Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 2391 • 2013 ACR/ARHP Annual Meeting
Pathogenic Pro-Inflammatory Cytokine Production Induced By Synovial Fluid From RA Patients Is Related To Levels Of Endogenous TLR4 Ligands and Is Blocked By a Novel Therapeutic Anti-Human TLR4 Monoclonal Antibody, NI-0101
Limin Shang¹, Greg Elson¹, Jeremy Sokolove², Iain B. McInnes³, James Reilly⁴, Eric Hatterer¹, Marie Kosco-Vilbois⁵, Walter Ferlin⁵, Emmanuel Monnet⁵ and Cristina de Min⁶, ¹NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom, ⁴University of Glasgow, Glasgow, United Kingdom, ⁵NovImmune S.A., Geneva, Switzerland, ⁶Novimmmune S.A., Plan-Les-Ouates, Geneva, Switzerland
Background/Purpose: Deregulation of Toll-Like Receptor 4 (TLR4) signaling is thought to play a role in the pathogenesis of certain autoimmune diseases. In rheumatoid arthritis (RA),…
Abstract Number: 1945 • 2013 ACR/ARHP Annual Meeting
Comparison Of Selected Joint Evaluation With Comprehensive Assessment In Musculoskeletal Ultrasonography For Detection Of Synovitis In Rheumatoid Arthritis
Ryusuke Yoshimi¹, Atsushi Ihata¹, Yosuke Kunishita¹, Daiga Kishimoto¹, Reikou Kamiyama¹, Kaoru Minegishi¹, Maasa Hama¹, Yohei Kirino¹, Yukiko Asami¹, Atsuhisa Ueda¹, Mitsuhiro Takeno¹, Ichiro Aoki² and Yoshiaki Ishigatsubo¹, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Musculoskeletal ultrasonography (US) is recognized as a useful tool for the diagnosis and monitoring of rheumatoid arthritis (RA), though a standard procedure has not…
Abstract Number: 938 • 2013 ACR/ARHP Annual Meeting
A Disintegrin and Metalloprotease-17 (ADAM-17) Is Expressed In Rheumatoid Arthritis and Mediates Monocyte Migration
Takeo Isozaki¹, Nao Oguro², Shinya Seki¹, Yoko Miura¹, Sho Ishii¹, Hiroyuki Tsukamoto¹, Takahiro Tokunaga¹, Masayu Umemura¹, Hidekazu Furuya¹, Ryo Yanai¹, Sakiko Isojima¹, Kuninobu Wakabayashi¹, Nobuyuki Yajima¹, Yusuke Miwa¹ and Tsuyoshi Kasama¹, ¹Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, ²Div of Rhemuatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized byinflammation and joint destruction. Migration of monocytes/macrophages into the synovium is important in a variety…
Abstract Number: 2380 • 2013 ACR/ARHP Annual Meeting
Is Isoniazid Treatment For LTBI Safe For RA Patients With TNF Inhibitor Therapy?
Yoon-Kyoung Sung^1,2, Soo-Kyung Cho^1,2, Soyoung Won³, Jeeseon Shim³, Dam Kim⁴, Ji-Young Choi¹, Chan-Nam Son⁵, Chan-Bum Choi⁴, Tae-Hwan Kim⁶, Jae-Bum Jun⁶, Dae-Hyun Yoo⁶ and Sang-Cheol Bae^1,2, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Department of Rheumatology, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ³Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁴Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ⁵Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea, ⁶Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Isoniazid (INH) is increasingly used in RA patients with evidence of latent tuberculosis infection (LTBI) for whom TNF inhibitor therapy is planned. The potential for…
Abstract Number: 1948 • 2013 ACR/ARHP Annual Meeting
Power Doppler Ultrasound 7-Joint Score Vs. Simplified Disease Activity Index In Rheumatoid Arthritis Associated With Fibromyalgia
Rafael Chakr¹, Marina Behar², José A. Mendonça³, Daniela Cervantes², Nizele Calegaro², Nicole Andrade², Iuri Siqueira², Daniel Zanchet², Andrese Gasparin², Penélope Esther Palominos², Charles Kohem⁴, Odirlei Andre Monticielo⁵, Claiton Brenol⁶, Ricardo M. Xavier² and João Carlos T. Brenol⁷, ¹Rheumatology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ²Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ³Rheumatology, Pontifical Catholic University of Campinas / Institute of Clinical Research – IPECC, Campinas, Brazil, ⁴Brazilian Registry of Spondyloarthritis, São Paulo, Brazil, ⁵Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁶Universidade Federal do Rio Grande do Sul, Porto Alegre RS, Brazil, ⁷Rheumatology Division, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Background/Purpose: Fibromyalgia (FM) falsely increases rheumatoid arthritis (RA) disease activity clinical composite scores, such as the simplified disease activity index (SDAI), recently incorporated into ACR/EULAR…
