Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 104 • 2019 ACR/ARP Annual Meeting
Novel, Selective, Orally Active PAD4 Inhibitors for the Treatment of Autoimmune Disorders
Santosh Vishwakarma¹, Gurulingappa Hallur ¹, Himanshu Agrawal ¹, Sharad Singh ¹, Annasaheb Kalange ¹, Seema Chikkur Gangadhar ¹, Shuvranshu PraharaJ ¹, Nafees Ahmad Quresh ¹, Srikanth Kanagal Gopinath ¹, Krishnakumar V ¹, Sameer Mahmood ¹, Rudresh G ¹, Mohd Zainuddin ¹, Rajendra Kristam ¹, Ishtiyaque Ahmad ¹, Ramachandraiah Gosu ¹, Purra Buchi Reddy ¹, N V S K Rao ¹, Saloni Mehra ², Jeyaraj D A ¹, Takeshi Yura ¹, Saravanakumar dhakshinamoorthy ¹, Sriram Rajagopal ¹, Dhanalakshmi Sivanandhan ³ and Sridharan Rajagopal ³, ¹Jubilant Biosys, Bangalore, India, ²Jubilant Chemsys, Noida, India, ³Jubilant Therapeutics, Bangalore, India
Background/Purpose: Citrullination of proteins is catalyzed by a family of enzymes called the peptidylarginine deiminases (PADs). While the citrullinated proteins may have physiological roles in differentiation,…
Abstract Number: 193 • 2019 ACR/ARP Annual Meeting
Diet as a Risk Factor for Rheumatoid Arthritis
Chelsea Guan ¹ and Shazia Beg², ¹University of Central Florida, Orlando, ²University of Central Florida College of Medicine, Orlando
Background/Purpose: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease affecting the joints that typically affects women more than men. An exact cause has yet…
Abstract Number: 284 • 2019 ACR/ARP Annual Meeting
Impact of Body Mass Index on the Agreement Between Ultrasound- and Clinical Assessments of Disease Activity in Rheumatoid Arthritis : Multicenter and Cross-sectional Study
Gaël Mouterde¹, Federico Manna ², Benoît Le Goff ³, Jean-David Albert ⁴, Sandrine Jousse-Joulin ⁵, Frédérique Gandjbakhch ⁶, Damien Loeuille ⁷, Philippe Gaudin ⁸, Muriel Piperno ⁹, Frédéric Banal ¹⁰, Bénédicte Jamard ¹¹, Carine Salliot ¹², Nicolas Molinari ², Bernard Combe ¹³, Maria-Antonietta D'Agostino ¹⁴ and Cédric Lukas ¹⁵, ¹CHU Montpellier and Univ Montpellier, Montpellier, France, ²Clinical Research and Epidemiology Unit, University Hospital, Montpellier, France, ³Rheumatology Department, CHU de Nantes and INSERM UMR 1238, Faculty of Biology of Nantes, Nantes, France, ⁴Rheumatology department, Rennes University Hospital and Institut NUMECAN, INSERM U 1241, Rennes, Bretagne, France, ⁵Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ⁶Rheumatology department, Pitié Salpêtrière hospital, APHP and Sorbonne University, Paris, France, ⁷Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France, ⁸Rheumatology Department, CHU Grenoble Alpes Hôpital Sud and GREPI - Université Grenoble Alpes, EA7408, Grenoble - Echirolles, France, ⁹Rheumatology Department, Hospices Civils de Lyon, centre hospitalier Lyon Sud, Pierre Bénite, France, ¹⁰Service rhumatologie, hôpital d'instruction des armées Bégin, Saint Mandé, France, ¹¹Department of Rheumatology, Purpan Teaching Hospital, Toulouse, France, ¹²Rheumatology Unit, centre hospitalier regional d'Orleans, Orléans, France, ¹³CHU Montpellier, Montpellier University, Montpellier, France, ¹⁴UMR1173, INSERM/Versailles-Saint Quentin University, France Ambroise Paré Hospital (AP-HP) Department of Rheumatology, Boulogne Billancourt, France, ¹⁵Rheumatology department, CHU Montpellier, Univ Montpellier, Montpellier, France
Background/Purpose: Clinical evaluation of synovitis in rheumatoid arthritis (RA) is difficult in obese (O) and overweight patients, due to the fat pad located around the…
Abstract Number: 449 • 2019 ACR/ARP Annual Meeting
The Course of Disability Related to Function of the Upper Extremities in Early Rheumatoid Arthritis over 10 Years of Follow-up
Maria Rydholm ¹, Ingegerd Wikström ², Maria Mellblom Bengtsson ¹, Sofia Hagel ³, Lennart Jacobsson ⁴ and Carl Turesson², ¹Skåne University Hospital, Malmö, Sweden, ²Lund University, Malmö, Sweden, ³Skåne University Hospital, Lund, Sweden, ⁴Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased disability, in particular due to involvement of the joints of the upper extremities. The Stanford Health Assessment…
