ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 572

Combining Tocilizumab with Methotrexate Improves Sustainability. Real World Evidence Report from Quebec Database Rhumadata®

Denis Choquette1, Louis Bessette2, Jacques Brown2, Boulos Haraoui1, Frédéric Massicotte1, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard1, Diane Sauvageau1, Angèle Turcotte2, Édith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Rheumatology, Centre de l'Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: methotrexate (MTX), rheumatoid arthritis (RA) and tocilizumab

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Sunday, October 21, 2018

Session Title: Rheumatoid Arthritis – Treatments Poster I: Strategy and Epidemiology

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Biologic therapy targeting TNF have consistently demonstrated better efficacy and effectiveness when combined with a conventional synthetic DMARD (csDMARD), most frequently methotrexate. Although pre-clinical protocols have shown the short-term efficacy of tocilizumab (TOCI) in monotherapy in very selected patients suffering from rheumatoid arthritis (RA), little is known on the long-term comparative sustainability of monotherapy (Mono) versus combo therapy (Combo). We evaluate here the comparative sustainability of tocilizumab in patients with rheumatoid arthritis initially treated with or without MTX.

Methods: Data from RHUMADATA® patients with RA prescribed TOCI either as an initial or second biologic was analyzed. Patients were followed until treatment discontinuation, loss to follow-up or April 22nd, 2018. The characteristics of selected patients were tabulated and the TOCI discontinuation rates of patients undergoing initial mono and combo therapy compared using Kaplan-Meier methods and Cox regression models adjusting for potential confounders.

Results: A total of 122 patients with RA received TOCI in first or second intention. Of those, 44(36.1%) and 78(63.9%) initially received mono and combo therapy respectively. Most patients were women (77%), mean age at diagnosis was 45.0 (SD=12.8) years, and the average age at treatment initiation was 54.5 (SD=11.8) years. HAQ and DAS28(4)-CRP at treatment initiation were respectively 1.21 (SD=0.57) and 4.64 (SD=1.01). Forty-nine and 11 percent of patients concomitantly received hydroxychloroquine (HCQ) and sulfasalazine (SSZ) respectively. Age-adjusted Carlson’s comorbidity index (ACCI) at baseline was 2.5 (SD=1.1), and 79% were RF-positive and 75% ACPA positive. Significant differences in retention rates between mono and combo TOCI therapy were observed (log-rank p-value =0.0002). Mean retention time for mono and combo-therapy were respectively 2.77(SE=0.41) and 5.13(SE=0.43) years. Use of MTX remains significant (p-value<.0001) after adjusting for gender, age and disease duration at treatment initiation, HAQ, DAS28(4)-CRP, RF and ACPA, ACCI, and concomitant use of HCQ and SSZ.

Conclusion: Combining tocilizumab with MTX significantly improves its sustainability.


Disclosure: D. Choquette, None; L. Bessette, None; J. Brown, None; B. Haraoui, Amgen Inc., 2, 9,Pfizer, Inc., 2, 8, 9,UCB, Inc., 2, 8, 9,AbbVie Inc., 2, 9,Bristol-Myers Squibb, 2, 9,Eli Lilly and Co., 9,Merck & Co., 9,Sandoz, 9,Hoffmann-LaRoche, 2, 9,Janssen, 2, 9; F. Massicotte, None; J. P. Pelletier, None; J. P. Raynauld, None; M. A. Rémillard, None; D. Sauvageau, None; A. Turcotte, None; É. Villeneuve, None; L. Coupal, None.

To cite this abstract in AMA style:

Choquette D, Bessette L, Brown J, Haraoui B, Massicotte F, Pelletier JP, Raynauld JP, Rémillard MA, Sauvageau D, Turcotte A, Villeneuve É, Coupal L. Combining Tocilizumab with Methotrexate Improves Sustainability. Real World Evidence Report from Quebec Database Rhumadata® [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/combining-tocilizumab-with-methotrexate-improves-sustainability-real-world-evidence-report-from-quebec-database-rhumadata/. Accessed March 4, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/combining-tocilizumab-with-methotrexate-improves-sustainability-real-world-evidence-report-from-quebec-database-rhumadata/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.