Abstracts tagged "radiography and rheumatoid arthritis (RA)"

Abstract Number: 2059 • 2015 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Inhibitor Tapering Induced Radiographic Progression Is Driven By Weighted Mean Disease Activity over Time, Not Flaring or Lower TNFi Exposition
Alfons A. den Broeder¹, Chantal A.M. Bouman¹, Aatke van der Maas², Frank H.J. van den Hoogen¹, Noortje van Herwaarden¹ and R. Landewe³, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Hengstdal 3, Sint Maartenskliniek, Nijmegen, Netherlands, ³Department of Internal Medicine, Division of Rheumatology, University Hospital Maastricht, Maastricht, Netherlands
Background/Purpose: DRESS, a randomized controlled strategy trial (RCT)1investigating disease activity guided tapering of etanercept and adalimumab compared to usual care in RA patients, indicated that…
Abstract Number: 2589 • 2015 ACR/ARHP Annual Meeting
Associations Between 49 Susceptibility SNPs and Disease Activity Including Radiographic Damage in Early Untreated Rheumatoid Arthritis
Christian G. Ammitzbøll¹, Rudi Steffensen², Martin Bøgsted^3,4, Kaspar Rene Nielsen², Torkell Ellingsen⁵, Merete Lund Hetland⁶, Peter Junker⁵, Jan Pødenphant⁷, Mikkel Østergaard⁸, Julia Johansen⁹, Kim Hørslev-Petersen¹⁰ and Kristian Stengaard-Pedersen¹, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ³Department of Haematology, Aalborg University Hospital, Aalborg, Denmark, ⁴Department of Mathematical Sciences, Aalborg University, Aalborg, Denmark, Aalborg, Denmark, ⁵Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁶DANBIO, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Glostrup, Denmark, ⁷Department of Rheumatology, Copenhagen University Hospital at Gentofte, Glostrup, Denmark, ⁸Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Glostrup, Denmark, ⁹Departments of Medicine and Oncology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark, ¹⁰Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark
Background/Purpose: Genome-wide association studies (GWAS) and meta-GWAS studies have identified >50 single nucleotide-polymorphisms (SNPs) that are associated with susceptibility to rheumatoid arthritis (RA). It is,…
Abstract Number: 2601 • 2015 ACR/ARHP Annual Meeting
The Multi-Biomarker Disease Activity Score in a TNF Inhibitor Tapering Study in Rheumatoid Arthritis Patients: Predictive Value for Successful Tapering, Flaring and Radiographic Progression
Chantal A.M. Bouman¹, Aatke van der Maas¹, Noortje van Herwaarden¹, Eric H. Sasso², Frank H.J. van den Hoogen¹ and Alfons A. den Broeder¹, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Crescendo Bioscience Inc., South San Francisco, CA
Background/Purpose: We evaluated the predictive value of the multi-biomarker disease activity (MBDA) score for clinical outcomes and radiographic progression in a TNFi tapering study in…
Abstract Number: 2693 • 2015 ACR/ARHP Annual Meeting
Comparing Eight Year Clinical and Radiographic Outcome in Two Cohorts of Patients with Rheumatoid Arthritis
Maria LE Andersson¹, Kristina Forslind² and Ingiäld Hafström³, ¹R&D Centre Spenshult,Halmstad, Halmstad, Sweden, ²Department of Medicine, Helsingborgs Lasarett, Section of Rheumatology, Helsingborg, Sweden, ³Rheumatology Dept, Karoliska Institute, Stockholm, Sweden
Background/Purpose: To compare patient and disease characteristics over the first 8 years of disease in a large inception cohort of early RA patients included 1992…
Abstract Number: 350 • 2015 ACR/ARHP Annual Meeting
Atypical Femur Fracture in Rheumatoid Arthritis Patients Treated with Bisphosphonates: A Nested Case-Control Study
JungHee Koh¹, Ji Hyeon Ju², Min Kyung Chung³, Ji Hun Kim³, Seung Min Jung⁴, Ji Yeon Lee², Jennifer Lee³, Seung-Ki Kwok⁵ and Sung-Hwan Park³, ¹Seochogu, Banpodaero, 222, Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, school of medicine, The catholic university of Korea, Seoul, South Korea, ⁵[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Patients with rheumatoid arthritis (RA) are diagnosed with osteoporosis earlier than and those without RA, and are therefore exposed to Bisphosphonates (BPs) for longer.…
