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Abstracts tagged "Rheumatoid arthritis (RA)"

  • Abstract Number: 537 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety Results from a Randomized Double-Blind Study That Compared the Proposed Biosimilar ABP 798 with Rituximab in Subjects with Moderate to Severe RA

    Gerd Burmester1, Edit Drescher 2, Pawel Hrycaj 3, David Chien 4, Zhiying Pan 4 and Stanley Cohen 5, 1Charité—University Medicine Berlin, Berlin, Germany, 22Veszprém Csolnoky Ferenc County Hospital, Veszprém, Hungary, 3Koscian Municipal Hospital, Koscian, Poland, 4Amgen, Thousand Oaks, CA, 5Metroplex Clinical Research Center, Dallas, TX

    Background/Purpose: ABP 798 is being developed as a biosimilar to rituximab, a CD20-directed cytolytic antibody that is approved in the US and EU for treatment…
  • Abstract Number: 842 • 2019 ACR/ARP Annual Meeting

    Mortality Ratio and Risk Factors in CT Confirmed Rheumatoid Arthritis Related Lung Disease: UIP, Pleural Effusion and the Time of Diagnosis of Rheumatoid Arthritis – Lung Disease

    Mustafa Ekici 1, Alper Sarı 2, Yusuf Baytar 3, Ertugrul Cagri Bolek 2, Berkan Armagan 4, Emre Bilgin 2, Bayram Farisoğulları 2, Omer Karadag 5, Ali İhsan Ertenli 2, Sedat Kiraz 5, Şule Apras Bilgen 5, Levent Kilic 5, Ali Akdoğan 2, Gamze durhan 3, Macit arıyürek 3 and Umut Kalyoncu6, 1Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, 2Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, 3Hacettepe University, Faculty of Medicine, Department of Radiology, Ankara, Turkey, 4Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Ankara, Turkey, 5Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, ankara, Turkey, 6Hacettepe University Department of Rheumatology, Ankara, Turkey

    Background/Purpose: The frequency of pulmonary involvement in rheumatoid arthritis varies between 7-35%. The most important cause of death in RA patients is lung disease in…
  • Abstract Number: 960 • 2019 ACR/ARP Annual Meeting

    Autoantibodies in Rheumatoid Arthritis Target Citrulline-Containing and Native Epitopes from Conformationally Disordered Regions of Proteins

    Zihao Zheng 1, Lauren Fahmy 1, Alan Bridges 2, Michael Newton 1 and Miriam Shelef1, 1University of Wisconsin - Madison, Madison, 2William S. Middleton Memorial Veterans Hospital, Madison

    Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are the main diagnostic and pathologic autoantibodies in rheumatoid arthritis. However, autoantibodies develop against proteins with…
  • Abstract Number: 1172 • 2019 ACR/ARP Annual Meeting

    The Relationship Between Subclinical Inflammation and Bone Damage in Patients with Rheumatoid Arthritis Using Multimodality Imaging

    Scott Brunet 1, Peter Salat 2, Glen Hazlewood 3, Klaus Engelke 4, Cheryl Barnabe 3 and Sarah Manske3, 1University of Calgary, Calgary, Canada, 2University of Calgary, Calary, Canada, 3University of Calgary, Calgary, AB, Canada, 4Erlangen University Hospital, Department of Medicine, Erlangen, Germany

    Background/Purpose: Many RA patients in clinical remission have evidence of bone marrow edema (BME) on magnetic resonance imaging (MRI), with radiographic bone damage progression appearing…
  • Abstract Number: 1344 • 2019 ACR/ARP Annual Meeting

    Increased High Molecular Weight Adiponectin and Lean Mass During Tocilizumab Treatment in Patients with Rheumatoid Arthritis: A 12 Month Multicenter Study

