ACR Meeting Abstracts

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Abstracts tagged "RANKL"

  • Abstract Number: 0041 • ACR Convergence 2024

    Disease Activity and Serological Inflammatory Markers Are Associated with TNF-a and IL-6-Induced Osteoclasts, but Not with RANKL-Induced Osteoclasts in Peripheral Blood Monocytes from Patients with Rheumatoid Arthritis

    Yokota Kazuhiro1, Yoshimi Aizaki1, Miyoko Sekikawa2, Hiroshi Kajiyama1, Yasuto Araki1, Yuho Kadono2, Yuji Akiyama1 and Toshihide Mimura1, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, Iruma-gun, Saitama, Japan, 2Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, Iruma-gun, Saitama, Japan

    Background/Purpose: We previously reported that a combination of TNF-α and IL-6 induces mouse osteoclast (OC)-like cells and human OCs with bone resorption activity [Arthritis &…
  • Abstract Number: 0400 • ACR Convergence 2024

    Osteoclastogenesis from Peripheral Blood Mononuclear Cells in Children with Chronic Nonbacterial Osteomyelitis Are Similar to Those from Healthy Children

    Jacqueline Bui1, Jacob Curry2, Jessica Kent3, Payton Danosky4, Kellen Sanders4, Sriya Paluvayi4, Wendy Garcia4, Alejandra Ruppe4, Megan Cheung4, Anna Saack4, Xinrui Bao4, Audrey Luey4, Michelle Kim4, Emily McDaniel4, Amanda Chiu4, Sophia Ahn5, Ji-Won Park4, Sudheshna Thirunahari4, Cammie Wei4, Liau Adriel5, Sophia Pham4, Sadie Van Den Bogaerde4, Joshua Scheck4, Ian Muse6, Ava Klein5, Xing Wang7, James Cassat8 and Yongdong Zhao6, 1Seattle Children’s Research Institute, University of Washington, Bellevue, WA, 2Seattle Children’s Research Institute, Vanderbilt University Medical Center, Seattle, WA, 3Seattle Children’s Research Institute, Medical College of Wisconsin, Seattle, WA, 4Seattle Children’s Research Institute, University of Washington, Seattle, WA, 5Seattle Children’s Research Institute, University of Washington, Seattle, 6Seattle Children's Research institute, Seattle, WA, 7Biostatistics Epidemiology and Analytics in Research, Seattle Children’s Research Institute, Seattle, WA, 8Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease in which osteoclastogenesis may play a critical role. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) was shown…
  • Abstract Number: 0937 • ACR Convergence 2024

    A Novel Quantitative Method Reveals Bone-Structural Changes During Course of Inflammatory Arthritis

    Anders Nguyen1, David McBride2, Miriam Bollmann1, Agnieszka Lastowska3 and Mattias Svensson4, 1University of Gothenburg, Göteborg, Sweden, 2Calibr-Skaggs Institute for Innovative Medicines, La Jolla, CA, 3University of Gothenburg, Goteborg, Sweden, 4University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by both localized and generalized bone loss. The inhibition of Receptor Activator of Nuclear Factor…
  • Abstract Number: 1204 • ACR Convergence 2024

    Immunobased Profiling of Knee Osteoarthritis Patients to Predict Response to Regenerative Treatment with Autologous Blood-derivative Platelet-Rich Plasma Injection

    Antonio Tonutti1, Valentina Granata2, Veronica Marrella2, Cristina Sobacchi2, Rita Ragusa3, Marzia Monferini3, Cristiano sconza3, Nicola rani4, Berardo Di Matteo5, Carlo Selmi6 and Angela Ceribelli5, 1Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy, 2Humanitas Research Hospital and Institute for Genetic and Biomedical Research, Rozzano, Italy, 3Humanitas Research Hospital, Rozzano, Italy, 4Rizzoli Orthopaedic Institute, Bologna, Italy, 5Humanitas University and Humanitas Research Hospital, Rozzano, Italy, 6Department of Biomedical Sciences, Humanitas University, Rozzano, Italy

    Background/Purpose: Osteoarthritis (OA) is a degenerative musculoskeletal disease causing chronic disability and elevated social costs worldwide. Its multifactorial origin contributes to different OA phenotypes and…
  • Abstract Number: 2134 • ACR Convergence 2024

    PEX5 Acts as a Negative Regulator of RANKL-induced Osteoclastogenesis In Vitro and Inflammatory Calvarial Bone Destruction In Vivo

    CHONG HYUK CHUNG1, Myeung-Su Lee1, Chang-hoon Lee2, Ju-Young Kim3, Yoon-Hee Cheon4, So Young Eun3 and Gyeung Do Park3, 1Wonkwang University Hospital, Iksan, South Korea, 2Wonkwang University Hospital, Iksan Jeonbuk, South Korea, 3Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Republic of Korea, 4Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University, Iksan, Cholla-bukto, Republic of Korea

    Background/Purpose: Peroxisomal biogenesis factor 5 (PEX5) is essential for regulating peroxisome function by recognizing and transporting peroxisome target sequence receptor substrate proteins to peroxisomes. PEX5…
  • Abstract Number: 2144 • ACR Convergence 2024