Abstract Number: 476 • 2019 ACR/ARP Annual Meeting
Decreased Muscle Mass, a Novel Predicting Indicator for One-year Radiographic Progression in Rheumatoid Arthritis: A Real-world Cohort Study
Jian-Zi Lin ¹, Jian-Da Ma ¹, Qian-Hua Li ¹, Ying-Qian Mo ¹, Li-Juan Yang ¹, Le-Feng Chen ¹, Chu-Tao Chen ¹, Jun-Wei Wang ¹, Dong-Hui Zheng ¹ and Lie Dai¹, ¹Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China (People's Republic)
Background/Purpose: Obesity paradox based on body mass index (BMI) in rheumatoid arthritis (RA) remain elusive. Our previous cross-sectional study has reported myopenia is associated with joint…
Abstract Number: 526 • 2019 ACR/ARP Annual Meeting
Factors Influencing Discontinuation in Long-term RA Treatment
Madison Grinnell¹, Sofia Pedro ² and Kaleb Michaud ³, ¹University of Nebraska College of Medicine, OMAHA, NE, ²FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: While medication persistence can act as a substitute metric for effectiveness, few studies have examined real-world patterns of bDMARD persistence by line of treatment…
Abstract Number: 823 • 2019 ACR/ARP Annual Meeting
The Risk of Venous Thromboembolism in Patients with Psoriatic Disease and Rheumatoid Arthritis, a Population-based Study
Lingyi Li¹, Na Lu ¹, Eric Sayre ¹, Hui Xie ², Diane Lacaille ³, John Esdaile ⁴ and J. Antonio Avina-Zubieta ⁵, ¹Arthritis Research Canada, Vancouver, BC, Canada, ²Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, ³Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, ⁵Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Venous thromboembolism (VTE, which includes pulmonary embolism [PE] and deep vein thrombosis [DVT]) is associated with increased morbidity and mortality. Previous studies have shown…
Abstract Number: 930 • 2019 ACR/ARP Annual Meeting
Neurostimulation for Treatment of Drug Refractory Rheumatoid Arthritis: A First-in-Human Study Using a Novel Vagus Nerve Stimulator
Norman Gaylis¹, David Sikes ², Alan Kivitz ³, Diane Horowitz ⁴, Charles Peterfy ⁵, Yaakov Levine ⁶, David Chernoff ⁶ and Mark Genovese ⁷, ¹Arthritis and Rheumatic Disease Specialties, Aventura, FL, ²Florida Medical Clinic, Land O Lakes, FL, ³Altoona Center for Clinical Research, Duncansville, PA, ⁴Northwell Health, Manhasset, NY, ⁵Spire Sciences Inc, Boca Raton, ⁶SetPoint Medical, Valencia, CA, ⁷Stanford University, Stanford, CA
Background/Purpose: The inflammatory reflex is an endogenous neuroimmune circuit that helps regulate innate and adaptive immunity (Annu. Rev. Immunol. 2012; 30:313). Activation of this reflex by…
Abstract Number: 1140 • 2019 ACR/ARP Annual Meeting
The Socioeconomic, Gender, Urban-rural, and Regional Disparities in the Risk of Acute Myocardial Infarction Among RA Patients
Yufei Zheng¹, Hui Xie ², J. Antonio Avina-Zubieta ³, Kia Yazdani ⁴, John Esdaile ⁵ and Diane Lacaille ⁶, ¹Arthritis Research Canada, Richmond, BC, Canada, ²Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, ³Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Richmond, ⁵Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, ⁶Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada
Background/Purpose: To assess socioeconomic (SES), gender, urban-rural, and regional disparities in the risk of acute myocardial infarction (MI) among rheumatoid arthritis patients.Methods: We conducted a…
Abstract Number: 1339 • 2019 ACR/ARP Annual Meeting
Risk of Immunotherapy Related Toxicity in Patients with Rheumatoid Arthritis
Elizaveta Efuni ¹, Samuel Cytryn ², Patrick Boland ² and Sabina Sandigursky³, ¹New York University School of Medicine, New York, NY, ²NYU Langone Health, New York, ³NYU Langone Health, New York, NY
Background/Purpose: Immune checkpoint inhibitors (ICIs) have changed the therapeutic landscape in oncology leading to cures in some cancer types. However, patients with pre-existing autoimmune diseases…
Abstract Number: 1366 • 2019 ACR/ARP Annual Meeting
Self-joint Counts by People with Rheumatoid Arthritis: Does a Video Increase Accuracy and Does It Matter?