    Eric Toussirot1, Hubert Marotte 2, denis Mulleman 3, gregoire Cormier 4, fabienne Coury-Lucas 5, Philippe Gaudin 6, Emmanuelle Dernis 7, christine bonnet 8, richard damade 9, jean-luc Grauer 10, Tassadit Ait Abdesselam 11, caroline Karras 12, frederic Liote 13, Pascal Hilliquin 14, antoinette sacchi 15, Jean-Marie Berthelot 16, marc puyraveau 1 and gilles dumoulin 1, 1University Hospital, Besancon, France, 2University Hospital, St Etienne, France, 3University hospital, Tours, France, 4CHD Vendée, La Roche sur Yon, France, 5University Hospital, Lyon, France, 6Rheumatology Department, CHU Grenoble Alpes Hôpital Sud and GREPI - Université Grenoble Alpes, EA7408, Grenoble - Echirolles, France, 7Rheumatology Department, Le Mans Central Hospital, Le Mans, France, 8University Hospital, Limoges, France, 9Centre Hospitalier, Chartres, France, 10Centre Hopsitalier, Montelimar, France, 11Centre Hospitalier, Meaux, France, 12Hôpital Saint Joseph, Marseille, France, 13AP-HP, Paris, France, 14Centre Hospitalier, Corbeil Essones, France, 15Centre Hospitalier, Mantes la Jolie, France, 16University Hospital, Nantes, France

    Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) diseases. Dyslipidemia is a known adverse reaction to tocilizumab (TCZ). TNFa blockade…
  • Abstract Number: 1371 • 2019 ACR/ARP Annual Meeting

    Create an Algorithm of Outcome Forecasting and Decision Making for RA Treatment: Data Mining and Machine Learning via the Smart System of Disease Management (SSDM)

    Rong Mu1, Chun Li 2, Jing Yang 3, Xiaohan Wang 4, Bin Wu 5, Fengxiao Zhang 6, Yong Wang 7, Li Qin 8, Cundong Mi 9, Huifang Guo 10, Wei Wei 11, Wei Liu 12, Qingchun Huang 13, Jing Lu 14, Yang Liu 15, Huiling Li 16, Bing Wu 17, Hui Xiao 18, Yuhua Jia 19 and Fei Xiao 20, 1People's Hospital, Beijing University Medical School, Beijing, China (People's Republic), 2People's Hospital, Beijing University Medical School, Beijing, Beijing, China (People's Republic), 3Central Hospital of MianYang, Mianyang, Sichuan, China (People's Republic), 4Anyang district hospital, Fuyang, Hainan, China (People's Republic), 5Chongqing Hospital of Traditional Chinese Medicine, Chongqing, Chongqing, China (People's Republic), 6Hebei General Hospital, Shijiazhuang, Hebei, China (People's Republic), 7The first Hospital Affiliated to AMU (Southernwest Hospital), Chongqing, China (People's Republic), 8The No.3 People’s Hospital of HuZhou City, Huzhou, Zhejiang, China (People's Republic), 9The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (People's Republic), 10The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (People's Republic), 11Tianjin Medical University General Hospital, Tianjin, Tianjin, China (People's Republic), 12First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China (People's Republic), 13The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China (People's Republic), 14First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China (People's Republic), 15Affiliated Hospital of Inner Mongolia Medical University, Huhehaote, Nei Mongol, China (People's Republic), 16Hubei Hospital of Traditional Chinese Medicine, Wuhan, Hubei, China (People's Republic), 17Shanghai Gothic Internet Technology Co., Ltd, Shanghai, China (People's Republic), 18Shanghai Gothic Internet Technology Co., Ltd, shanghai, Shanghai, China (People's Republic), 19Shanghai Gothic Internet Technology Co., Ltd., Shanghai, Shanghai, China (People's Republic), 20Shanghai Gothic Internet Technology Co., Ltd., shanghai, China (People's Republic)

    Background/Purpose: Daily health care deals with a wide spectrum of RA patients from statuses of remission (R) to disease activities at low (L), moderate (M)…
  • Abstract Number: 1408 • 2019 ACR/ARP Annual Meeting

