Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 2399 • 2019 ACR/ARP Annual Meeting
Changes in the Initial Usage Pattern of Biologic Disease-modifying Antirheumatic Drugs in Rheumatic Diseases During the past Twelve Years: A Real-world Setting Analysis
Carlos Sánchez-Piedra¹, María Colazo ², Rosa Roselló ³, Cristina Campos ⁴, P. Vela ⁵, Cristina Bohorquez ⁶, Carolina Pérez-García ⁷, Manuel Pombo-Suarez ⁸, Carlos Fernández-López ⁹, Dolores Ruiz-Montesinos ¹⁰, Fernando Alonso ¹¹, Federico Diaz-Gonzalez ¹² and Juan Jesús Gómez-Reino ¹³, ¹Research Unit, Spanish Society of Rheumatology, Madrid, Spain, ²Hospital de Burgos, Burgos, ³Hospital San Jorge, Huesca, ⁴Hospital General de Valencia, Valencia, ⁵Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana, Spain, ⁶Universitary Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcala de Henares, Spain, ⁷Rheumatology, Hospital del Mar, Barcelona, Catalonia, Spain, ⁸Unit Research, Spanish Society of Rheumatology, Madrid, Spain, ⁹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ¹⁰Hospital Virgen Macarena, Sevilla, ¹¹Unidad Investigación SER, Madrid, Spain, ¹²Hospital de Canarias, Tenerife, ¹³Hospital de Santiago, Santiago de Compostela
Background/Purpose: During the past 15 years, advancements in the understanding of the safety and effectiveness, as well as the expanding access and availability of biologic…
Abstract Number: 2816 • 2019 ACR/ARP Annual Meeting
An Expanded Granzyme K+ CD8 T Cell Population Induces Inflammatory Responses in Rheumatoid Arthritis Synovium
Anna Helena Jonsson¹, Fan Zhang ², Gerald Watts ², Kevin Wei ¹, Deepak Rao ², Soumya Raychaudhuri ² and Michael Brenner ³, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women’s Hospital:, Boston
Background/Purpose: CD8 T cells represent nearly half of T cells in inflamed synovium from patients with rheumatoid arthritis (RA). Research to date has focused on…
Abstract Number: 2909 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of the Selective Interleukin-1 Receptor Associated Kinase 4 Inhibitor, PF-06650833, in Patients with Active Rheumatoid Arthritis and Inadequate Response to Methotrexate
Spencer I Danto¹, Negin Shojaee ¹, Ravi Shankar P Singh ¹, Zorayr Manukyan ², Jessica Mancuso ¹, Elena Peeva ¹, Michael Vincent ¹ and Jean Beebe ¹, ¹Pfizer Worldwide Research & Development, Immunology, and Inflammation Research Unit, Cambridge, MA, ²Pfizer Worldwide Research & Development, Immunology, and Inflammation Research Unit, ..
Background/Purpose: Adaptive and innate immune pathways are involved in inflammation and pathogenesis of rheumatoid arthritis (RA). Toll-like receptor (TLR) stimulation activates the innate immune system,…
Abstract Number: 47 • 2019 ACR/ARP Annual Meeting
Autoreactivity to Acetylated Histones Defines a Subset of RA Patients and Is Associated with Acetyl – Citrulline Anti-Modified Protein Autoantibody (AMPA) Cross-Reactivity
Peter Sahlström ¹, Lisa Liljefors ¹, Vijay Joshua ², Natalia Sherina ¹, Radha Thyagarajan ¹, Lena Israelsson ², Ragnhild Stålesen ², Monika Hansson ³, Khaled Amara ², Ulf Reimer ⁴, Leonid Padyukov ¹, Elisabet Svenungsson ⁵, Karin Lundberg ¹, Anca Catrina ³, Lars Klareskog ³, Vivianne Malmström ² and Caroline Grönwall², ¹Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, ³Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ⁴JPT Peptide Technologies, Berlin, Germany, ⁵Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Serum anti-citrullinated protein autoantibodies (ACPA) in rheumatoid arthritis (RA) display reactivity to a variety of cit-autoantigens. Studies of human ACPA mAbs have revealed that…
Abstract Number: 180 • 2019 ACR/ARP Annual Meeting
Identifying Comorbidities and Seropositivity in Rheumatoid Arthritis Patients Using Single-specialty Electronic Health Record Data
Huifeng Yun¹, Fenglong Xie ², Lang Chen ¹, Shuo Yang ¹ and Jeffrey Curtis ¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham
Background/Purpose: Comorbidities are associated with worse clinical outcomes among patients with rheumatoid arthritis (RA), as does seropositive disease. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide…
Abstract Number: 250 • 2019 ACR/ARP Annual Meeting
