Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 1647 • 2016 ACR/ARHP Annual Meeting
Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Safety and Efficacy in Open-Label, Long-Term Extension Studies over 8 Years
Jürgen Wollenhaupt¹, Joel Silverfield², Eun Bong Lee³, Ketti Terry⁴, Kenneth Kwok⁵, Staci Abramsky⁵, Min Wang⁵, Chudy Nduaka⁶, Ryan DeMasi⁵ and Lisy Wang⁴, ¹Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ²Healthpoint Medical Group, Tampa, FL, ³Seoul National University, Seoul, South Korea, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc, New York, NY, ⁶Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. The objective of this analysis was to report tofacitinib safety and tolerability…
Abstract Number: 2571 • 2016 ACR/ARHP Annual Meeting
Distinct Oral and Fecal Community Profiles Enriched in Opportunistic Pathogens in RA Patients and First Degree Relatives Are Influenced By Environmental Risk Factors, Including Smoking, Dental History and Lung Infection
Helen Benham^1,2,3, Muralidhara Maradana⁴, Vanessa Anne Lakis¹, Paraic O Cuiv⁵, John Wood⁶, Lisa Nagl¹, Nishta Rammouth¹, Clare Owens³, Joshua Daly⁷, Nancy Lachner⁷, Mark Morrison¹, Philip Hugenholtz⁷, Kim-Anh Lê Cao¹ and Ranjeny Thomas¹, ¹Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, ²University of Queensland School of Medicine, Brisbane, Australia, ³Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, ⁴Translational Research Institute, The University of Queensland Diamantina Institute, Wooloongabba, Australia, ⁵Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Rheumatology Department, Princess Alexandra Hospital, Woolloongabba, Australia, ⁷The University of Queensland, Australian Centre for Ecogenomics, Brisbane, Australia
Background/Purpose: In the Rheumatoid Arthritis (RA) prodrome, genetic predisposition intersects with environmental risk factors, such as smoking, periodontal disease and respiratory infection, however no studies…
Abstract Number: 134 • 2016 ACR/ARHP Annual Meeting
Synovitis Assessed By the German 7-Joint Ultrasound Score (US7S) Is Associated with the Reversible Activity-Related Component of Physical Disability in Patients with Rheumatoid Arthritis
Jakub Zavada¹, Petra Hanova¹, Jana Hurnakova¹, Lenka Szczukova², Michal Uher², Šárka Forejtová¹, Martin Klein¹, Heřman F Mann¹, Marta Olejarova¹, Olga Sleglova¹, Olga Ruzickova¹ and Karel Pavelka¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Brno, Czech Republic
Background/Purpose: Restoring normal functioning is a major therapeutic aim. Differences in the sources of functional limitations should be considered in the interpretation of functional measures.…
Abstract Number: 1054 • 2016 ACR/ARHP Annual Meeting
Self-Reported Psychological Impact and Coping Strategies of Men with RA
Caroline Flurey¹, Sarah Hewlett², Karen Rodham³, Alan White⁴, Robert Noddings⁵ and John Kirwan⁶, ¹Faculty of Health and Life Sciences, University of the West of England, Bristol, United Kingdom, ²Academic Rheumatology, University of West of England, Bristol, United Kingdom, ³Psychology, Sport and Exercise, Staffordshire University, Stoke on Trent, United Kingdom, ⁴Centre for Men's Health, Leeds Beckett University, Leeds, United Kingdom, ⁵Academic Rheumatology Unit, Bristol Royal Infirmary, Bristol, United Kingdom, ⁶University of Bristol, Bristol, United Kingdom
Background/Purpose: Current RA research reflects the preponderance of women with the condition (30% male). Research in other conditions suggests men need their own health strategy.…
Abstract Number: 1737 • 2016 ACR/ARHP Annual Meeting