Abstract Number: 439 • 2015 ACR/ARHP Annual Meeting
Progression of Radiographic Joint Destruction in Patients with Rheumatoid Arthritis Treated with a Biologic Agent in Combination with Methotrexate Versus a Biologic Alone: A Systematic Review and Meta-Analysis of Randomized Trials
Tanja Schjødt Jørgensen¹, Simon Tarp¹, Daniel E. Furst², Anna Døssing¹, Peter C. Taylor³, Henning Bliddal¹ and Robin Christensen¹, ¹Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ²Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal, Sciences, Kennedy Institute of Rheumatology, University of Oxford,, Oxford, United Kingdom
Background/Purpose : One of the frequently claimed advantages of biologic agents is their potential to arrest radiographic progression. The ability of disease-modifying antirheumatic drugs (DMARDs;…
Abstract Number: 462 • 2015 ACR/ARHP Annual Meeting
Radiographic Progression in Patients with Early Rheumatoid Arthritis Has Not Become Milder over the Past Decades
Carola Wassenberg¹, Rolf Rau², Siegfried Wassenberg³, Dietmar Krause⁴ and Christoph Fiehn⁵, ¹Radiology, Friedrich Ebert Krankenhaus, Neumünster, Germany, ²Expert in Rheumatology, Düsseldorf, Germany, ³Rheumaklinik, Themistocles Gluck hospital - Rheumazentrum Ratingen, Ratingen, Germany, ⁴Dept. for Medical Informatics, Biometry and Epidemiology, Ruhr University, Bochum, Germany, ⁵ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany
Background/Purpose: Retrospective studies have promoted the idea that RA has become a milder disease over the past decades[i], [ii]. These findings are questionable because of…
Abstract Number: 1310 • 2015 ACR/ARHP Annual Meeting
Efficacy of Abatacept in Patients with Rheumatoid Arthritis Assessed By MRI Scans of Bilateral Hands
Yuji Kukida¹, Akiko Kasahara¹, Takahiro Seno^1,2, Yu Isoda¹, Tomoya Sagawa¹, Takuya Inoue¹, Naoka Kamio¹, Risa Sagawa¹, Takashi Kida¹, Amane Nakabayashi¹, Hidetake Nagahara³, Ken Murakami¹, Aihiro Yamamoto¹, Satoshi Morita⁴, Hirotoshi Ito⁵, Masataka Kohno¹ and Yutaka Kawahito¹, ¹Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ²Department of Rheumatic Diseases and Joint Function, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ³Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, ⁴Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵Department of Radiology, Kajiicho Medical Imaging Center, Kyoto, Japan
Background/Purpose: Previous radiographic and MRI studies have demonstrated that abatacept (ABT) can inhibit the progression of bone and joint destruction in patients with rheumatoid arthritis…
Abstract Number: 1321 • 2015 ACR/ARHP Annual Meeting
Inter-Reader Agreement of a Novel Method of Radiographic Scoring of Rheumatoid Arthritis
Priyanka Vashisht¹, Abhijeet Danve², Harlan Sayles³, Ted R. Mikuls³ and Alan R. Erickson⁴, ¹Division of Rheumatology and Department of Immunology, University of Nebraska Medical Center, Omaha, NE, ²Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Although widely used in research studies, most of the radiographic scoring systems for Rheumatoid Arthritis (RA) are not feasible in routine clinical practice as…
Abstract Number: 1324 • 2015 ACR/ARHP Annual Meeting
Simplified Larsen Erosion Score Is Compatible with the Classic Larsen Score but Less Time Consuming in Practice
Michael Ziegelasch¹, Alf Kastbom², Thomas Skogh³, Kristina Forslind⁴ and Alf Kastbom, ¹Rheumatology Department, Rheumatology/AIR, Linkoping, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping, Sweden, ³IKE/Rheumatology, Linköping University, Linköping, Sweden, ⁴Department of Medicine, Helsingborgs Lasarett, Section of Rheumatology, Helsingborg, Sweden
Background/Purpose: Untreated rheumatoid arthritis (RA) often leads to joint space narrowing (JSN) and erosions in synovial joints. Scoring systems like Sharp van der Heijde and…
Abstract Number: 2131 • 2014 ACR/ARHP Annual Meeting
the Impact of Patient-Reported Flares on Radiographic Progression in Rheumatoid Arthritis Patients with Low-Disease Activity: Secondary Analyses from a Randomized Trial