Treatment Patterns, Dose Change, and Treatment Discontinuation in RA Patients Switching from First Biologic DMARD to Another Treatment in the US
Robin Dore¹, Jenya Antonova ², Chakkarin Burudpakdee ³, Lawrence Chang ², Jing He ⁴ and Mark Genovese ⁵, ¹Private practice, Tustin, CA, ²Gilead Sciences, Foster City, CA, ³IQVIA, Falls Church, VA, ⁴IQVIA, Plymouth meeting, PA, ⁵Stanford University, Stanford, CA
Background/Purpose: For RA patients not meeting their treat-to-target goals despite treatment with their first biologic (b)DMARD, ACR guidelines recommend switching to a different bDMARD or…
Abstract Number: 429 • 2019 ACR/ARP Annual Meeting
Concordance Between Physician and Patient Assessment of Disease Activity in Rheumatoid Arthritis Using Disease Activity Score: Phase II Results
Nelly Ziade¹, Samar Alemadi ², Mohammad Abu Jbara ³, Sahar Saad ⁴, Lina El-Kibbi ⁵, Manal Al-Mashaleh ⁶, Bassel El-Zorkany ⁷, Georges Merheb ⁸, Elie Alam ⁹, Alla Aiko ¹⁰, Jamil Messaykeh ¹¹, Nelly Salloum ¹², Amani Daher ¹, Hussein Halabi ¹³, Kamel Mroue' ¹⁴, Basel Masri ¹⁵, Humeira Badsha ¹⁶, Ghita Harifi ¹⁶ and Thurrayya Arayssi ¹⁷, ¹Saint-Joseph University, Beirut, Lebanon, ²Hamad medical corporation, Doha, Qatar, ³Jordan, Amman, Jordan, ⁴King Hamad University Hospital, Bahrain, Bahrain, ⁵Specialized Medical Center, Riyadh, Saudi Arabia, ⁶King Hussein Medical Center, Amman, Jordan, ⁷Cairo University, Cairo, Egypt, ⁸Holy Spirit University of Kaslik, Kaslik, Lebanon, ⁹Levant Hospital, Beirut, Lebanon, ¹⁰Beirut, Beirut, Lebanon, ¹¹Monla Hospital, Tripoli, Lebanon, ¹²RN, Beirut, Lebanon, ¹³King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia, ¹⁴Bahman Hospital, Beirut, Lebanon, ¹⁵Jordan Hospital, Amman, Jordan, ¹⁶Dr Humeira Badsha Medical Center, Dubai, United Arab Emirates, ¹⁷Weill Cornell Medicine-Qatar, Doha, Qatar
Background/Purpose: Involving patients with rheumatoid arthritis (RA) in the assessment of their disease may increase adherence to treatment, improve disease outcomes and reduce consultation time.…
Abstract Number: 463 • 2019 ACR/ARP Annual Meeting
High-titer Rheumatoid Factor Impacts Real-life Management Outcomes of Rheumatoid Arthtitis
Cleandro Albuquerque¹, Ana Reis ², Ana Santos ³, Claiton Brenol ⁴, Ivanio Pereira ⁵, Karina Bonfiglioli ⁶, Manoel Bertolo ⁷, Maria Guimarães ⁸, Maria Sauma ⁹, Paulo Filho ¹⁰, Rina Giorgi ¹¹, Sebastião Radominski ¹², Licia Mota ¹ and Geraldo Castelar ³, ¹UnB, Brasília, Brazil, ²UniCeub, Brasília, Brazil, ³UERJ, Rio de Janeiro, Brazil, ⁴Universidade Federal do Rio Grande do Sul, Porto Alegre, ⁵UFSC, Florianópolis, Brazil, ⁶Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ⁷University of Campinas, Campinas, Brazil, ⁸UFMG, Belo Horizonte, Brazil, ⁹UFPA, Belém, Brazil, ¹⁰USP, São Paulo, Brazil, ¹¹Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil, ¹²Universidade Federal do Paraná, Curitiba, Brazil
Background/Purpose: The rheumatoid factors (RF) have established roles in rheumatoid arthritis (RA) diagnosis, prediction of disease onset and drug response, and in classifying patients as…
Abstract Number: 499 • 2019 ACR/ARP Annual Meeting
The Generation of Anti-CCP Tests Affects Diagnostic Accuracy in Rheumatoid Arthiritis: A Systematic Literature Review and Meta-Analysis
Barbara Mascialino¹, Linda Mathsson-Alm ¹, Maryam Poorafshar ¹ and Teresa Tarrant ², ¹Thermo Fisher Scientific, Uppsala, Uppsala Lan, Sweden, ²Duke School of Medicine, Division of Rheumatology and Immunology, Durham, NC
Background/Purpose: The detection of antibodies to cyclic citrullinated peptides (anti-CCP) may occur long before the onset of rheumatoid arthritis (RA) symptoms.Several versions of CCP antigen…
Abstract Number: 546 • 2019 ACR/ARP Annual Meeting
Change in Rheumatoid Arthritis (RA)-Related Autoantibody Profile and Risk of Disease Flare After Withdrawal of Therapy in Patients with Early RA Treated with Abatacept and MTX
René Toes¹, Thomas Lehman ², Joshua Bryson ³, Amy Min Kim ², Sandhya Balachandar ², Sumanta Mukherjee ², Michael Maldonado ², Sean Connolly ² and Thomas Huizinga ¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Bristol-Myers Squibb, Princeton, NJ, ³Bristol-Myers Squibb, Princeton
Background/Purpose: An emerging concept of “immunologic remission” in RA raises questions about the relevance of the RA autoantibody profile in patients (pts) who are otherwise…
