacept, which is a…
Abstract Number: 2392 • 2019 ACR/ARP Annual Meeting
The Effectiveness of anti-IL-6 Therapy to Elderly-onset Rheumatoid Arthritis
Takayasu Ando¹, Takeshi Suzuki ², Yutaka Gotou ¹ and Kimito Kawahata ³, ¹Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan, ²Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ³Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan
Background/Purpose: In daily practice, our rheumatologist has experienced different clinical feature of elderly-onset rheumatoid arthritis (EORA) compared with younger-onset RA (YORA). In EORA patients, serological…
Abstract Number: 2793 • 2019 ACR/ARP Annual Meeting
Methotrexate Intolerance: A Qualitative Descriptive Study of the Adult Rheumatoid Arthritis Patients’ Perspectives
Elizabeth Salt¹, Mary Kay Rayens ², Leslie Crofford ³ and Jamie Studts ², ¹University of Kentucky, Lexington, KY, ²University of Kentucky, Lexington, ³Vanderbilt University, Nashville
Background/Purpose: An estimated 11% to 33% of persons taking methotrexate for rheumatoid arthritis (RA) are reported to be at least moderately intolerant to this medication.…
Abstract Number: 2890 • 2019 ACR/ARP Annual Meeting
The Effect of Rheumatoid Arthritis and Biologics on the Acquisition of Subsequent Diseases and Adverse Events: A Matched Longitudinal Population Study
Mark Tatangelo¹, George Tomlinson ², Edward Keystone ³, Michael Paterson ⁴, Nick Bansback ⁵ and Claire Bombardier ⁶, ¹University of Toronto, Toronto, Canada, ²University of Toronto, Toronto, ON, Canada, ³Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ⁴Institute for Clinical Evaluative Sciences, Toronto, Canada, ⁵University of British Columbia, Vancouver, Canada, ⁶Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: The direct and indirect effects of rheumatoid arthritis (RA) are difficult to measure in observational studies because: (1) The inflammatory effects of RA are…
Abstract Number: 2822 • 2019 ACR/ARP Annual Meeting
Depression and Subsequent Risk for Incident Seronegative Rheumatoid Arthritis Among Women
Jeffrey Sparks¹, Susan Malspeis ¹, Jill Hahn ², Andrea Roberts ², Laura Kubzansky ² and Karen Costenbader ¹, ¹Brigham and Women's Hospital, Boston, MA, ²Harvard School of Public Health, Boston, MA
Background/Purpose: Depression is associated with elevated systemic inflammation and risk of several chronic diseases including lupus, psoriasis, and inflammatory bowel disease. However, the association between…
Abstract Number: 40 • 2019 ACR/ARP Annual Meeting
Inflammation and Neuronal Growth Factors in Rheumatoid Arthritis
Caroline Wasén¹, Lovisa Leifsdottir ², Roda Abdalla ¹, Lina Juzokaite ¹, Karin Andersson ¹, Malin Erlandsson ¹, Marie Kalm ³ and Maria Bokarewa ¹, ¹Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden, ²Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, Gotheburg, Sweden, ³hDepartment of Pharmacology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden
Background/Purpose: Depression and cognitive impairment are frequently reported in rheumatoid arthritis (RA). We have recently presented that reduced hippocampus volume may be linked to functional…

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