    Impact of Immunogenicity on Clinical Outcomes in Postmenopausal Women with Osteoporosis: Results from a Randomized Controlled Phase 3 Study to Compare CT-P41 (Proposed Denosumab Biosimilar) and Reference Denosumab

    Jean-Yves Reginster1, Stuart L. Silverman2, Edward Czerwinski3, Przemyslaw Borowy4, Tomasz Budlewski5, Joanna Kwiatek6, Svitlana Postol7, Airi Põder8, Jerzy Supronik9, SungHyun Kim10, JeeHye Suh10, GoEun Yang10, NooRi Han10, NaHyun Kim10 and SeoHee Bae10, 1Biochemistry Dept, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia, CLARENS, Switzerland, 2OMC clinical research center and Cedars Sinai Medical Center, Beverly Hills, CA, 3Krakowskie Centrum Medyczne, Kraków, Poland, 4Krakowskie Centrum Medyczne, Krakow, Poland, 5Department of Rheumatology, Medical University of Lodz, Lodz, Poland, 6Centrum Medyczne Poznan - PRATIA, Skorzewo, Poland, 7Medical Center of Medbud - Clinic LLC, Kyiv, Ukraine, 8Clinical Research Centre Ltd, Tartu, Estonia, 9Osteo-Medic s.c., Białystok, Poland, 10Celltrion, Inc., Incheon, Republic of Korea

    Background/Purpose: CT-P41 has been developed as a proposed biosimilar of the reference denosumab (DEN), a fully human monoclonal antibody that binds the cytokine receptor activator…
  • Abstract Number: 2563 • ACR Convergence 2024

    Efficacy and Safety Results of CT-P41 (Proposed Denosumab Biosimilar) Compared to Reference Denosumab in Postmenopausal Women with Osteoporosis: 78-Week Results from Phase 3 Randomized Controlled Trial

    Jean-Yves Reginster1, Stuart L. Silverman2, Edward Czerwinski3, Przemyslaw Borowy4, Tomasz Budlewski5, Joanna Kwiatek6, Svitlana Postol7, Airi Põder8, Jerzy Supronik9, SungHyun Kim10, JeeHye Suh10, GoEun Yang10, NooRi Han10, NaHyun Kim10 and SeoHee Bae10, 1Biochemistry Dept, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia, CLARENS, Switzerland, 2OMC clinical research center and Cedars Sinai Medical Center, Beverly Hills, CA, 3Krakow Medical Centre, Kraków, Poland, 4Krakowskie Centrum Medyczne, Krakow, Poland, 5Department of Rheumatology, Medical University of Lodz, Lodz, Poland, 6Centrum Medyczne Poznan - PRATIA, Skorzewo, Poland, 7Medical Center of Medbud - Clinic LLC, Kyiv, Ukraine, 8Clinical Research Centre Ltd, Tartu, Estonia, 9Osteo-Medic s.c., Białystok, Poland, 10Celltrion, Inc., Incheon, Republic of Korea

    Background/Purpose: CT-P41 is a proposed biosimilar of the reference denosumab (DEN), a fully human monoclonal antibody that binds the cytokine receptor activator of NF-κb ligand…
  • Abstract Number: 2441 • ACR Convergence 2023

    Upregulation of RANKL in the Skin of Patients with Psoriatic Arthritis

    Maria de la Luz Garcia-Hernandez1, Takeshi Yoshida2, Javier Rangel-Moreno2, Alicia Lieberman3, Ananta Paine4, Joshua Weitz2, Francisco Tausk5, Lisa A Beck2 and Christopher T Ritchlin6, 1University of Rochester, West Henrietta, NY, 2University of Rochester, Rochester, NY, 3University of Rochester, Batavia, NY, 4ORNA Tx, Southborough, MA, 5Universiy of Rochester, Rochester, NY, 6University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects the skin and joints. Circulating Osteoclast precursors (OCP) are elevated in the blood of…
  • Abstract Number: 1679 • ACR Convergence 2023

    Effects of Janus Kinase Inhibitor on TNF-a and IL-6-Induced Osteoclasts and RANKL-Induced Osteoclasts in Peripheral Blood Monocytes from Patients with Rheumatoid Arthritis

    Kazuhiro Yokota1, Yoshimi Aizaki2, Takuma Tsuzuki Wada1, Hiroshi Kajiyama1, Yasuto Araki2, Hiroaki Yazawa2, Yuji Akiyama2 and Toshihide Mimura1, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: We have previously demonstrated that a combination of TNF-a and IL-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in…
  • Abstract Number: 1997 • ACR Convergence 2023

    A Randomized, Double-blind, Phase III Study to Compare SB16 (Proposed Denosumab Biosimilar) to Reference Denosumab in Patients with Postmenopausal Osteoporosis

