ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and tocilizumab"

  • Abstract Number: 1398 • 2019 ACR/ARP Annual Meeting

    Sarilumab and Tocilizumab Receptor Occupancy (RO), and Effects on C-Reactive Protein (CRP) Levels, in Patients with Rheumatoid Arthritis (RA)

    Christine Xu1, Patrick Nolain 2, Qiang Lu 3, Anne Paccaly 4, Melitza Iglesias-Rodriguez 5, Gregory St John 6, Chad Nivens 4, Rafael Maldonado 7, Tomonori Ishii 8, Ernest Choy 9 and Vanaja Kanamaluru 3, 1Sanofi, Bridgewater, NJ, 2Sanofi-Aventis, Montpellier, France, 3Sanofi, Bridgewater, 4Regeneron Pharmaceuticals, Inc., Tarrytown, 5Sanofi Genzyme, Cambridge, MA, 6Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 7Pompeu Fabra University, Barcelona, Spain, 8Tohoku University Hospital, Sendai, Japan, 9Cardiff University School of Medicine, Cardiff, United Kingdom

    Background/Purpose: The in vitro binding affinity of sarilumab (KD 61.9 pM) for the human interleukin-6 receptor (IL-6R) is 15–22-fold higher than that of tocilizumab. This…
  • Abstract Number: L18 • 2018 ACR/ARHP Annual Meeting

    A Randomized Controlled 24-Week Trial Evaluating the Safety and Efficacy of Blinded Tapering Versus Continuation of Long-Term Prednisone (5 mg/day) in Patients with Rheumatoid Arthritis Who Achieved Low Disease Activity or Remission on Tocilizumab

    Gerd R. Burmester1, Frank Buttgereit1, Corrado Bernasconi2, Jose Maria Alvaro-Gracia3, Nidia Castro2, Maxime Dougados4, Cem Gabay5, Jacob van Laar6, J. Michael Nebesky2, Attila Pethö-Schramm2, Carlo Salvarani7, Marc Y. Donath8 and Markus R. John2, 1Charité-Universitätsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany, 2F. Hoffmann-La Roche, Basel, Switzerland, 3Hospital Universitario de La Princesa IIS-IP, Madrid, Spain, 4Université Paris-Descartes, Paris, France, 5University Hospitals of Geneva, Geneva, Switzerland, 6University Medical Centre Utrecht, Utrecht, Netherlands, 7Università de Modena e Reggio Emilia, Modena, Italy, 8University Hospital Basel, Basel, Switzerland

    Background/Purpose: Guidelines recommend low-dose, short-duration glucocorticoid (GC) treatment for RA,1,2  but long-term use, especially at prednisone-equivalent doses >5 mg/d, should be avoided.2 Many patients (pts)…
  • Abstract Number: 570 • 2018 ACR/ARHP Annual Meeting

    Evaluation of CXCL13, sICAM1, MMP-3 and S100A8/A9 As Serum Biomarkers in Patients with Rheumatoid Arthritis Treated with Subcutaneous Tocilizumab

    D. James Haddon, Thierry Sornasse, Michael J. Townsend, Jinglan Pei and Margaret Michalska, Genentech, Inc., South San Francisco, CA

    Background/Purpose: Serum levels of C-X-C motif chemokine ligand 13 (CXCL13) and soluble intercellular adhesion molecule-1 (sICAM-1) have been associated with outcomes in patients with rheumatoid…
  • Abstract Number: 572 • 2018 ACR/ARHP Annual Meeting

    Combining Tocilizumab with Methotrexate Improves Sustainability. Real World Evidence Report from Quebec Database Rhumadata®

    Denis Choquette1, Louis Bessette2, Jacques Brown2, Boulos Haraoui1, Frédéric Massicotte1, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard1, Diane Sauvageau1, Angèle Turcotte2, Édith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Rheumatology, Centre de l'Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada

    Background/Purpose: Biologic therapy targeting TNF have consistently demonstrated better efficacy and effectiveness when combined with a conventional synthetic DMARD (csDMARD), most frequently methotrexate. Although pre-clinical…
  • Abstract Number: 573 • 2018 ACR/ARHP Annual Meeting

    Subcutaneous Tocilizumab in Monotherapy or in Combination with DMARD in Patients with Moderate to Severe Active Rheumatoid Arthritis: Observational Study to Describe Real-World Drug Retention Rate at 12 Months, Interim Analysis

