Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 2861 • 2019 ACR/ARP Annual Meeting
Lung-Related Factors Are Associated with Transitions from Systemic Anti-CCP Antibody Positivity to Classified RA
Ashley Visser ¹, Marie Feser ², Chelsie Fleischer ³, Laura Lenis-Charry ¹, Justin August ¹, Elizabeth Bemis ⁴, Jill Norris ⁵, V. Michael Holers ⁶, Kevin Deane ² and M. Kristen Demoruelle⁷, ¹University of Colorado Denver, Aurora, ²University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ³University of Colorado Denver, Division of Rheumatology, Aurora, CO USA, Aurora, ⁴University of Colorado Denver, School of Public Health, Aurora, CO USA, Aurora, ⁵Colorado School of Public Health, Aurora, ⁶University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ⁷University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora
Background/Purpose: Systemic autoimmunity associated with RA precedes the onset of inflammatory arthritis (IA) by several years. In particular, the presence of systemic anti-cyclic citrullinated peptide…
Abstract Number: 34 • 2019 ACR/ARP Annual Meeting
The Role of NFAT5-p65 Complex Enhanceosome in the Inflammatory Responses of Rheumatoid Arthritis Synovial Fibroblasts via TLR4 Signaling
Kunihiko Umekita¹, Yumi Kariya ¹, Chihiro Iwao ¹, Masatoshi Kimura ¹, Risa Kudo ¹, Yuki Rikitake ¹, Shunichi Miyauchi ² and Akihiko Okayama ¹, ¹University of Miyazaki, Miyazaki, Japan, ²University of Miyazaki, Miyazaki
Background/Purpose: Transcription factors belonging to the family of nuclear factors of activated T cells (NFAT) play an essential role in diverse biological processes, such as…
Abstract Number: 116 • 2019 ACR/ARP Annual Meeting
Defective EZH2 Expression Attenuates Treg Differentiation in Rheumatoid Arthritis
Xinyue Xiao¹, Yueting Li ², Hua Chen ¹ and Xuan Zhang ², ¹Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, Beijing, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College; The Ministry of Education Key Laboratory, Beijing, China, Beijing, China (People's Republic)
Background/Purpose: To explore the role of EZH2, a histone methylation regulator, in the pathogenesis of rheumatoid arthritis (RA).Methods: Forty treatment-naïve patients with active disease and…
Abstract Number: 195 • 2019 ACR/ARP Annual Meeting
The Clinical Characteristics of Patients with Inflammatory Arthritis and a Persistently Low Alkaline Phosphatase Level in a Veteran Affairs Rheumatology Clinic
Luke Monteagudo¹, Amy Gravely ², Peter Valen ³ and David Ewart ³, ¹The University of Minnesota, Minneapolis, ²Minneapolis Veteran Affairs Medical Center, Minneapolis, ³University of Minnesota School of Medicine/ Minneapolis Veteran Affairs Medical Center, Minneapolis
Background/Purpose: Background: The biochemical hallmark of hypophosphatasia (HPP) is a low alkaline phosphatase (ALP) level. It is recognized that some forms of HPP present in adulthood…
Abstract Number: 300 • 2019 ACR/ARP Annual Meeting
Proliferative Globular Synovitis, an Ultrasound Pattern Associated with Seropositive Rheumatoid Arthritis
Ana Belén Azuaga-Piñango¹, Beatriz Frade-Sosa ², Roberto Gumucio ³, Katherine Cajiao-Sanchez ², Stanislava Mandelikova ², Virginia Ruiz-Esquide ⁴, Raul Castellanos-Moreira ², Raimon Sanmarti ⁵, Juan Cañete ⁵ and Julio Ramirez ¹, ¹Hospital Clinic, Barcelona, Spain, Barcelona, Spain, ²Hospital Clinic, Barcelona, Spain, Barcelona, Catalonia, Spain, ³Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, ⁴Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, ⁵Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain
Background/Purpose: Rheumatoid Arthritis (RA) has a synovial ultrasound (US) pattern, while soft tissue involvement is more frequently found in Psoriatic Arthritis (PsA). No previous studies…
Abstract Number: 453 • 2019 ACR/ARP Annual Meeting
Including Pain, Fatigue and Functionality Regularly in the Assessment of Patients with Early Rheumatoid Arthritis Separately Adds to the Evaluation of Disease Status
Sofia Pazmino¹, Anikó Lovik ², Annelies Boonen ³, Diederik De Cock ¹, Veerle Stouten ¹, Johan Joly ⁴, Kristien Van der Elst ⁵, Delphine Bertrand ¹, Rene Westhovens ⁶ and Patrick Verschueren ⁵, ¹KU Leuven, Leuven, Belgium, ²Leuven Biostatistics and Statistical Bioinformatics Center, KU Leuven, Leuven, Vlaams-Brabant, Belgium, ³Maastricht University Medical Center, Maastricht, Netherlands, ⁴University Hospitals Leuven, Leuven, Vlaams-Brabant, Belgium, ⁵University Hospital Leuven, Leuven, Belgium, ⁶University Hospitals, Leuven, Belgium
Background/Purpose: Rheumatoid arthritis (RA) level of disease activity, cannot be evaluated by a single clinical or laboratory measurement. Hence, composite indices have been created via…
Abstract Number: 478 • 2019 ACR/ARP Annual Meeting
The Influence of Gender on Composite Disease Activity Indices for Rheumatoid Arthritis
Takahiro NIshino¹, Atsushi Hasimoto ¹, Shigeto Tohma ² and Toshihiro Matsui ¹, ¹National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan, ²National Hospital Organization Tokyo National Hospital, Tokyo, Japan
Background/Purpose: Disease activity of patients with rheumatoid arthritis should be assessed equally independent of gender, age, or disease duration. However, at present, they are not…
