Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 2938 • 2017 ACR/ARHP Annual Meeting
Is Synovial Hypertrophy without Doppler Activity in Rheumatoid Arthritis Joints Sensitive to Change ? – Results of a Longitudinal Ultrasound Study
Lene Terslev¹, Mikkel Østergaard¹, Joseph Sexton² and Hilde B Hammer², ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Ultrasound (US) is used to assess diseases activity in rheumatoid arthritis (RA). Gray scale (GS) US shows the synovial hypertrophy (SH) and Doppler the…
Abstract Number: 456 • 2017 ACR/ARHP Annual Meeting
Time from First Symptom Onset to First Advanced Therapy Amongst RA Patients in Latin America
Ivanio Pereira¹, Valderilio F Azevedo², Wilson Bautista-Molano³, Julio Casasola⁴, Generoso Guerra⁵, David Vega-Morales⁶, Enrique R Soriano⁷, Diana Rocio Gil⁸, José Antonio Maldonado-Cocco⁹, Leandro Aldunate¹⁰ and Steve Lobosco¹¹, ¹Rheumatology, Universidade Federal de Santa Catarina, Hospital Universitário, Divisão de Reumatologia.Brazil, Florianopolis, Brazil, ²Adjunct Professor of Rheumatology, Federal University of Paraná; Brazil, Curitiba, Brazil, ³School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department Hospital Militar. Colombia, Bogotá, Colombia, ⁴Rheumatology, Hospital General de Mexico, Mexico, Mexico, ⁵Centro Médico Paitilla Internal Medicine and Rheumatology Department. Panama, Panama City, Panama, ⁶Universidad Autónoma de Nuevo León. Rheumatology Service, Internal Medicine Department, Hospital Universitario "Dr. José Eleuterio González". Mexico, Monterrey, Mexico, ⁷Argentina, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸ART Medica - Hospital Universitario Mayor MEDERI Internal Medicine and Rheumatology. Colombia., Bogota, Colombia, ⁹Buenos Aires University, Consulting Professor of Rheumatology, Buenos Aires University. Argentina, Buenos Aires, Argentina, ¹⁰Immunology, Janssen Latin America, Buenos Aires, Argentina, ¹¹Adelphi, Immunology Director- Adelphi Group, Manchester, United Kingdom
Background/Purpose: To understand the RA patient pathway in Latin America from first symptom onset; including time to diagnosis and to first advanced treatment. Methods: Data…
Abstract Number: 1332 • 2017 ACR/ARHP Annual Meeting
Periostin Deficiency Exacerbates Joint Inflammation and Bone Destruction in Mouse Models of Rheumatoid Arthritis
Yun-Hong Cheon, Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea, Republic of (South)
Background/Purpose: Periostin (POSTN), a matricellular protein, is involved in many fundamental biological processes such as bone metabolism, cell proliferation, cell invasion, and angiogenesis. Also, POSTN…
Abstract Number: 2356 • 2017 ACR/ARHP Annual Meeting
Disease Severity Impacts the Relationships of Apelin Concentrations with Arterial Function in Patients with Rheumatoid Arthritis
Sule Gunter¹, Chanel Robinson¹, Gavin Norton¹, Angela Woodiwiss¹, Hon-Chun Hsu¹, Linda Tsang², Aletta Millen¹ and Patrick Dessein³, ¹Physiology, University of Witwatersrand, Johannesburg, South Africa, ²Rheumatology, Universitair Ziekenhuis Brussel, Brussels, Belgium, ³Rheumatology, Vrije Universiteit Brussel and Universitair Ziekenhuis Brussel, Brussels, Belgium
Background/Purpose: Patients with (RA) experience impaired inflammation induced arterial and endothelial function. Apelin can improve arterial function by enhancing the expression of endothelial nitric oxide…
Abstract Number: 2963 • 2017 ACR/ARHP Annual Meeting
Sirukumab Improves Synovial Vascularity As Measured By Power Doppler Sonography in Rheumatoid Arthritis Patients from As Early As Week 4 in a Phase 3 Trial
Bidisha Dasgupta¹, Kristen Sweet¹, Dick DeVries², Benjamin Hsu¹, Ian Gourley¹, Matthew Loza¹ and Peter C. Taylor³, ¹Janssen Research & Development, LLC, Spring House, PA, ²Janssen Biologics Europe, Leiden, Netherlands, ³Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
Background/Purpose: Ultrasound (US) is an established non-invasive tool for sensitively assessing disease activity at the individual‐joint level in rheumatoid arthritis (RA). Synovial thickness is detectable…
Abstract Number: 457 • 2017 ACR/ARHP Annual Meeting
Levels of Satisfaction with RA Treatment and Associated Alignment between Rheumatologists and Their Patients across Latin America