    Pascal Hilliquin1, Thomas Barnetche2, Guy Baudens3, Ralph Niarra4, Isabelle Idier5 and Alain Saraux6, 1Rheumatology, Hôpital Sud Francilien, Corbeil-Essonne, France, 2Rheumatology Department, FHU ACRONIM, Bordeaux University Hospital, Bordeaux, France, 3Rheumatology, CHR Valenciennes, Valenciennes, France, 4Biostatistics, Keyrus of behalf of Roche SAS, Boulogne-Billancourt, France, 5Medical department, Chugai Pharma France, Paris La Defense, France, 6Rheumatology, CHU Brest, Brest, France

    Background/Purpose: In France, tocilizumab (TCZ) subcutaneous (sc) 1st prescription and yearly renewal are restricted to hospital. Monitoring may be done by both office-based or hospital…
  • Abstract Number: 594 • 2018 ACR/ARHP Annual Meeting

    Identification of Tocilizumab Treated RA Patients, Whom Are Not Likely to Show Long-Term Clinical Benefit; Reanalysis of the Biomarker Sub-Study of LITHE

    Anne C. Bay-Jensen1, Christian S. Thudium1, Claus Christiansen2 and Morten A. Karsdal1, 1Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Clinical Development, Herlev, Denmark

    Background/Purpose: Tocilizumab, anti-interleukin 6 receptor (IL-6R) therapy, is an effective treatment of rheumatoid arthritis (RA). However, a significant amount of patients do not respond adequately…
  • Abstract Number: 615 • 2018 ACR/ARHP Annual Meeting

    The Comparative Observational Study about Efficacy, Safety and Adherence between Tocilizumab and Infliximab in Patients with Rheumatoid Arthritis

    Mayumi Matsuda1, Yu Funakubo Asanuma2, Yoshinobu Nakao3, Hiroaki Yazawa2, Takuma Tsuzuki Wada4, Noritsune Kouzu5 and Toshihide Mimura2, 1Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 3Department of Rheumatology, Saga University Hospital, Saga, Japan, 4Department of Rheumatology and Applied Immunology, Faculty of Medicine,, Saitama Medical University, Saitama, Japan, 5Saitama Medical University, Moroyama, Japan

    Background/Purpose: Since 2003 in Japan, biologic agents have become widely used for RA patients in whom csDMARDs were ineffective. Tocilizumab (TCZ) was approved for marketing…
  • Abstract Number: 958 • 2018 ACR/ARHP Annual Meeting

    Tocilizumab and the Risk for Cardiovascular Disease Events Among Rheumatoid Arthritis Patients: A Direct Comparison in Real World Setting

    Fenglong Xie1, Huifeng Yun1, Emily Levitan2, Paul M. Muntner2 and Jeffrey R. Curtis1, 1University of Alabama at Birmingham, Birmingham, AL, 2Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Multiple studies have observed unfavorable changes in lipid profile associated with tocilizumab (TCZ, anti-IL6 receptor antagonists) and some other rheumatoid arthritis (RA) therapies. The…
  • Abstract Number: 1174 • 2018 ACR/ARHP Annual Meeting

    Comparative Cost per Response for Four Clinical Outcomes of Tocilizumab Monotherapy Versus Adalimumab Monotherapy in a Head-to-Head Randomized Double-Blind Superiority Trial in Patients with Rheumatoid Arthritis

    Jennie H. Best and Jinglan Pei, Genentech, Inc., South San Francisco, CA

    Background/Purpose: The cost-effectiveness of different biologic therapies is an important component in guiding treatment decisions for patients with rheumatoid arthritis (RA). The objective of this…
  • Abstract Number: 1514 • 2018 ACR/ARHP Annual Meeting

    Impact of Comorbidity Burden and Obesity on the Effectiveness of Tocilizumab in Patients with Rheumatoid Arthritis

    Dimitrios A. Pappas1, Carol J. Etzel2, Margaux Crabtree3, Jennie H. Best4, Steve Zlotnick4 and Joel Kremer5, 1Columbia University, New York, NY, 2Corrona LLC, Waltham, MA, 3Corrona, LLC, Waltham, MA, 4Genentech, Inc., South San Francisco, CA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Few real-world studies have evaluated the impact of comorbidity burden or obesity on the effectiveness of tocilizumab (TCZ) for the improvement of rheumatoid arthritis…
  • Abstract Number: 1543 • 2018 ACR/ARHP Annual Meeting