    Efficacy of Pharmacological Treatment in Rheumatoid Arthritis: A Systematic Literature Review Informing the 2019 Update of the EULAR Recommendations for Management of Rheumatoid Arthritis

    Andreas Kerschbaumer1, Alexandre Sepriano 2, Josef Smolen 1, Désirée van der Heijde 2, Maxime Dougados 3, Ronald F Van Vollenhoven 4, Iain McInnes 5, Johannes Bijlsma 6, Gerd Burmester 7, Maarten de Wit 8, Louise Falzon 9 and Robert B.M. Landewé 10, 1Medical University of Vienna, Vienna, Austria, 2Leiden University Medical Center, Leiden, Netherlands, 3Cochin Hospital, Paris, France, 4Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, 5Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 6UMC Utrecht, Department of Rheumatology & Clinical Immunology, Utrecht, The Netherlands, Utrecht, Netherlands, 7Charité—University Medicine Berlin, Berlin, Germany, 8Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam University Medical Centre, Amsterdam, Netherlands, 9Northwell Health, New York, 10Amsterdam University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Via a systematic literature review of contemporary efficacy data of pharmacological therapies in RA we sought to inform the 2019 update of the EULAR…
  • Abstract Number: 1440 • 2019 ACR/ARP Annual Meeting

    Relationship Between Adalimumab Concentrations, Plasma Cytokines, Anti-drug Antibodies and Disease Activity in Rheumatoid Arthritis

    Lisa Stamp1, Paula Keating 2, Christopher Frampton 3, Murray Barclay 3, Niamh Fanning 3, Melanie Millier 4, Paul Hessian 4 and John O'Donnell 5, 1University of Otago, Christchurch, Christchurch, Canterbury, New Zealand, 2Canterbury Health Laboratories, Christchurch, New Zealand, 3University of Otago, Christchurch, Christchurch, New Zealand, 4University of Otago, Dunedin, New Zealand, 5Christchurch Hospital, Christchurch, New Zealand

    Background/Purpose: Therapeutic drug monitoring (TDM) would be important if there was evidence to support the utility of measured drug concentrations in making changes to dose…
  • Abstract Number: 1889 • 2019 ACR/ARP Annual Meeting

    Biomarkers of Clinical Relapse and Radiological Progression in Patients with Rheumatoid Arthritis in Remission: Observational Study of 5 Years of Follow-up

    Julio Ramirez1, Andrea Cuervo Aguilera 2, Raquel Celis 3, Virginia Ruiz-Esquide 3, Raul Castellanos-Moreira 4, Jose Gomez-Puerta 5, Raimon Sanmarti 5 and Juan Cañete 5, 1Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 2Hospital Clínic Barcelona, Spain, Barcelona, Spain, 3Hospital Clínic, Barcelona, Spain, 4Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, 5Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain

    Background/Purpose: To search biomarkers of clinical relapse and radiological progression in patients with RA in clinical remissionMethods: RA patients in clinical remission (defined as DAS28-ESR…
  • Abstract Number: 2005 • 2019 ACR/ARP Annual Meeting

    Circulating Mitochondrial Danger-Associated Molecular Patterns as Novel Biomarkers of Disease Activity and Inflammation in Rheumatoid Arthritis

    Bhargavi Duvvuri1 and Christian Lood 1, 1University of Washington, Seattle

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease causing erosive and disabling joint damage. We recently found that mitochondria are extruded upon formation of…
  • Abstract Number: 2163 • 2019 ACR/ARP Annual Meeting

    Prevalence of Postoperative Anemia in Patients with Rheumatoid Arthritis and Psoriatic Arthritis Undergoing Total Knee Arthroplasty: A Study of National Inpatient Sample 2010-2014

    Karan Jatwani 1, Karan Chugh 2, Bikramjit Bindra 3 and Shraddha Jatwani2, 1Mount Sinai West - St Luke’s Hospital, New York, 2St. Vincent Evansville, Evansville, 3Government Medical College & Hospital, Chandigarh, India

