Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 296 • 2019 ACR/ARP Annual Meeting
Prevalence of Elbow Arthritis in Patients with Rheumatoid Arthritis: A Prospective Ultrasound Study
Diana Vossen ¹, Valentin Schaefer², Florian Recker ³, Isabelle Geffken ⁴, Eva Matuschek ⁵ and Wolfgang Hartung ⁶, ¹Departement for Internal Medicine and Rheumatology, Rheinisches Rheumazentrum Meerbusch, St. Elisabeth-Hospital, Meerbusch, Germany; German Society for Rheumatology (Working Group Young Rheumatology), Meerbusch, Germany, ²Medical Clinic III , Rheumatology und clinical Immunology, University Hospital Bonn, Bonn, Germany, ³1. Medical Clinic III , Rheumatology und clinical Immunology, University Hospital Bonn and 2. Department for Obstetrics and Gynecology, University Hospital Bonn, Bonn, Germany, ⁴Departement for Internal Medicine and Rheumatology, Rheinisches Rheumazentrum Meerbusch, St.Elisabeth Hospital, Düsseldorf, Germany, ⁵Department for Internal Medicine, Dreifaltigkeits-Krankenhaus Wesseling, bonn, Germany, ⁶Rheumatology und clinical Immunology, Asklepios Klinik, 93077 Bad Abbach, Bad Abbach, Germany
Background/Purpose: Musculoskeletal ultrasound is an important imaging method in the diagnosis of arthritis, especially rheumatoid arthritis (RA). The prevalence of elbow joint arthritis in RA…
Abstract Number: 453 • 2019 ACR/ARP Annual Meeting
Including Pain, Fatigue and Functionality Regularly in the Assessment of Patients with Early Rheumatoid Arthritis Separately Adds to the Evaluation of Disease Status
Sofia Pazmino¹, Anikó Lovik ², Annelies Boonen ³, Diederik De Cock ¹, Veerle Stouten ¹, Johan Joly ⁴, Kristien Van der Elst ⁵, Delphine Bertrand ¹, Rene Westhovens ⁶ and Patrick Verschueren ⁵, ¹KU Leuven, Leuven, Belgium, ²Leuven Biostatistics and Statistical Bioinformatics Center, KU Leuven, Leuven, Vlaams-Brabant, Belgium, ³Maastricht University Medical Center, Maastricht, Netherlands, ⁴University Hospitals Leuven, Leuven, Vlaams-Brabant, Belgium, ⁵University Hospital Leuven, Leuven, Belgium, ⁶University Hospitals, Leuven, Belgium
Background/Purpose: Rheumatoid arthritis (RA) level of disease activity, cannot be evaluated by a single clinical or laboratory measurement. Hence, composite indices have been created via…
Abstract Number: 478 • 2019 ACR/ARP Annual Meeting
The Influence of Gender on Composite Disease Activity Indices for Rheumatoid Arthritis
Takahiro NIshino¹, Atsushi Hasimoto ¹, Shigeto Tohma ² and Toshihiro Matsui ¹, ¹National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan, ²National Hospital Organization Tokyo National Hospital, Tokyo, Japan
Background/Purpose: Disease activity of patients with rheumatoid arthritis should be assessed equally independent of gender, age, or disease duration. However, at present, they are not…
Abstract Number: 531 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Gonadotropin-Releasing Hormone Antagonism in Severe Biologic Refractory Rheumatoid Arthritis
Anita Kass¹, Hans Christian Gulseth ¹ and Camilla Zettel ¹, ¹Betanien Hospital, Skien, Norway
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and additional therapeutic approaches are needed. The improvement of RA disease activity during pregnancy, and flares during the…
Abstract Number: 839 • 2019 ACR/ARP Annual Meeting
Disease Activity, Cytokine Profiles, and the Risk of Incident Diabetes in Rheumatoid Arthritis
Joshua Baker¹, Bryant England ², Michael George ³, Grant Cannon ⁴ and Ted Mikuls ⁵, ¹University of Pennsylvania, Philadelphia, PA, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, ³University of Pennsylvania, Philadelphia, ⁴Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, ⁵VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis is associated with a higher risk of diabetes mellitus (DM) and cardiovascular disease. While disproportional obesity and visceral fat accumulation may contribute…
