ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and tocilizumab"

  • Abstract Number: 1336 • 2012 ACR/ARHP Annual Meeting

    Changes in the Levels of Anti-Cyclic Citrullinated Protein Antibody and Immunoglobulins in Rheumatoid Arthritis Patients After Administration of Tocilizumab

    Masao Sato1, Masao Takemura2, Ryuki Shinohe3, Tsuneo Watanabe2 and Katsuji Shimizu3, 1Rheumatology, Matsunami General Hospital, Gifu, Japan, 2Informative Clinical Medicine, Gifu University, Gifu, Japan, 3Orthopaedic Surgery, Gifu University, Gifu, Japan

    Background/Purpose: The recently established scoring system of American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) early arthritis diagnosis criteria have assigned scores of 0, 1,…
  • Abstract Number: 1762 • 2012 ACR/ARHP Annual Meeting

    IL-6 Receptor Inhibition by Tocilizumab Modulates Double Negative (CD19+IgD-CD27-) B Cells in RA

    Zafar Mahmood1, Khalid Muhammad1, Petra Roll2, Stefan Kleinert3, Thomas Dörner4 and Hans Peter Tony5, 1Department of Medicine II, Rheumatology/Clinical Immunology, University of Würzburg, Würzburg, Germany, 2Department of Medicine II, Rheumatology/Clinical immunology, University of Würzburg, Würzburg, Germany, 3Rheumatology/Clinical Immunology,, University Hospital Würzburg, Würzburg, Germany, 4CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, 5Rheumatology/Immunology, University of Würzburg, Würzburg, Germany

    Background/Purpose: Double negative (CD19+IgD-CD27-) B cells have been reported to be part of human memory B cell compartment. Detailed studies of DN B cells in…
  • Abstract Number: 2121 • 2012 ACR/ARHP Annual Meeting

    A Multi-Biomarker Disease Activity (VECTRA™ DA Algorithm) Score Reflects Clinical Disease Activity and Structural Changes in Rheumatoid Arthritis Patients Treated with Tocilizumab

    Yoshiya Tanaka1, Kentaro Hanami2, Hisashi Tasaka1, Shunsuke Fukuyo1, Douglas J. Haney3, Nadine Defranoux3, Rebecca Bolce3, Guy Cavet3, David Chernoff3, Kunihiro Yamaoka1, Kazuyoshi Saito1 and Shintaro Hirata1, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2The First Department of Internal Medicinei, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 3Crescendo Bioscience Inc., South San Francisco, CA

    Background/Purpose: The multi-biomarker disease activity (MBDA) score assessed with 0.2 mL serum has been reported as a novel composite disease activity index for patients with…
  • Abstract Number: 2156 • 2012 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Protein Antibodies As a Predictor of Response to Tocilizumab in Patients with Rheumatoid arthritis   A Prospective Study

    Kensuke Kume1, Kanzo Amano1, Susumu Yamada1, Kuniki Amano2, Kazuhiko Hatta3, Hiroyuki Ohta4 and Noriko Kuwaba5, 1Rheumatology, Hiroshima Clinic, Hiroshima, Japan, 2Rheumatology, Sky Clinic, Hiroshima, Japan, 3Rheumatology, Hatta Clinic, Kure, Japan, 4Medical Research, hiroshima clinic, Hiroshima, Japan, 5Medical Research, Sanki Clinical Link, Hiroshima, Japan

    Background/Purpose:  Tocilizumab, interleukin-6 receptor antibody is very effective in patients with rheumatoid arthritis (RA). Anti-cyclic citrullinated protein antibodies (ACPA) are highly specific and sensitive for…
  • Abstract Number: 2167 • 2012 ACR/ARHP Annual Meeting

    Serum Based Biomarkers of Joint Destruction Can Identify Responders and Non-Responder to Tocilizumab

    Anne C. Bay-Jensen1, Inger Byrjalsen2, Claus Christiansen3 and Morten Asser Karsdal4, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Research & Development, Nordic Bioscience, Herlev, Denmark, 3CCBR, Ballerup, Denmark, 4Nordic Bioscience A/S, Herlev, Denmark

    Background/Purpose: RA is characterized by synovial inflammation, cartilage loss and erosion of subchondral bone. It is critical to diagnose and effectively treat the disease early…
  • Abstract Number: 2166 • 2012 ACR/ARHP Annual Meeting

    Identification of Serological Biomarker Profiles Associated with Response to IL-6 Intervention in Rheumatoid Arthritis

    Morten Asser Karsdal1, Anne C. Bay-Jensen2, Inger Byrjalsen3, Andrew Kenwright4, Adam Platt4, Thierry Sornasse5 and Claus Christiansen6, 1Nordic Bioscience A/S, Herlev, Denmark, 2Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 3Research & Development, Nordic Bioscience, Herlev, Denmark, 4Roche, Welwyn Garden City, United Kingdom, 5Product Development Immunology, Genentech, Inc., South San Francisco, USA, San Fransisco, CA, 6CCBR, Ballerup, Denmark

    Background/Purpose: RA is characterized by poly-articular synovial inflammation, cartilage loss and erosion of subchondral bone. It is critical to diagnose and effectively treat the disease…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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