    Background/Purpose: Total knee arthroplasty (TKA) is a valuable option for improving function and pain control in patients with end-stage arthritis, especially those with inflammatory arthritis…
  • Abstract Number: 2302 • 2019 ACR/ARP Annual Meeting

    Comparison Between Fibromyalgia and Neuropathic Pain in Patients with Established Rheumatoid Arthritis

    Yong Gil Hwang1, Lei Zhu 1 and Larry Moreland 1, 1University of Pittsburgh, PITTSBURGH, PA

    Background/Purpose: Our objectives were (1) to identify similarities and differences of pain symptoms identified by fibromyalgia (FM) and neuropathic pain (NP) screening tool (2) to…
  • Abstract Number: 2323 • 2019 ACR/ARP Annual Meeting

    The Association Between Disease Activity with Coronary Microvascular Dysfunction in Rheumatoid Arthritis

    Sicong Huang 1, Zeling He 1, Daniel Solomon 2, Elena Massarotti 3, Charlotte Golnik 1, Thany Seyok 1, Seth Brownmiller 4, Tianrun Cai 3, Nicole Yang 3, Laurel Campbell 3, Leanne Barrett 3, Courtney Bibbo 3, Kenneth Pariser 3, Derrick Todd 3, Marcy Bolster 4, Marcelo Di Carli 3 and Katherine Liao1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, 3Brigham and Women's Hospital, Boston, 4Massachusetts General Hospital, Boston, MA

    Background/Purpose: Inflammation accounts for much of the excess cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA).  We hypothesize that increased systemic inflammation leads to…
  • Abstract Number: 2342 • 2019 ACR/ARP Annual Meeting

    Association of Serum KL-6 Level and Change of Pulmonary Function in Interstitial Lung Disease of Rheumatoid Arthritis – Data from Prospective KOrean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) Study

    Jeong Seok Lee1, Young Im Yoon 2, Eun Young Lee 3, Jung Yoon Choe 4, Hwa Jung Lee 5, Yong-Beom Park 6, Eun Ha Kang 7, You-Jung Ha 7, Yeon-Ah Lee 8 and Seong Hye Jang 9, 1Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2Seoul National University Hospital, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, 4Division of Rheumatology, Daegu Catholic University Medical Center, Daegu, Republic of Korea, 5DAEGU CATHOLIC UNIVERSITY, Daegu, Republic of Korea, 6Yonsei university college of medicine, severance hospital, Seodaemun-gu, Seoul-t'ukpyolsi, Republic of Korea, 7Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, 8School of Medicine, Kyung Hee University, Seoul, Republic of Korea, 9Soonchunhyang University, Cheonan, Republic of Korea

    Background/Purpose: Interstitial lung disease (ILD) is the most common lung disease among rheumatoid arthritis (RA) patients. Although the overall mortality rates for RA have decreased…
  • Abstract Number: 2368 • 2019 ACR/ARP Annual Meeting

    Risk of Diverticulitis and Gastro-Intestinal Perforation in Rheumatoid Arthritis Treated with Tocilizumab Compared to Rituximab and Abatacept: A Prospective Propensity-matched Cohort Study

    Claire Rempenault1, Cédric Lukas 1, Bernard Combe 2, Isabelle Pane 3, Xavier Mariette 4, Jacques-Eric Gottenberg 5 and Jacques Morel 1, 1Department of Rheumatology, Montpellier University Hospital, Montpellier, France, Montpellier, Languedoc-Roussillon, France, 2CHU Montpellier, Montpellier University, Montpellier, France, 3Centre de Recherche en Epidémiologie et Statistiques, INSERM U1153, Centre d'Épidémiologie Clinique, Hôpital Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris (AP-HP), Descartes University, Paris, France., Paris, Ile-de-France, France, 4Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, 5Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: Several studies have reported an increased risk of gastro-intestinal perforation (GIP) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ) compared to conventional synthetic…
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