Adherence to Subcutaneous Biological Therapies Among Inflammatory Arthropaty Patients from a University Hospital
Catalina Gómez-Arango¹, M. Luz García-Vivar¹, Montserrat Alonso-Diez², M. Milagros Alvarez-Lavin², Eva Galindez-Agirregoikoa³, Olaia Fernández-Berrizbeitia³, Esther Ruíz-Lucea¹, Juan María Blanco-Madrigal¹, Jose Francisco Garcia-Llorente¹, Lidia Estopiñán-Fortea³, Ignacio Torre-Salaberri⁴, Edurne Guerrero-Basterretxea³, Itziar Calvo-Zorrilla³, Amaia Bilbao-González⁵ and Natalia Rivera-García⁵, ¹Rheumatology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ²Pharmacy Department, Basurto University Hospital, Bilbao, Spain, ³Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁴Rheumaytology, Rheumatology Department, Basurto University Hospital, Bilbao, Spain, ⁵Research Department, Basurto University Hospital, Bilbao, Spain
Background/Purpose: Rheumatic inflammatory arthropaties such as Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA) and Spondyloarthrities (SpA) are chronic diseases that require adequate therapies, sometimes biological drugs,…
Abstract Number: 2595 • 2016 ACR/ARHP Annual Meeting
Real World Results from a Post-Approval Safety Surveillance of Tofacitinib (Xeljanz): Over 3 Year Results from an Ongoing US-Based Rheumatoid Arthritis Registry
Arthur F. Kavanaugh¹, Jamie Geier², Clifton Bingham III³, Connie Chen², George W. Reed^4,5, Katherine C. Saunders⁴, Yan Chen⁶, Andrew Koenig⁶, Laura Cappelli⁷, Jeffrey D. Greenberg^4,8 and Joel M. Kremer⁹, ¹University of California, San Diego School of Medicine, LaJolla, CA, ²Pfizer, Inc., New York, NY, ³Johns Hopkins University, Baltimore, MD, ⁴Corrona, LLC, Southborough, MA, ⁵University of Massachusetts Medical School, Worcester, MA, ⁶Pfizer, Inc., Collegeville, PA, ⁷Medicine/Rheumatology, Johns Hopkins University, Baltimore, MD, ⁸NYU School of Medicine, New York, NY, ⁹Albany Medical College and the Center for Rheumatology, Albany, NY
Background/Purpose: An interim analysis of a prospective observational 3+ year study, embedded within the US Corrona Rheumatoid Arthritis (RA) registry (14 years and ongoing), was…
Abstract Number: 135 • 2016 ACR/ARHP Annual Meeting
The 8-Joint Ultrasound Score Is a Useful Marker for Monitoring Therapeutic Response in Rheumatoid Arthritis
Ryusuke Yoshimi¹, Yukihiro Toyota¹, Naomi Tsuchida¹, Yumiko Sugiyama¹, Yosuke Kunishita¹, Daiga Kishimoto¹, Reikou Kamiyama¹, Kaoru Minegishi², Maasa Tamura¹, Yukiko Asami¹, Yohei Kirino¹, Shigeru Ohno² and Hideaki Nakajima¹, ¹Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan, ²Center for Rheumatic Disease, Yokohama City University Medical Center, Yokohama, Japan
Background/Purpose: Musculoskeletal ultrasonography (US) is one of the standard tools for the diagnosis and monitoring of rheumatoid arthritis (RA). Although we and other groups have…
Abstract Number: 1114 • 2016 ACR/ARHP Annual Meeting
Extracellular Vesicles in the Circulating of Rheumatoid Arthritis Patients Are Pro-Inflammatory
Onno J. Arntz¹, Bartijn C.H. Pieters¹, Rogier Thurlings², Peter L. E. M. van Lent³, Peter M. van der Kraan³, Marije I. Koenders¹, FHJ van den Hoogen² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboudumc, Nijmegen, Netherlands, ²Rheumatology, Radboudumc, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a progressive and degenerative joint disease with chronic synovial inflammation in multiple joints. Interestingly, the symmetry and spreading of the…
Abstract Number: 1973 • 2016 ACR/ARHP Annual Meeting
Intramuscular Versus Ultrasound Guided Peritendinous Glucocorticoid Injection for Tenosynovitis in Patients with Rheumatoid Arthritis – a Randomised, Double-Blind, Controlled Study