Abstract Number: 953 • 2019 ACR/ARP Annual Meeting
Treatment Patterns and Persistency Following the First Biologic DMARD in Patients with Rheumatoid Arthritis: Real-World Analysis of 2012–2016 US Medicare Data
Robin Dore¹, Lawrence Chang ², Yuanyuan Ji ³, Suying Li ³, Jenya Antonova ² and Mark Genovese ⁴, ¹Private practice, Tustin, CA, ²Gilead Sciences, Foster City, CA, ³Chronic Disease Research Group, Minneapolis, MN, ⁴Stanford University, Stanford, CA
Background/Purpose: In RA patients not meeting treat-to-target goals despite treatment with a biologic (b)DMARD, ACR guidelines1 recommend using other targeted immunomodulators (TIM): TNF-α inhibitor (TNFi),…
Abstract Number: 1156 • 2019 ACR/ARP Annual Meeting
Differences in Clinical Outcomes According to the Healthcare Regime in Colombian Patients with Rheumatoid Arthritis
Julian Barahona-Correa¹, Jorge Florez ¹, Mateo Rodriguez ², Karen Ramirez ³, Paul Mendez-Patarroyo ¹, Paola Coral-Alvarado ¹ and Gerardo Quintana-López ¹, ¹Reumavance Group, section of Rheumatology, Fundacion Santa Fe de Bogota University Hospital, Bogota DC, Distrito Capital de Bogota, Colombia, ²School of Medicine, Universidad de Los Andes, Bogota, Distrito Capital de Bogota, Colombia, ³School of Medicine, Universidad Nacional de Colombia, Bogota DC, Distrito Capital de Bogota, Colombia
Background/Purpose: Rheumatoid Arthritis (RA) generates high impact on patients and healthcare systems. Adequate control of disease activity depends to a large extent on the access…
Abstract Number: 1342 • 2019 ACR/ARP Annual Meeting
Identification of Heterogenous Treatment Response Trajectories to anti-IL6 Receptor Treatment in Rheumatoid Arthritis
Joseph Patrick Michele Blair¹, Cecilie Bager ², Man Hung Eric Tang ², Morten Karsdal ³, Anne Bay-Jensen ⁴ and Søren Brunak ⁵, ¹Univeristy of Copenahgen, Copenhagen, Denmark, ²Nordic Bioscience ProScion, Copenhagen, Denmark, ³Nordic Bioscience, Copenhagen, Denmark, ⁴Nordic Bioscience, Herlev, Denmark, ⁵Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disease with a fluctuating course of disease activity and progression. Although treatments have improved substantially in recent…
Abstract Number: 1369 • 2019 ACR/ARP Annual Meeting
Angiogenic Factors for Assessing Rheumatoid Arthritis in the Era of Sonographic Diagnosis and Biologic Therapy
Ji-Won Kim¹, Jin-Sun Kong ², Youngjae Park ³ and Wan-Uk Kim ³, ¹Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, ²Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Background/Purpose: Previously, we demonstrated the direct pro-inflammatory role of the vascular endothelial growth factor (VEGF) and the placenta growth factor (PlGF), and angiogenic factors in…
Abstract Number: 1396 • 2019 ACR/ARP Annual Meeting
Persistence of Tocilizumab Therapy Among Patients with Rheumatoid Arthritis: Data from the US-Based Corrona Rheumatoid Arthritis Registry
Dimitrios Pappas¹, Taylor Blachley ², Jennie Best ³, Steve Zlotnick ³, Kelechi Emeanuru ² and Joel Kremer ⁴, ¹Columbia University, New York, NY, ²Corrona, LLC, Waltham, MA, ³Genentech, Inc., South San Francisco, CA, ⁴Albany Medical College and The Center for Rheumatology; Corrona, LLC, Albany, NY
Background/Purpose: Understanding persistence of biologic therapies and factors associated with discontinuation can help inform treatment decisions for patients with rheumatoid arthritis (RA). We sought to…
Abstract Number: 1434 • 2019 ACR/ARP Annual Meeting