Enrique R Soriano¹, José Antonio Maldonado-Cocco², David Vega-Morales³, Diana Rocio Gil⁴, Ivanio Pereira⁵, Generoso Guerra⁶, Wilson Bautista-Molano⁷, Julio Casasola⁸, Valderilio F Azevedo⁹, Leandro Aldunate¹⁰ and Steve Lobosco¹¹, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, CABA, Argentina, ²Buenos Aires University, Consulting Professor of Rheumatology, Buenos Aires University. Argentina, Buenos Aires, Argentina, ³Universidad Autónoma de Nuevo León. Rheumatology Service, Internal Medicine Department, Hospital Universitario "Dr. José Eleuterio González". Mexico, Monterrey, Mexico, ⁴ART Medica - Hospital Universitario Mayor MEDERI Internal Medicine and Rheumatology. Colombia., Bogota, Colombia, ⁵Rheumatology, Universidade Federal de Santa Catarina, Hospital Universitário, Divisão de Reumatologia.Brazil, Florianopolis, Brazil, ⁶Centro Médico Paitilla Internal Medicine and Rheumatology Department. Panama, Panama City, Panama, ⁷School of Medicine, Universidad Militar Nueva Granada and Rheumatology Department Hospital Militar. Colombia, Bogotá, Colombia, ⁸Rheumatology, Hospital General de Mexico, Mexico, Mexico, ⁹Adjunct Professor of Rheumatology, Federal University of Paraná; Brazil, Curitiba, Brazil, ¹⁰Immunology, Janssen Latin America, Buenos Aires, Argentina, ¹¹Adelphi, Immunology Director- Adelphi Group, Manchester, United Kingdom
Background/Purpose: To assess levels of rheumatologist and patient satisfaction with RA treatment across Latin America and any disconnects that may exist between the two in…
Abstract Number: 1342 • 2017 ACR/ARHP Annual Meeting
Comprehensive Provider Judgment Outweighs Disease Activity Measures in the Decision to Not Escalate Therapy in Patients with Moderate to Severe Rheumatoid Arthritis
Jacob R. Stever¹, Brian Sauer², Chia-Chen Teng, MS¹, Neil Accortt³, David Collier⁴ and Grant Cannon¹, ¹Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²IDEAS Center and Division of Epidemiology, HSR&D SLC VA Medical Center and University of Utah, Salt Lake City, UT, ³Center for Observational Research, Amgen, Inc., Thousand Oaks, CA, ⁴Amgen, Inc., Thousand Oaks, CA
Title: Comprehensive provider judgment outweighs disease activity measures in the decision to not escalate therapy in patients with moderate to severe rheumatoid arthritis. Authors: Stever,…
Abstract Number: 2365 • 2017 ACR/ARHP Annual Meeting
Poor Cardiovascular Risk Management in Rheumatoid Arthritis Patients Despite an Explicit Cardiovascular Risk Management Program
Maaike Heslinga¹, Inge van den Oever², E. Griep³, Hanneke Griep-Wentink³, Yvo M. Smulders⁴, WF Lems⁵, Maarten Boers⁶, Alexandre Voskuyl⁷, Mike J.L. Peters⁴, Dirkjan van Schaardenburg² and Michael Nurmohamed⁸, ¹Amsterdam Rheumatology immunology Center | Reade, Amsterdam, Netherlands, ²Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ³Rheumatology, Antonius Hospital, Sneek, Netherlands, ⁴Internal Medicine, VU University Medical Center, Amsterdam, Netherlands, ⁵Amsterdam Rheumatology and immunology Center | VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁶Epidemiology & Biostatistics, VU Univ Medical Center F-wing, Amsterdam, Netherlands, ⁷Department of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ⁸Rheumatology, Reade, Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands
Background/Purpose: In 2011, we started a cardiovascular (CV) risk management program for rheumatoid arthritis (RA) patients visiting Reade in the Netherlands. We previously reported the…
Abstract Number: 2967 • 2017 ACR/ARHP Annual Meeting
Adding Ultrasound to the Treat-to-Target Strategy Shows No Benefit in Achievement of Remission: Results from the Biodam Cohort
Alexandre Sepriano¹, Sofia Ramiro², Robert B.M. Landewé³, Désirée van der Heijde¹, Sarah Ohrndorf⁴, Oliver FitzGerald⁵, Marina Backhaus⁶, Maggie Larche⁷, Joanne Homik⁸, Alain Saraux⁹, Hilde B. Hammer¹⁰, Lene Terslev¹¹, Mikkel Østergaard¹¹, Gerd R. Burmester¹², Bernard Combe¹³, Maxime Dougados¹⁴, Carol A Hitchon¹⁵, Gilles Boire¹⁶, Robert G. Lambert⁸, Rana Dadashova¹⁷, Joel Paschke¹⁸, Edna Hutchings¹⁷ and Walter P. Maksymowych¹⁷, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ³University of Amsterdam and Atrium Medical Center, Amsterdam, Netherlands, ⁴Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, ⁵ASRI, Dublin, Ireland, Dublin, Ireland, ⁶Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, ⁷Medicine, McMaster University, Hamilton, ON, Canada, ⁸University of Alberta, Edmonton, AB, Canada, ⁹Rheumatology Department, Rheumatology Department, CHU de la Cavale Blanche, Brest, France, Brest Cedex, France, ¹⁰Dept. of Rheumtology, Diakonhjemmet Hospital, Oslo, Norway, ¹¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ¹²Department of Rheumatology and Clinical Immunolgy, Charité University Hospital, Berlin, Germany, ¹³Rheumatology, Lapeyronie Hospital, Montpellier I university, Montpellier, France, ¹⁴Paris-Descartes University,, Paris, France, ¹⁵University of Manitoba, Winnipeg, MB, Canada, ¹⁶Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ¹⁷CaRE Arthritis, Edmonton, AB, Canada, ¹⁸CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: While, a Treat-to-Target strategy (T2T), treating patients with rheumatoid arthritis (RA) towards a certain target (eg. clinical remission; T2T-REM), is highly recommended, several patients…