Mads Ammitzbøll-Danielsen^1,2, Mikkel Ostergaard^2,3, Viktoria Fana⁴, Daniel Glinatsi^2,5, Uffe Møller Døhn⁶, Lykke Midtbøll Ørnbjerg⁷, Esperanza Naredo⁸ and Lene Terslev⁶, ¹Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ²Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ³Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁴Center for Rheumatology and Spine Diseases, Rigshospitalet , Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ⁵Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Glostrup, Denmark, ⁶Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen Center for Arthritis Research (COPECARE), Copenhagen, Denmark, ⁷Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ⁸Rheumatology, Hospital General Universitario Gregorio Marañón and Universidad Complutense, Madrid, Spain
Background/Purpose: The aim of this study was to compare the efficacy of intramuscular versus ultrasound (US)-guided peritendinous glucocorticoid injection in providing disease control after…
Abstract Number: 2604 • 2016 ACR/ARHP Annual Meeting
Ultrasound and Immunological Changes and Associations after One Year of IL-6/IL- 6R Blockade with Tocilizumab in Rheumatoid Arthritis Patients
Cesar Diaz-Torne¹, Juan Jose De Agustin², Patricia Moya¹, Maria A. Ortiz³, Delia Reina⁴, Carme Moragues⁵, Sergi Ros⁶, Emili Gomez⁷, Enrique Casado Burgos⁸, Eli Garcia⁹, Manel Pujol¹⁰, Maria Pilar Lisbona Perez¹¹, Andrés Ponce¹², V Torrente¹³, P. Estrada¹⁴, Silvia Vidal³ and ECOCAT group, ¹Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, ²Rheumatology, Hospital Baix de Llobregat, Barcelona, Spain, ³Institut de Recerca Sant Pau, Barcelona, Spain, ⁴Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, ⁵Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ⁶Rheumatology, Hospital de Viladecans, Viladecans, Spain, ⁷Rheumatology, Hospital Clínic, Barcelona, Spain, ⁸Hospital Universitari Parc Taulí, Sabadell, Spain, ⁹Rheumatology, Hospital de Mollet, Mollet, Spain, ¹⁰Hospital Mútua de Terrassa, Terrassa, Spain, ¹¹Rheumatology, Hospital de Sabadell, Sabadell, Spain, ¹²Rheumatology. Internal Medicine, Hospital General de Granollers, Granollers, Spain, ¹³Hospital de L'Hospitalet, L'Hospitalet de Llobregat, Spain, ¹⁴Rheumatology, Hospital Moises Broggi, Barcelona, Spain
Background/Purpose: Management of RA patients has improved in the last two decades in part with the use of ultrasound (US) in daily clinical practice. The…
Abstract Number: 136 • 2016 ACR/ARHP Annual Meeting
The 7-Joints Musculoskeletal Ultrasound Score (US7 score) Predicts Therapeutic Change in Patients with Early Rheumatoid Arthritis
Sarah Ohrndorf¹, Philipp Daniel Oberdorfer², Lien Le³, Ulrich Mansmann³, Lisa Ines Sprenger², Thomas Häupl⁴, Sandra Hermann², Gabriela Schmittat², Silvia Pade², GR Burmester⁵, Anne-Marie Glimm² and Marina Backhaus⁶, ¹Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ³Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität Munich, Munich, Germany, ⁴Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁵Charité – University Medicine Berlin, Berlin, Germany, ⁶Department of Rheumatology & Immunology, University Medicine Charit, Berlin, Germany
Background/Purpose: Treatment decisions in patients with Rheumatoid Arthritis (RA) after the “Treat to Target (T2T)” - principle is widely recommended, as this management strategy leads…
Abstract Number: 1117 • 2016 ACR/ARHP Annual Meeting
EGCG Down-Regulates TNF-α-Induced Mcl-1 Expression By Modulating Mule/Huwe1, β-TrCP, and USP9X Ubiquitin/De-Ubiquitin Ligases in Rheumatoid Arthritis Synovial Fibroblasts