Improvement in Matrix metalloproteinase-3 Levels at 12 Weeks Independently Predicts Achievement of Low Disease Activity at 52 Weeks in Bio-switch Patients with Rheumatoid Arthritis Treated with Abatacept
Nobunori Takahashi¹, Toshihisa Kojima ¹, Kenya Terabe ¹, Shuji Asai ¹ and Naoki Ishiguro ¹, ¹Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
Background/Purpose: Japanese post-marketing surveillance (PMS) data demonstrated that effectiveness of abatacept in rheumatoid arthritis (RA) patients with previous biologics treatment (bio-switch) was significantly lower than…
Abstract Number: 1886 • 2019 ACR/ARP Annual Meeting
Antibody Systems Targeting Citrullinated, Carbamylated, and Peptidyl Arginine Deaminase Autoantigens Distinguish Rheumatoid Arthritis in Combination with Rheumatoid Factors
Thierry Dervieux¹, Joel Kremer ², John Conklin ¹, Kelley Brady ¹, Roberta Alexander ¹, Tyler O'Malley ³, Jing Shi ¹, Claudia Ibarra ¹, Michael Mahler ⁴, Michael Weinblatt ⁵ and Arthur Weinstein ¹, ¹Exagen, Vista, CA, ²Albany Medical College and The Center for Rheumatology; Corrona, LLC, Albany, NY, ³Exagen, Oceanside, CA, ⁴Inova Diagnostics, San Diego, CA, ⁵Brigham and Women's Hospital, Boston, MA
Background/Purpose: Novel antibody systems including anti-carbamylated protein antibody (anti-CarP IgG) and anti-peptidyl arginine deiminase antibody (anti-PAD4 IgG) are emerging as independent diagnostic and prognostic biomarkers…
Abstract Number: 1998 • 2019 ACR/ARP Annual Meeting
Major Histocompatibility Antigen HLA-DQB1*0601 Is Associated with Rheumatoid Arthritis Among Indians in a Replication Study: Evidence of Gene-Environment Interaction with LPG Stove Use
Able Lawrence¹, Anshul Dhar ², Swayam Prakash ³, Suvrat Arya ⁴, Amita Aggarwal ⁵ and Suraksha Agrawal ⁶, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, ²SGPGIMS, Lucknow, India, ³Cellular and Molecular Immunology Laboratory University of California Irvine, School of Medicine USA, Irvine, CA, ⁴Sanjay Gandhi Postgraduate Institute, Lucknow, India, Lucknow, India, ⁵Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, ⁶SGPGIMS, Lucknow, Uttar Pradesh, India
Background/Purpose: Shared epitope smoking interaction does not fully explain MHC association in Rheumatoid Arthritis (RA). We have previously shown HLA-DQB1*0601 (DQ6.1) to be a susceptibility…
Abstract Number: 2133 • 2019 ACR/ARP Annual Meeting
Acute Myocardial Infarction in Rheumatoid Arthritis, Gout, and Osteoarthritis: A Retrospective Study Using the National Inpatient Sample from 2002-2016
Rouhin Sen¹, Sarah Aurit ², Luay Sarsam ³, Osman Bhatty ⁴, Mukund Kumar ¹ and Joseph Nahas ¹, ¹Creighton University Medical Center, Omaha, NE, ²Creighton University Medical Center, Omaha, ³Arnot Health, Elmira, NY, ⁴Montefiore Medical Center Wakefield Campus, Bronx, NY
Background/Purpose: Inflammation is a risk factor in the development of cardiovascular disease. The proposed etiology centers around accelerated atherosclerosis involving various cytokines in the TNF…
Abstract Number: 2288 • 2019 ACR/ARP Annual Meeting
Pregnancy Outcomes in Women Exposed to Golimumab
Suzan Esslinger¹, Susan Gabriel ², Marijo Otero-Lobato ³, Michael Clark ⁴, Pamela Sheridan ⁴ and Anja Geldhof ⁵, ¹Janssen Biologics BV, Leiden, Netherlands, ²Janssen Rearch & Development, LLC, Horsham, PA, ³Janssen Biologics BV, Leiden, Zuid-Holland, Netherlands, ⁴Janssen Research & Development, LLC, Horsham, PA, ⁵Janssen Research & Development, LLC, Leiden, Netherlands
Background/Purpose: Rheumatologic disorders and inflammatory bowel disease can affect women of childbearing potential. Golimumab (GLM) is approved for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic…

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