Abstract Number: 474 • 2017 ACR/ARHP Annual Meeting
Comparison of Tofacitinib Efficacy in Patients with Moderate Vs Severe Rheumatoid Arthritis: Pooled Analysis of Phase 3 Studies
Sergio Schwartzman¹, Prashanth Sunkureddi², Liza Takiya³, Mark Snyder³, Haiyun Fan⁴, Tatjana Lukic⁵, Jacqui Roberts⁶ and William F C Rigby⁷, ¹Hospital for Special Surgery, New York, NY, ²Clear Lake Rheumatology, Nassau Bay, TX, ³Pfizer Inc, Collegeville, PA, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc, New York, NY, ⁶Pfizer Inc, Tadworth, United Kingdom, ⁷Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We evaluated tofacitinib 5 and 10 mg twice daily (BID)…
Abstract Number: 1347 • 2017 ACR/ARHP Annual Meeting
Ultrasonography and Synovial Histology in the RA Patients in Remission
Asami Abe¹, Hajime Ishikawa² and Kunihiko Wakaki³, ¹Rheumatplogy, Niigata Rheumatic Center, Shibata, Japan, ²Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, ³Pathology, Niigata Prefectural Shibata Hospital, Shibata, Japan
Background/Purpose: In the treatment of rheumatoid arthritis (RA), the early diagnosis and early medical treatment via tight control have become increasingly important with the advent…
Abstract Number: 2373 • 2017 ACR/ARHP Annual Meeting
Low or High BMI Negatively Impacts RA Disease Activity in an Asian RA Cohort
Claire Teo¹, KP Leong², CM Woo³, X Tang³, J WL Tan⁴, TY Lian⁴ and ET Koh², ¹Rheumatology, Allergy and Immunology Department, Tan Tock Seng Hospital, Singapore, Singapore, ²Rheumatology/Allerg/Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ³Clinical Research and Innovation Office, Tan Tock Seng Hospital, Singapore, Singapore, ⁴Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore
Background/Purpose: The association of body mass index (BMI) with the outcomes of rheumatoid arthritis (RA) has been inconsistent in the literature. It is postulated that…
Abstract Number: 123 • 2017 ACR/ARHP Annual Meeting
Relationship between Shift Work and the Onset of Rheumatoid Arthritis; Results from a Swedish Case-Control Study
Lars Alfredsson¹, Anna Karin Hedström², Torbjörn Åkerstedt³ and Lars Klareskog⁴, ¹The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Stockholm University; Karolinska Intitutet, Stockholm, Sweden, ⁴Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Shift work has previously been associated with increased RA risk in females. The aim of this study was to investigate the potential association between…
Abstract Number: 475 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patient Characteristics Also Predict Response to Therapy with Biologic Agents: Results from the Corrona Certain Study
Dimitrios A. Pappas¹, James Murray², Carol J. Etzel¹, David R Nelson², Bernice Gershenson³, Katherine C. Saunders¹, Sabrina Rebello¹ and Joel Kremer⁴, ¹Corrona, LLC, Southborough, MA, ²Eli Lilly and Company, Indianapolis, IN, ³University of Massachusetts Medical School, Worcester, MA, ⁴Albany Medical College and The Center for Rheumatology, Albany, NY
Background/Purpose: Response to biologic agents approved for RA may be associated with patient reported factors that are not related to disease and usually not included…
Abstract Number: 1403 • 2017 ACR/ARHP Annual Meeting
Mediterranean Diet Is Inversely Associated with Risk of Rheumatoid Arthritis: A Swedish Population Based Case-Control Study
Daniela Di Giuseppe¹, Kari Johansson², Johan Askling³ and Lars Alfredsson⁴, ¹Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Karolinska Institutet, Solna, Sweden, ³Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁴Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The Mediterranean Diet has been associated with lower mortality and risk of cardiovascular diseases and cancer. Although its components have been analyzed in several…

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