Rebecca Grainger¹, Simon Stebbings ², William Taylor ¹, Andrew Harrison ¹, Celina Capistrano ¹, Niamh Fanning ³ and Lisa Stamp ⁴, ¹University of Otago, Wellington, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, Christchurch, New Zealand, ⁴University of Otago, Christchurch, New Zealand
Background/Purpose: As a tool for self-monitoring and reporting RA disease activity, a smartphone app was developed to enable people with rheumatoid arthritis (RA) to record…
Abstract Number: 1394 • 2019 ACR/ARP Annual Meeting
Association Between Baseline Anti-CCP2 Antibody Concentration and Clinical Response After 6 Months of Treatment with Abatacept or a TNF Inhibitor in Biologic-Experienced Patients with RA: Results from a US National Observational Study
Leslie Harrold ¹, Joshua Bryson², Thomas Lehman ³, Joe Zhuo ³, Sheng Gao ³, Xue Han ⁴, Amy Schrader ⁵, Sabrina Rebello ⁶ and Joel Kremer ⁷, ¹University of Massachusetts and Corrona, LLC, Waltham, MA, ²Bristol-Myers Squibb, Princeton, ³Bristol-Myers Squibb, Princeton, NJ, ⁴Bristol-Myers Squibb Company, Princeton, NJ, ⁵Corrona, LLC, Waltham, ⁶Corrona, LLC, Waltham, MA, ⁷Albany Medical College, Albany, NY
Background/Purpose: In the AMPLE trial, patients (pts) with RA with higher baseline anti-CCP2 antibody concentrations showed a better response to treatment with abatacept (ABA) than…
Abstract Number: 1430 • 2019 ACR/ARP Annual Meeting
Predictors of Response to Etanercept-Methotrexate Treatment: Post-hoc Analysis of a Randomized, Open-label Study in Latin American Patients with Rheumatoid Arthritis
Maria de la Vega¹, Generoso Guerra Bautista ², Ricardo Machado Xavier ³, César Pacheco-Tena ⁴, Gastón Solano ⁵, Ronald Pedersen ⁶, Cecila Borlenghi ⁷, Karina Santana ⁸ and Bonnie Vlahos ⁶, ¹CEIM Investigaciones Medicas, Buenos Aires, Argentina, ²Centro de Investigacion Marbella, Panama, Panama, ³Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, ⁴Universidad Autónoma de Chihuahua, Chihuahua, Mexico, ⁵Pfizer, San Jose, Costa Rica, ⁶Pfizer, Collegeville, ⁷Pfizer, Buenos Aires, Argentina, ⁸Pfizer Inc, Mexico City, Mexico
Background/Purpose: Etanercept (ETN) plus methotrexate (MTX) was shown to be superior to MTX plus another conventional disease-modifying anti-rheumatic drug (DMARD) in an open-label, randomized study…
Abstract Number: 1881 • 2019 ACR/ARP Annual Meeting
Association of Pain Centralization with DMARD Response in Active RA
Andrew Heisler¹, Jing Song ², Dorothy Dunlop ¹, Alyssa Wohlfahrt ³, Marcy Bolster ⁴, Wendy Marder ⁵, Clifton Bingham ⁶, Daniel Clauw ⁷, Tuhina Neogi ⁸ and Yvonne Lee ⁹, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Worthington, OH, ³Brigham and Woman's Hospital, Boston, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, ⁶Johns Hopkins University, Baltimore, MD, ⁷Division of Rheumatology, Department of Internal Medicine and Division of Anesthesia, Michigan Medicine, Ann Arbor, MI, ⁸Boston University School of Medicine, Boston, MA, ⁹Northwestern University Feinberg School of Medicine, Chicago
Background/Purpose: Despite the availability of potent disease modifying anti-rheumatic drugs (DMARDs), a significant percentage of rheumatoid arthritis (RA) patients do not achieve low disease activity…
Abstract Number: 1981 • 2019 ACR/ARP Annual Meeting
Functional Differences Between Osteoclasts and Osteoclast-like Cells Differentiated from Peripheral Blood Mononuclear Cells in Patients with Rheumatoid Arthritis
Kazuhiro Yokota¹, Yoshimi Aizaki ¹, Shinya Tanaka ², Kojiro Sato ³, Yasuto Araki ¹, Noritsune Kouzu ⁴, Yuho Kadono ², Hiromi Oda ⁵ and Toshihide Mimura ¹, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, ³Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Tochigi, Japan, ⁴Medical Kouzu orthopedic and Yachiyo radiation center, Chiba, Japan, ⁵Department of Orthopedic Surgery, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose: Osteoclasts (OCs) are giant multinucleated cells formed from precursors of the monocyte/macrophage lineage and are believe to play a major role in the bone…

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