Abstract Number: 915 • 2013 ACR/ARHP Annual Meeting
IL-6R Inhibition Reduces Activation Of Different Peripheral Memory B Cell Subsets In RA
Zafar Mahmood¹, Khalid Muhammad¹, Marc Schmalzing², Petra Roll³, Kathrina Eckert¹, Thomas Dörner⁴ and Hans-Peter Tony⁵, ¹Rheumatology and Clinical Immunology, University of Würzburg, Würzburg, Germany, ²Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany, ³Rheumatology and Clinical immunology, University of Würzburg, Würzburg, Germany, ⁴CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ⁵Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany
Background/Purpose: Enhanced B cell activity has been proposed as part of the pathogenesis of rheumatoid arthritis also based on the clinical experiences obtained by B…
Abstract Number: 2383 • 2013 ACR/ARHP Annual Meeting
A Useful Mathematical Model Able To Predict The Early Response To Tocilizumab In Rheumatoid Arthritis
Chiara Stagnaro¹, Claudia Ferrari², Rosaria Talarico³, Camillo Giacomelli¹, Stefano Bombardieri¹ and Laura Bazzichi¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, Pisa, Italy
Background/Purpose: In the last few year the introduction of biological agents has radically changed the clinical outcome of patients with Rheumatoid Arthritis (RA). However, no…
Abstract Number: 1888 • 2013 ACR/ARHP Annual Meeting
Transcriptional Regulation Of Peptidylarginine Deiminase Type IV: Implications For Rheumatoid Arthritis
Ali Abbas¹, Kevin Le¹, Virginia Pimmett¹, David A. Bell², Ewa Cairns² and Rodney P. DeKoter¹, ¹Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: High titers of anti-citrullinated protein/peptide antibodies (ACPA) have been detected in sera of rheumatoid arthritis (RA) patients, implicating citrullinating enzymes in the pathogenesis of…
Abstract Number: 877 • 2013 ACR/ARHP Annual Meeting
Results From The RATE-RA Study: A Multicenter, Single-Arm Study To Evaluate The Safety Of Administering Rituximab At a More Rapid Infusion Rate In Patients With Rheumatoid Arthritis
Charles H. Pritchard¹, Maria W. Greenwald², Joel M. Kremer³, Norman B. Gaylis⁴, William Rigby⁵, Steve Zlotnick⁶, Carol Chung⁷, Birgit Jaber⁸ and William Reiss⁹, ¹Rheumatology, Drexel University College of Medicine, Willow Grove, PA, ²Desert Medical Advances, Palm Desert, CA, ³Center for Rheumatology, Albany Medical College, Albany, NY, ⁴Arthritis & Rheumatic Disease Specialties, Aventura, FL, ⁵Department of Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁶Genentech, Inc., a Member of the Roche Group, South San Francisco, CA, ⁷Genentech Inc., South San Francisco, CA, ⁸F. Hoffmann-La Roche Ltd., Basel, Switzerland, ⁹Genentech, South San Francisco, CA
Background/Purpose: The FDA-approved dose of rituximab (RTX) in rheumatoid arthritis (RA) is 2 × 1000 mg IV infusions given 2 weeks apart (1 course), with…
Abstract Number: 2335 • 2013 ACR/ARHP Annual Meeting
Epstein-Barr Virus In Peripheral Blood Of Rheumatoid Arthritis Patients Predicts Response To Rituximab Therapy
Heikki Valleala¹, Markku Korpela², Markku J. Kauppi³ and Yrjo T. Konttinen⁴, ¹Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland, ²Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital, Tampere, Finland, ³Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland, ⁴Dept of Medicine, Helsinki Univ Central Hospital, Helsinki, Finland
Background/Purpose: Autoreactive B-cells infected by Epstein-Barr virus (EBV) are suspected to be involved in the aetiology of various human chronic autoimmune diseases. The aim of…
Abstract Number: 1833 • 2013 ACR/ARHP Annual Meeting