Nahid Akhtar¹, Sadiq Umar², David Fox³ and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Science, Washington State University, College of Pharmacy, Spokane, WA, ³Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI
Background/Purpose: Myeloid cell leukemia (Mcl-1) phosphorylation at Ser64 position (p-Mcl-1Ser64) has been shown to enhance Mcl-1’s stability and resistance to proteasomal degradation. However, the…
Abstract Number: 1975 • 2016 ACR/ARHP Annual Meeting
Severity and Improvement of Morning Stiffness Independently Associate with Tenosynovitis in Patients with Rheumatoid Arthritis
Yoshihisa Kobayashi^1,2,3, Kei Ikeda¹, Takayuki Nakamura^1,4, Mieko Yamagata^1,5, Takuya Nakazawa^1,6, Shigeru Tanaka¹, Shunsuke Furuta¹, Takeshi Umibe³ and Hiroshi Nakajima¹, ¹Chiba University Hospital, Chiba, Japan, ²Chiba Aoba Municipal Hospital, Chiba, Japan, ³Matudo City Hospital, Matudo, Japan, ⁴Asahi General Hospital, Asahi, Japan, ⁵National Hospital Organization Shimoshizu National Hospital, Yotsukaido, Japan, ⁶National Hospital Organization Chiba-East Hospital, Chiba, Japan
Background/Purpose: Morning stiffness has long been recognized by both patients and rheumatologists as a characteristic feature of rheumatoid arthritis (RA). However, morning stiffness is no…
Abstract Number: 2609 • 2016 ACR/ARHP Annual Meeting
The Effectiveness of Zoster Vaccine in RA Patients Subsequently Treated up to 19 Months with Tofacitinib
Kevin L Winthrop¹, Ann Wouters², Ernest H. Choy^3,4, Chudy Nduaka², Staci Abramsky², Pinaki Biswas², Lisy Wang⁵, Jennifer Hodge², Irina Lazariciu⁶, Koshika Soma², Christopher F Mojcik² and William F.C Rigby⁷, ¹Oregon Health and Sciences University, Portland, OR, ²Pfizer Inc, New York, NY, ³CREATE Center, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, Great Britain, ⁴CREATE Center, Division of Infection and Immunity,, Cardiff University, Cardiff, United Kingdom, ⁵Pfizer Inc, Groton, CT, ⁶Quintiles, Saint-Laurent, QC, Canada, ⁷Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: Rheumatoid arthritis (RA) patients are at increased risk for herpes zoster (HZ), and vaccination is recommended in patients over the age of 50 years,…
Abstract Number: 144 • 2016 ACR/ARHP Annual Meeting
Safety, Tolerability and Feasibility of Minimally Invasive Ultrasound-Guided Synovial Biopsyof Wrist and Metacarpophalangeal Joints – an Ultrasound Follow-up Study
Laurent Meric de Bellefon¹, Patrick Durez², Christine Galant³, Adrien Nzeusseu Toukap⁴, Aleksandra Avramovska⁵, Bernard R. Lauwerys⁶, Frédéric A. Houssiau⁷ and Maria S. Stoenoiu⁸, ¹Rheumatology, Cliniques Universitaires Saint-Luc, CHU Saint-Pierre Brussels, Clinique Notre-Dame de Grâce, Gosselies, Brussels, Belgium, ²Rheumatology, Univ Catholique de Louvain, Brussels, Belgium, ³Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ⁴Department of Rheumatology, Cliniques Universitaires St Luc, Brussels, Belgium, ⁵Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium, ⁶Department of Rheumatology, Université catholique de Louvain, Brussels, Belgium, ⁷Rheumatology, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, ⁸Service de Rhumatologie, Cliniques Universitaires Saint-Luc,Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain,, Brussels, Belgium
Background/Purpose: The development of ultrasound-guided synovial biopsy will enable synovial tissue collection from small joints and will facilitate molecular studies, thus improving the understanding…

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