    Richard Eastell1, Bente Langdahl2, Yoon-Sok Chung3, Rafal Plebanski4, Edward Czerwinski5, Eva Dokoupilova6, Jerzy Supronik7, Jan Rosa8, Anna Rowińska-Osuch9, Ki-Hyun Baek10, Audrone Urboniene11, Sohui Ahn12, Younghee Rho12 and Jisuk Ban12, 1University of Sheffield, Sheffield, United Kingdom, 2Aarhus University Hospital, Aarhus, Denmark, 3Ajou University Hospital, Suwon, South Korea, 4Klinika Zdrowej Kosci, Łódź, Poland, 5Futuremeds, Krakowskie Centrum Medyczne sp z oo, Krakow, Poland, 6Masaryk University, Faculty of Pharmacy, Department of Pharmaceutical Technology; MEDICAL PLUS sro, Brno, Czech Republic, 7OsteoMedic sc A Racewicz J Supronik, Bialystok, Poland, 8Affidea Praha, s.r.o.; Faculty of Medicine in Hradec Kralove, Charles University, Prague; Hradec Kralove, Czech Republic, 9ETG Warszawa, Warszawa, Poland, 10Yeouido ST. Mary's Hospital, Seoul, South Korea, 11JSC Saules seimos medicinos centras, Kaunas, Lithuania, 12Samsung Bioepis, Incheon, South Korea

    Background/Purpose: SB16 is a human monoclonal antibody to the receptor activator of nuclear factor κΒ ligand that has been developed as a proposed biosimilar to…
  • Abstract Number: 2150 • ACR Convergence 2023

    Novel Biologic IRL201805 Inhibits Osteoclastogenesis in Monocytic Cells from RA Patients

    Yuriko Yamamura1, Valerie Corrigall2, Lara Ravanetti3, Jorge De Alba3, Roly Foulkes4, Paul Eggleton5 and Carl Goodyear6, 1School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom, 2Revolo Biotherapeutics, Tadworth, United Kingdom, 3Revolo Biotherapeutics, London, United Kingdom, 4Revolo Biotherapeutics, Slough, United Kingdom, 5Revolo Biotherapeutics, Exeter, United Kingdom, 6University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: In Rheumatoid arthritis (RA), osteoclasts derived from CD14+ Monocytes are associated with a risk of progressive bone and joint destruction, which fundamentally impacts quality-of-life.…
  • Abstract Number: L05 • ACR Convergence 2022

    Effect of Denosumab on Structure Modification in Erosive Hand Osteoarthritis: Results of a 48-Week, Monocentric, Randomized, Placebo-controlled, Double-blind Phase 2 Study and Open Label Extension Phase

    Ruth Wittoek1, August Verbruggen2, Tine Vanhaverbeke2 and Dirk Elewaut3, 1Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Oost-Vlaanderen, Belgium, 2Ghent University Hospital, Ghent, Belgium, 3Ghent University and VIB Center for Inflammation Research, Ghent, Belgium

    Background/Purpose: Erosive hand osteoarthritis (OA) is a disabling disease with limited therapeutic options. Denosumab, a Receptor Activator of Nuclear Factor kappa-b Ligand inhibitor, affects bone…
  • Abstract Number: 0588 • ACR Convergence 2022

    S-nitrosoglutathione Reductase (GSNOR) Regulates Osteoclast Differentiation

    Toshihiro Tanioka1, Kohei Maeda1, Rei Takahashi1 and Takeo Isozaki2, 1Division of Pathogenesis and Translational Medicine, Department of Clinical Pharmacy, Showa University School of Pharmacy, Tokyo, Japan, 2Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

    Background/Purpose: S-nitrosoglutathione (GSNO) reductase (GSNOR) is an enzyme which decomposes GSNO and downregulates protein S-nitrosylation. It has been reported that GSNOR KO mice have enhanced…
  • Abstract Number: 0030 • ACR Convergence 2021

    Interleukin-9 Enhances the Osteoclastogenesis in Rheumatoid Arthritis

    Santanu Kar1, Dipendra Mitra2, Vijay Kumar D1 and Sushmita Chakraborty1, 1AIIMS, New Delhi, India, 2ALL INDIAN INSTITUTE OF MEDICAL SCIENCES, New Delhi, India

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation leading to bone destruction. Bone erosion in RA results from excessive resorption…
  • Abstract Number: 1472 • ACR Convergence 2021

    Characterization and Function of Tumor Necrosis Factor α and Interleukin-6–Induced Osteoclasts in Rheumatoid Arthritis

    Kazuhiro Yokota1, Kojiro Sato2, Yoshimi Aizaki3, Shinya Tanaka4, Miyoko Sekikawa4, Noritsune Kozu5, Yuho Kadono4, Hiromi Oda6 and Toshihide Mimura7, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Jichi Medical University, Tochigi, Japan, 3Saitama Medical University, Saitama, Japan, 4Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, 5Kozu Orthopaedic Clinic, Chiba, Japan, 6Department of Orthopaedic Surgery, National Hospital Organization Ibusuki Medical Center, Kagoshima, Japan, 7Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama, Japan

    Background/Purpose: We have previously reported that stimulation of mouse bone marrow–derived macrophages with a combination of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) induces…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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