Dorota Kuettel¹, Jette Primdahl^2,3,4,5, Lykke Midtbøll Ørnbjerg⁶, Hans Christian Horn⁷, Robin Christensen⁸ and Kim Hørslev-Petersen⁹, ¹Rheumatological, King Christian X's Hospital for Rheumatic Diseases, Graasten, Denmark, ²Rheumatology, King Christian X's Hospital for Rheumatic Diseases, Graasten, Denmark, ³Institute for Regional Health Research, University of Southern Denmark, Graasten, Denmark, ⁴Hospital of Southern Jutland, Soenderborg, Denmark, ⁵Danbio Registry, Glostrup, Denmark, ⁶Copenhagen Center for Arthritis Reasearch, Center for Rheumatology and Spine diseases, Glostrup Hospital, Copenhagen, Denmark, ⁷Internal Medicine/Rheumatology, Odense University Hospital, Odense, Denmark, ⁸Rheumatology, MSU, The Parker Institute, Copenhagen University Hospital, Frederiksberg, Denmark, ⁹Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark
Background/Purpose Flares, potentially disabling and disease worsening even when a patient is in low disease activity, are common features in patients with rheumatoid arthritis (RA)…
Abstract Number: 2137 • 2014 ACR/ARHP Annual Meeting
Linear Extrapolation of Missing Radiographic Progression Scores Does Not Spuriously overestimate overall Radiographic Progression in Rheumatoid Arthritis
Iris Markusse¹, Robert Landewé^2,3, Meilien Ho⁴, Martin Jenkins⁴ and Desiree van der Heijde⁵, ¹Leiden University Medical Center, Leiden, Netherlands, ²Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Atrium Medical Center, Heerlen, Netherlands, ⁴AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose : Linear Extrapolation (LE) is a frequently applied method to impute missing radiographic data in trials. However, there is frequent critique that LE overestimates…
Abstract Number: 1890 • 2014 ACR/ARHP Annual Meeting
Consistent Inhibition of Bone Destruction By Denosumab in Important Subgroups of Japanese Patients with Rheumatoid Arthritis
Naoki Ishiguro¹, Yoshiya Tanaka², Hisashi Yamanaka³, Toshiyuki Yoneda⁴, Takeshi Ohira⁵, Naoki Okubo⁶, Harry K. Genant⁷, Desiree van der Heijde⁸ and Tsutomu Takeuchi⁹, ¹Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan, ⁴Indiana University School of Medicine, Indianapolis, IN, ⁵Daiich Sankyo Co. Ltd, Tokyo, Japan, ⁶1-2-58, Hiromachi, Daiichi Sankyo Co. Ltd, Tokyo, Japan, ⁷University of California, San Francisco, CCBR-Synarc, Newark, Tiburon, CA, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose Denosumab is a fully human monoclonal antibody (IgG2 subclass) that binds specifically to RANKL, inhibits osteoclast-induced bone resorption by preventing the binding of RANKL…
Abstract Number: 1474 • 2014 ACR/ARHP Annual Meeting
Anti-Peptidyl Arginine Deiminase 4 Antibodies in African-Americans with Rheumatoid Arthritis and Radiographic Scores
Iris Navarro-Millan¹, Andrew Westfall², Erika Darrah^3,4, Antony Rosen⁵, Ted R. Mikuls⁶, Richard Reynolds², Maria I. Danila⁷, Jeffrey R. Curtis² and S. Louis Bridges Jr.^2,8, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Division of Rheumatology, The Johns Hopkins University, Baltimore, MD, ⁴5200 Eastern Ave MFL Bldg Cntr, The Johns Hopkins University, Division of Rheumatology, Baltimore, MD, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The presence of serum autoantibodies to peptidyl arginine deiminase 4 (PAD4) have been associated with erosive rheumatoid arthritis (RA) in populations that were composed…
Abstract Number: 1431 • 2014 ACR/ARHP Annual Meeting
Influence of Radiographic Joint Damage in Mortality Risk in a Cohort of Rheumatoid Arthritis Patients: A 20 Years Survival Study
L. Rodriguez-Rodriguez^1,2, J. Ivorra-Cortes³, Lydia Abasolo^1,4, Leticia Leon^1,4, Oscar Fontsere⁵, B. Fernández-Gutiérrez^1,5 and Juan A Jover^1,4, ¹Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, ²Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ³Rheumatology, University Hospital la Fe, Valencia, Spain, ⁴Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, ⁵Rheumatology, Hospital Clínico San Carlos, Madrid, Spain
Background/Purpose Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased mortality and reduced life expectancy compared with the general population. This mortality gap…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].