Combination Of TNF and IL-6 Induces Osteoclast-Like Cells With Bone-Resorption Activity Both In Vitro and In Vivo
Kazuhiro Yokota, Kojiro Sato and Toshihide Mimura, Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Although TNF inhibitors suppress bone destruction in patients with rheumatoid arthritis (RA), TNFα stimulation alone does not directly induce osteoclasts, bone-resorbing cells. With the…
Abstract Number: 772 • 2013 ACR/ARHP Annual Meeting
Neovascularization and CD15s Influence Long Distance Migration Of Synovial Fibroblasts From Patients With Rheumatoid Arthritis
Birgit Zimmermann¹, Sina Köppert¹, Stephanie Lefèvre¹, Stefan Rehart², Ulf Müller-Ladner¹ and Elena Neumann³, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ³Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Rheumatoid arthritis (RA) synovial fibroblasts (SF) are central cells of cartilage destruction and neoangiogenesis. RASF show an increased migratory potential in the synovium towards…
Abstract Number: 2342 • 2013 ACR/ARHP Annual Meeting
Long-Term Safety Of Rituximab: Pooled Analysis Of The Rheumatoid Arthritis Global Clinical Trial Program Over 11 Years
Ronald van Vollenhoven¹, Paul Emery^2,3, Clifton O. Bingham III⁴, Edward Keystone⁵, Roy Fleischmann⁶, Daniel Furst⁷, Eva W. Hessey⁸, Abdul Mehbob⁸ and Patricia B. Lehane⁹, ¹Karolinska Institute, Stockholm, Sweden, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD, ⁵University of Toronto, Toronto, ON, Canada, ⁶University of Texas Southwestern Medical Center, Dallas, TX, ⁷Medicine, University of California, Los Angeles, Los Angeles, CA, ⁸Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁹Roche Products Ltd, Welwyn Garden City, United Kingdom
Background/Purpose: This analysis evaluated the long-term safety of rituximab (RTX) in rheumatoid arthritis (RA) patients in a global clinical trial program. Methods: Pooled observed case…
Abstract Number: 1734 • 2013 ACR/ARHP Annual Meeting
A Phase Ib Clinical Trial With Dekavil (F8-IL10), An Immunoregulatory ‘Armed Antibody’ For The Treatment Of Rheumatoid Arthritis, Used In Combination With Methotrexate
M. Galeazzi¹, L Bazzichi², E Prisco³, G D Sebastiani⁴, D. Neri⁵, L Giovannoni⁶, F Bacchion⁷, M Bardelli¹, C Baldi¹, E Selvi¹, G Minisola⁸, R Caporali⁹ and S Bombardieri¹⁰, ¹Rheumatology Unit, University Hospital of Siena, Siena, Siena, Italy, ²Division of Rheumatology, University of Pisa, Pisa, Pisa, Italy, ³Rheumatology, Deptartment of Rheumatology, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Pavia, Italy, ⁴Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Rome, Italy, ⁵Chemistry and Applied Sciences, Swiss Federal Institute of Technology, Zurich, Zurich, Switzerland, ⁶Clinical Research Unit, Philogen S.p.A., Siena, Sovicille - (SI), Italy, ⁷Clinical Research Unit, Philogen S.p.A, Siena, Sovicille - (SI), Italy, ⁸Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Rome, Italy, ⁹Department of Rheumatology, University of Pavia, IRCSS Policlinico San Matteo Foundation, Pavia, Pavia, Italy, ¹⁰Department of Clinical and Experimental Medicine, Department of Rheumatology, University of Pisa, Pisa, Pisa, Italy
Background/Purpose: A therapeutic strategy based on the selective delivery of an immuno-regulatory cytokine to the sites of inflammatory disease has been developed. DEKAVIL is an…
Abstract Number: 776 • 2013 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha Modifies Chromatin Landscape and Amplifies Inflammatory Responses To Subsequent Stimuli In Synovial Fibroblasts
Angela Lee¹, Lionel B. Ivashkiv² and George D. Kalliolias¹, ¹Medicine, Hospital for Special Surgery, New York, NY, ²Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Fibroblast-like synoviocytes (FLS) cross-talk with macrophages (Mf) during the course of rheumatoid arthritis (RA). Our group has shown that TNFa, primarily Mf-derived within synovium,…

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