Abstract Number: 531 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Gonadotropin-Releasing Hormone Antagonism in Severe Biologic Refractory Rheumatoid Arthritis
Anita Kass¹, Hans Christian Gulseth ¹ and Camilla Zettel ¹, ¹Betanien Hospital, Skien, Norway
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and additional therapeutic approaches are needed. The improvement of RA disease activity during pregnancy, and flares during the…
Abstract Number: 839 • 2019 ACR/ARP Annual Meeting
Disease Activity, Cytokine Profiles, and the Risk of Incident Diabetes in Rheumatoid Arthritis
Joshua Baker¹, Bryant England ², Michael George ³, Grant Cannon ⁴ and Ted Mikuls ⁵, ¹University of Pennsylvania, Philadelphia, PA, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, ³University of Pennsylvania, Philadelphia, ⁴Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, ⁵VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis is associated with a higher risk of diabetes mellitus (DM) and cardiovascular disease. While disproportional obesity and visceral fat accumulation may contribute…
Abstract Number: 953 • 2019 ACR/ARP Annual Meeting
Treatment Patterns and Persistency Following the First Biologic DMARD in Patients with Rheumatoid Arthritis: Real-World Analysis of 2012–2016 US Medicare Data
Robin Dore¹, Lawrence Chang ², Yuanyuan Ji ³, Suying Li ³, Jenya Antonova ² and Mark Genovese ⁴, ¹Private practice, Tustin, CA, ²Gilead Sciences, Foster City, CA, ³Chronic Disease Research Group, Minneapolis, MN, ⁴Stanford University, Stanford, CA
Background/Purpose: In RA patients not meeting treat-to-target goals despite treatment with a biologic (b)DMARD, ACR guidelines1 recommend using other targeted immunomodulators (TIM): TNF-α inhibitor (TNFi),…
Abstract Number: 1156 • 2019 ACR/ARP Annual Meeting
Differences in Clinical Outcomes According to the Healthcare Regime in Colombian Patients with Rheumatoid Arthritis
Julian Barahona-Correa¹, Jorge Florez ¹, Mateo Rodriguez ², Karen Ramirez ³, Paul Mendez-Patarroyo ¹, Paola Coral-Alvarado ¹ and Gerardo Quintana-López ¹, ¹Reumavance Group, section of Rheumatology, Fundacion Santa Fe de Bogota University Hospital, Bogota DC, Distrito Capital de Bogota, Colombia, ²School of Medicine, Universidad de Los Andes, Bogota, Distrito Capital de Bogota, Colombia, ³School of Medicine, Universidad Nacional de Colombia, Bogota DC, Distrito Capital de Bogota, Colombia
Background/Purpose: Rheumatoid Arthritis (RA) generates high impact on patients and healthcare systems. Adequate control of disease activity depends to a large extent on the access…
Abstract Number: 1342 • 2019 ACR/ARP Annual Meeting
Identification of Heterogenous Treatment Response Trajectories to anti-IL6 Receptor Treatment in Rheumatoid Arthritis
Joseph Patrick Michele Blair¹, Cecilie Bager ², Man Hung Eric Tang ², Morten Karsdal ³, Anne Bay-Jensen ⁴ and Søren Brunak ⁵, ¹Univeristy of Copenahgen, Copenhagen, Denmark, ²Nordic Bioscience ProScion, Copenhagen, Denmark, ³Nordic Bioscience, Copenhagen, Denmark, ⁴Nordic Bioscience, Herlev, Denmark, ⁵Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark
Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disease with a fluctuating course of disease activity and progression. Although treatments have improved substantially in recent…
Abstract Number: 1369 • 2019 ACR/ARP Annual Meeting
Angiogenic Factors for Assessing Rheumatoid Arthritis in the Era of Sonographic Diagnosis and Biologic Therapy
Ji-Won Kim¹, Jin-Sun Kong ², Youngjae Park ³ and Wan-Uk Kim ³, ¹Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, ²Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Background/Purpose: Previously, we demonstrated the direct pro-inflammatory role of the vascular endothelial growth factor (VEGF) and the placenta growth factor (PlGF), and angiogenic factors in…
Abstract Number: 1396 • 2019 ACR/ARP Annual Meeting
Persistence of Tocilizumab Therapy Among Patients with Rheumatoid Arthritis: Data from the US-Based Corrona Rheumatoid Arthritis Registry
Dimitrios Pappas¹, Taylor Blachley ², Jennie Best ³, Steve Zlotnick ³, Kelechi Emeanuru ² and Joel Kremer ⁴, ¹Columbia University, New York, NY, ²Corrona, LLC, Waltham, MA, ³Genentech, Inc., South San Francisco, CA, ⁴Albany Medical College and The Center for Rheumatology; Corrona, LLC, Albany, NY
Background/Purpose: Understanding persistence of biologic therapies and factors associated with discontinuation can help inform treatment decisions for patients with rheumatoid arthritis (RA). We sought to…
Abstract Number: 1434 • 2019 ACR/ARP Annual Meeting
Improvement in Matrix metalloproteinase-3 Levels at 12 Weeks Independently Predicts Achievement of Low Disease Activity at 52 Weeks in Bio-switch Patients with Rheumatoid Arthritis Treated with Abatacept
Nobunori Takahashi¹, Toshihisa Kojima ¹, Kenya Terabe ¹, Shuji Asai ¹ and Naoki Ishiguro ¹, ¹Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
Background/Purpose: Japanese post-marketing surveillance (PMS) data demonstrated that effectiveness of abatacept in rheumatoid arthritis (RA) patients with previous biologics treatment (bio-switch) was significantly lower than…

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