    The Efficacy, Safety and Adherence of Biologicbiological Disease-Modifying Anti Rheumatic Drugs, Infliximab, Tocilizumab and Abatacept, in Elderly Patients with Rheumatoid Arthritis

    Takuma Tsuzuki Wada1, Yu Funakubo Asanuma2, Mayumi Matsuda3, Hiroaki Yazawa2, Yoshinobu Nakao4, Noritsune Kozu5 and Toshihide Mimura2, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine,, Saitama Medical University, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 3Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, 4Department of Rheumatology, Saga University Hospital, Saga, Japan, 5Kozu Orthopedic Clinic, Yachiyo, Japan

    Background/Purpose: Elderly patients with rheumatoid arthritis (RA) have declined physical performances and increased various complications. We are concerned about decrease of efficacy and increase of…
  • Abstract Number: 447 • 2017 ACR/ARHP Annual Meeting

    Tocilizumab Had Acceptable Retention Rate in Both Randomized Controlled Trials and Observational Studies: Systematic Review of Rheumatoid Arthritis

    Levent Kilic1, Orhan Kucuksahin2, Zeynep Ozbalkan3, Cemal Bes4, Veli Yazisiz5, Ayten Yazici6, Dilek Solmaz7, Timucin Kasifoglu8 and Umut Kalyoncu9, 1Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 2Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey, 3Rheumatology, Ankara Numune Education and Research Hospital, Ankara, Turkey, 4Rheumatology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey, 5Rheumatology, Akdeniz University Faculty of Medicine, Ankara, Turkey, 6Department of Rheumatology, Kocaeli University, Faculty of Medicine, Kocaeli, Turkey, 7Rheumatology, Katip Çelebi University Faculty of Medicine, İzmir, Turkey, 8Rheumatology, Eskisehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey, 9Department of Internal Medicine, Divison of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: In general, retention rate in biological DMARDs represent both efficacy and safety. Tocilizumab (TOC) is a humanized monoclonal antibody that binds to the interleukin-6…
  • Abstract Number: 2469 • 2017 ACR/ARHP Annual Meeting

    Median Time to Lda Is Shorter in Tocilizumab Combination Therapy with Csdmards As Compared to Monotherapy in Patients with Active Rheumatoid Arthritis and Inadequate Responses to Csdmards and/or TNF Inhibitors: Sub-Analysis of the Swiss and Austrian Patients from the ACT-SURE Study

    Ruediger Mueller1, Winfried Graninger2, Páris Sidiropoulos3, Christoph Goger4 and Johannes von Kempis5, 1Rheumatology, MD, St. Gallen, Switzerland, 2Rheumatology and Immunology, Medical University of Graz, Graz, Austria, 3F. Hoffmann-La Roche Ltd, South San Francisco, CA, 4Roche Austria GmbH, Vienna, Austria, 5Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland

    Background/Purpose: To analyze efficacy and safety of tocilizumab in patients with rheumatoid arthritis (RA) and an inadequate response to conventional synthetic disease modifying anti-rheumatic drugs…
  • Abstract Number: 453 • 2017 ACR/ARHP Annual Meeting

    The Therapy with Tocilizumab Is Not Associated with Periarticular Demineralisation and Finger Joint Space Narrowing in Rheumatoid Arthritis

    Alexander Pfeil1, Ottar Gadeholt2, Joachim Böttcher3, Diane Renz4, Peter Oelzner1 and Gunter Wolf1, 1Department of Internal Medicine III, Jena University Hospital, Jena, Germany, 2Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 3Institut of Interventional and Diagnostic Radiology, SRH Waldklinikum Gera, Gera, Germany, 4Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Jena, Germany

    Background/Purpose: Digital X-ray Radiogrammetry (DXR) and Computer-Aided Joint Space Analysis (CAJSA) are established computer based techniques for the quantification of metacarpal bone mineral density and…
  • Abstract Number: 2474 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety of Extending Tocilizumab Infusion Intervals from 4 Weeks to 6 Weeks in Patients with Rheumatoid Arthritis

    Hiroshi Uda1 and Osamu Saiki2, 1Rheumatology, Higashiosaka City Medical Center, Higashiosaka, Japan, 2Rheumatology, Higashiosaka City General Hospital, Higashiosaka, Japan

    Background/Purpose : A period of 4 weeks (w) has been recommended for rheumatoid arthritis (RA) patients as the interval between tocilizumab (TCZ, 8mg/kg) infusions. However,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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