Abstract Number: 849 • 2019 ACR/ARP Annual Meeting
Risk of Malignancies Associated with Biologics in Rheumatoid Arthritis: Analysis of a National Claim Database
Raphaèle Seror¹, Alexandre Lafourcade ², yann De Rycke ², Bruno Fautrel ³, Xavier Mariette ⁴ and Florence Tubach ⁵, ¹Université Paris Sud, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM UMR 1184, Le Kremlin-Bicêtre, France, ²Biostatistics, Public Health and Medical Information department, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, Paris, France, ³Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, ⁴Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, ⁵Pitié Salpétrière University-Hospital, Paris, Ile-de-France, France
Background/Purpose: Our objectives were to estimate and compare the incidence rate of malignancies between biologic and csDMARD-treated RA patients.Methods: We conducted an historical cohort study…
Abstract Number: 985 • 2019 ACR/ARP Annual Meeting
Inhibition of Calcium/calmodulin-dependent Protein Kinase IV in Rheumatoid Arthritis: Dual Effect on Th17 Cell Activation and Osteoclastogenesis
Tomohiro Koga¹, Tomohito Sato ², Yushiro Endo ¹, Sosuke Tsuji ¹, Ayuko Takatani ¹, Toshimasa Shimizu ¹, Remi Sumiyoshi ¹, Takashi Igawa ¹, Shin-ya Kawashiri ¹, Naoki Iwamoto ¹, Kunihiro Ichinose ¹, Mami Tamai ¹, Hideki Nakamura ¹, Tomoki Origuchi ³, Nobuya Yoshida ⁴, Masataka Umeda ⁵, George Tsokos ⁴ and Atsushi Kawakami ⁶, ¹Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki, Japan, ²Nagasaki University, Nagasaki, Japan, ³Nagasaki University School of health sciences, Division of physical therapy, Nagasaki, Japan, ⁴Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Beth Israel Deaconess Medical Center, Boston, MA, ⁶Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki
Background/Purpose: Background: CD4 + T cells are important in the pathogenesis of rheumatoid arthritis (RA), and therapies targeting the differentiation of osteoclasts are attracting attention. Calcium/calmodulin-dependent…
Abstract Number: 1200 • 2019 ACR/ARP Annual Meeting
Influenza Vaccination Rates Among Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis on Immunosuppressive Therapy: Findings from a Large Public Hospital
Judith Aniekwena¹, Titilope Olanipekun ² and Valery Effoe ², ¹Morehouse School of Medicine, Atlanta, GA, ²Morehouse School of Medicine, Atlanta
Background/Purpose: Influenza infection constitutes a significant cause of morbidity and mortality in patients living with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). The risk…
Abstract Number: 1348 • 2019 ACR/ARP Annual Meeting
Impact of Tofacitinib on the Individual Components of the ACR Composite Score in Patients with Rheumatoid Arthritis: A Post Hoc Analysis of Phase 3 Trials
Louis Bessette¹, Maxime Dougados ², Eduardo Mysler ³, Mark Genovese ⁴, Cassandra Kinch ⁵, Kenneth Kwok ⁶, Tatjana Lukic ⁶, Tanya Girard ⁵, Pierre-Alexandre Landry ⁵ and Ronald van Vollenhoven ⁷, ¹Laval University, Quebec City, QC, Canada, ²Cochin Hospital, Paris, France, ³Organización Médica de Investigación, Buenos Aires, Argentina, ⁴Stanford University, Stanford, CA, ⁵Pfizer Canada ULC, Kirkland, QC, Canada, ⁶Pfizer Inc, New York, NY, ⁷Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands
Background/Purpose: Tofacitinib is an oral JAK inhibitor for the treatment of RA. In clinical trials, standard criteria for measuring treatment efficacy in patients (pts) with…
Abstract Number: 1378 • 2019 ACR/ARP Annual Meeting
High Baseline Serum IL-6 Predicts Increased Sarilumab Treatment Response for Patient Reported Symptoms and Health-Related Quality of Life Among Rheumatoid Arthritis Patients with Inadequate Response to Methotrexate
Vibeke Strand¹, Jerome Msihid ², Toshio Kimura ³, Anita Boyapati ³, Gregory St John ⁴ and Wenhui Wei ³, ¹Division of Immunology/Rheumatology, Stanford University, Stanford, CA, ²Sanofi, Chilly-Mazarin, France, ³Regeneron Pharmaceuticals, Inc, Tarrytown, NY, ⁴Regeneron Pharmaceuticals, Inc., Tarrytown, NY
Background/Purpose: IL-6 is a key cytokine in the pathogenesis of rheumatoid arthritis (RA) and is elevated in serum and synovial fluid of RA patients. However,…

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